JP2022501408A5 - - Google Patents
Info
- Publication number
- JP2022501408A5 JP2022501408A5 JP2021517865A JP2021517865A JP2022501408A5 JP 2022501408 A5 JP2022501408 A5 JP 2022501408A5 JP 2021517865 A JP2021517865 A JP 2021517865A JP 2021517865 A JP2021517865 A JP 2021517865A JP 2022501408 A5 JP2022501408 A5 JP 2022501408A5
- Authority
- JP
- Japan
- Prior art keywords
- peg
- aminolipidized
- tertiary
- cationic peptide
- modified cationic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862738717P | 2018-09-28 | 2018-09-28 | |
| US62/738,717 | 2018-09-28 | ||
| US201962885036P | 2019-08-09 | 2019-08-09 | |
| US62/885,036 | 2019-08-09 | ||
| PCT/US2019/053655 WO2020069442A1 (en) | 2018-09-28 | 2019-09-27 | Tertiary amino lipidated cationic peptides for nucleic acid delivery |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022501408A JP2022501408A (ja) | 2022-01-06 |
| JP2022501408A5 true JP2022501408A5 (enExample) | 2022-10-05 |
| JP7418419B2 JP7418419B2 (ja) | 2024-01-19 |
Family
ID=69952323
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021517865A Active JP7418419B2 (ja) | 2018-09-28 | 2019-09-27 | 核酸送達のための第三級アミノ脂質化カチオン性ペプチド |
| JP2021517802A Active JP7430713B2 (ja) | 2018-09-28 | 2019-09-27 | 核酸送達のための脂質化カチオン性ペプチド化合物を含む脂質ナノ粒子製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021517802A Active JP7430713B2 (ja) | 2018-09-28 | 2019-09-27 | 核酸送達のための脂質化カチオン性ペプチド化合物を含む脂質ナノ粒子製剤 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US20210322575A1 (enExample) |
| EP (2) | EP3856757A4 (enExample) |
| JP (2) | JP7418419B2 (enExample) |
| KR (2) | KR20210068093A (enExample) |
| CN (2) | CN112789031B (enExample) |
| AU (2) | AU2019351268A1 (enExample) |
| BR (2) | BR112021004929A2 (enExample) |
| CA (2) | CA3110914A1 (enExample) |
| IL (2) | IL281135B2 (enExample) |
| MX (2) | MX2021003420A (enExample) |
| MY (1) | MY204458A (enExample) |
| SG (2) | SG11202102164PA (enExample) |
| WO (2) | WO2020069442A1 (enExample) |
| ZA (2) | ZA202101376B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3856757A4 (en) * | 2018-09-28 | 2022-06-29 | Nutcracker Therapeutics, Inc. | Tertiary amino lipidated cationic peptides for nucleic acid delivery |
| AU2020329156A1 (en) * | 2019-08-09 | 2022-03-03 | Nutcracker Therapeutics, Inc. | Lipidated cationic peptide-PEG compositions for nucleic acid delivery |
| TW202206083A (zh) * | 2020-04-22 | 2022-02-16 | 美商胡桃夾子治療公司 | mRNA治療奈米粒子 |
| WO2022032058A1 (en) | 2020-08-07 | 2022-02-10 | Nutcracker Therapeutics, Inc. | Multicomponent delivery systems for polyanionic cargo compound delivery |
| NL2026825B1 (en) | 2020-08-07 | 2022-04-05 | Nutcracker Therapeutics Inc | Multicomponent delivery system for polyanionic cargo compound delivery |
| IL303434A (en) * | 2020-12-07 | 2023-08-01 | Tufts College | Lipidoid preparations and methods of using them |
| US20220378702A1 (en) * | 2021-05-05 | 2022-12-01 | Arcturus Therapeutics, Inc. | Peptide-lipid conjugates |
| NL2029057B1 (en) | 2021-08-06 | 2023-02-21 | Nutcracker Therapeutics Inc | Compositions comprising hydroxyethyl-capped cationic peptoids |
