JP2022512401A5 - - Google Patents
Info
- Publication number
- JP2022512401A5 JP2022512401A5 JP2021533540A JP2021533540A JP2022512401A5 JP 2022512401 A5 JP2022512401 A5 JP 2022512401A5 JP 2021533540 A JP2021533540 A JP 2021533540A JP 2021533540 A JP2021533540 A JP 2021533540A JP 2022512401 A5 JP2022512401 A5 JP 2022512401A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- linker
- cancer
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024176340A JP2025020131A (ja) | 2018-12-13 | 2024-10-08 | ハーボキシジエンスプライシング調節薬抗体－薬物コンジュゲート及びその使用方法 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862779400P | 2018-12-13 | 2018-12-13 | |
| US201862779406P | 2018-12-13 | 2018-12-13 | |
| US62/779,400 | 2018-12-13 | ||
| US62/779,406 | 2018-12-13 | ||
| US201962941220P | 2019-11-27 | 2019-11-27 | |
| US62/941,220 | 2019-11-27 | ||
| PCT/US2019/066029 WO2020123836A2 (en) | 2018-12-13 | 2019-12-12 | Herboxidiene splicing modulator antibody-drug conjugates and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024176340A Division JP2025020131A (ja) | 2018-12-13 | 2024-10-08 | ハーボキシジエンスプライシング調節薬抗体－薬物コンジュゲート及びその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022512401A JP2022512401A (ja) | 2022-02-03 |
| JP2022512401A5 true JP2022512401A5 (https=) | 2022-12-19 |
| JP7570329B2 JP7570329B2 (ja) | 2024-10-21 |
Family
ID=69160369
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021533540A Active JP7570329B2 (ja) | 2018-12-13 | 2019-12-12 | ハーボキシジエンスプライシング調節薬抗体－薬物コンジュゲート及びその使用方法 |
| JP2024176340A Pending JP2025020131A (ja) | 2018-12-13 | 2024-10-08 | ハーボキシジエンスプライシング調節薬抗体－薬物コンジュゲート及びその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024176340A Pending JP2025020131A (ja) | 2018-12-13 | 2024-10-08 | ハーボキシジエンスプライシング調節薬抗体－薬物コンジュゲート及びその使用方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US12514928B2 (https=) |
| EP (1) | EP3893937A2 (https=) |
| JP (2) | JP7570329B2 (https=) |
| KR (1) | KR20210102274A (https=) |
| CN (2) | CN113271981B (https=) |
| AU (1) | AU2019397062A1 (https=) |
| BR (1) | BR112021010936A2 (https=) |
| CA (1) | CA3114931A1 (https=) |
| CL (4) | CL2021001534A1 (https=) |
| CO (1) | CO2021006503A2 (https=) |
| IL (1) | IL283787A (https=) |
| JO (1) | JOP20210045A1 (https=) |
| MX (3) | MX2021005878A (https=) |
| PE (1) | PE20211473A1 (https=) |
| PH (1) | PH12021551389A1 (https=) |
| SG (1) | SG11202102419VA (https=) |
| TW (2) | TWI853863B (https=) |
| WO (1) | WO2020123836A2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3801523B1 (en) | 2018-06-01 | 2024-09-11 | Eisai R&D Management Co., Ltd. | Splicing modulators |
| CN119405832A (zh) | 2018-06-01 | 2025-02-11 | 卫材R&D管理有限公司 | 剪接调节抗体-药物缀合物及其使用方法 |
| SG11202102419VA (en) | 2018-12-13 | 2021-04-29 | Eisai R&D Man Co Ltd | Herboxidiene splicing modulator antibody-drug conjugates and methods of use |
| WO2021090062A1 (en) | 2019-11-07 | 2021-05-14 | Eisai R&D Management Co., Ltd. | Anti-mesothelin eribulin antibody-drug conjugates and methods of use |
