JP2022506685A5 - - Google Patents

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Publication number
JP2022506685A5
JP2022506685A5 JP2021524225A JP2021524225A JP2022506685A5 JP 2022506685 A5 JP2022506685 A5 JP 2022506685A5 JP 2021524225 A JP2021524225 A JP 2021524225A JP 2021524225 A JP2021524225 A JP 2021524225A JP 2022506685 A5 JP2022506685 A5 JP 2022506685A5
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JP2021524225A
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JP7170133B2 (ja
JP2022506685A (ja
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Priority claimed from PCT/US2019/060155 external-priority patent/WO2020097265A1/en
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Priority to JP2022174578A priority Critical patent/JP7357135B2/ja
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JP2021524225A 2018-11-06 2019-11-06 ピリダジノン化合物およびその使用 Active JP7170133B2 (ja)

Priority Applications (1)

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JP2022174578A JP7357135B2 (ja) 2018-11-06 2022-10-31 ピリダジノン化合物およびその使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862756539P 2018-11-06 2018-11-06
US62/756,539 2018-11-06
PCT/US2019/060155 WO2020097265A1 (en) 2018-11-06 2019-11-06 Pyridazinone compounds and uses thereof

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JP2022174578A Division JP7357135B2 (ja) 2018-11-06 2022-10-31 ピリダジノン化合物およびその使用

Publications (3)

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JP2022506685A JP2022506685A (ja) 2022-01-17
JP2022506685A5 true JP2022506685A5 (https=) 2022-05-17
JP7170133B2 JP7170133B2 (ja) 2022-11-11

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JP2022174578A Active JP7357135B2 (ja) 2018-11-06 2022-10-31 ピリダジノン化合物およびその使用

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US (3) US11236065B2 (https=)
EP (2) EP3877052B1 (https=)
JP (2) JP7170133B2 (https=)
KR (1) KR102885525B1 (https=)
CN (1) CN113272014B (https=)
AU (1) AU2019376647B2 (https=)
BR (1) BR112021008903A2 (https=)
CA (1) CA3118908A1 (https=)
DK (1) DK3877052T3 (https=)
EA (1) EA202191082A1 (https=)
ES (1) ES2957383T3 (https=)
IL (1) IL282997B1 (https=)
MX (1) MX2021005348A (https=)
PL (1) PL3877052T3 (https=)
SG (1) SG11202104710WA (https=)
WO (1) WO2020097265A1 (https=)
ZA (1) ZA202103231B (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019126731A1 (en) * 2017-12-22 2019-06-27 Petra Pharma Corporation Aminopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors
