JP2022511732A5 - - Google Patents
Info
- Publication number
- JP2022511732A5 JP2022511732A5 JP2021527977A JP2021527977A JP2022511732A5 JP 2022511732 A5 JP2022511732 A5 JP 2022511732A5 JP 2021527977 A JP2021527977 A JP 2021527977A JP 2021527977 A JP2021527977 A JP 2021527977A JP 2022511732 A5 JP2022511732 A5 JP 2022511732A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharmaceutically acceptable
- coo
- cooh
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862773063P | 2018-11-29 | 2018-11-29 | |
| US62/773,063 | 2018-11-29 | ||
| US201862777643P | 2018-12-10 | 2018-12-10 | |
| US62/777,643 | 2018-12-10 | ||
| US201962796524P | 2019-01-24 | 2019-01-24 | |
| US62/796,524 | 2019-01-24 | ||
| US201962828354P | 2019-04-02 | 2019-04-02 | |
| US62/828,354 | 2019-04-02 | ||
| US201962832118P | 2019-04-10 | 2019-04-10 | |
| US62/832,118 | 2019-04-10 | ||
| PCT/US2019/062798 WO2020112542A1 (en) | 2018-11-29 | 2019-11-22 | Combination compositions comprising a beta-lactamase inhibitor and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022511732A JP2022511732A (ja) | 2022-02-01 |
| JP2022511732A5 true JP2022511732A5 (https=) | 2022-11-30 |
| JP7558165B2 JP7558165B2 (ja) | 2024-09-30 |
Family
ID=70852663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021527977A Active JP7558165B2 (ja) | 2018-11-29 | 2019-11-22 | β－ラクタマーゼ阻害剤を含む組み合わせ組成物およびその使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US12544395B2 (https=) |
| EP (1) | EP3886798B1 (https=) |
| JP (1) | JP7558165B2 (https=) |
| KR (1) | KR20210097758A (https=) |
| CN (1) | CN113382713A (https=) |
| AU (1) | AU2019386849B2 (https=) |
| BR (1) | BR112021010095A2 (https=) |
| CA (1) | CA3121130A1 (https=) |
| DK (1) | DK3886798T3 (https=) |
| FI (1) | FI3886798T3 (https=) |
| IL (1) | IL283330B2 (https=) |
| MA (1) | MA54319A (https=) |
| SG (1) | SG11202105505TA (https=) |
| TW (1) | TWI846759B (https=) |
| WO (1) | WO2020112542A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2943204B1 (en) | 2013-01-10 | 2019-03-13 | Venatorx Pharmaceuticals Inc | Beta-lactamase inhibitors |
| PT3154989T (pt) | 2014-06-11 | 2021-05-18 | Venatorx Pharmaceuticals Inc | Inibidores de beta-lactamase |
| CN108472284A (zh) | 2015-09-11 | 2018-08-31 | 维纳拓尔斯制药公司 | β-内酰胺酶抑制剂 |
| ES2894251T3 (es) | 2016-06-30 | 2022-02-14 | Qpex Biopharma Inc | Derivados de ácido borónico y usos terapéuticos de los mismos |
| EP3494121B1 (en) | 2016-08-04 | 2021-10-06 | Venatorx Pharmaceuticals, Inc. | Boron-containing compounds |
| MA47743A (fr) | 2017-03-06 | 2020-01-15 | Venatorx Pharmaceuticals Inc | Formes solides et compositions de combinaison comprenant un inhibiteur de bêta-lactamase et leurs utilisations |
| US11332485B2 (en) | 2017-05-26 | 2022-05-17 | VenatoRx Pharmaceuticals, Inc. | Penicillin-binding protein inhibitors |
