|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
USRE30985E
(en)
|
1978-01-01 |
1982-06-29 |
|
Serum-free cell culture media
|
|
US4419446A
(en)
|
1980-12-31 |
1983-12-06 |
The United States Of America As Represented By The Department Of Health And Human Services |
Recombinant DNA process utilizing a papilloma virus DNA as a vector
|
|
NZ201705A
(en)
|
1981-08-31 |
1986-03-14 |
Genentech Inc |
Recombinant dna method for production of hepatitis b surface antigen in yeast
|
|
US4601978A
(en)
|
1982-11-24 |
1986-07-22 |
The Regents Of The University Of California |
Mammalian metallothionein promoter system
|
|
US4560655A
(en)
|
1982-12-16 |
1985-12-24 |
Immunex Corporation |
Serum-free cell culture medium and process for making same
|
|
US4657866A
(en)
|
1982-12-21 |
1987-04-14 |
Sudhir Kumar |
Serum-free, synthetic, completely chemically defined tissue culture media
|
|
US4767704A
(en)
|
1983-10-07 |
1988-08-30 |
Columbia University In The City Of New York |
Protein-free culture medium
|
|
GB8516415D0
(en)
|
1985-06-28 |
1985-07-31 |
Celltech Ltd |
Culture of animal cells
|
|
US4927762A
(en)
|
1986-04-01 |
1990-05-22 |
Cell Enterprises, Inc. |
Cell culture medium with antioxidant
|
|
ATE135397T1
(de)
|
1988-09-23 |
1996-03-15 |
Cetus Oncology Corp |
Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte
|
|
FR2646437B1
(fr)
|
1989-04-28 |
1991-08-30 |
Transgene Sa |
Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
JP3051145B2
(ja)
|
1990-08-28 |
2000-06-12 |
住友製薬株式会社 |
新規なポリエチレングリコール誘導体修飾ペプチド
|
|
US5122469A
(en)
|
1990-10-03 |
1992-06-16 |
Genentech, Inc. |
Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
|
|
DK0752248T3
(da)
|
1992-11-13 |
2000-11-13 |
Idec Pharma Corp |
Terapeutisk anvendelse af kimæriske og radioaktivt mærkede antistoffer mod humant B-lymfocytbegrænset differentieringsantig
|
|
US5932462A
(en)
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
|
US6261804B1
(en)
|
1997-01-21 |
2001-07-17 |
The General Hospital Corporation |
Selection of proteins using RNA-protein fusions
|
|
ATE332368T1
(de)
|
1997-01-21 |
2006-07-15 |
Gen Hospital Corp |
Selektion von proteinen mittels rns-protein fusionen
|
|
EP1958962A3
(en)
*
|
1997-06-12 |
2013-05-01 |
Novartis International Pharmaceutical Ltd. |
Artificial antibody polypeptides
|
|
DK1137941T4
(da)
|
1998-12-10 |
2014-01-06 |
Brystol Myers Squibb Company |
Protein-scaffolds til antistof-mimetika og andre bindingsproteiner
|
|
US6818418B1
(en)
|
1998-12-10 |
2004-11-16 |
Compound Therapeutics, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
|
US7115396B2
(en)
*
|
1998-12-10 |
2006-10-03 |
Compound Therapeutics, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
|
JP4118462B2
(ja)
|
1999-07-19 |
2008-07-16 |
株式会社リコー |
携帯電子機器
|
|
EP1074563A1
(en)
|
1999-08-02 |
2001-02-07 |
F. Hoffmann-La Roche Ag |
Chimeric polypeptides enhancing dimer formation through electrostatic interactions and disulfide bond, method for production and uses thereof
|
|
US20050287153A1
(en)
|
2002-06-28 |
2005-12-29 |
Genentech, Inc. |
Serum albumin binding peptides for tumor targeting
|
|
AU4445601A
(en)
|
2000-03-31 |
2001-10-08 |
Centre National De La Recherche Scientifique-Cnrs |
Peptides blocking vascular endothelial growth factor (vegf)-mediated angiogenesis, polynucleotides encoding said peptides and methods of use thereof
|
|
US6545853B1
(en)
|
2000-07-10 |
2003-04-08 |
Hughes Electronics Corporation |
Alternate grounding method
|
|
EP2141243A3
(en)
*
|
2000-10-16 |
