JP2022105138A5 - - Google Patents
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- JP2022105138A5 JP2022105138A5 JP2022075664A JP2022075664A JP2022105138A5 JP 2022105138 A5 JP2022105138 A5 JP 2022105138A5 JP 2022075664 A JP2022075664 A JP 2022075664A JP 2022075664 A JP2022075664 A JP 2022075664A JP 2022105138 A5 JP2022105138 A5 JP 2022105138A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- antibody
- binding protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16305923.1 | 2016-07-18 | ||
| EP16305923 | 2016-07-18 | ||
| JP2019502257A JP7071329B2 (ja) | 2016-07-18 | 2017-07-17 | Ｃｄ３およびｃｄ１２３に特異的に結合する二重特異性抗体様結合タンパク質 |
| PCT/EP2017/068020 WO2018015340A1 (en) | 2016-07-18 | 2017-07-17 | Bispecific antibody-like binding proteins specifically binding to cd3 and cd123 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019502257A Division JP7071329B2 (ja) | 2016-07-18 | 2017-07-17 | Ｃｄ３およびｃｄ１２３に特異的に結合する二重特異性抗体様結合タンパク質 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022105138A JP2022105138A (ja) | 2022-07-12 |
| JP2022105138A5 true JP2022105138A5 (https=) | 2022-10-12 |
Family
ID=56507555
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019502257A Expired - Fee Related JP7071329B2 (ja) | 2016-07-18 | 2017-07-17 | Ｃｄ３およびｃｄ１２３に特異的に結合する二重特異性抗体様結合タンパク質 |
| JP2022075664A Pending JP2022105138A (ja) | 2016-07-18 | 2022-05-02 | Ｃｄ３およびｃｄ１２３に特異的に結合する二重特異性抗体様結合タンパク質 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019502257A Expired - Fee Related JP7071329B2 (ja) | 2016-07-18 | 2017-07-17 | Ｃｄ３およびｃｄ１２３に特異的に結合する二重特異性抗体様結合タンパク質 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20190241657A1 (https=) |
| EP (1) | EP3484924A1 (https=) |
| JP (2) | JP7071329B2 (https=) |
| KR (1) | KR20190028771A (https=) |
| CN (1) | CN109715665A (https=) |
| AR (1) | AR109264A1 (https=) |
| AU (1) | AU2017299125A1 (https=) |
| BR (1) | BR112019000770A2 (https=) |
| CA (1) | CA3030943A1 (https=) |
| CL (1) | CL2019000119A1 (https=) |
| CO (1) | CO2019001367A2 (https=) |
| CR (1) | CR20190072A (https=) |
| DO (1) | DOP2019000011A (https=) |
| EA (1) | EA201990321A1 (https=) |
| EC (1) | ECSP19011185A (https=) |
| IL (1) | IL264248A (https=) |
| MA (1) | MA45680A (https=) |
| MX (1) | MX2019000844A (https=) |
| PE (1) | PE20190514A1 (https=) |
| PH (1) | PH12019500122A1 (https=) |
| SG (1) | SG11201900400QA (https=) |
| TN (1) | TN2019000015A1 (https=) |
| TW (1) | TWI790206B (https=) |
| WO (1) | WO2018015340A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CR20170383A (es) | 2015-01-23 | 2017-11-22 | Sanofi Sa | Anticuerpos anti-cd3, anticuerpos anti-cd-123 y anticuerpos biespecíficos que se unen específicamente a cd3 y/o cd123 |
| TWI744242B (zh) | 2015-07-31 | 2021-11-01 | 德商安美基研究（慕尼黑）公司 | Egfrviii及cd3抗體構築體 |
| TWI796283B (zh) | 2015-07-31 | 2023-03-21 | 德商安美基研究（慕尼黑）公司 | Ｍｓｌｎ及ｃｄ３抗體構築體 |
| EA039859B1 (ru) | 2015-07-31 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
