JP2022501408A5 - - Google Patents
Info
- Publication number
- JP2022501408A5 JP2022501408A5 JP2021517865A JP2021517865A JP2022501408A5 JP 2022501408 A5 JP2022501408 A5 JP 2022501408A5 JP 2021517865 A JP2021517865 A JP 2021517865A JP 2021517865 A JP2021517865 A JP 2021517865A JP 2022501408 A5 JP2022501408 A5 JP 2022501408A5
- Authority
- JP
- Japan
- Prior art keywords
- peg
- aminolipidized
- tertiary
- cationic peptide
- modified cationic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862738717P | 2018-09-28 | 2018-09-28 | |
| US62/738,717 | 2018-09-28 | ||
| US201962885036P | 2019-08-09 | 2019-08-09 | |
| US62/885,036 | 2019-08-09 | ||
| PCT/US2019/053655 WO2020069442A1 (en) | 2018-09-28 | 2019-09-27 | Tertiary amino lipidated cationic peptides for nucleic acid delivery |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022501408A JP2022501408A (ja) | 2022-01-06 |
| JP2022501408A5 true JP2022501408A5 (enExample) | 2022-10-05 |
| JP7418419B2 JP7418419B2 (ja) | 2024-01-19 |
Family
ID=69952323
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021517802A Active JP7430713B2 (ja) | 2018-09-28 | 2019-09-27 | 核酸送達のための脂質化カチオン性ペプチド化合物を含む脂質ナノ粒子製剤 |
| JP2021517865A Active JP7418419B2 (ja) | 2018-09-28 | 2019-09-27 | 核酸送達のための第三級アミノ脂質化カチオン性ペプチド |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021517802A Active JP7430713B2 (ja) | 2018-09-28 | 2019-09-27 | 核酸送達のための脂質化カチオン性ペプチド化合物を含む脂質ナノ粒子製剤 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US20210322575A1 (enExample) |
| EP (2) | EP3856146A4 (enExample) |
| JP (2) | JP7430713B2 (enExample) |
| KR (2) | KR20210068093A (enExample) |
| CN (2) | CN112805294A (enExample) |
| AU (2) | AU2019347774A1 (enExample) |
| BR (2) | BR112021004929A2 (enExample) |
| CA (2) | CA3110914A1 (enExample) |
| IL (2) | IL281135B2 (enExample) |
| MX (2) | MX2021003421A (enExample) |
| MY (1) | MY204458A (enExample) |
| SG (2) | SG11202102163SA (enExample) |
| WO (2) | WO2020069445A1 (enExample) |
| ZA (2) | ZA202101376B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210322575A1 (en) * | 2018-09-28 | 2021-10-21 | Nutcracker Therapeutics, Inc. | Lipid nanoparticle formulations comprising lipidated cationic peptide compounds for nucleic acid delivery |
| CN114555130A (zh) * | 2019-08-09 | 2022-05-27 | 胡桃钳医疗公司 | 用于核酸递送的脂化阳离子肽-peg组合物 |
| BR112022021380A2 (pt) * | 2020-04-22 | 2022-12-06 | Nutcracker Therapeutics Inc | Nanopartículas de rna mensageiro para tratamento |
| NL2026825B1 (en) | 2020-08-07 | 2022-04-05 | Nutcracker Therapeutics Inc | Multicomponent delivery system for polyanionic cargo compound delivery |
| US20230293706A1 (en) | 2020-08-07 | 2023-09-21 | Nutcracker Therapeutics, Inc. | Multicomponent Delivery Systems for Polyanionic Cargo Compound Delivery |
| IL303434A (en) * | 2020-12-07 | 2023-08-01 | Tufts College | Lipidoid preparations and methods of using them |
| WO2022235923A2 (en) * | 2021-05-05 | 2022-11-10 | Arcturus Therapeutics, Inc. | Peptide-lipid conjugates |
| US20240307526A1 (en) | 2021-08-06 | 2024-09-19 | Nutcracker Therapeutics, Inc. | Compositions comprising hydroxyethyl-capped cationic peptoids |