| CA3227513A1 (en) | 2021-08-06 | 2023-02-09 | Colin James MCKINLAY | Compositions comprising hydroxyethyl-capped cationic peptoids |
| CN114778712B (zh) * | 2022-03-21 | 2023-06-02 | 天津键凯科技有限公司 | 一种聚乙二醇脂质及含有该脂质的脂质纳米粒含量的检测方法 |
| JP2025531758A (ja) | 2022-09-09 | 2025-09-25 | ナッツクラッカー セラピューティクス， インコーポレイテッド | 核酸送達のための２－アミノプロパン－１，３－ジオールでキャップされたカチオン性ペプトイド |
| US20250026779A1 (en) | 2023-06-29 | 2025-01-23 | Nutcracker Therapeutics, Inc. | Ethyl modified rna caps and methods of use |
| CN121793991A (zh) * | 2023-09-05 | 2026-04-03 | 韩国生命工学研究院 | 使用脂质纳米颗粒的核酸递送系统 |
| WO2025137277A1 (en) | 2023-12-19 | 2025-06-26 | Nutcracker Therapeutics, Inc. | Degradable peptoids |
| TW202543585A (zh) | 2024-03-08 | 2025-11-16 | 美商健臻公司 | 脂質奈米粒子 |
| WO2026003582A2 (en) | 2024-06-27 | 2026-01-02 | Axelyf ehf. | Lipids and lipid nanoparticles |
| WO2026030375A2 (en) | 2024-07-30 | 2026-02-05 | Genzyme Corporation | Lipid nanoparticles and methods of manufacture and use thereof |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5981501A (en) | 1995-06-07 | 1999-11-09 | Inex Pharmaceuticals Corp. | Methods for encapsulating plasmids in lipid bilayers |
| US7422902B1 (en) | 1995-06-07 | 2008-09-09 | The University Of British Columbia | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer |
| AU733310C (en) | 1997-05-14 | 2001-11-29 | University Of British Columbia, The | High efficiency encapsulation of charged therapeutic agents in lipid vesicles |
| US6191115B1 (en) * | 1998-08-12 | 2001-02-20 | Abbott Laboratories | C-terminus modified heptapeptide LHRH analogs |
| ATE388226T1 (de) * | 1999-08-27 | 2008-03-15 | Novartis Vaccines & Diagnostic | Chimerische antisense-oligonukleotide und zelltransfektions-zusammensetzungen davon |
| JP2004535388A (ja) * | 2001-04-30 | 2004-11-25 | ターゲティッド ジェネティクス コーポレイション | 脂質含有薬物送達複合体およびそれらの生成方法 |
| EP1519714B1 (en) | 2002-06-28 | 2010-10-20 | Protiva Biotherapeutics Inc. | Method and apparatus for producing liposomes |
| CA2532228C (en) * | 2003-07-16 | 2017-02-14 | Protiva Biotherapeutics, Inc. | Lipid encapsulated interfering rna |
| EP1709195B1 (en) * | 2003-12-19 | 2014-01-22 | Novartis Vaccines and Diagnostics, Inc. | Cell transfecting formulations of small interfering rna, related compositions and methods of making and use |
| ITMI20061607A1 (it) * | 2006-08-09 | 2008-02-10 | Maria Vincenza Carriero | Peptidi con attivita farmacologica |
| CN106267902B (zh) | 2007-06-04 | 2019-08-20 | 高压生物科学公司 | 分子的压力提高的提取和分配 |
| CA2721333C (en) | 2008-04-15 | 2020-12-01 | Protiva Biotherapeutics, Inc. | Novel lipid formulations for nucleic acid delivery |
| WO2009132131A1 (en) * | 2008-04-22 | 2009-10-29 | Alnylam Pharmaceuticals, Inc. | Amino lipid based improved lipid formulation |
| CN111808084A (zh) | 2008-11-10 | 2020-10-23 | 阿布特斯生物制药公司 | 用于递送治疗剂的新型脂质和组合物 |
| US20110305769A1 (en) * | 2008-11-17 | 2011-12-15 | Enzon Pharmaceuticals, Inc. | Branched cationic lipids for nucleic acids delivery system |
| WO2011000107A1 (en) | 2009-07-01 | 2011-01-06 | Protiva Biotherapeutics, Inc. | Novel lipid formulations for delivery of therapeutic agents to solid tumors |