| TWI829617B (zh) | 2015-07-31 | 2024-01-21 | 德商安美基研究（慕尼黑）公司 | Ｆｌｔ３及ｃｄ３抗體構築體 |
| EP3411404B1 (en) | 2016-02-03 | 2022-11-09 | Amgen Research (Munich) GmbH | Psma and cd3 bispecific t cell engaging antibody constructs |
| TWI790206B (zh) * | 2016-07-18 | 2023-01-21 | 法商賽諾菲公司 | 特異性結合至ｃｄ３和ｃｄ１２３的雙特異性抗體樣結合蛋白 |
| CN119280393A (zh) * | 2018-10-30 | 2025-01-10 | 宏观基因有限公司 | 用于治疗血液系统恶性肿瘤的双特异性CD123 x CD3双抗体 |
| JP7566766B2 (ja) * | 2019-03-11 | 2024-10-15 | ヤンセン バイオテツク，インコーポレーテツド | 抗Ｖβ１７／抗ＣＤ１２３二重特異性抗体 |
| US11613576B2 (en) | 2019-04-09 | 2023-03-28 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
| CN111349163B (zh) * | 2020-02-05 | 2024-07-16 | 北京智仁美博生物科技有限公司 | 针对cd123的单克隆抗体 |
| TWI874613B (zh) * | 2020-03-17 | 2025-03-01 | 美商西雅圖免疫公司 | 微型導引和導航控制(miniGNC)類抗體蛋白及其製造和使用方法 |
| EP4192481A4 (en) | 2020-08-10 | 2024-09-11 | Janssen Biotech, Inc. | MATERIALS AND METHODS FOR THE PRODUCTION OF VIRUS-SPECIFIC BIOMODIFIED LYMPHOCYTES |
| US12448449B2 (en) | 2020-09-11 | 2025-10-21 | Janssen Biotech, Inc. | Immune targeting molecules and uses thereof |
| MX2023002948A (es) | 2020-09-11 | 2023-05-22 | Janssen Biotech Inc | Métodos y composiciones para modular la inmunidad mediada por cadena beta. |
| MX2023007901A (es) * | 2020-12-31 | 2023-07-11 | Sanofi Sa | Acopladores de celulas asesinas naturales (nk) multifuncionales que se unen a nkp46 y a cd123. |
| FI4284512T3 (fi) | 2021-01-28 | 2025-05-22 | Regeneron Pharma | Koostumuksia ja menetelmiä sytokiinien vapautumisoireyhtymän hoitamiseksi |
| JP2024508709A (ja) * | 2021-02-17 | 2024-02-28 | アイジーエム バイオサイエンシズ インコーポレイテッド | 抗ｃｄ１２３結合分子及びその使用法 |
| CN113368232B (zh) * | 2021-06-02 | 2022-08-26 | 上海交通大学 | 多特异性抗原结合蛋白及其应用 |
| EP4380693A1 (en) * | 2021-08-06 | 2024-06-12 | Universität Basel | Discernible cell surface protein variants for use in cell therapy |
| CN119546329A (zh) | 2022-04-11 | 2025-02-28 | 瑞泽恩制药公司 | 用于通用肿瘤细胞杀伤的组合物和方法 |
| KR20250151441A (ko) | 2023-02-17 | 2025-10-21 | 리제너론 파마슈티칼스 인코포레이티드 | Cd3/taa 이중특이적 항체에 대해 반응성인 유도된 nk 세포 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4361549A (en) | 1979-04-26 | 1982-11-30 | Ortho Pharmaceutical Corporation | Complement-fixing monoclonal antibody to human T cells, and methods of preparing same |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| DE3675588D1 (de) | 1985-06-19 | 1990-12-20 | Ajinomoto Kk | Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist. |
| AU597574B2 (en) | 1986-03-07 | 1990-06-07 | Massachusetts Institute Of Technology | Method for enhancing glycoprotein stability |
| US4861719A (en) | 1986-04-25 | 1989-08-29 | Fred Hutchinson Cancer Research Center | DNA constructs for retrovirus packaging cell lines |
| US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| US5202238A (en) | 1987-10-27 | 1993-04-13 | Oncogen | Production of chimeric antibodies by homologous recombination |