| AU2021284401A1 (en) | 2020-06-05 | 2023-01-05 | Eisai R&D Management Co., Ltd. | Anti-BCMA antibody-drug conjugates and methods of use |
| US20240043928A1 (en) | 2020-11-04 | 2024-02-08 | Eisai R&D Management Co., Ltd. | Biomarkers for myelodysplastic syndrome (mds) and methods of using the same |
| WO2023131866A1 (en) | 2022-01-05 | 2023-07-13 | Eisai R&D Management Co., Ltd. | Biomarkers for myelodysplastic syndrome (mds) and methods of using the same |
| AU2023271885A1 (en) * | 2022-05-20 | 2024-12-12 | Les Laboratoires Servier | Epha2 bcl-xl inhibitor antibody-drug conjugates and methods of use thereof |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4880935A (en) | 1986-07-11 | 1989-11-14 | Icrf (Patents) Limited | Heterobifunctional linking agents derived from N-succinimido-dithio-alpha methyl-methylene-benzoates |
| US4880078A (en) | 1987-06-29 | 1989-11-14 | Honda Giken Kogyo Kabushiki Kaisha | Exhaust muffler |
| IL106992A (en) | 1988-02-11 | 1994-06-24 | Bristol Myers Squibb Co | Acylhydrazone derivatives of anthracycline and methods for their preparation |
| EP0368684B2 (en) | 1988-11-11 | 2004-09-29 | Medical Research Council | Cloning immunoglobulin variable domain sequences. |
| CA2017507C (en) | 1989-05-25 | 1996-11-12 | Gary Van Nest | Adjuvant formulation comprising a submicron oil droplet emulsion |
| CA2109528A1 (en) | 1991-05-01 | 1992-11-02 | Gregory A. Prince | A method for treating infectious respiratory diseases |
| EP1400536A1 (en) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| US5622929A (en) | 1992-01-23 | 1997-04-22 | Bristol-Myers Squibb Company | Thioether conjugates |
| US5934272A (en) | 1993-01-29 | 1999-08-10 | Aradigm Corporation | Device and method of creating aerosolized mist of respiratory drug |
| US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
| US6019968A (en) | 1995-04-14 | 2000-02-01 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
| AU705688B2 (en) | 1995-11-10 | 1999-05-27 | Cytogen Corporation | Peptides which enhance transport across tissues and methods of identifying and using the same |
| DK0871490T3 (da) | 1995-12-22 | 2003-07-07 | Bristol Myers Squibb Co | Forgrenede hydrazonlinkere |
| JP3795604B2 (ja) * | 1995-12-28 | 2006-07-12 | 協和醗酵工業株式会社 | Ｇｅｘ１化合物 |
| AU703922B2 (en) | 1995-12-28 | 1999-04-01 | Kyowa Hakko Kogyo Co. Ltd. | Compound gexi |
| ATE508733T1 (de) | 1996-03-04 | 2011-05-15 | Penn State Res Found | Materialien und verfahren zur steigerung der zellulären internalisierung |
| US5855913A (en) | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US5985309A (en) | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| CA2277801C (en) | 1997-01-16 | 2002-10-15 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| WO1999066903A2 (en) | 1998-06-24 | 1999-12-29 | Advanced Inhalation Research, Inc. | Large porous particles emitted from an inhaler |