JP2021514010A (ja) * 2018-02-20 2021-06-03 エッジワイズ セラピューティクス, インコーポレイテッド 運動障害を処置するための方法および組成物
ES2958954T3 (es) * 2018-11-06 2024-02-16 Edgewise Therapeutics Inc Compuestos de piridazinona y usos de los mismos
EP3877052B1 (en) 2018-11-06 2023-08-16 Edgewise Therapeutics, Inc. Pyridazinone compounds and uses thereof
WO2020097258A1 (en) 2018-11-06 2020-05-14 Edgewise Therapeutics, Inc. Pyridazinone compounds and uses thereof
TW202112767A (zh) 2019-06-17 2021-04-01 美商佩特拉製藥公司 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物
WO2021231546A1 (en) * 2020-05-13 2021-11-18 Edgewise Therapeutics, Inc. Substituted pyridazinone for use in the treatment of neuromuscular diseases
EP4149620B1 (en) * 2020-05-13 2024-10-23 Edgewise Therapeutics, Inc. Pyridazinone compounds for the treatment of neuromuscular diseases
WO2021231630A1 (en) * 2020-05-13 2021-11-18 Edgewise Therapeutics, Inc. Substituted pyridazinone for use in the treatment of neuromuscular diseases
JP7758687B2 (ja) * 2020-05-13 2025-10-22 エッジワイズ セラピューティクス, インコーポレイテッド 神経筋疾患の処置のためのピリダジノン化合物
KR20230035049A (ko) * 2020-07-02 2023-03-10 데날리 테라퓨틱스 인크. 화합물, 조성물 및 방법
EP4433473A1 (en) * 2021-11-17 2024-09-25 Edgewise Therapeutics, Inc. Pyridazinone compounds and uses thereof
WO2024015527A1 (en) * 2022-07-13 2024-01-18 Bayesian Biotech, Llc Therapeutic combinations of drugs, companion diagnostics and methods for dosaging and using them
JP2025530218A (ja) 2022-09-09 2025-09-11 エッジワイズ セラピューティクス, インコーポレイテッド 神経筋の状態の処置のためのピリダジノン組成物
WO2024206339A1 (en) 2023-03-27 2024-10-03 Edgewise Therapeutics, Inc. Quinolinone amide compounds and uses thereof
EP4688756A1 (en) 2023-03-27 2026-02-11 Edgewise Therapeutics, Inc. Quinazoline dione compounds and uses thereof
WO2025207665A1 (en) * 2024-03-26 2025-10-02 Edgewise Therapeutics, Inc. Quinolinone compounds and uses thereof
WO2025207622A1 (en) * 2024-03-26 2025-10-02 Edgewise Therapeutics, Inc. Quinolinone, benzoxazinone, and quinoline compounds and uses thereof
WO2025207677A1 (en) * 2024-03-26 2025-10-02 Edgewise Therapeutics, Inc. Quinazolinone compounds and uses thereof
WO2025207679A1 (en) * 2024-03-26 2025-10-02 Edgewise Therapeutics, Inc. Quinazoline dione compounds and uses thereof
GB2640329A (en) * 2024-04-09 2025-10-15 Imperial College Innovations Ltd Hedgehog acyltransferase inhibitors
WO2025215121A1 (en) * 2024-04-09 2025-10-16 Imperial College Innovations Limited Hedgehog acyltransferase inhibitors