| NL2029057B1 (en) | 2021-08-06 | 2023-02-21 | Nutcracker Therapeutics Inc | Compositions comprising hydroxyethyl-capped cationic peptoids |
| CN114778712B (zh) * | 2022-03-21 | 2023-06-02 | 天津键凯科技有限公司 | 一种聚乙二醇脂质及含有该脂质的脂质纳米粒含量的检测方法 |
| EP4584278A1 (en) | 2022-09-09 | 2025-07-16 | Nutcracker Therapeutics, Inc. | 2-aminopropane-1,3-diol-capped cationic peptoids for nucleic acid delivery |
| CN121752579A (zh) | 2023-06-29 | 2026-03-27 | 胡桃夹子治疗公司 | 乙基修饰的rna帽和使用方法 |
| KR20250036032A (ko) * | 2023-09-05 | 2025-03-13 | 한국생명공학연구원 | 지질 나노 입자를 이용한 핵산 전달 시스템 |
| WO2025137277A1 (en) | 2023-12-19 | 2025-06-26 | Nutcracker Therapeutics, Inc. | Degradable peptoids |
| US20250381150A1 (en) | 2024-03-08 | 2025-12-18 | Genzyme Corporation | Lipid nanoparticles |
| WO2026003582A2 (en) | 2024-06-27 | 2026-01-02 | Axelyf ehf. | Lipids and lipid nanoparticles |
| WO2026030375A2 (en) | 2024-07-30 | 2026-02-05 | Genzyme Corporation | Lipid nanoparticles and methods of manufacture and use thereof |
| WO2026142951A1 (en) | 2024-12-23 | 2026-07-02 | Genzyme Corporation | Pharmaceutical system |
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| US5981501A (en) | 1995-06-07 | 1999-11-09 | Inex Pharmaceuticals Corp. | Methods for encapsulating plasmids in lipid bilayers |
| US7422902B1 (en) | 1995-06-07 | 2008-09-09 | The University Of British Columbia | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer |
| CA2289702C (en) | 1997-05-14 | 2008-02-19 | Inex Pharmaceuticals Corp. | High efficiency encapsulation of charged therapeutic agents in lipid vesicles |
| US6191115B1 (en) * | 1998-08-12 | 2001-02-20 | Abbott Laboratories | C-terminus modified heptapeptide LHRH analogs |
| JP4652648B2 (ja) | 1999-08-27 | 2011-03-16 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | キメラアンチセンスオリゴヌクレオチド、およびその細胞トランスフェクション処方物 |
| JP2004535388A (ja) * | 2001-04-30 | 2004-11-25 | ターゲティッド ジェネティクス コーポレイション | 脂質含有薬物送達複合体およびそれらの生成方法 |
| EP1519714B1 (en) | 2002-06-28 | 2010-10-20 | Protiva Biotherapeutics Inc. | Method and apparatus for producing liposomes |
| AU2004257373B2 (en) * | 2003-07-16 | 2011-03-24 | Arbutus Biopharma Corporation | Lipid encapsulated interfering RNA |
| AU2004305111B2 (en) * | 2003-12-19 | 2011-04-28 | Novartis Vaccines And Diagnostics, Inc. | Cell transfecting formulations of small interfering RNA, related compositions and methods of making and use |
| ITMI20061607A1 (it) * | 2006-08-09 | 2008-02-10 | Maria Vincenza Carriero | Peptidi con attivita farmacologica |
| US9458190B2 (en) | 2007-06-04 | 2016-10-04 | Pressure Biosciences, Inc. | Extraction and partitioning of molecules |
| EP2279254B1 (en) | 2008-04-15 | 2017-07-05 | Protiva Biotherapeutics Inc. | Novel lipid formulations for nucleic acid delivery |
| WO2009132131A1 (en) * | 2008-04-22 | 2009-10-29 | Alnylam Pharmaceuticals, Inc. | Amino lipid based improved lipid formulation |
| EP3699172A3 (en) | 2008-11-10 | 2020-11-18 | Arbutus Biopharma Corporation | Novel lipids and compositions for the delivery of therapeutics |
| EP2350296A4 (en) * | 2008-11-17 | 2013-04-03 | Enzon Pharmaceuticals Inc | BRANCHED CATIONIC LIPIDS FOR THE SYSTEM FOR INTRODUCING NUCLEIC ACIDS |
