JP2018533369A5 - - Google Patents
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- JP2018533369A5 JP2018533369A5 JP2018534505A JP2018534505A JP2018533369A5 JP 2018533369 A5 JP2018533369 A5 JP 2018533369A5 JP 2018534505 A JP2018534505 A JP 2018534505A JP 2018534505 A JP2018534505 A JP 2018534505A JP 2018533369 A5 JP2018533369 A5 JP 2018533369A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- polypeptide
- fbs
- nos
- drug conjugate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 31
- 229920001184 polypeptide Polymers 0.000 claims 30
- 102000004196 processed proteins & peptides Human genes 0.000 claims 30
- 229940079593 drug Drugs 0.000 claims 21
- 239000003814 drug Substances 0.000 claims 21
- 150000001413 amino acids Chemical group 0.000 claims 11
- 235000018417 cysteine Nutrition 0.000 claims 10
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 10
- 229910052717 sulfur Inorganic materials 0.000 claims 8
- 125000004434 sulfur atom Chemical group 0.000 claims 8
- 102000010956 Glypican Human genes 0.000 claims 5
- 108050001154 Glypican Proteins 0.000 claims 5
- 108050007237 Glypican-3 Proteins 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 235000001014 amino acid Nutrition 0.000 claims 3
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 3
- -1 Cit-Cit Chemical compound 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 102000007562 Serum Albumin Human genes 0.000 claims 2
- 108010071390 Serum Albumin Proteins 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- AGGWFDNPHKLBBV-YUMQZZPRSA-N (2s)-2-[[(2s)-2-amino-3-methylbutanoyl]amino]-5-(carbamoylamino)pentanoic acid Chemical group CC(C)[C@H](N)C(=O)N[C@H](C(O)=O)CCCNC(N)=O AGGWFDNPHKLBBV-YUMQZZPRSA-N 0.000 claims 1
- CCUAQNUWXLYFRA-IMJSIDKUSA-N Ala-Asn Chemical compound C[C@H]([NH3+])C(=O)N[C@H](C([O-])=O)CC(N)=O CCUAQNUWXLYFRA-IMJSIDKUSA-N 0.000 claims 1
- ZIBWKCRKNFYTPT-ZKWXMUAHSA-N Ala-Asn-Val Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(O)=O ZIBWKCRKNFYTPT-ZKWXMUAHSA-N 0.000 claims 1
- LIWMQSWFLXEGMA-WDSKDSINSA-N Ala-Val Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@H](C)N LIWMQSWFLXEGMA-WDSKDSINSA-N 0.000 claims 1
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 1
- 102000002090 Fibronectin type III Human genes 0.000 claims 1
- 108050009401 Fibronectin type III Proteins 0.000 claims 1
- 101001014668 Homo sapiens Glypican-3 Proteins 0.000 claims 1
- 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 claims 1
- 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 claims 1
- NVGBPTNZLWRQSY-UWVGGRQHSA-N Lys-Lys Chemical compound NCCCC[C@H](N)C(=O)N[C@H](C(O)=O)CCCCN NVGBPTNZLWRQSY-UWVGGRQHSA-N 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
- 102000004338 Transferrin Human genes 0.000 claims 1
- 108090000901 Transferrin Proteins 0.000 claims 1
- QRZVUAAKNRHEOP-GUBZILKMSA-N Val-Ala-Val Chemical compound [H]N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(O)=O QRZVUAAKNRHEOP-GUBZILKMSA-N 0.000 claims 1
- AEMPCGRFEZTWIF-IHRRRGAJSA-N Val-Leu-Lys Chemical compound CC(C)[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(O)=O AEMPCGRFEZTWIF-IHRRRGAJSA-N 0.000 claims 1
- JKHXYJKMNSSFFL-IUCAKERBSA-N Val-Lys Chemical compound CC(C)[C@H](N)C(=O)N[C@H](C(O)=O)CCCCN JKHXYJKMNSSFFL-IUCAKERBSA-N 0.000 claims 1
- 208000008383 Wilms tumor Diseases 0.000 claims 1