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE286354C (https=)
JPS6140270A (ja) 1984-08-01 1986-02-26 Morishita Seiyaku Kk ピリダジノン誘導体
DE69131268T2 (de) 1990-09-21 1999-12-30 Rohm And Haas Co., Philadelphia Dihydropyridazinone und Pyridazinone als Fungizide
US6334997B1 (en) 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
ES2293638T3 (es) 1994-03-25 2008-03-16 Isotechnika, Inc. Mejora de la eficacia de farmacos por deuteracion.
IL118631A (en) 1995-06-27 2002-05-23 Tanabe Seiyaku Co History of pyridazinone and processes for their preparation
DE19629817A1 (de) 1996-07-24 1998-01-29 Hoechst Ag Neue Imino-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
NZ522882A (en) 2000-06-05 2004-07-30 Altana Pharma Bv Pyridazinone compounds effective as beta-2-adrenoreceptor agonists as well as PDE4-inhibitors
WO2004022540A2 (en) * 2002-09-06 2004-03-18 Fujisawa Pharmaceutical Co., Ltd. Pyridazinone and pyridone derivatives as adenosine antagonists
BRPI0407519A (pt) 2003-03-07 2006-02-14 Kowa Co derivados de benzofurano
WO2006095666A1 (ja) 2005-03-07 2006-09-14 Kyorin Pharmaceutical Co., Ltd. ピラゾロピリジン-4-イルピリダジノン誘導体とその付加塩及びそれらを有効成分とするpde阻害剤
WO2007044796A2 (en) 2005-10-11 2007-04-19 Nps Pharmaceuticals, Inc. Pyridazinone compounds as calcilytics
DE102005057924A1 (de) 2005-12-05 2007-06-06 Merck Patent Gmbh Pyridazinonderivate
HRP20130044T1 (hr) 2006-07-25 2013-02-28 Cephalon, Inc. Derivati piridizinona
MX2009008531A (es) 2007-02-16 2009-08-26 Amgen Inc Cetonas de heterociclilo que contienen nitrogeno y su uso como inhibidores de c-met.
DE102007025717A1 (de) 2007-06-01 2008-12-11 Merck Patent Gmbh Arylether-pyridazinonderivate
DE102007025718A1 (de) 2007-06-01 2008-12-04 Merck Patent Gmbh Pyridazinonderivate
DE102007032507A1 (de) 2007-07-12 2009-04-02 Merck Patent Gmbh Pyridazinonderivate
GB0715087D0 (en) * 2007-08-03 2007-09-12 Summit Corp Plc Drug combinations for the treatment of duchenne muscular dystrophy
DE102007038957A1 (de) 2007-08-17 2009-02-19 Merck Patent Gmbh 6-Thioxo-pyridazinderivate
DE102008019907A1 (de) 2008-04-21 2009-10-22 Merck Patent Gmbh Pyridazinonderivate
WO2009142732A2 (en) * 2008-05-20 2009-11-26 Cephalon, Inc. Substituted pyridazinone derivatives as histamine-3 (h3) receptor ligands
WO2010048149A2 (en) 2008-10-20 2010-04-29 Kalypsys, Inc. Heterocyclic modulators of gpr119 for treatment of disease
AR081331A1 (es) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
AR081626A1 (es) * 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
WO2012021707A2 (en) 2010-08-11 2012-02-16 The Regents Of The University Of California Premature-termination-codons readthrough compounds
US8975260B2 (en) 2010-09-01 2015-03-10 Genetech, Inc Pyridazinones, method of making, and method of use thereof
US8759380B2 (en) 2011-04-22 2014-06-24 Cytokinetics, Inc. Certain heterocycles, compositions thereof, and methods for their use
WO2013057101A1 (de) 2011-10-17 2013-04-25 Bayer Intellectual Property Gmbh Substituierte oxadiazolylpyridinone und - pyridazinone als hif - hemmer
CN103570730A (zh) 2012-08-01 2014-02-12 中国科学院上海药物研究所 具有桥环结构的稠环哒嗪酮类化合物及其制备方法和用途
WO2014031928A2 (en) 2012-08-24 2014-02-27 Philip Jones Heterocyclic modulators of hif activity for treatment of disease
US9566310B2 (en) * 2012-09-10 2017-02-14 Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Reno Methods of treating muscular dystrophy
US9216180B2 (en) 2012-10-02 2015-12-22 New York University Pharmaceutical compositions and treatment of genetic diseases associated with nonsense mediated RNA decay
JP2016507496A (ja) 2012-12-21 2016-03-10 ゼニス・エピジェネティクス・コーポレイションZenith Epigenetics Corp. ブロモドメイン阻害剤としての新規複素環式化合物