| US20110053829A1 (en) * | 2009-09-03 | 2011-03-03 | Curevac Gmbh | Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids |
| CN107028886A (zh) | 2009-11-04 | 2017-08-11 | 不列颠哥伦比亚大学 | 含有核酸的脂质粒子及相关的方法 |
| EP3318248B1 (en) | 2009-12-01 | 2019-04-10 | Translate Bio, Inc. | Delivery of mrna for the augmentation of proteins and enzymes in human genetic diseases |
| DK2575767T3 (en) | 2010-06-04 | 2017-03-13 | Sirna Therapeutics Inc | HOWEVER UNKNOWN LOW MOLECULAR CATIONIC LIPIDS TO PROCESS OIGONUCLEOTIDES |
| US9006417B2 (en) | 2010-06-30 | 2015-04-14 | Protiva Biotherapeutics, Inc. | Non-liposomal systems for nucleic acid delivery |
| DK2631291T3 (da) | 2010-10-22 | 2019-06-11 | Olix Pharmaceuticals Inc | Nukleinsyremolekyler, der inducerer rna-interferens, og anvendelser deraf |
| EP2686342A2 (en) * | 2011-04-12 | 2014-01-22 | The Government of The United States of America, as represented by The Secretary, Department of Health and Human Services | Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use |
| RU2013154295A (ru) | 2011-06-08 | 2015-07-20 | Шир Хьюман Дженетик Терапис, Инк. | КОМПОЗИЦИИ ЛИПИДНЫХ НАНОЧАСТИЦ И СПОСОБЫ ДЛЯ ДОСТАВКИ мРНК |
| US9579338B2 (en) | 2011-11-04 | 2017-02-28 | Nitto Denko Corporation | Method of producing lipid nanoparticles for drug delivery |
| US9035039B2 (en) | 2011-12-22 | 2015-05-19 | Protiva Biotherapeutics, Inc. | Compositions and methods for silencing SMAD4 |
| AU2013240051B2 (en) | 2012-03-27 | 2017-11-30 | Sirna Therapeutics, Inc. | Diether based biodegradable cationic lipids for siRNA delivery |
| KR101480055B1 (ko) | 2012-04-04 | 2015-01-09 | 주식회사 삼양바이오팜 | 음이온성 약물 전달체의 제조 방법 |
| EP2858679B2 (en) | 2012-06-08 | 2024-06-05 | Translate Bio, Inc. | Pulmonary delivery of mrna to non-lung target cells |
| WO2013192310A1 (en) | 2012-06-19 | 2013-12-27 | Massachusetts Institute Of Technology | Mass production and size control of nanoparticles through controlled microvortices |
| TW201408625A (zh) | 2012-07-06 | 2014-03-01 | Kyowa Hakko Kirin Co Ltd | 陽離子性脂質 |
| WO2014089239A1 (en) | 2012-12-07 | 2014-06-12 | Alnylam Pharmaceuticals, Inc. | Improved nucleic acid lipid particle formulations |
| EP3750903A1 (en) | 2013-03-14 | 2020-12-16 | Translate Bio, Inc. | Ribonucleic acids with 4'-thio-modified nucleotides and related methods |
| KR102354389B1 (ko) | 2013-08-21 | 2022-01-20 | 큐어백 아게 | Rna―암호화된 단백질의 발현을 증가시키는 방법 |
| PL4023249T3 (pl) | 2014-04-23 | 2025-03-10 | Modernatx, Inc. | Szczepionki z kwasem nukleinowym |
| EP3155116A4 (en) | 2014-06-10 | 2017-12-27 | Massachusetts Institute Of Technology | Method for gene editing |
| ES2555160B1 (es) | 2014-06-24 | 2016-10-25 | Aptus Biotech, S.L. | Aptámeros específicos de TLR-4 y usos de los mismos |
| DK3569711T3 (da) | 2014-12-15 | 2021-02-22 | Dicerna Pharmaceuticals Inc | Ligandmodificerede dobbeltstrengede nukleinsyrer |
| HUE053990T2 (hu) | 2015-07-22 | 2021-08-30 | Nitto Denko Corp | Nanorészecske liofilizált formák készítményei és eljárások |
| EP4011451A1 (en) | 2015-10-22 | 2022-06-15 | ModernaTX, Inc. | Metapneumovirus mrna vaccines |
