JP7627209B2 - 置換インドール及びその使用方法 - Google Patents

置換インドール及びその使用方法 Download PDF

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JP7627209B2
JP7627209B2 JP2021507444A JP2021507444A JP7627209B2 JP 7627209 B2 JP7627209 B2 JP 7627209B2 JP 2021507444 A JP2021507444 A JP 2021507444A JP 2021507444 A JP2021507444 A JP 2021507444A JP 7627209 B2 JP7627209 B2 JP 7627209B2
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alkyl
group
hydroxy
amino
substituted
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JP2021536428A (ja
JP2021536428A5 (https=
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ジョン ランプ，
ジョン キャンベル，
ケネス ダンカン，
メーガン エイリーン クルーナン フォーリー，
ダレン マーティン ハービー，
マイケル ジョン マンチホフ，
マイケル トーメニアス，
ローレンス アラン ライター，
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エピザイム，インコーポレイティド
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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JP2021507444A 2018-08-14 2019-08-14 置換インドール及びその使用方法 Active JP7627209B2 (ja)

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US201862718746P 2018-08-14 2018-08-14
US62/718,746 2018-08-14
US201862773770P 2018-11-30 2018-11-30
US62/773,770 2018-11-30
US201962857120P 2019-06-04 2019-06-04
US62/857,120 2019-06-04
PCT/US2019/046569 WO2020037079A1 (en) 2018-08-14 2019-08-14 Substituted indoles and methods of use thereof

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EP (1) EP3837240A4 (https=)
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KR (1) KR20210065097A (https=)
CN (1) CN112585119A (https=)
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MX2021006347A (es) * 2018-11-30 2021-10-13 Epizyme Inc Metodos de tratamiento de cánceres que sobreexpresan whsc1 mediante la inhibición de setd2.
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