HUE032863T2 (en) 2013-02-07 2017-11-28 Merck Patent Gmbh Piridazinonamid derivatives
EP2968323A4 (en) 2013-03-13 2016-12-14 Flatley Discovery Lab PYRIDAZINONE COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS
WO2014189634A1 (en) * 2013-04-19 2014-11-27 University Of Iowa Research Foundation Angiotensins in muscular dystrophy
WO2019051125A1 (en) * 2017-09-06 2019-03-14 Translational Drug Development, Llc AMINOBENZIMIDAZOLE DERIVATIVES, TREATMENTS AND METHODS FOR INHIBITING HISTONE DEACETYLASE
CA2987980A1 (en) * 2015-06-05 2016-12-08 Ptc Therapeutics, Inc. Use of an aminoglycoside for nonsense mutation suppression and the treatment of disease
EP3307891B8 (en) * 2015-06-10 2019-11-13 Association Institut de Myologie Combined therapy for duchenne muscular dystrophy
CN106467495A (zh) 2015-08-19 2017-03-01 中国科学院上海药物研究所 哒嗪酮类化合物、其制备方法、药物组合物及用途
WO2017046117A1 (en) 2015-09-15 2017-03-23 Abbvie Inc. Substituted isoxazolopyridazinones and isothiazolopyridazinones and methods of use
WO2018081378A1 (en) * 2016-10-26 2018-05-03 Proteostasis Therapeutics, Inc. Compounds, compositions, and methods for modulating cftr
CA3041675A1 (en) * 2016-10-26 2018-05-03 Proteostasis Therapeutics, Inc. N-phenyl-2-(3-phenyl-6-oxo-1,6-dihydropyridazin-1-yl)acetamide derivatives for treating cystic fibrosis
WO2018081381A1 (en) 2016-10-26 2018-05-03 Proteostasis Therapeutics, Inc Pyridazine derivatives, compositions and methods for modulating cftr
CN110573161A (zh) 2017-03-28 2019-12-13 勃林格殷格翰国际有限公司 用于治疗肌营养不良的方法的尼达尼布
TWI829634B (zh) 2017-04-06 2024-01-21 美商富曼西公司 殺真菌之噁二唑
US20180303821A1 (en) 2017-04-24 2018-10-25 BraneQuest, Inc. Membrane active molecules
BE1025518B1 (fr) 2017-08-30 2019-04-03 E2 Drives Sa Groupe motopropulseur
US11065243B2 (en) 2017-10-27 2021-07-20 Sonic Master Limited Inhibitors of DUX4 induction for regulation of muscle function
JP7623680B2 (ja) 2018-05-17 2025-01-29 ボルト スレッズ インコーポレイテッド 組換えタンパク質の分泌を改善するためのsec改変株
EP4685140A1 (en) 2018-06-04 2026-01-28 Ohio State Innovation Foundation Eaat2 activators and methods of using thereof
EP3828174A4 (en) 2018-07-19 2022-08-17 Sumitomo Pharma Co., Ltd. PYRIDAZINONE DERIVATIVE
CN108947912B (zh) 2018-07-31 2021-10-01 中国人民解放军总医院 一种靶向Neddylation通路的抗肿瘤化合物
WO2020097258A1 (en) 2018-11-06 2020-05-14 Edgewise Therapeutics, Inc. Pyridazinone compounds and uses thereof
EP3877052B1 (en) 2018-11-06 2023-08-16 Edgewise Therapeutics, Inc. Pyridazinone compounds and uses thereof
ES2958954T3 (es) * 2018-11-06 2024-02-16 Edgewise Therapeutics Inc Compuestos de piridazinona y usos de los mismos
EP4149620B1 (en) 2020-05-13 2024-10-23 Edgewise Therapeutics, Inc. Pyridazinone compounds for the treatment of neuromuscular diseases
JP7758687B2 (ja) 2020-05-13 2025-10-22 エッジワイズ セラピューティクス, インコーポレイテッド 神経筋疾患の処置のためのピリダジノン化合物
WO2021231630A1 (en) 2020-05-13 2021-11-18 Edgewise Therapeutics, Inc. Substituted pyridazinone for use in the treatment of neuromuscular diseases
WO2021231546A1 (en) 2020-05-13 2021-11-18 Edgewise Therapeutics, Inc. Substituted pyridazinone for use in the treatment of neuromuscular diseases
WO2021231615A1 (en) 2020-05-13 2021-11-18 Edgewise Therapeutics, Inc. Substituted pyridazinone for use in the treatment of neuromuscular diseases
JP7694135B2 (ja) 2021-05-11 2025-06-18 株式会社大林組 接続構造及び接続方法
EP4433473A1 (en) 2021-11-17 2024-09-25 Edgewise Therapeutics, Inc. Pyridazinone compounds and uses thereof
EP4522599A1 (en) 2022-05-11 2025-03-19 Edgewise Therapeutics, Inc. Methods of manufacturing pyridazinone compounds
JP2025530218A (ja) 2022-09-09 2025-09-11 エッジワイズ セラピューティクス, インコーポレイテッド 神経筋の状態の処置のためのピリダジノン組成物

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