| EP3630783A4 (en) | 2017-05-26 | 2021-03-03 | Venatorx Pharmaceuticals, Inc. | PENICILLIN-BINDING PROTEIN INHIBITORS |
| US12016868B2 (en) | 2018-04-20 | 2024-06-25 | Qpex Biopharma, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| EP3802551A4 (en) | 2018-05-25 | 2022-03-02 | Venatorx Pharmaceuticals, Inc. | Penicillin-binding protein inhibitors |
| CN113382713A (zh) | 2018-11-29 | 2021-09-10 | 维纳拓尔斯制药公司 | 包含β-内酰胺酶抑制剂的组合式组合物及其用途 |
| BR112021019656A2 (pt) * | 2019-04-02 | 2022-01-18 | Venatorx Pharmaceuticals Inc | Formas sólidas de um inibidor de beta-lactamase dispensado por via oral e usos das mesmas |
| BR112022022367A2 (pt) | 2020-05-05 | 2023-01-10 | Qpex Biopharma Inc | Derivados e síntese de ácido borônico, formas polimórficas e usos terapêuticos dos mesmos |
| EP4319760A4 (en) * | 2021-04-05 | 2025-01-08 | Qpex Biopharma, Inc. | CEFTIBUTENE DOSAGE REGIMEN |
| WO2025111328A1 (en) * | 2023-11-21 | 2025-05-30 | VenatoRx Pharmaceuticals, Inc. | Citrate coordination complex of an orally-delivered beta-lactamase inhibitor and uses thereof |
Family Cites Families (54)
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|---|---|---|---|---|
| US1A (en) * | 1836-07-13 | John Ruggles | Locomotive steam-engine for rail and other roads | |
| NZ177159A (en) | 1974-04-20 | 1978-03-06 | Beecham Group Ltd | Clavulanic acid, salts, esters and preparation thereof from streptomyces clavuligerus: pharmaceutical compositions |
| US7271186B1 (en) | 2002-12-09 | 2007-09-18 | Northwestern University | Nanomolar β-lactamase inhibitors |
| CA2528587A1 (en) | 2003-06-10 | 2005-01-20 | Fulcrum Pharmaceuticals, Inc. | .beta.-lactamase inhibitors and methods of use thereof |
| ME01975B (me) | 2004-03-30 | 2015-05-20 | Millennium Pharm Inc | Sinteza jedinjenja estra organoborne kiseline i organoborne kiseline |
| CN1965838A (zh) | 2005-11-17 | 2007-05-23 | 李海超 | 含头孢匹胺和β－内酰胺酶抑制剂的药物组合物 |
| CA2783572C (en) | 2005-12-07 | 2016-08-09 | Basilea Pharmaceutica Ag | Useful combinations of monobactam antibiotics with beta-lactamase inhibitors |
| CN101129382B (zh) | 2006-08-25 | 2013-12-25 | 天津和美生物技术有限公司 | 含β-内酰胺类抗生素和缓冲组分的抗生素复方 |
| JP2011504468A (ja) | 2007-11-13 | 2011-02-10 | プロテズ・ファーマシューティカルズ・インコーポレイテッド | β−ラクタマーゼ阻害剤 |
| US20100120715A1 (en) * | 2007-11-13 | 2010-05-13 | Burns Christopher J | Beta-lactamase inhibitors |
| ES2533826T3 (es) | 2008-01-18 | 2015-04-15 | Merck Sharp & Dohme Corp. | Inhibidores de beta-lactamasa |
| WO2010049751A1 (en) | 2008-10-29 | 2010-05-06 | Institut National De La Recherche Agronomique | Lipochitooligosaccharides stimulating arbuscular mycorrhizal symbiosis |
| US20100292185A1 (en) | 2009-05-12 | 2010-11-18 | Burns Christopher J | Beta-lactamase inhibitors |
| MX2012001156A (es) | 2009-07-28 | 2012-05-08 | Anacor Pharmaceuticals Inc | Moleculas que contienen boro trisustituidas. |