| ES2613498T3 (es) | 2009-07-01 | 2017-05-24 | Protiva Biotherapeutics Inc. | Nuevas formulaciones de lípidos para el suministro de agentes terapéuticos a tumores sólidos |
| US20110053829A1 (en) * | 2009-09-03 | 2011-03-03 | Curevac Gmbh | Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids |
| RU2573409C2 (ru) | 2009-11-04 | 2016-01-20 | Дзе Юниверсити Оф Бритиш Коламбиа | Содержащие нуклеиновые кислоты липидные частицы и относящиеся к ним способы |
| SI2506857T1 (en) | 2009-12-01 | 2018-08-31 | Translate Bio, Inc. | Delivery of mRNA for the enrichment of proteins and enzymes in human genetic diseases |
| DK2575767T3 (en) | 2010-06-04 | 2017-03-13 | Sirna Therapeutics Inc | HOWEVER UNKNOWN LOW MOLECULAR CATIONIC LIPIDS TO PROCESS OIGONUCLEOTIDES |
| US9006417B2 (en) | 2010-06-30 | 2015-04-14 | Protiva Biotherapeutics, Inc. | Non-liposomal systems for nucleic acid delivery |
| CN103328633B (zh) | 2010-10-22 | 2018-07-10 | 成均馆大学校产学协力团 | 诱导rna干扰的核酸分子及其用途 |
| CA2832073A1 (en) * | 2011-04-12 | 2012-10-18 | Terrence R. Burke | Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use |
| KR20220025112A (ko) | 2011-06-08 | 2022-03-03 | 샤이어 휴먼 지네틱 테라피즈 인크. | Mrna 전달을 위한 지질 나노입자 조성물 및 방법 |
| CA2853689C (en) | 2011-11-04 | 2020-06-30 | Nitto Denko Corporation | Method of producing lipid nanoparticles for drug delivery |
| US9035039B2 (en) | 2011-12-22 | 2015-05-19 | Protiva Biotherapeutics, Inc. | Compositions and methods for silencing SMAD4 |
| CA2867323C (en) | 2012-03-27 | 2020-07-07 | Sirna Therapeutics, Inc. | Diether based biodegradable cationic lipids for sirna delivery |
| ES2836279T3 (es) | 2012-04-04 | 2021-06-24 | Samyang Biopharmaceuticals | Método de preparación de una composición para administrar un fármaco aniónico |
| EA201492055A1 (ru) | 2012-06-08 | 2015-11-30 | Шир Хьюман Дженетик Терапис, Инк. | ИНГАЛЯЦИОННАЯ ДОСТАВКА мРНК В НЕЛЕГОЧНЫЕ КЛЕТКИ-МИШЕНИ |
| WO2013192310A1 (en) | 2012-06-19 | 2013-12-27 | Massachusetts Institute Of Technology | Mass production and size control of nanoparticles through controlled microvortices |
| TW201726599A (zh) | 2012-07-06 | 2017-08-01 | 協和醱酵麒麟有限公司 | 陽離子性脂質 |
| AU2013355258A1 (en) | 2012-12-07 | 2015-06-11 | Alnylam Pharmaceuticals, Inc. | Improved nucleic acid lipid particle formulations |
| US10266559B2 (en) | 2013-03-14 | 2019-04-23 | Translate Bio, Inc. | Ribonucleic acids with 4′-thio-modified nucleotides and related methods |
| SG10201801428RA (en) | 2013-08-21 | 2018-03-28 | Curevac Ag | Method for increasing expression of rna-encoded proteins |
| HRP20220070T1 (hr) | 2014-04-23 | 2022-04-01 | Modernatx, Inc. | Cjepiva nukleinske kiseline |
| WO2015191693A2 (en) | 2014-06-10 | 2015-12-17 | Massachusetts Institute Of Technology | Method for gene editing |
| ES2555160B1 (es) | 2014-06-24 | 2016-10-25 | Aptus Biotech, S.L. | Aptámeros específicos de TLR-4 y usos de los mismos |
| EP3865576A1 (en) | 2014-12-15 | 2021-08-18 | Dicerna Pharmaceuticals, Inc. | Ligand-modified double-stranded nucleic acids |
| CN113679689B (zh) | 2015-07-22 | 2023-09-01 | 日东电工株式会社 | 用于纳米粒冷冻干燥物形式的组合物及方法 |
| DE20164728T1 (de) | 2015-10-22 | 2021-09-30 | Modernatx, Inc. | Impfstoffe gegen atemwegsvirus |