| US5204244A (en) | 1987-10-27 | 1993-04-20 | Oncogen | Production of chimeric antibodies by homologous recombination |
| US5278056A (en) | 1988-02-05 | 1994-01-11 | The Trustees Of Columbia University In The City Of New York | Retroviral packaging cell lines and process of using same |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US6406696B1 (en) | 1989-10-27 | 2002-06-18 | Tolerance Therapeutics, Inc. | Methods of stimulating the immune system with anti-CD3 antibodies |
| AU6642390A (en) | 1989-10-27 | 1991-05-31 | Arch Development Corporation | Methods and compositions for promoting immunopotentiation |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| US5670488A (en) | 1992-12-03 | 1997-09-23 | Genzyme Corporation | Adenovirus vector for gene therapy |
| EP0563296B1 (en) | 1990-12-20 | 1999-03-17 | Ixsys, Inc. | Optimization of binding proteins |
| DE69434860T2 (de) | 1993-02-22 | 2007-03-15 | The Rockefeller University | Herstellung von helfer-freien retroviren mit hohem titer mittels transienter transfektion |
| US5885573A (en) | 1993-06-01 | 1999-03-23 | Arch Development Corporation | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
| FR2712812B1 (fr) | 1993-11-23 | 1996-02-09 | Centre Nat Rech Scient | Composition pour la production de produits thérapeutiques in vivo. |
| IL116816A (en) | 1995-01-20 | 2003-05-29 | Rhone Poulenc Rorer Sa | Cell for the production of a defective recombinant adenovirus or an adeno-associated virus and the various uses thereof |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| CN1241944C (zh) | 1995-09-11 | 2006-02-15 | 协和发酵工业株式会社 | 抗人白介素－5受体α链的抗体 |
| US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
| US6177078B1 (en) | 1995-12-29 | 2001-01-23 | Medvet Science Pty Limited | Monoclonal antibody antagonists to IL-3 |
| DE19721700C1 (de) | 1997-05-23 | 1998-11-19 | Deutsches Krebsforsch | Mutierter OKT3-Antikörper |
| CZ302070B6 (cs) | 1998-04-21 | 2010-09-29 | Micromet Ag | Jednoretezcový multifunkcní polypeptid, polynukleotid, vektor obsahující tento polynukleotid, bunka transfekovaná tímto polynukleotidem, prostredek obsahující tento polypeptid, polynukleotid nebo vektor a jejich použití a zpusob identifikace aktiváto |
| ATE510855T1 (de) | 2000-03-06 | 2011-06-15 | Univ Kentucky Res Found | Verwendung eines antikörpers oder eines immunotoxins, der bzw. das selektiv an cd123 bindet zur beeinträchtigung hämatologischer krebs-vorläuferzellen |
| CN111909273B (zh) | 2007-08-29 | 2024-03-26 | 塞诺菲-安万特股份有限公司 | 人源化的抗-cxcr5抗体、其衍生物及它们的应用 |
| EP2050764A1 (en) | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
| NZ591087A (en) * | 2008-10-01 | 2012-08-31 | Micromet Ag | Cross-species-specific pscaxcd3, cd19xcd3, c-metxcd3, endosialinxcd3, epcamxc d3, igf-1rxcd3 or fapalpha xcd3 bispecific single chain antibody |
| TWI588156B (zh) | 2011-03-28 | 2017-06-21 | 賽諾菲公司 | 具有交叉結合區定向之雙重可變區類抗體結合蛋白 |