| RS60310B1 (sr) | 2010-08-10 | 2020-07-31 | Rempex Pharmaceuticals Inc | Ciklični derivati estra boronske kiseline, postupak za pripremu injihove terapeutske upotrebe |
| EP2768503A1 (en) | 2011-07-26 | 2014-08-27 | Wockhardt Limited | Pharmaceutical compositions comprising beta-lactam antibiotic, sulbactam and beta-lactamase inhibitor |
| WO2013053372A1 (en) | 2011-10-13 | 2013-04-18 | Therabor Pharmaceuticals | Boronic acid inhibitors of beta-lactamases |
| WO2013056163A1 (en) | 2011-10-14 | 2013-04-18 | The Regents Of The University Of California | Beta-lactamase inhibitors |
| KR101288157B1 (ko) | 2011-12-07 | 2013-07-19 | 백병하 | 기존 세파계 항생제 및 베타 락타마제 저해제로 배합된 내성균주에 기인한 감염증의 치료 및 예방을 위한 복합항생제 |
| SG11201403254QA (en) | 2011-12-22 | 2014-07-30 | Ares Trading Sa | Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors |
| EP2814483A2 (en) | 2012-02-15 | 2014-12-24 | Rempex Pharmaceuticals, Inc. | Methods of treating bacterial infections |
| DE102012101680A1 (de) | 2012-02-29 | 2013-08-29 | Aicuris Gmbh & Co. Kg | Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat |
| MX2015006715A (es) | 2012-12-03 | 2015-08-14 | Hoffmann La Roche | Compuestos de acido triazolboronico sustituido. |
| CN105026407B (zh) | 2012-12-07 | 2017-09-08 | 维纳拓尔斯制药公司 | β‑内酰胺酶抑制剂 |
| US9101638B2 (en) | 2013-01-04 | 2015-08-11 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| KR20150103270A (ko) | 2013-01-04 | 2015-09-09 | 렘펙스 파머수티클스 인코퍼레이티드 | 보론산 유도체 및 그의 치료적 용도 |
| KR20150103269A (ko) | 2013-01-04 | 2015-09-09 | 렘펙스 파머수티클스 인코퍼레이티드 | 보론산 유도체 및 그의 치료적 용도 |
| EP2943204B1 (en) | 2013-01-10 | 2019-03-13 | Venatorx Pharmaceuticals Inc | Beta-lactamase inhibitors |
| WO2014151958A1 (en) | 2013-03-14 | 2014-09-25 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| US9120796B2 (en) | 2013-10-02 | 2015-09-01 | Cubist Pharmaceuticals, Inc. | B-lactamase inhibitor picoline salt |
| BR112016016130A2 (pt) | 2014-01-10 | 2017-08-08 | Glaxosmithkline Ip No 2 Ltd | Compostos e métodos |
| WO2015157618A1 (en) | 2014-04-11 | 2015-10-15 | The Texas A&M University System | Novel inhibitors of the new delhi metallo beta lactamase (ndm-1) |
| EP3139930B1 (en) | 2014-05-05 | 2024-08-14 | Melinta Therapeutics, Inc. | Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof |
| SI3140310T1 (sl) | 2014-05-05 | 2020-01-31 | Rempex Pharmaceuticals, Inc. | Sinteza boronatnih soli in njihova uporaba |
| WO2015179308A1 (en) | 2014-05-19 | 2015-11-26 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| US20150361108A1 (en) | 2014-06-11 | 2015-12-17 | VenatoRx Pharmaceuticals, Inc. | Orally bioavailable beta-lactamase inhibitors |
| PT3154989T (pt) * | 2014-06-11 | 2021-05-18 | Venatorx Pharmaceuticals Inc | Inibidores de beta-lactamase |
| US20150361107A1 (en) | 2014-06-11 | 2015-12-17 | VenatoRx Pharmaceuticals, Inc. | Orally bioavailable beta-lactamase inhibitors |