| WO2017100154A1 (en) * | 2015-12-07 | 2017-06-15 | Purdue Research Foundation | Inhibitors for proliferating cell nuclear antigen and uses |
| AU2016371624B2 (en) | 2015-12-13 | 2020-08-27 | Nitto Denko Corporation | siRNA structures for high activity and reduced off target |
| WO2018064755A1 (en) * | 2016-10-03 | 2018-04-12 | Precision Nanosystems Inc. | Compositions for transfecting resistant cell types |
| CN116549671A (zh) | 2016-11-10 | 2023-08-08 | 川斯勒佰尔公司 | 用于递送mrna的改进的基于ice的脂质纳米颗粒制剂 |
| US12564558B2 (en) | 2016-12-09 | 2026-03-03 | Board Of Regents, The University Of Texas System | Hybrid exosomal-polymeric (hexpo) nano-platform for delivery of RNAi therapeutics |
| WO2018237245A1 (en) | 2017-06-23 | 2018-12-27 | University Of Massachusetts | TWO TAIL SELF-ADMINISTRATION SIRNA AND ASSOCIATED METHODS |
| US20210322575A1 (en) * | 2018-09-28 | 2021-10-21 | Nutcracker Therapeutics, Inc. | Lipid nanoparticle formulations comprising lipidated cationic peptide compounds for nucleic acid delivery |
-
2019
- 2019-09-27 US US17/279,460 patent/US20210322575A1/en not_active Abandoned
- 2019-09-27 AU AU2019347774A patent/AU2019347774A1/en not_active Abandoned
- 2019-09-27 IL IL281135A patent/IL281135B2/en unknown
- 2019-09-27 BR BR112021004929-0A patent/BR112021004929A2/pt not_active IP Right Cessation
- 2019-09-27 KR KR1020217012769A patent/KR20210068093A/ko not_active Ceased
- 2019-09-27 MX MX2021003421A patent/MX2021003421A/es unknown
- 2019-09-27 JP JP2021517802A patent/JP7430713B2/ja active Active
- 2019-09-27 JP JP2021517865A patent/JP7418419B2/ja active Active
- 2019-09-27 US US17/279,508 patent/US20210324002A1/en not_active Abandoned
- 2019-09-27 MX MX2021003420A patent/MX2021003420A/es unknown
- 2019-09-27 WO PCT/US2019/053661 patent/WO2020069445A1/en not_active Ceased
- 2019-09-27 KR KR1020217012768A patent/KR20210068092A/ko not_active Ceased
- 2019-09-27 SG SG11202102163SA patent/SG11202102163SA/en unknown
- 2019-09-27 WO PCT/US2019/053655 patent/WO2020069442A1/en not_active Ceased
- 2019-09-27 CA CA3110914A patent/CA3110914A1/en active Pending
- 2019-09-27 CA CA3111476A patent/CA3111476A1/en active Pending
- 2019-09-27 MY MYPI2021001653A patent/MY204458A/en unknown
- 2019-09-27 CN CN201980062070.0A patent/CN112805294A/zh active Pending
- 2019-09-27 EP EP19864088.0A patent/EP3856146A4/en not_active Withdrawn
- 2019-09-27 EP EP19866196.9A patent/EP3856757A4/en active Pending
- 2019-09-27 BR BR112021005815-0A patent/BR112021005815A2/pt not_active IP Right Cessation
- 2019-09-27 SG SG11202102164PA patent/SG11202102164PA/en unknown
- 2019-09-27 CN CN201980062278.2A patent/CN112789031B/zh not_active Expired - Fee Related
- 2019-09-27 AU AU2019351268A patent/AU2019351268A1/en not_active Abandoned
-
2021
- 2021-02-26 ZA ZA2021/01376A patent/ZA202101376B/en unknown
- 2021-03-03 ZA ZA2021/01465A patent/ZA202101465B/en unknown
- 2021-03-19 IL IL281653A patent/IL281653A/en unknown
- 2021-06-14 US US17/347,539 patent/US11446394B2/en active Active
- 2021-06-14 US US17/347,498 patent/US11701434B2/en active Active
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