| MY169358A (en) | 2011-08-23 | 2019-03-26 | Roche Glycart Ag | Bispecific t cell activating antigen binding molecules |
| US9745381B2 (en) * | 2012-05-18 | 2017-08-29 | Scott & White Healthcare (Swh) | Bispecific scFv immunofusion (BIf) |
| EP2839842A1 (en) | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bi-specific monovalent diabodies that are capable of binding CD123 and CD3 and uses thereof |
| EP3080156A1 (en) * | 2013-12-10 | 2016-10-19 | F. Hoffmann-La Roche AG | Use of the binding domain of a subunit of a multi-subunit structure for targeted delivery of pharmaceutically active entities to the multi-subunit structure |
| JO3568B1 (ar) * | 2014-09-05 | 2020-07-05 | Janssen Pharmaceutica Nv | عوامل ربط cd123 واستخداماتها |
| CN110894240B (zh) * | 2014-11-26 | 2022-04-15 | 森科股份有限公司 | 结合cd3和肿瘤抗原的异二聚体抗体 |
| CR20170383A (es) * | 2015-01-23 | 2017-11-22 | Sanofi Sa | Anticuerpos anti-cd3, anticuerpos anti-cd-123 y anticuerpos biespecíficos que se unen específicamente a cd3 y/o cd123 |
| TWI790206B (zh) * | 2016-07-18 | 2023-01-21 | 法商賽諾菲公司 | 特異性結合至ｃｄ３和ｃｄ１２３的雙特異性抗體樣結合蛋白 |
-
2017
- 2017-07-14 TW TW106123588A patent/TWI790206B/zh not_active IP Right Cessation
- 2017-07-17 WO PCT/EP2017/068020 patent/WO2018015340A1/en not_active Ceased
- 2017-07-17 SG SG11201900400QA patent/SG11201900400QA/en unknown
- 2017-07-17 MA MA045680A patent/MA45680A/fr unknown
- 2017-07-17 BR BR112019000770A patent/BR112019000770A2/pt not_active IP Right Cessation
- 2017-07-17 AU AU2017299125A patent/AU2017299125A1/en not_active Abandoned
- 2017-07-17 US US16/318,599 patent/US20190241657A1/en not_active Abandoned
- 2017-07-17 CR CR20190072A patent/CR20190072A/es unknown
- 2017-07-17 JP JP2019502257A patent/JP7071329B2/ja not_active Expired - Fee Related
- 2017-07-17 EA EA201990321A patent/EA201990321A1/ru unknown
- 2017-07-17 MX MX2019000844A patent/MX2019000844A/es unknown
- 2017-07-17 AR ARP170101993A patent/AR109264A1/es unknown
- 2017-07-17 EP EP17749380.6A patent/EP3484924A1/en not_active Withdrawn
- 2017-07-17 CN CN201780056945.7A patent/CN109715665A/zh active Pending
- 2017-07-17 KR KR1020197004345A patent/KR20190028771A/ko not_active Withdrawn
- 2017-07-17 CA CA3030943A patent/CA3030943A1/en active Pending
- 2017-07-17 TN TNP/2019/000015A patent/TN2019000015A1/en unknown
- 2017-07-17 PE PE2019000065A patent/PE20190514A1/es not_active Application Discontinuation
-
2019
- 2019-01-15 IL IL264248A patent/IL264248A/en unknown
- 2019-01-16 DO DO2019000011A patent/DOP2019000011A/es unknown
- 2019-01-16 PH PH12019500122A patent/PH12019500122A1/en unknown
- 2019-01-16 CL CL2019000119A patent/CL2019000119A1/es unknown
- 2019-02-15 CO CONC2019/0001367A patent/CO2019001367A2/es unknown
- 2019-02-15 EC ECSENADI201911185A patent/ECSP19011185A/es unknown
-
2022
- 2022-05-02 JP JP2022075664A patent/JP2022105138A/ja active Pending
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