JP2021536428A5 - - Google Patents
Info
- Publication number
- JP2021536428A5 JP2021536428A5 JP2021507444A JP2021507444A JP2021536428A5 JP 2021536428 A5 JP2021536428 A5 JP 2021536428A5 JP 2021507444 A JP2021507444 A JP 2021507444A JP 2021507444 A JP2021507444 A JP 2021507444A JP 2021536428 A5 JP2021536428 A5 JP 2021536428A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- hydroxy
- independently selected
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025010749A JP2025063306A (ja) | 2018-08-14 | 2025-01-24 | 置換インドール及びその使用方法 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862718746P | 2018-08-14 | 2018-08-14 | |
| US62/718,746 | 2018-08-14 | ||
| US201862773770P | 2018-11-30 | 2018-11-30 | |
| US62/773,770 | 2018-11-30 | ||
| US201962857120P | 2019-06-04 | 2019-06-04 | |
| US62/857,120 | 2019-06-04 | ||
| PCT/US2019/046569 WO2020037079A1 (en) | 2018-08-14 | 2019-08-14 | Substituted indoles and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025010749A Division JP2025063306A (ja) | 2018-08-14 | 2025-01-24 | 置換インドール及びその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021536428A JP2021536428A (ja) | 2021-12-27 |
| JP2021536428A5 true JP2021536428A5 (https=) | 2022-08-23 |
| JP7627209B2 JP7627209B2 (ja) | 2025-02-05 |
Family
ID=69525931
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021507444A Active JP7627209B2 (ja) | 2018-08-14 | 2019-08-14 | 置換インドール及びその使用方法 |
| JP2025010749A Pending JP2025063306A (ja) | 2018-08-14 | 2025-01-24 | 置換インドール及びその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025010749A Pending JP2025063306A (ja) | 2018-08-14 | 2025-01-24 | 置換インドール及びその使用方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US12116358B2 (https=) |
| EP (1) | EP3837240A4 (https=) |
| JP (2) | JP7627209B2 (https=) |
| KR (1) | KR20210065097A (https=) |
| CN (1) | CN112585119A (https=) |
| AU (2) | AU2019321464B2 (https=) |
| BR (1) | BR112021002633A2 (https=) |
| CA (1) | CA3109214A1 (https=) |
| CO (1) | CO2021003300A2 (https=) |
| IL (2) | IL280709B2 (https=) |
| MA (1) | MA53235A (https=) |
| MX (2) | MX2021001690A (https=) |
| MY (1) | MY207663A (https=) |
| PH (1) | PH12021550296A1 (https=) |
| SG (1) | SG11202101367YA (https=) |
| WO (1) | WO2020037079A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119405809A (zh) | 2017-08-14 | 2025-02-11 | Epizyme股份有限公司 | 通过抑制setd2治疗癌症的方法 |
| MX2021006347A (es) * | 2018-11-30 | 2021-10-13 | Epizyme Inc | Metodos de tratamiento de cánceres que sobreexpresan whsc1 mediante la inhibición de setd2. |
| WO2021032935A1 (en) * | 2019-08-21 | 2021-02-25 | Kalvista Pharmaceuticals Limited | Enzyme inhibitors |
| CN115151540A (zh) | 2019-12-02 | 2022-10-04 | 风暴治疗有限公司 | 作为mettl3抑制剂的多杂环化合物 |
| IL295654A (en) * | 2020-02-19 | 2022-10-01 | Epizyme Inc | Setd2 inhibitors and related methods and uses, including combination therapies |
| KR102682775B1 (ko) * | 2020-06-26 | 2024-07-08 | 홀로스메딕 주식회사 | 신규한 화합물의 제조방법 |
| CN115536648B (zh) * | 2021-06-29 | 2024-09-17 | 深圳开悦生命科技有限公司 | 一类抑制rna解旋酶dhx33的多环化合物及其应用 |
| US20240228667A9 (en) * | 2021-02-26 | 2024-07-11 | Celgene Corporation | Methods for Treating Multiple Myeloma |
| KR20220148758A (ko) * | 2021-04-29 | 2022-11-07 | 홀로스메딕 주식회사 | 신규한 화합물 및 이를 포함하는 암 예방 또는 치료용 약학 조성물 |
| IL308868A (en) * | 2021-06-09 | 2024-01-01 | Epizyme Inc | Combined treatments with SETD2 inhibitors |