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims 1
- 102000023732 binding proteins Human genes 0.000 claims 1
- 108091008324 binding proteins Proteins 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 208000006359 hepatoblastoma Diseases 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 102000048373 human GPC3 Human genes 0.000 claims 1
- 125000005597 hydrazone group Chemical group 0.000 claims 1
- 102000028557 immunoglobulin binding proteins Human genes 0.000 claims 1
- 108091009323 immunoglobulin binding proteins Proteins 0.000 claims 1
- 201000005243 lung squamous cell carcinoma Diseases 0.000 claims 1
- 108010054155 lysyllysine Proteins 0.000 claims 1
- 125000005439 maleimidyl group Chemical group C1(C=CC(N1*)=O)=O 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 201000008026 nephroblastoma Diseases 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 claims 1
- 150000003568 thioethers Chemical class 0.000 claims 1
- 239000012581 transferrin Substances 0.000 claims 1
- 108010073969 valyllysine Proteins 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021155065A JP7336494B2 (ja) | 2015-09-23 | 2021-09-24 | グリピカン－３結合フィブロネクチンベース足場分子 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562222633P | 2015-09-23 | 2015-09-23 | |
| US62/222,633 | 2015-09-23 | ||
| PCT/US2016/053185 WO2017053619A1 (en) | 2015-09-23 | 2016-09-22 | Glypican-3binding fibronectin based scafflold molecules |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021155065A Division JP7336494B2 (ja) | 2015-09-23 | 2021-09-24 | グリピカン－３結合フィブロネクチンベース足場分子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018533369A JP2018533369A (ja) | 2018-11-15 |
| JP2018533369A5 true JP2018533369A5 (https=) | 2019-11-21 |
| JP6951340B2 JP6951340B2 (ja) | 2021-10-20 |
Family
ID=57068233
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018534505A Active JP6951340B2 (ja) | 2015-09-23 | 2016-09-22 | グリピカン−３結合フィブロネクチンベース足場分子 |
| JP2021155065A Active JP7336494B2 (ja) | 2015-09-23 | 2021-09-24 | グリピカン－３結合フィブロネクチンベース足場分子 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021155065A Active JP7336494B2 (ja) | 2015-09-23 | 2021-09-24 | グリピカン－３結合フィブロネクチンベース足場分子 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US10584160B2 (https=) |
| EP (2) | EP3353198B1 (https=) |
| JP (2) | JP6951340B2 (https=) |
| KR (1) | KR102818445B1 (https=) |
| CN (1) | CN108884147B (https=) |
| ES (1) | ES2809125T3 (https=) |
| WO (1) | WO2017053619A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2943228C (en) | 2014-03-20 | 2023-03-14 | Bristol-Myers Squibb Company | Stabilized fibronectin based scaffold molecules |
| CA2969067A1 (en) | 2014-11-25 | 2016-06-02 | Bristol-Myers Squibb Company | Novel pd-l1 binding polypeptides for imaging |
| CN107207379B (zh) | 2014-11-25 | 2021-08-10 | 百时美施贵宝公司 | 用于生物制品的18f-放射性标记的方法和组合物 |
| CN108884147B (zh) | 2015-09-23 | 2024-02-27 | 百时美施贵宝公司 | 结合磷脂酰肌醇蛋白聚糖3的基于纤连蛋白的支架分子 |
| KR20180090290A (ko) | 2015-12-04 | 2018-08-10 | 시애틀 지네틱스, 인크. | 사차화 튜불리신 화합물들의 컨쥬게이트들 |
| US11793880B2 (en) | 2015-12-04 | 2023-10-24 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| JP7016323B2 (ja) | 2016-06-01 | 2022-02-21 | ブリストル－マイヤーズ スクイブ カンパニー | Ｐｄ－ｌ１結合ポリペプチドを用いるｐｅｔ造影 |
| US10994033B2 (en) | 2016-06-01 | 2021-05-04 | Bristol-Myers Squibb Company | Imaging methods using 18F-radiolabeled biologics |
