JP2022036981A5 - - Google Patents
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- JP2022036981A5 JP2022036981A5 JP2021188565A JP2021188565A JP2022036981A5 JP 2022036981 A5 JP2022036981 A5 JP 2022036981A5 JP 2021188565 A JP2021188565 A JP 2021188565A JP 2021188565 A JP2021188565 A JP 2021188565A JP 2022036981 A5 JP2022036981 A5 JP 2022036981A5
- Authority
- JP
- Japan
- Prior art keywords
- trpv1
- blend
- trpv3
- alkanediol
- modulator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims description 55
- 102000003566 TRPV1 Human genes 0.000 claims description 26
- 102000003568 TRPV3 Human genes 0.000 claims description 26
- 101150016206 Trpv1 gene Proteins 0.000 claims description 26
- 101150043371 Trpv3 gene Proteins 0.000 claims description 26
- 125000004432 carbon atom Chemical group C* 0.000 claims description 12
- LSKFRYMLGSVAPL-UHFFFAOYSA-N 4-[(4-hydroxy-3-methoxyphenyl)methoxymethyl]-2-methoxyphenol Chemical compound C1=C(O)C(OC)=CC(COCC=2C=C(OC)C(O)=CC=2)=C1 LSKFRYMLGSVAPL-UHFFFAOYSA-N 0.000 claims description 9
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 claims description 8
- 210000004400 mucous membrane Anatomy 0.000 claims description 7
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 6
- 229940031723 1,2-octanediol Drugs 0.000 claims description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 239000001257 hydrogen Substances 0.000 claims description 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 6
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 claims description 6
- 229920005862 polyol Polymers 0.000 claims description 6
- 150000003077 polyols Chemical class 0.000 claims description 6
- 239000002537 cosmetic Substances 0.000 claims description 5
- -1 cyclic acetal Chemical class 0.000 claims description 5
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 claims description 4
- 229920001144 Hydroxy alpha sanshool Polymers 0.000 claims description 4
- PSKIOIDCXFHNJA-UHFFFAOYSA-N Sanshool Natural products CC=CC=CC=CCCC=CC=CC(=O)NC(C)C PSKIOIDCXFHNJA-UHFFFAOYSA-N 0.000 claims description 4
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 claims description 4
- ZOJBYZNEUISWFT-UHFFFAOYSA-N allyl isothiocyanate Chemical compound C=CCN=C=S ZOJBYZNEUISWFT-UHFFFAOYSA-N 0.000 claims description 4
- SBXYHCVXUCYYJT-UEOYEZOQSA-N alpha-Sanshool Chemical compound C\C=C\C=C\C=C/CC\C=C\C(=O)NCC(C)C SBXYHCVXUCYYJT-UEOYEZOQSA-N 0.000 claims description 4
- 229960002504 capsaicin Drugs 0.000 claims description 4
- 235000017663 capsaicin Nutrition 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 244000131415 Zanthoxylum piperitum Species 0.000 claims description 3
- 235000008853 Zanthoxylum piperitum Nutrition 0.000 claims description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 2
- SZSSMFVYZRQGIM-UHFFFAOYSA-N 2-(hydroxymethyl)-2-propylpropane-1,3-diol Chemical compound CCCC(CO)(CO)CO SZSSMFVYZRQGIM-UHFFFAOYSA-N 0.000 claims description 2
- TXBCBTDQIULDIA-UHFFFAOYSA-N 2-[[3-hydroxy-2,2-bis(hydroxymethyl)propoxy]methyl]-2-(hydroxymethyl)propane-1,3-diol Chemical compound OCC(CO)(CO)COCC(CO)(CO)CO TXBCBTDQIULDIA-UHFFFAOYSA-N 0.000 claims description 2
- VLDFMKOUUQYFGF-UHFFFAOYSA-N 4-(butoxymethyl)-2-methoxyphenol Chemical group CCCCOCC1=CC=C(O)C(OC)=C1 VLDFMKOUUQYFGF-UHFFFAOYSA-N 0.000 claims description 2
- TZZAKSLHHIJRLL-UHFFFAOYSA-N 4-hydroxy-3-methoxybenzamide Chemical compound COC1=CC(C(N)=O)=CC=C1O TZZAKSLHHIJRLL-UHFFFAOYSA-N 0.000 claims description 2
- ZJCCRDAZUWHFQH-UHFFFAOYSA-N Trimethylolpropane Chemical compound CCC(CO)(CO)CO ZJCCRDAZUWHFQH-UHFFFAOYSA-N 0.000 claims description 2
- 244000273928 Zingiber officinale Species 0.000 claims description 2
- 235000006886 Zingiber officinale Nutrition 0.000 claims description 2