| US9511142B2 (en) | 2014-06-11 | 2016-12-06 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| EA201692301A1 (ru) | 2014-07-01 | 2017-06-30 | Ремпекс Фармасьютикалз, Инк. | Производные бороновой кислоты и их терапевтическое применение |
| JP6218204B2 (ja) | 2014-09-04 | 2017-10-25 | 塩野義製薬株式会社 | カテコール基を有するセファロスポリン類を含有する製剤 |
| EP3233869B1 (en) | 2014-12-19 | 2019-09-25 | Rempex Pharmaceuticals, Inc. | Apparatus and continuous flow process for production of boronic acid derivatives |
| CN108472284A (zh) | 2015-09-11 | 2018-08-31 | 维纳拓尔斯制药公司 | β-内酰胺酶抑制剂 |
| WO2017100537A1 (en) | 2015-12-10 | 2017-06-15 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| CN105801610B (zh) | 2016-04-19 | 2018-05-18 | 武汉维舜医药科技有限公司 | 新型广谱β-内酰胺酶抑制剂 |
| ES2894251T3 (es) | 2016-06-30 | 2022-02-14 | Qpex Biopharma Inc | Derivados de ácido borónico y usos terapéuticos de los mismos |
| EP3494121B1 (en) | 2016-08-04 | 2021-10-06 | Venatorx Pharmaceuticals, Inc. | Boron-containing compounds |
| MA47743A (fr) | 2017-03-06 | 2020-01-15 | Venatorx Pharmaceuticals Inc | Formes solides et compositions de combinaison comprenant un inhibiteur de bêta-lactamase et leurs utilisations |
| CN106946924A (zh) | 2017-05-11 | 2017-07-14 | 蚌埠中实化学技术有限公司 | 一种3‑羧基苯硼酸的制备方法 |
| EP3630783A4 (en) | 2017-05-26 | 2021-03-03 | Venatorx Pharmaceuticals, Inc. | PENICILLIN-BINDING PROTEIN INHIBITORS |
| EP3849562B1 (en) | 2018-09-12 | 2024-06-26 | Venatorx Pharmaceuticals, Inc. | Combination compositions comprising a beta-lactamase inhibitor |
| CN113382713A (zh) | 2018-11-29 | 2021-09-10 | 维纳拓尔斯制药公司 | 包含β-内酰胺酶抑制剂的组合式组合物及其用途 |
| BR112021019656A2 (pt) | 2019-04-02 | 2022-01-18 | Venatorx Pharmaceuticals Inc | Formas sólidas de um inibidor de beta-lactamase dispensado por via oral e usos das mesmas |
| EP4225321A4 (en) | 2020-10-07 | 2024-11-20 | Venatorx Pharmaceuticals, Inc. | PROCESS FOR BORON-CONTAINING COMPOUNDS |
-
2019
- 2019-11-22 CN CN201980090780.4A patent/CN113382713A/zh active Pending
- 2019-11-22 SG SG11202105505TA patent/SG11202105505TA/en unknown
- 2019-11-22 JP JP2021527977A patent/JP7558165B2/ja active Active
- 2019-11-22 BR BR112021010095-4A patent/BR112021010095A2/pt unknown
- 2019-11-22 FI FIEP19890645.5T patent/FI3886798T3/fi active
- 2019-11-22 WO PCT/US2019/062798 patent/WO2020112542A1/en not_active Ceased
- 2019-11-22 IL IL283330A patent/IL283330B2/en unknown
- 2019-11-22 MA MA054319A patent/MA54319A/fr unknown
- 2019-11-22 KR KR1020217020342A patent/KR20210097758A/ko not_active Ceased
- 2019-11-22 EP EP19890645.5A patent/EP3886798B1/en active Active
- 2019-11-22 US US17/296,371 patent/US12544395B2/en active Active
- 2019-11-22 DK DK19890645.5T patent/DK3886798T3/da active
- 2019-11-22 AU AU2019386849A patent/AU2019386849B2/en active Active
- 2019-11-22 CA CA3121130A patent/CA3121130A1/en active Pending
- 2019-11-22 TW TW108142575A patent/TWI846759B/zh active
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