JP2022017221A5 - - Google Patents
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- JP2022017221A5 JP2022017221A5 JP2021145986A JP2021145986A JP2022017221A5 JP 2022017221 A5 JP2022017221 A5 JP 2022017221A5 JP 2021145986 A JP2021145986 A JP 2021145986A JP 2021145986 A JP2021145986 A JP 2021145986A JP 2022017221 A5 JP2022017221 A5 JP 2022017221A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharmaceutically acceptable
- compound according
- acceptable salt
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000217 alkyl group Chemical group 0.000 claims 110
- 150000001875 compounds Chemical class 0.000 claims 101
- 150000003839 salts Chemical class 0.000 claims 88
- 125000005843 halogen group Chemical group 0.000 claims 40
- 125000003118 aryl group Chemical group 0.000 claims 32
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 31
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 26
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 25
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 23
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 22
- 229910052799 carbon Inorganic materials 0.000 claims 21
- 125000004432 carbon atom Chemical group C* 0.000 claims 19
- 125000001424 substituent group Chemical group 0.000 claims 19
- 229910052760 oxygen Inorganic materials 0.000 claims 10
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 6
- 125000006713 (C5-C10) cycloalkyl group Chemical group 0.000 claims 6
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 5
- 125000006193 alkinyl group Chemical group 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 5
- 125000006568 (C4-C7) heterocycloalkyl group Chemical group 0.000 claims 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 125000004076 pyridyl group Chemical group 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 3
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims 3
- 125000002950 monocyclic group Chemical group 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 238000000634 powder X-ray diffraction Methods 0.000 claims 3
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 3
- 206010009944 Colon cancer Diseases 0.000 claims 2
- -1 SCH 3 Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 238000001938 differential scanning calorimetry curve Methods 0.000 claims 2
- 125000003367 polycyclic group Chemical group 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 101000735473 Homo sapiens Protein mono-ADP-ribosyltransferase TIPARP Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 102100034905 Protein mono-ADP-ribosyltransferase TIPARP Human genes 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000006593 Urologic Neoplasms Diseases 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 201000007455 central nervous system cancer Diseases 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 210000004798 organs belonging to the digestive system Anatomy 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862664544P | 2018-04-30 | 2018-04-30 | |
| US62/664,544 | 2018-04-30 | ||
| PCT/US2019/029582 WO2019212937A1 (en) | 2018-04-30 | 2019-04-29 | Pyridazinones as parp7 inhibitors |
| JP2020560916A JP6942896B2 (ja) | 2018-04-30 | 2019-04-29 | Ｐａｒｐ７阻害剤としてのピリダジノン |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020560916A Division JP6942896B2 (ja) | 2018-04-30 | 2019-04-29 | Ｐａｒｐ７阻害剤としてのピリダジノン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022017221A JP2022017221A (ja) | 2022-01-25 |
| JP2022017221A5 true JP2022017221A5 (https=) | 2022-06-10 |
| JP7518049B2 JP7518049B2 (ja) | 2024-07-17 |
Family
ID=66476851
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020560916A Active JP6942896B2 (ja) | 2018-04-30 | 2019-04-29 | Ｐａｒｐ７阻害剤としてのピリダジノン |