| KR102617252B1 (ko) | 2018-05-21 | 2023-12-26 | 삼성전자주식회사 | 전자 장치 및 그 파노라마 촬영 모드 자동 전환 방법 |
| SG11202104136YA (en) | 2018-10-23 | 2021-05-28 | Dragonfly Therapeutics Inc | Heterodimeric fc-fused proteins |
| KR102154683B1 (ko) * | 2019-11-08 | 2020-09-11 | 주식회사 압타머사이언스 | 글리피칸-3 특이적 변형 압타머 및 이의 용도 |
| MX2022013112A (es) | 2020-04-22 | 2023-01-16 | Dragonfly Therapeutics Inc | Fórmulacion, regimen de dosificación y proceso de manufactura de proteínas heterodiméricas fusionadas con fc. |
| AU2021377232A1 (en) * | 2020-11-10 | 2023-06-15 | New York University | Macropinocytosis selective monobody-drug conjugates |
| AU2022260298A1 (en) * | 2021-04-23 | 2023-11-02 | Shanghai Henlius Biotech, Inc. | Anti-gpc3 antibodies, multispecific antibodies and methods of use |
| KR20260022328A (ko) * | 2023-06-07 | 2026-02-19 | 레이즈바이오, 인크. | 글리피칸-3을 표적화하는 방사성제약 조성물 및 그의 용도 |
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| AR090263A1 (es) | 2012-03-08 | 2014-10-29 | Hoffmann La Roche | Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma |
| RU2670743C9 (ru) | 2012-05-11 | 2018-12-19 | Файв Прайм Терапьютикс, Инк. | Способы лечения состояний антителами, которые связывают рецептор колониестимулирующего фактора 1 (csf1r) |
| CN107759690A (zh) | 2012-08-31 | 2018-03-06 | 戊瑞治疗有限公司 | 用结合群落刺激因子1受体(csf1r)的抗体治疗病状的方法 |
| ES2984405T3 (es) * | 2012-09-13 | 2024-10-29 | Bristol Myers Squibb Co | Proteínas de dominio de andamio basadas en fibronectina que se unen a la miostatina |
| LT2956173T (lt) | 2013-02-14 | 2017-06-26 | Bristol-Myers Squibb Company | Tubulizino junginiai, gavimo ir panaudojimo būdai |
| US9433689B2 (en) | 2013-03-12 | 2016-09-06 | The Board Of Trustees Of The Leland Stanford Junio | Probes and methods of imaging non-Hodgkins lymphoma |
| WO2014159087A1 (en) * | 2013-03-14 | 2014-10-02 | The Board Of Trustees Of The Leland Stanford Junior University | Radiolabeled anti-glypican-3 immunoconjugates for immuno-pet imaging of hepatocellular carcinoma |
| AU2014306592B2 (en) | 2013-08-14 | 2019-04-04 | Bristol-Myers Squibb Company | Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents |
| CA2943228C (en) * | 2014-03-20 | 2023-03-14 | Bristol-Myers Squibb Company | Stabilized fibronectin based scaffold molecules |
| CN108884147B (zh) | 2015-09-23 | 2024-02-27 | 百时美施贵宝公司 | 结合磷脂酰肌醇蛋白聚糖3的基于纤连蛋白的支架分子 |
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2016
- 2016-09-22 CN CN201680068052.XA patent/CN108884147B/zh active Active
- 2016-09-22 EP EP16775949.7A patent/EP3353198B1/en active Active
- 2016-09-22 WO PCT/US2016/053185 patent/WO2017053619A1/en not_active Ceased
- 2016-09-22 JP JP2018534505A patent/JP6951340B2/ja active Active
- 2016-09-22 KR KR1020187010908A patent/KR102818445B1/ko active Active
- 2016-09-22 EP EP20168319.0A patent/EP3733698A1/en not_active Withdrawn
- 2016-09-22 US US15/760,449 patent/US10584160B2/en active Active
- 2016-09-22 ES ES16775949T patent/ES2809125T3/es active Active
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2020
- 2020-01-24 US US16/751,788 patent/US11524992B2/en active Active
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2021
- 2021-09-24 JP JP2021155065A patent/JP7336494B2/ja active Active
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2022
- 2022-11-10 US US17/985,012 patent/US12492238B2/en active Active
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