| US10758588B2 (en) * | 2015-12-07 | 2020-09-01 | Purdue Research Foundation | Inhibitors for proliferating cell nuclear antigen and uses |
| BR112018008344A2 (pt) | 2015-12-13 | 2018-10-30 | Nitto Denko Corp | molécula de ácido nucleico, composição farmacêutica, vetor ou célula, método para prevenir, tratar ou melhorar uma doença, e, uso de uma composição |
| WO2018064755A1 (en) * | 2016-10-03 | 2018-04-12 | Precision Nanosystems Inc. | Compositions for transfecting resistant cell types |
| CA3043033A1 (en) | 2016-11-10 | 2018-05-17 | Translate Bio, Inc. | Improved ice-based lipid nanoparticle formulation for delivery of mrna |
| WO2018107061A1 (en) | 2016-12-09 | 2018-06-14 | Board Of Regents, The University Of Texas System | Hybrid exosomal-polymeric (hexpo) nano-platform for delivery of rnai therapeutics |
| JP7406793B2 (ja) | 2017-06-23 | 2023-12-28 | ユニバーシティー オブ マサチューセッツ | ２テイル自己デリバリー型ｓｉＲＮＡおよび関連方法 |
| EP3856757A4 (en) * | 2018-09-28 | 2022-06-29 | Nutcracker Therapeutics, Inc. | Tertiary amino lipidated cationic peptides for nucleic acid delivery |
-
2019
- 2019-09-27 EP EP19866196.9A patent/EP3856757A4/en active Pending
- 2019-09-27 CA CA3110914A patent/CA3110914A1/en active Pending
- 2019-09-27 WO PCT/US2019/053655 patent/WO2020069442A1/en not_active Ceased
- 2019-09-27 MX MX2021003420A patent/MX2021003420A/es unknown
- 2019-09-27 MY MYPI2021001653A patent/MY204458A/en unknown
- 2019-09-27 CN CN201980062278.2A patent/CN112789031B/zh not_active Expired - Fee Related
- 2019-09-27 BR BR112021004929-0A patent/BR112021004929A2/pt not_active IP Right Cessation
- 2019-09-27 KR KR1020217012769A patent/KR20210068093A/ko not_active Ceased
- 2019-09-27 AU AU2019351268A patent/AU2019351268A1/en not_active Abandoned
- 2019-09-27 JP JP2021517865A patent/JP7418419B2/ja active Active
- 2019-09-27 CA CA3111476A patent/CA3111476A1/en active Pending
- 2019-09-27 IL IL281135A patent/IL281135B2/en unknown
- 2019-09-27 SG SG11202102164PA patent/SG11202102164PA/en unknown
- 2019-09-27 KR KR1020217012768A patent/KR20210068092A/ko not_active Ceased
- 2019-09-27 MX MX2021003421A patent/MX2021003421A/es unknown
- 2019-09-27 AU AU2019347774A patent/AU2019347774A1/en not_active Abandoned
- 2019-09-27 SG SG11202102163SA patent/SG11202102163SA/en unknown
- 2019-09-27 WO PCT/US2019/053661 patent/WO2020069445A1/en not_active Ceased
- 2019-09-27 BR BR112021005815-0A patent/BR112021005815A2/pt not_active IP Right Cessation
- 2019-09-27 EP EP19864088.0A patent/EP3856146A4/en not_active Withdrawn
- 2019-09-27 US US17/279,460 patent/US20210322575A1/en not_active Abandoned
- 2019-09-27 JP JP2021517802A patent/JP7430713B2/ja active Active
- 2019-09-27 CN CN201980062070.0A patent/CN112805294A/zh active Pending
- 2019-09-27 US US17/279,508 patent/US20210324002A1/en not_active Abandoned
-
2021
- 2021-02-26 ZA ZA2021/01376A patent/ZA202101376B/en unknown
- 2021-03-03 ZA ZA2021/01465A patent/ZA202101465B/en unknown
- 2021-03-19 IL IL281653A patent/IL281653A/en unknown
- 2021-06-14 US US17/347,498 patent/US11701434B2/en active Active
- 2021-06-14 US US17/347,539 patent/US11446394B2/en active Active
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