| WO2023077117A1 (en) * | 2021-11-01 | 2023-05-04 | Epizyme, Inc. | Crystalline forms of n-((1r,3s)-3-(4-acetylpiperazin-1-yl)cyclohexyl)-4-fluoro-7-methyl-1h-indole-2-carboxamide |
| CN116794170B (zh) * | 2022-03-18 | 2025-11-14 | 上海润石医药科技有限公司 | 一种化合物的生物样品检测方法 |
| CN117800944A (zh) * | 2022-09-30 | 2024-04-02 | 苏州阿尔脉生物科技有限公司 | 吡啶酰胺类衍生物、包含其的药物组合物及其医药用途 |
| WO2024091450A1 (en) * | 2022-10-24 | 2024-05-02 | The Regents Of The University Of California | Compounds and methods for treating cancer |
| KR20250095720A (ko) * | 2022-10-31 | 2025-06-26 | 일라이 릴리 앤드 캄파니 | Ahr 효능제 |
| EP4652168A1 (en) * | 2023-01-19 | 2025-11-26 | Beone Medicines I GmbH | 5-amino-1h-pyrrolo [3, 2-b] pyridine-2-carboxamide derivatives as mta-cooperative inhibitors of prmt5 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL63907A0 (en) | 1980-09-24 | 1981-12-31 | Cetus Corp | Diagnostic method and antibody probe for use therein |
| US4582788A (en) | 1982-01-22 | 1986-04-15 | Cetus Corporation | HLA typing method and cDNA probes used therein |
| ATE53862T1 (de) | 1982-01-22 | 1990-06-15 | Cetus Corp | Verfahren zur charakterisierung von hla und die darin benutzten cdns-testmittel. |
| US4683194A (en) | 1984-05-29 | 1987-07-28 | Cetus Corporation | Method for detection of polymorphic restriction sites and nucleic acid sequences |
| US4595766A (en) | 1984-10-26 | 1986-06-17 | Ciba-Geigy Corporation | Process for the preparation of an indoline carboxylic acid |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| CA1284931C (en) | 1986-03-13 | 1991-06-18 | Henry A. Erlich | Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids |
| CA1338457C (en) | 1986-08-22 | 1996-07-16 | Henry A. Erlich | Purified thermostable enzyme |
| US6921763B2 (en) | 1999-09-17 | 2005-07-26 | Abbott Laboratories | Pyrazolopyrimidines as therapeutic agents |
| AU2003265382A1 (en) | 2002-08-23 | 2004-03-11 | Pharmacia & Upjohn Company Llc | Antibacterial benzoic acid derivatives |
| US20040110802A1 (en) * | 2002-08-23 | 2004-06-10 | Atli Thorarensen | Antibacterial benzoic acid derivatives |
| EP1880994A4 (en) | 2005-05-11 | 2010-04-14 | Eisai R&D Man Co Ltd | INDOLE DERIVED CRYSTAL COMPRISING A PIPERIDINE CYCLE AND PROCESS FOR SYNTHESIZING SAID CRYSTAL |
| CA2628074C (en) * | 2005-10-25 | 2014-01-14 | Shionogi & Co., Ltd. | Aminodihydrothiazine derivative |
| US7838542B2 (en) * | 2006-06-29 | 2010-11-23 | Kinex Pharmaceuticals, Llc | Bicyclic compositions and methods for modulating a kinase cascade |
| WO2009158375A1 (en) * | 2008-06-25 | 2009-12-30 | Abbott Laboratories | Aza-cylic indole- 2 -carboxamides and methods of use thereof |
| AU2009289649B2 (en) * | 2008-09-03 | 2016-05-05 | Biomarin Pharmaceutical Inc. | Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors |
| WO2011011366A2 (en) | 2009-07-20 | 2011-01-27 | Constellation Pharmaceuticals | Agents for stimulating activity of methyl modifying enzymes and methods of use thereof |
| AU2010333779A1 (en) * | 2009-12-23 | 2012-07-12 | Sanofi | Indolyl-piperidinyl benzylamines as beta-tryptase inhibitors |
| JP2013518560A (ja) | 2010-02-03 | 2013-05-23 | オンコセラピー・サイエンス株式会社 | がんの治療および診断の標的遺伝子としてのｗｈｓｃ１およびｗｈｓｃ１ｌ１ |
| JP2012107001A (ja) * | 2010-10-22 | 2012-06-07 | Shionogi & Co Ltd | インドールアミド化合物を含有する医薬 |
| CA2853501A1 (en) | 2011-10-27 | 2013-05-02 | Memorial Sloan-Kettering Cancer Center | Methyltransferase inhibitors for treating cancer |
| US9446064B2 (en) | 2013-03-14 | 2016-09-20 | Epizyme, Inc. | Combination therapy for treating cancer |