- 150000001241 acetals Chemical class 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- 235000016720 allyl isothiocyanate Nutrition 0.000 claims description 2
- 239000007795 chemical reaction product Substances 0.000 claims description 2
- 238000009833 condensation Methods 0.000 claims description 2
- ZITKDVFRMRXIJQ-UHFFFAOYSA-N dodecane-1,2-diol Chemical compound CCCCCCCCCCC(O)CO ZITKDVFRMRXIJQ-UHFFFAOYSA-N 0.000 claims description 2
- 239000000284 extract Substances 0.000 claims description 2
- 235000008397 ginger Nutrition 0.000 claims description 2
- 229930182478 glucoside Natural products 0.000 claims description 2
- GCXZDAKFJKCPGK-UHFFFAOYSA-N heptane-1,2-diol Chemical compound CCCCCC(O)CO GCXZDAKFJKCPGK-UHFFFAOYSA-N 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 210000004877 mucosa Anatomy 0.000 claims description 2
- LJZULWUXNKDPCG-UHFFFAOYSA-N nonane-1,2-diol Chemical compound CCCCCCCC(O)CO LJZULWUXNKDPCG-UHFFFAOYSA-N 0.000 claims description 2
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 claims description 2
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 claims description 2
- 235000020744 piper nigrum extract Nutrition 0.000 claims description 2
- MXXWOMGUGJBKIW-YPCIICBESA-N piperine Chemical compound C=1C=C2OCOC2=CC=1/C=C/C=C/C(=O)N1CCCCC1 MXXWOMGUGJBKIW-YPCIICBESA-N 0.000 claims description 2
- WVWHRXVVAYXKDE-UHFFFAOYSA-N piperine Natural products O=C(C=CC=Cc1ccc2OCOc2c1)C3CCCCN3 WVWHRXVVAYXKDE-UHFFFAOYSA-N 0.000 claims description 2
- QXJQHYBHAIHNGG-UHFFFAOYSA-N trimethylolethane Chemical compound OCC(C)(CO)CO QXJQHYBHAIHNGG-UHFFFAOYSA-N 0.000 claims description 2
- BUMVVNKGNPPUME-UHFFFAOYSA-N undecane-1,2-diol Chemical compound CCCCCCCCCC(O)CO BUMVVNKGNPPUME-UHFFFAOYSA-N 0.000 claims description 2
- 229940078465 vanillyl butyl ether Drugs 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 244000145321 Acmella oleracea Species 0.000 claims 2
- YSRSBDQINUMTIF-UHFFFAOYSA-N decane-1,2-diol Chemical compound CCCCCCCCC(O)CO YSRSBDQINUMTIF-UHFFFAOYSA-N 0.000 claims 1
- NLDDIKRKFXEWBK-AWEZNQCLSA-N gingerol Chemical compound CCCCC[C@H](O)CC(=O)CCC1=CC=C(O)C(OC)=C1 NLDDIKRKFXEWBK-AWEZNQCLSA-N 0.000 claims 1
- JZLXEKNVCWMYHI-UHFFFAOYSA-N gingerol Natural products CCCCC(O)CC(=O)CCC1=CC=C(O)C(OC)=C1 JZLXEKNVCWMYHI-UHFFFAOYSA-N 0.000 claims 1
- 235000002780 gingerol Nutrition 0.000 claims 1
- 239000008601 oleoresin Substances 0.000 claims 1
- GTLGHKNKLRZSMO-UHFFFAOYSA-N 4-(3-hydroxybutyl)-2-methoxyphenol Chemical compound COC1=CC(CCC(C)O)=CC=C1O GTLGHKNKLRZSMO-UHFFFAOYSA-N 0.000 description 2
- 206010016334 Feeling hot Diseases 0.000 description 2
- HOSGXJWQVBHGLT-UHFFFAOYSA-N 6-hydroxy-3,4-dihydro-1h-quinolin-2-one Chemical group N1C(=O)CCC2=CC(O)=CC=C21 HOSGXJWQVBHGLT-UHFFFAOYSA-N 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000002009 diols Chemical class 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021188565A JP2022036981A (ja) | 2016-12-02 | 2021-11-19 | 化粧品ブレンド |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2016/079591 WO2018099570A1 (en) | 2016-12-02 | 2016-12-02 | Cosmetic blends |
| JP2019529495A JP7441042B2 (ja) | 2016-12-02 | 2016-12-02 | 化粧品ブレンド |
| JP2021188565A JP2022036981A (ja) | 2016-12-02 | 2021-11-19 | 化粧品ブレンド |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019529495A Division JP7441042B2 (ja) | 2016-12-02 | 2016-12-02 | 化粧品ブレンド |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022036981A JP2022036981A (ja) | 2022-03-08 |
| JP2022036981A5 true JP2022036981A5 (https=) | 2022-06-29 |
Family
ID=57471884
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019529495A Active JP7441042B2 (ja) | 2016-12-02 | 2016-12-02 | 化粧品ブレンド |
| JP2021188565A Pending JP2022036981A (ja) | 2016-12-02 | 2021-11-19 | 化粧品ブレンド |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019529495A Active JP7441042B2 (ja) | 2016-12-02 | 2016-12-02 | 化粧品ブレンド |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11123272B2 (https=) |