2010-01-27 |
Brystol-Myers Squibb Company |
Protein scaffolds for antibody mimics and other binding proteins
|
|
US6989452B2
(en)
|
2001-05-31 |
2006-01-24 |
Medarex, Inc. |
Disulfide prodrugs and linkers and stabilizers useful therefor
|
|
US7696320B2
(en)
|
2004-08-24 |
2010-04-13 |
Domantis Limited |
Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
|
|
EP1900753B1
(en)
|
2002-11-08 |
2017-08-09 |
Ablynx N.V. |
Method of administering therapeutic polypeptides, and polypeptides therefor
|
|
CN1816356A
(zh)
|
2003-05-14 |
2006-08-09 |
免疫原公司 |
药物缀合物组合物
|
|
EP2478912B1
(en)
|
2003-11-06 |
2016-08-31 |
Seattle Genetics, Inc. |
Auristatin conjugates with anti-HER2 or anti-CD22 antibodies and their use in therapy
|
|
HUE027902T2
(en)
|
2004-02-09 |
2016-11-28 |
Human Genome Sciences Inc Corp Service Company |
Albumin fusion proteins
|
|
CA2556752C
(en)
|
2004-02-23 |
2016-02-02 |
Genentech, Inc. |
Heterocyclic self-immolative linkers and conjugates
|
|
US7778814B2
(en)
|
2004-03-30 |
2010-08-17 |
Siemens Aktiengesellschaft |
Method and device for simulating an automation system
|
|
US7691962B2
(en)
|
2004-05-19 |
2010-04-06 |
Medarex, Inc. |
Chemical linkers and conjugates thereof
|
|
JP4806680B2
(ja)
|
2004-05-19 |
2011-11-02 |
メダレックス インコーポレイテッド |
自己犠牲リンカー及び薬剤複合体
|
|
US7714016B2
(en)
|
2005-04-08 |
2010-05-11 |
Medarex, Inc. |
Cytotoxic compounds and conjugates with cleavable substrates
|
|
EP2354163A3
(en)
|
2005-09-26 |
2013-04-24 |
Medarex, Inc. |
Conjugates of duocarmycin and anti-CD70 or anti-PSMA antibodies
|
|
WO2007038868A2
(en)
|
2005-10-03 |
2007-04-12 |
The University Of British Columbia |
Novel enediyne compound and uses thereof
|
|
RS52100B
(sr)
|
2005-10-26 |
2012-06-30 |
Medarex, Inc. |
Postupci i jedinjenja za pripremu analoga cc-1065
|
|
WO2007059404A2
(en)
|
2005-11-10 |
2007-05-24 |
Medarex, Inc. |
Duocarmycin derivatives as novel cytotoxic compounds and conjugates
|
|
US20070269422A1
(en)
|
2006-05-17 |
2007-11-22 |
Ablynx N.V. |
Serum albumin binding proteins with long half-lives
|
|
AR062448A1
(es)
|
2006-05-25 |
2008-11-12 |
Endocyte Inc |
Conjugados de analogos de aziridinil-epotilona y composiciones farmaceuticas que comprenden los mismos
|
|
PE20080316A1
(es)
|
2006-05-25 |
2008-04-10 |
Bristol Myers Squibb Co |
Compuestos de aziridinil-epotilona
|
|
TWI412367B
(zh)
|
2006-12-28 |
2013-10-21 |
梅達雷克斯有限責任公司 |
化學鏈接劑與可裂解基質以及其之綴合物
|
|
AR065404A1
(es)
|
2007-02-21 |
2009-06-03 |
Medarex Inc |
Conjugados farmaco-ligando, los que se unen a citotoxinas potentes, composicion farmaceutica que los contienen y su uso para retardar o detener el crecimiento de un tumor en un mamifero
|
|
WO2009073115A1
(en)
*
|
2007-11-28 |
2009-06-11 |
Bristol-Myers Squibb Company |
Combination vegfr2 therapy with mtor inhibitors
|
|
WO2009083804A2
(en)
|
2007-12-27 |
2009-07-09 |
Novartis Ag |
Improved fibronectin-based binding molecules and their use
|
|
EA201001734A1
(ru)
*
|
2008-05-02 |
2011-10-31 |
Новартис Аг |
Улучшенные связывающие молекулы на основе фибронектина и их применение
|
|
WO2009142773A2
(en)
*
|
2008-05-22 |
2009-11-26 |
Bristol-Myers Squibb Company |
Multivalent fibronectin based scaffold domain proteins
|
|
US8394922B2
(en)
|
2009-08-03 |
2013-03-12 |
Medarex, Inc. |
Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof
|
|
ES2722300T3
(es)
|
2009-12-10 |
2019-08-09 |
Hoffmann La Roche |
Anticuerpos que se unen preferentemente al dominio extracelular 4 de CSF1R y su uso
|
|
JP2013520426A
(ja)
*
|
2010-02-18 |
2013-06-06 |