| WO2015143424A2 (en) | 2014-03-21 | 2015-09-24 | Glaxosmithkline Intellectual Property (No. 2) Limited | Methods of treating cancer |
| US10167257B2 (en) | 2014-04-04 | 2019-01-01 | Iomet Pharma Ltd. | Indole derivatives for use in medicine |
| WO2015164482A1 (en) * | 2014-04-22 | 2015-10-29 | The Johns Hopkins University | Inhibitors of drug-resistant mycobacterium tuberculosis |
| US9902702B2 (en) * | 2014-07-15 | 2018-02-27 | Bristol-Myers Squibb Company | Spirocycloheptanes as inhibitors of rock |
| AU2015301746A1 (en) | 2014-08-13 | 2017-02-16 | Celgene Corporation | Combination therapy for treating cancer |
| BR112017004612A2 (pt) * | 2014-09-10 | 2018-01-30 | Epizyme, Inc. | compostos, composição farmacêutica, usos de um composto, e kit |
| WO2016079321A1 (en) | 2014-11-20 | 2016-05-26 | Cemm Forschungszentrum Für Molekulare Medizin Gmbh | Antagonists of setdb2 for use in the therapy of infectious diseases |
| US9717745B2 (en) | 2015-03-19 | 2017-08-01 | Zhejiang DTRM Biopharma Co. Ltd. | Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases |
| US20190026440A1 (en) | 2015-12-17 | 2019-01-24 | Albert Einstein College Of Medicine, Inc. | Nuclear receptor set domain containing protein 2 transition state and uses thereof |
| CN106317043B (zh) * | 2016-08-19 | 2018-11-02 | 成都理工大学 | 一种大麻素受体2激动剂 |
| CN119405809A (zh) | 2017-08-14 | 2025-02-11 | Epizyme股份有限公司 | 通过抑制setd2治疗癌症的方法 |
| MX2021006347A (es) | 2018-11-30 | 2021-10-13 | Epizyme Inc | Metodos de tratamiento de cánceres que sobreexpresan whsc1 mediante la inhibición de setd2. |
| IL295654A (en) | 2020-02-19 | 2022-10-01 | Epizyme Inc | Setd2 inhibitors and related methods and uses, including combination therapies |
| IL308868A (en) | 2021-06-09 | 2024-01-01 | Epizyme Inc | Combined treatments with SETD2 inhibitors |
| WO2023077117A1 (en) | 2021-11-01 | 2023-05-04 | Epizyme, Inc. | Crystalline forms of n-((1r,3s)-3-(4-acetylpiperazin-1-yl)cyclohexyl)-4-fluoro-7-methyl-1h-indole-2-carboxamide |
-
2019
- 2019-08-14 CN CN201980054976.8A patent/CN112585119A/zh active Pending
- 2019-08-14 IL IL280709A patent/IL280709B2/en unknown
- 2019-08-14 MX MX2021001690A patent/MX2021001690A/es unknown
- 2019-08-14 IL IL310632A patent/IL310632A/en unknown
- 2019-08-14 SG SG11202101367YA patent/SG11202101367YA/en unknown
- 2019-08-14 US US17/268,151 patent/US12116358B2/en active Active
- 2019-08-14 EP EP19849109.4A patent/EP3837240A4/en active Pending
- 2019-08-14 MY MYPI2021000755A patent/MY207663A/en unknown
- 2019-08-14 MA MA053235A patent/MA53235A/fr unknown
- 2019-08-14 WO PCT/US2019/046569 patent/WO2020037079A1/en not_active Ceased
- 2019-08-14 KR KR1020217006988A patent/KR20210065097A/ko active Pending
- 2019-08-14 CA CA3109214A patent/CA3109214A1/en active Pending
- 2019-08-14 BR BR112021002633-9A patent/BR112021002633A2/pt unknown
- 2019-08-14 AU AU2019321464A patent/AU2019321464B2/en active Active
- 2019-08-14 JP JP2021507444A patent/JP7627209B2/ja active Active
-
2021
- 2021-02-10 PH PH12021550296A patent/PH12021550296A1/en unknown
- 2021-02-11 MX MX2025006292A patent/MX2025006292A/es unknown
- 2021-03-12 CO CONC2021/0003300A patent/CO2021003300A2/es unknown
-
2025
- 2025-01-24 JP JP2025010749A patent/JP2025063306A/ja active Pending
- 2025-06-19 AU AU2025204601A patent/AU2025204601A1/en active Pending
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