| JP2021145986A Active JP7518049B2 (ja) | 2018-04-30 | 2021-09-08 | Ｐａｒｐ７阻害剤としてのピリダジノン |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020560916A Active JP6942896B2 (ja) | 2018-04-30 | 2019-04-29 | Ｐａｒｐ７阻害剤としてのピリダジノン |
Country Status (36)
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2019212946A1 (en) | 2018-04-30 | 2019-11-07 | Ribon Therapeutics Inc. | Screening methods for parp modulators |
| EP3788040B1 (en) | 2018-04-30 | 2023-04-12 | Ribon Therapeutics Inc. | Pyridazinones as parp7 inhibitors |
| WO2019241131A1 (en) | 2018-06-11 | 2019-12-19 | Pipeline Therapeutics, Inc. | Muscarinic acetylcholine m1 receptor antagonists |
| US12054487B2 (en) | 2018-09-04 | 2024-08-06 | Contineum Therapeutics, Inc. | Muscarinic acetylcholine M1 receptor antagonists |
| CN113939295B (zh) * | 2019-03-20 | 2025-05-16 | 金翅雀生物公司 | 哒嗪酮及其使用方法 |
| US12371421B2 (en) | 2019-04-29 | 2025-07-29 | Ribon Therapeutics, Inc. | Solid forms of a PARP7 inhibitor |
| IL326597A (en) * | 2019-10-07 | 2026-04-01 | Contineum Therapeutics Inc | Muscarinic M1 acetylcholine receptor antagonists |
| KR20220109401A (ko) * | 2019-10-30 | 2022-08-04 | 리본 테라퓨틱스 인코포레이티드 | Parp7 억제제로서의 피리다진온 |
| WO2021087018A1 (en) * | 2019-10-30 | 2021-05-06 | Ribon Therapeutics, Inc. | Pyridazinones as parp7 inhibitors |
| US11752149B2 (en) | 2019-12-02 | 2023-09-12 | Pipeline Therapeutics, Inc. | Muscarinic acetylcholine M1 receptor antagonists |
| US11807626B2 (en) * | 2020-04-23 | 2023-11-07 | Opna Bio SA | Compounds and methods for CD73 modulation and indications therefor |
| AU2021287462A1 (en) * | 2020-06-09 | 2023-02-09 | Relive Therapeutics Inc. | Compounds comprising a three ring core as PD-1/PD-L1 blockers |
| EP4174069A4 (en) * | 2020-07-03 | 2024-07-10 | Wuhan LL Science and Technology Development Co., Ltd. | HETEROCYCLIC COMPOUND AND ASSOCIATED USE |
| WO2022111700A1 (zh) * | 2020-11-27 | 2022-06-02 | 成都百裕制药股份有限公司 | 哒嗪酮衍生物及其在医药上的应用 |
| JP7623826B2 (ja) * | 2020-12-18 | 2025-01-29 | 株式会社 資生堂 | Ｔｉｐａｒｐ産生促進剤 |
| WO2022156708A1 (en) * | 2021-01-20 | 2022-07-28 | Jacobio Pharmaceuticals Co., Ltd. | Parp7 enzyme inhibitor |
| CN116724044B (zh) * | 2021-02-03 | 2025-10-31 | 上海湃隆生物科技有限公司 | 三并杂环类化合物、其制备方法及其应用 |
| US20240317755A1 (en) * | 2021-02-07 | 2024-09-26 | Wuhan Ll Science And Technology Development Co., Ltd. | Heterocyclic compound, and intermediate thereof, preparation method therefor and use thereof |
| EP4291560A4 (en) * | 2021-02-09 | 2025-01-15 | Jacobio Pharmaceuticals Co., Ltd. | TRICYCLIC DERIVATIVES USEFUL AS PARP7 INHIBITORS |
| KR20230146593A (ko) * | 2021-02-16 | 2023-10-19 | 리본 테라퓨틱스 인코포레이티드 | Parp7 억제제에 대한 투여량 레지멘 |
| CN115028648B (zh) * | 2021-03-03 | 2024-08-30 | 武汉誉祥医药科技有限公司 | 三并环化合物及其药物组合物和应用 |
| WO2022188889A1 (zh) * | 2021-03-12 | 2022-09-15 | 杭州英创医药科技有限公司 | 作为parp7抑制剂的化合物 |
| WO2022194122A1 (zh) * | 2021-03-16 | 2022-09-22 | 上海翰森生物医药科技有限公司 | 含氮杂环的多环化合物及其制备方法和应用 |
| GB202114315D0 (en) * | 2021-10-06 | 2021-11-17 | Duke Street Bio Ltd | Pharmaceutical compound |
| US20240217968A1 (en) * | 2021-03-31 | 2024-07-04 | Duke Street Bio Limited | Pharmaceutical compound |
| CN117083274A (zh) * | 2021-04-23 | 2023-11-17 | 四川海思科制药有限公司 | 一种并环杂环衍生物及其在医药上的应用 |
| CN117279917A (zh) * | 2021-05-21 | 2023-12-22 | 成都百裕制药股份有限公司 | 哌嗪衍生物及其在医药上的应用 |
| WO2022247839A1 (zh) * | 2021-05-25 | 2022-12-01 | 山东轩竹医药科技有限公司 | Parp7抑制剂 |
| CN115477640A (zh) * | 2021-05-31 | 2022-12-16 | 由理生物医药（上海）有限公司 | 作为parp7抑制剂的哒嗪酮类化合物 |
| CN117751108A (zh) * | 2021-07-21 | 2024-03-22 | 南京明德新药研发有限公司 | 哒嗪酮类化合物 |
| WO2023001296A1 (zh) * | 2021-07-23 | 2023-01-26 | 武汉人福创新药物研发中心有限公司 | 作为parp7抑制剂的哒嗪酮类化合物 |
