IL282577B2 - Antibody-drug conjugates that include actinskidin derivatives - Google Patents

Antibody-drug conjugates that include actinskidin derivatives

Info

Publication number
IL282577B2
IL282577B2 IL282577A IL28257721A IL282577B2 IL 282577 B2 IL282577 B2 IL 282577B2 IL 282577 A IL282577 A IL 282577A IL 28257721 A IL28257721 A IL 28257721A IL 282577 B2 IL282577 B2 IL 282577B2
Authority
IL
Israel
Prior art keywords
substituted
group
alkylene
unsubstituted
formula
Prior art date
Application number
IL282577A
Other languages
English (en)
Hebrew (he)
Other versions
IL282577A (en
IL282577B1 (en
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Publication of IL282577A publication Critical patent/IL282577A/en
Publication of IL282577B1 publication Critical patent/IL282577B1/en
Publication of IL282577B2 publication Critical patent/IL282577B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL282577A 2018-10-25 2019-10-25 Antibody-drug conjugates that include actinskidin derivatives IL282577B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18382759 2018-10-25
PCT/EP2019/079188 WO2020084115A1 (en) 2018-10-25 2019-10-25 Antibody drug conjugates comprising ecteinascidin derivatives

Publications (3)

Publication Number Publication Date
IL282577A IL282577A (en) 2021-06-30
IL282577B1 IL282577B1 (en) 2023-06-01
IL282577B2 true IL282577B2 (en) 2023-10-01

Family

ID=64426824

Family Applications (1)

Application Number Title Priority Date Filing Date
IL282577A IL282577B2 (en) 2018-10-25 2019-10-25 Antibody-drug conjugates that include actinskidin derivatives

Country Status (37)

Country Link
US (1) US12653900B2 (cg-RX-API-DMAC10.html)
EP (1) EP3870234B1 (cg-RX-API-DMAC10.html)
JP (1) JP7629400B2 (cg-RX-API-DMAC10.html)
KR (1) KR20210086669A (cg-RX-API-DMAC10.html)
CN (1) CN113226377B (cg-RX-API-DMAC10.html)
AR (1) AR117657A1 (cg-RX-API-DMAC10.html)
AU (1) AU2019368687B2 (cg-RX-API-DMAC10.html)
BR (1) BR112021007718A2 (cg-RX-API-DMAC10.html)
CA (1) CA3117268C (cg-RX-API-DMAC10.html)
CL (1) CL2021001039A1 (cg-RX-API-DMAC10.html)
CO (1) CO2021006838A2 (cg-RX-API-DMAC10.html)
DK (1) DK3870234T3 (cg-RX-API-DMAC10.html)
EA (1) EA202191131A1 (cg-RX-API-DMAC10.html)
EC (1) ECSP21035414A (cg-RX-API-DMAC10.html)
ES (1) ES2939494T3 (cg-RX-API-DMAC10.html)
FI (1) FI3870234T3 (cg-RX-API-DMAC10.html)
HR (1) HRP20230275T1 (cg-RX-API-DMAC10.html)
HU (1) HUE061606T2 (cg-RX-API-DMAC10.html)
IL (1) IL282577B2 (cg-RX-API-DMAC10.html)
JO (1) JOP20210083B1 (cg-RX-API-DMAC10.html)
LT (1) LT3870234T (cg-RX-API-DMAC10.html)
MA (1) MA59661B1 (cg-RX-API-DMAC10.html)
MD (1) MD3870234T2 (cg-RX-API-DMAC10.html)
MX (1) MX2021004746A (cg-RX-API-DMAC10.html)
MY (1) MY206221A (cg-RX-API-DMAC10.html)
PH (1) PH12021550930A1 (cg-RX-API-DMAC10.html)
PL (1) PL3870234T3 (cg-RX-API-DMAC10.html)
PT (1) PT3870234T (cg-RX-API-DMAC10.html)
RS (1) RS64068B1 (cg-RX-API-DMAC10.html)
SA (1) SA521421855B1 (cg-RX-API-DMAC10.html)
SG (1) SG11202104154WA (cg-RX-API-DMAC10.html)
SI (1) SI3870234T1 (cg-RX-API-DMAC10.html)
SM (1) SMT202300076T1 (cg-RX-API-DMAC10.html)
TW (1) TWI824043B (cg-RX-API-DMAC10.html)
UA (1) UA129803C2 (cg-RX-API-DMAC10.html)
WO (1) WO2020084115A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA202103478B (cg-RX-API-DMAC10.html)