ブリストル−マイヤーズ スクイブ カンパニー |
Il−23に結合する、フィブロネクチンをベースとする足場ドメインタンパク質
|
|
US9169323B2
(en)
|
2010-03-05 |
2015-10-27 |
Hoffmann-La Roche Inc. |
Antibodies against human CSF-1R
|
|
JP5989547B2
(ja)
|
2010-03-05 |
2016-09-07 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
ヒトcsf−1rに対する抗体及びその使用
|
|
EP2556087A1
(en)
|
2010-04-09 |
2013-02-13 |
Novozymes Biopharma DK A/S |
Albumin derivatives and variants
|
|
WO2011130324A1
(en)
|
2010-04-13 |
2011-10-20 |
Medimmune, Llc |
Fibronectin type iii domain-based multimeric scaffolds
|
|
EP2558491B1
(en)
*
|
2010-04-13 |
2018-07-04 |
Bristol-Myers Squibb Company |
Fibronectin based scaffold domain proteins that bind pcsk9
|
|
CA2795349C
(en)
|
2010-04-15 |
2016-11-29 |
Seattle Genetics, Inc. |
Targeted pyrrolobenzodiazepine conjugates
|
|
JP5875083B2
(ja)
|
2010-04-15 |
2016-03-02 |
メディミューン リミテッド |
増殖性疾患治療用ピロロベンゾジアゼピン
|
|
HRP20190047T1
(hr)
|
2010-05-04 |
2019-02-22 |
Five Prime Therapeutics, Inc. |
Protutijela koja se vežu na csf1r
|
|
CN107903321A
(zh)
|
2010-07-30 |
2018-04-13 |
诺华有限公司 |
纤连蛋白摇篮分子和其库
|
|
US20130225496A1
(en)
|
2010-11-01 |
2013-08-29 |
Novozymes Biopharma Dk A/S |
Albumin Variants
|
|
AU2011331232B2
(en)
*
|
2010-11-15 |
2015-05-07 |
Pieris Ag |
Muteins of human lipocalin 2 with affinity for Glypican-3 (GPC3)
|
|
EP2647706B1
(en)
*
|
2010-11-30 |
2023-05-17 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly
|
|
US8852599B2
(en)
|
2011-05-26 |
2014-10-07 |
Bristol-Myers Squibb Company |
Immunoconjugates, compositions for making them, and methods of making and use
|
|
SG11201400770SA
(en)
|
2011-09-20 |
2014-04-28 |
Spirogen Sarl |
Pyrrolobenzodiazepines as unsymmetrical dimeric pbd compounds for inclusion in targeted conjugates
|
|
RU2658603C2
(ru)
|
2011-12-15 |
2018-06-21 |
Ф.Хоффманн-Ля Рош Аг |
Антитела против человеческого csf-1r и их применения
|
|
KR20140127855A
(ko)
|
2012-02-06 |
2014-11-04 |
제넨테크, 인크. |
Csf1r 억제제를 사용하는 조성물 및 방법
|
|
HUE033704T2
(en)
|
2012-02-13 |
2017-12-28 |
Bristol Myers Squibb Co |
Enediyne compounds, conjugates thereof, and uses and methods therefor
|
|
AR090263A1
(es)
|
2012-03-08 |
2014-10-29 |
Hoffmann La Roche |
Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma
|
|
RU2670743C9
(ru)
|
2012-05-11 |
2018-12-19 |
Файв Прайм Терапьютикс, Инк. |
Способы лечения состояний антителами, которые связывают рецептор колониестимулирующего фактора 1 (csf1r)
|
|
CN107759690A
(zh)
|
2012-08-31 |
2018-03-06 |
戊瑞治疗有限公司 |
用结合群落刺激因子1受体(csf1r)的抗体治疗病状的方法
|
|
ES2984405T3
(es)
*
|
2012-09-13 |
2024-10-29 |
Bristol Myers Squibb Co |
Proteínas de dominio de andamio basadas en fibronectina que se unen a la miostatina
|
|
LT2956173T
(lt)
|
2013-02-14 |
2017-06-26 |
Bristol-Myers Squibb Company |
Tubulizino junginiai, gavimo ir panaudojimo būdai
|
|
US9433689B2
(en)
|
2013-03-12 |
2016-09-06 |
The Board Of Trustees Of The Leland Stanford Junio |
Probes and methods of imaging non-Hodgkins lymphoma
|
|
WO2014159087A1
(en)
*
|
2013-03-14 |
2014-10-02 |
The Board Of Trustees Of The Leland Stanford Junior University |
Radiolabeled anti-glypican-3 immunoconjugates for immuno-pet imaging of hepatocellular carcinoma
|
|
AU2014306592B2
(en)
|
2013-08-14 |
2019-04-04 |
Bristol-Myers Squibb Company |
Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents
|
|
CA2943228C
(en)
*
|
2014-03-20 |
2023-03-14 |
Bristol-Myers Squibb Company |
Stabilized fibronectin based scaffold molecules
|
|
CN108884147B
(zh)
|
2015-09-23 |
2024-02-27 |
百时美施贵宝公司 |
结合磷脂酰肌醇蛋白聚糖3的基于纤连蛋白的支架分子
|