| CN117279907A (zh) * | 2021-08-06 | 2023-12-22 | 成都百裕制药股份有限公司 | 吡咯烷酮衍生物及其在医药上的应用 |
| CN117377665B (zh) * | 2021-08-16 | 2026-04-21 | 重庆华森英诺生物科技有限公司 | Parp7抑制剂及其应用 |
| US20240343727A1 (en) * | 2021-08-17 | 2024-10-17 | InventisBio Co., Ltd. | Pyridazinone or pyridinone compounds, preparation methods and uses thereof |
| US20230183216A1 (en) | 2021-10-28 | 2023-06-15 | Gilead Sciences, Inc. | Pyridizin-3(2h)-one derivatives |
| CN115745971B (zh) * | 2021-12-20 | 2024-07-30 | 北京华森英诺生物科技有限公司 | Parp7抑制剂及其应用 |
| CN116375688B (zh) * | 2021-12-23 | 2025-04-11 | 中国药科大学 | 哒嗪酮类化合物及其制备方法、药物组合物和应用 |
| CN116444497B (zh) * | 2022-01-14 | 2025-06-24 | 如东凌达生物医药科技有限公司 | 一类哒嗪酮类化合物、制备及其应用 |
| CN116535395B (zh) * | 2022-01-26 | 2024-07-09 | 中国药科大学 | 2h-吲唑-7-甲酰胺类化合物、制备方法、药物组合物和应用 |
| WO2023143236A1 (zh) * | 2022-01-26 | 2023-08-03 | 中国药科大学 | 2h-吲唑-7-甲酰胺类化合物、制备方法、药物组合物和应用 |
| TW202340168A (zh) | 2022-01-28 | 2023-10-16 | 美商基利科學股份有限公司 | Ｐａｒｐ７抑制劑 |
| AU2022451580B2 (en) * | 2022-04-01 | 2024-11-07 | Novostar Pharmaceuticals, Ltd. | Parp7 inhibitor and use thereof |
| TW202346294A (zh) * | 2022-04-21 | 2023-12-01 | 大陸商四川海思科製藥有限公司 | 吡嗪酮衍生物及其在醫藥上的應用 |
| CN117586263B (zh) * | 2022-08-09 | 2026-04-10 | 康百达（四川）生物医药科技有限公司 | 哌嗪衍生物及其在医药上的应用 |
| AU2023321459A1 (en) * | 2022-08-09 | 2025-02-13 | Kangbaida (Sichuan) Biotechnology Co., Ltd. | Composition of piperazine compound and pd-1 inhibitor or pd-l1 inhibitor and use thereof in treating tumors |
| AU2023321458A1 (en) * | 2022-08-09 | 2025-02-13 | Kangbaida (Sichuan) Biotechnology Co., Ltd. | Use of piperazine compound in combination with radiotherapy for treatment of tumor |
| TW202416984A (zh) * | 2022-08-17 | 2024-05-01 | 大陸商北京加科思新藥研發有限公司 | 化合物i或其鹽的固體形式 |
| GB202213819D0 (en) | 2022-09-22 | 2022-11-09 | Duke Street Bio Ltd | Pharmaceutical compound |
| CN115490671B (zh) * | 2022-10-21 | 2024-05-14 | 水木未来(北京)科技有限公司 | Parp7抑制剂及其制备方法 |
| CN117551080A (zh) * | 2022-11-11 | 2024-02-13 | 杭州师范大学 | 一种靶向降解parp7的protac化合物及其制备方法与应用 |
| EP4620958A1 (en) * | 2022-11-14 | 2025-09-24 | Kangbaida (Sichuan) Biotechnology Co., Ltd. | Crystal of substituted piperazine derivative and preparation method therefor |
| GB202217888D0 (en) | 2022-11-29 | 2023-01-11 | Duke Street Bio Ltd | Pharmaceutical compound |
| TW202430518A (zh) * | 2023-01-06 | 2024-08-01 | 大陸商齊魯製藥有限公司 | Parp7抑制劑的製備方法 |
| CN120917010A (zh) * | 2023-01-10 | 2025-11-07 | 嘉兴和剂药业有限公司 | Parp7抑制剂及其用途 |
| WO2024149234A1 (en) * | 2023-01-10 | 2024-07-18 | Angel Pharmaceutical Co., Ltd. | Parp7 inhibitors and uses thereof |
| CN118388414A (zh) * | 2023-01-17 | 2024-07-26 | 中国药科大学 | 哒嗪酮类化合物及其制备方法、药物组合物和应用 |
| CN121729220A (zh) * | 2023-08-17 | 2026-03-24 | 康百达（四川）生物医药科技有限公司 | 一种哌嗪衍生物的药物制剂、其制备方法及其用途 |
| CN121752568A (zh) * | 2023-08-29 | 2026-03-27 | 康百达（四川）生物医药科技有限公司 | 一种哌嗪衍生物的制备工艺及其中间体 |
| WO2025087383A1 (zh) * | 2023-10-26 | 2025-05-01 | 深圳众格生物科技有限公司 | 作为parp7抑制剂的化合物 |
| TW202519233A (zh) * | 2023-11-13 | 2025-05-16 | 大陸商康百達（四川）生物醫藥科技有限公司 | 一種parp7抑制劑聯合用藥的藥物組合及其治療腫瘤的用途 |
| CN117342983B (zh) * | 2023-12-05 | 2024-02-06 | 康羽生命科学技术(苏州)有限公司 | 过乙酰化GalNAc-L96合成方法 |
| WO2025209574A1 (zh) * | 2024-04-03 | 2025-10-09 | 康百达（四川）生物医药科技有限公司 | 用于预防或治疗肿瘤的parp7抑制剂 |
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-
2019
- 2019-04-29 EP EP19723272.1A patent/EP3788040B1/en active Active
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2020
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2021
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2022
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2023
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2024
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