| EP (2) | EP4483953A3 (https=) |
| JP (2) | JP7441042B2 (https=) |
| CN (1) | CN110149795B (https=) |
| BR (1) | BR112019010812A2 (https=) |
| WO (1) | WO2018099570A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2020014332A (es) * | 2018-06-22 | 2021-03-09 | Procter & Gamble | Composiciones dentifricas. |
| US20230104634A1 (en) * | 2020-05-05 | 2023-04-06 | Indian Institute Of Technology Bombay | Nutraceutical composition and method of production thereof |
| CN111568811A (zh) * | 2020-05-21 | 2020-08-25 | 鹂诺生物医药科技(上海)有限公司 | 一种护肤面霜及其制备方法 |
| FR3111076B1 (fr) * | 2020-06-08 | 2023-10-27 | Oreal | Composition aqueuse de soin et/ou du maquillage des matières kératiniques comprenant un monoester d’acide gras, un sel d’acide gras, un pullulane et un polyol |
| WO2022122131A1 (en) * | 2020-12-09 | 2022-06-16 | Symrise Ag | Compositions comprising lipophilic compounds and one or more (bio)-alkanediols |
| WO2022122132A1 (en) * | 2020-12-09 | 2022-06-16 | Symrise Ag | Compositions comprising natural polymers and one or more (bio)-alkanediols |
| WO2022122137A1 (en) * | 2020-12-09 | 2022-06-16 | Symrise Ag | Compositions comprising antimicrobials and (bio)-alkanediols for skin protection |
| WO2022122135A1 (en) * | 2020-12-09 | 2022-06-16 | Symrise Ag | Compositions comprising (bio)-alkanediols with antimicrobials for product protection |
| WO2022122140A1 (en) * | 2020-12-09 | 2022-06-16 | Symrise Ag | Compositions comprising one or more (bio)-alkanediols with active ingredients |
| WO2022122134A1 (en) * | 2020-12-09 | 2022-06-16 | Symrise Ag | Compositions with (bio)-alkanediols and cooling agents |
| WO2022122136A1 (en) | 2020-12-09 | 2022-06-16 | Symrise Ag | Compositions comprising one or more (bio)-alkanediols with antioxidants |
| WO2022122133A1 (en) * | 2020-12-09 | 2022-06-16 | Symrise Ag | Compositions comprising uv-filters and one or more (bio)-alkanediols |
| CN112526052A (zh) * | 2020-12-22 | 2021-03-19 | 陕西省石油化工研究设计院 | 一种气相色谱法测定化妆品防腐剂中辛甘醇的方法 |
| CN115212175B (zh) * | 2022-07-08 | 2023-06-13 | 四川大学 | 光损修复天然多酚-山椒素纳米组装体的制备方法及应用 |
| CN115154348B (zh) * | 2022-07-08 | 2023-08-22 | 四川昇嘉科技有限公司 | 抑制自由基的山椒素有机-无机杂化光防护材料制备方法 |
| CN115281191B (zh) * | 2022-07-26 | 2023-04-25 | 中国科学院新疆生态与地理研究所 | 土曲霉酮在农作物抗旱促生中的应用及其处理方法 |
| CN116286616A (zh) * | 2023-04-06 | 2023-06-23 | 华南农业大学 | 提高卵母细胞体外成熟质量的添加剂及应用 |
| CN118420043B (zh) * | 2024-07-03 | 2024-09-06 | 神美科技有限公司 | 一种去除电镀废水中次/亚磷酸的药剂及其制备方法 |
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| KR101347910B1 (ko) * | 2012-01-31 | 2014-01-08 | 계명대학교 산학협력단 | 생강 초임계 추출물 및 발효 미나리 박 추출물을 함유하는 식품 조성물, 화장료 조성물 및 약학 조성물 |
| EP2695597B1 (en) * | 2012-08-07 | 2019-07-24 | Symrise AG | Cosmetic compositions |
| EP2700431A1 (en) | 2012-08-24 | 2014-02-26 | AnalytiCon Discovery GmbH | Plant extracts for modulating TRPV1 function |
| JP6087099B2 (ja) | 2012-10-01 | 2017-03-01 | 花王株式会社 | 皮膚外用剤 |
| US9782333B2 (en) * | 2015-01-21 | 2017-10-10 | Chattem Inc. | Oral composition for xerostomia |
| JP5966231B1 (ja) * | 2015-12-14 | 2016-08-10 | 有限会社アント | アミノ酸配合顔用皮膚外用剤 |
| CN105853278A (zh) * | 2016-04-26 | 2016-08-17 | 广州市涵美化妆品有限公司 | 一种润肤胸膜及其制备方法 |
-
2016
- 2016-12-02 US US16/465,228 patent/US11123272B2/en active Active
- 2016-12-02 EP EP24213369.2A patent/EP4483953A3/en active Pending
- 2016-12-02 EP EP16805429.4A patent/EP3547991B1/en active Active
- 2016-12-02 WO PCT/EP2016/079591 patent/WO2018099570A1/en not_active Ceased
- 2016-12-02 JP JP2019529495A patent/JP7441042B2/ja active Active
- 2016-12-02 CN CN201680091143.5A patent/CN110149795B/zh active Active
- 2016-12-02 BR BR112019010812A patent/BR112019010812A2/pt not_active Application Discontinuation
-
2021
- 2021-11-19 JP JP2021188565A patent/JP2022036981A/ja active Pending
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