| EP1212422B1 (en) | 1999-08-24 | 2007-02-21 | Medarex, Inc. | Human ctla-4 antibodies and their uses |
| PL207087B1 (pl) | 2001-04-26 | 2010-10-29 | Biogen | Przeciwciało, które wiąże się swoiście z białkiem Cripto, zawierająca je kompozycja farmaceutyczna i zastosowanie przeciwciała |
| JP4452787B2 (ja) * | 2003-03-11 | 2010-04-21 | アステラス製薬株式会社 | 新規発酵生産物 |
| EP3101034A1 (en) | 2004-02-12 | 2016-12-07 | Morphotek, Inc. | Monoclonal antibodies that specifically bind to folate receptor alpha |
| DK1791565T3 (en) | 2004-09-23 | 2016-08-01 | Genentech Inc | Cysteingensplejsede antibodies and conjugates |
| EP1928912A4 (en) | 2005-09-07 | 2010-02-24 | Medimmune Inc | EPH ANTI-RECEPTOR ANTIBODIES CONJUGATED TO TOXINS |
| BRPI0717638A2 (pt) | 2006-10-27 | 2013-11-12 | Genentech Inc | Anticorpors e imunoconjugados e usos para os mesmos |
| EP2546345A1 (en) | 2008-06-04 | 2013-01-16 | Eisai R&D Management Co., Ltd. | DNA encoding polypeptide involved in biosynthesis of herboxidiene |
| JPWO2011074621A1 (ja) | 2009-12-18 | 2013-04-25 | 株式会社医学生物学研究所 | メソセリン（ｍｓｌｎ）に対する抗体及びその用途 |
| HK1203971A1 (en) | 2012-05-15 | 2015-11-06 | Bristol-Myers Squibb Company | Cancer immunotherapy by disrupting pd-1/pd-l1 signaling |
| CN104640572B (zh) | 2012-05-15 | 2018-04-27 | 索伦托医疗有限公司 | 药物偶联物，偶联方法，及其用途 |
| US20140069822A1 (en) | 2012-09-10 | 2014-03-13 | Antec Leyden B.V. | Electrochemical reduction of disulfide bonds in proteinaceous substances and electrochemical cell for carrying out such reduction |
| CN105121421B (zh) | 2012-11-05 | 2020-10-02 | 辉瑞公司 | 司普力西欧他汀类似物 |
| US9909128B2 (en) | 2012-11-15 | 2018-03-06 | The Regents Of The University Of California | Splice modulating oligonucleotides that inhibit cancer |
| GB201312318D0 (en) | 2013-07-09 | 2013-08-21 | Isomerase Therapeutics Ltd | Novel methods and compounds |
| CA2924398A1 (en) | 2013-11-05 | 2015-05-14 | Immunomedics, Inc. | Humanized anti-ceacam5 antibody and uses thereof |
| KR102428737B1 (ko) | 2013-11-19 | 2022-08-02 | 퍼듀 리서치 파운데이션 | 항암제 및 그의 제제 |
| RU2715038C2 (ru) | 2014-07-11 | 2020-02-21 | Дженентек, Инк. | Антитела анти-pd-l1 и способы их диагностического применения |
| PE20231050A1 (es) | 2016-03-02 | 2023-07-11 | Eisai Randd Man Co Ltd | Conjugados de anticuerpo y farmaco basados en eribulina y metodos para su uso |
| WO2017156454A1 (en) * | 2016-03-10 | 2017-09-14 | The Regents Of The University Of California | Anti-cancer and splce modulating compounds and methods |
| EP3464379B1 (en) | 2016-06-06 | 2023-09-27 | Abzena (UK) Limited | Antibodies, uses thereof and conjugates thereof |
| JP2019524650A (ja) | 2016-06-08 | 2019-09-05 | ウィリアム マーシュ ライス ユニバーシティＷｉｌｌｉａｍ Ｍａｒｓｈ Ｒｉｃｅ Ｕｎｉｖｅｒｓｉｔｙ | タイランスタチンａの誘導体、それについての治療方法および合成方法 |
| US20200046696A1 (en) | 2017-02-14 | 2020-02-13 | Celgene Corporation | Treatment of cancer with smg1-inhibitors |
| CA3056389A1 (en) | 2017-03-15 | 2018-09-20 | Eisai R&D Management Co., Ltd. | Spliceosome mutations and uses thereof |