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WO2021218896A1 (zh) * 2020-04-26 2021-11-04 江苏恒瑞医药股份有限公司 海鞘素类衍生物及其制备方法与医药用途
US11124568B1 (en) * 2020-08-19 2021-09-21 Vitruviae LLC CD3/CD25 antibodies for neuro-immune diseases
IL308389A (en) * 2021-05-19 2024-01-01 Pharma Mar Sa Dosing regimens for acubactadine
KR102625740B1 (ko) * 2021-07-15 2024-01-17 주식회사 새한비엠 폐수지 재료 및 미네랄 바인더를 이용한 단열차음재의 제조 방법 및 그 단열차음재
KR20250079227A (ko) * 2022-10-25 2025-06-04 머크 샤프 앤드 돔 엘엘씨 엑사테칸-유래 adc 링커-페이로드, 제약 조성물, 및 그의 용도
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CN118878690B (zh) * 2023-11-28 2026-01-09 南京大学 一种抗地高辛纳米抗体的制备及其应用
WO2025228595A1 (en) * 2024-04-30 2025-11-06 Pharma Mar, S.A. Use of compound ia in the treatment of cancers including combination therapy with atezolizumab.
WO2025228597A1 (en) * 2024-04-30 2025-11-06 Pharma Mar, S.A. Combination of compound ia and a topoisomerase i inhibitor in the treatment of cancer
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WO2026098196A1 (zh) * 2024-11-08 2026-05-15 映恩生物科技(上海)有限公司 海鞘素类化合物、其偶联物及其制备方法和用途

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Also Published As

Publication number Publication date
US12653900B2 (en) 2026-06-16
ZA202103478B (en) 2022-12-21
MA59661B1 (fr) 2023-03-31
HRP20230275T1 (hr) 2023-04-28
BR112021007718A2 (pt) 2021-08-10
SG11202104154WA (en) 2021-05-28
US20230012681A1 (en) 2023-01-19
ES2939494T3 (es) 2023-04-24
AU2019368687B2 (en) 2025-10-23
EP3870234A1 (en) 2021-09-01
CN113226377B (zh) 2022-10-18
ECSP21035414A (es) 2021-06-30
AR117657A1 (es) 2021-08-25
LT3870234T (lt) 2023-03-27
FI3870234T3 (fi) 2023-03-23
JOP20210083A1 (ar) 2023-01-30
CO2021006838A2 (es) 2021-06-10
SMT202300076T1 (it) 2023-05-12
JP2022512830A (ja) 2022-02-07
TWI824043B (zh) 2023-12-01
RS64068B1 (sr) 2023-04-28
JOP20210083B1 (ar) 2024-12-22
KR20210086669A (ko) 2021-07-08
TW202034957A (zh) 2020-10-01
MY206221A (en) 2024-12-04
AU2019368687A1 (en) 2021-06-10
MX2021004746A (es) 2021-08-24
CA3117268A1 (en) 2020-04-30
MD3870234T2 (ro) 2023-05-31
SI3870234T1 (sl) 2023-06-30
CA3117268C (en) 2023-11-21
EA202191131A1 (ru) 2021-10-15
UA129803C2 (uk) 2025-08-06
HUE061606T2 (hu) 2023-07-28
EP3870234B1 (en) 2022-12-21
IL282577A (en) 2021-06-30
WO2020084115A1 (en) 2020-04-30
PT3870234T (pt) 2023-03-06
JP7629400B2 (ja) 2025-02-13
DK3870234T3 (da) 2023-03-20
SA521421855B1 (ar) 2023-12-11
CN113226377A (zh) 2021-08-06
PL3870234T3 (pl) 2023-04-24
PH12021550930A1 (en) 2021-11-22
IL282577B1 (en) 2023-06-01
CL2021001039A1 (es) 2021-10-01

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