| WO2018185618A1 (en) | 2017-04-03 | 2018-10-11 | Novartis Ag | Anti-cdh6 antibody drug conjugates and anti-gitr antibody combinations and methods of treatment |
| GB201711068D0 (en) | 2017-07-10 | 2017-08-23 | Crescendo Biologics Ltd | Therapeutic molecules binding PSMA |
| US11807631B2 (en) * | 2017-07-26 | 2023-11-07 | Purdue Research Foundation | Herboxidiene derivatives and uses thereof |
| EP3801523B1 (en) | 2018-06-01 | 2024-09-11 | Eisai R&D Management Co., Ltd. | Splicing modulators |
| CN119405832A (zh) | 2018-06-01 | 2025-02-11 | 卫材R&D管理有限公司 | 剪接调节抗体-药物缀合物及其使用方法 |
| SG11202102419VA (en) | 2018-12-13 | 2021-04-29 | Eisai R&D Man Co Ltd | Herboxidiene splicing modulator antibody-drug conjugates and methods of use |
| WO2021090062A1 (en) | 2019-11-07 | 2021-05-14 | Eisai R&D Management Co., Ltd. | Anti-mesothelin eribulin antibody-drug conjugates and methods of use |
| JP7821733B2 (ja) | 2020-01-22 | 2026-02-27 | 上海森輝医薬有限公司 | エリブリン誘導体の薬物複合体、その調製方法及びその医薬的応用 |
| AU2021284401A1 (en) | 2020-06-05 | 2023-01-05 | Eisai R&D Management Co., Ltd. | Anti-BCMA antibody-drug conjugates and methods of use |
-
2019
- 2019-12-12 SG SG11202102419VA patent/SG11202102419VA/en unknown
- 2019-12-12 US US17/312,320 patent/US12514928B2/en active Active
- 2019-12-12 EP EP19836349.1A patent/EP3893937A2/en active Pending
- 2019-12-12 TW TW108145609A patent/TWI853863B/zh active
- 2019-12-12 CN CN201980081875.XA patent/CN113271981B/zh active Active
- 2019-12-12 WO PCT/US2019/066029 patent/WO2020123836A2/en not_active Ceased
- 2019-12-12 PE PE2021000860A patent/PE20211473A1/es unknown
- 2019-12-12 BR BR112021010936-6A patent/BR112021010936A2/pt unknown
- 2019-12-12 KR KR1020217018846A patent/KR20210102274A/ko not_active Ceased
- 2019-12-12 MX MX2021005878A patent/MX2021005878A/es unknown
- 2019-12-12 CA CA3114931A patent/CA3114931A1/en active Pending
- 2019-12-12 CN CN202510341677.XA patent/CN120189526A/zh active Pending
- 2019-12-12 PH PH1/2021/551389A patent/PH12021551389A1/en unknown
- 2019-12-12 JP JP2021533540A patent/JP7570329B2/ja active Active
- 2019-12-12 AU AU2019397062A patent/AU2019397062A1/en active Pending
- 2019-12-12 TW TW113128578A patent/TW202519271A/zh unknown
-
2020
- 2020-06-13 JO JOP/2021/0045A patent/JOP20210045A1/ar unknown
-
2021
- 2021-05-19 MX MX2025013917A patent/MX2025013917A/es unknown
- 2021-05-19 MX MX2025013916A patent/MX2025013916A/es unknown
- 2021-05-20 CO CONC2021/0006503A patent/CO2021006503A2/es unknown
- 2021-06-07 IL IL283787A patent/IL283787A/en unknown
- 2021-06-10 CL CL2021001534A patent/CL2021001534A1/es unknown
-
2024
- 2024-01-30 CL CL2024000285A patent/CL2024000285A1/es unknown
- 2024-01-30 CL CL2024000286A patent/CL2024000286A1/es unknown
- 2024-01-30 CL CL2024000282A patent/CL2024000282A1/es unknown
- 2024-10-08 JP JP2024176340A patent/JP2025020131A/ja active Pending
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