CN112585119A - 经取代的吲哚及其使用方法 - Google Patents

经取代的吲哚及其使用方法 Download PDF

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Publication number
CN112585119A
CN112585119A CN201980054976.8A CN201980054976A CN112585119A CN 112585119 A CN112585119 A CN 112585119A CN 201980054976 A CN201980054976 A CN 201980054976A CN 112585119 A CN112585119 A CN 112585119A
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group
alkyl
alkyl group
hydroxy
cycloalkyl
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Chinese (zh)
Inventor
约翰·兰普
约翰·坎贝尔
肯尼思·邓肯
梅根·艾琳·克卢南·弗雷
达伦·马丁·哈维
迈克尔·约翰·芒赤霍夫
迈克尔·托梅纽斯
劳伦斯·艾伦·赖特
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Epizyme Inc
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Epizyme Inc
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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CN201980054976.8A 2018-08-14 2019-08-14 经取代的吲哚及其使用方法 Pending CN112585119A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862718746P 2018-08-14 2018-08-14
US62/718,746 2018-08-14
US201862773770P 2018-11-30 2018-11-30
US62/773,770 2018-11-30
US201962857120P 2019-06-04 2019-06-04
US62/857,120 2019-06-04
PCT/US2019/046569 WO2020037079A1 (en) 2018-08-14 2019-08-14 Substituted indoles and methods of use thereof

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CN112585119A true CN112585119A (zh) 2021-03-30

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EP (1) EP3837240A4 (https=)
JP (2) JP7627209B2 (https=)
KR (1) KR20210065097A (https=)
CN (1) CN112585119A (https=)
AU (2) AU2019321464B2 (https=)
BR (1) BR112021002633A2 (https=)
CA (1) CA3109214A1 (https=)
CO (1) CO2021003300A2 (https=)
IL (2) IL310632A (https=)
MA (1) MA53235A (https=)
MX (2) MX2021001690A (https=)
MY (1) MY207663A (https=)
PH (1) PH12021550296A1 (https=)
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023274251A1 (zh) * 2021-06-29 2023-01-05 深圳开悦生命科技有限公司 一类抑制rna解旋酶dhx33的多环化合物及其应用
WO2024067709A1 (zh) * 2022-09-30 2024-04-04 苏州阿尔脉生物科技有限公司 吡啶酰胺类衍生物、包含其的药物组合物及其医药用途

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020530844A (ja) 2017-08-14 2020-10-29 エピザイム，インコーポレイティド Ｓｅｔｄ２を阻害することにより癌を処置する方法
SG11202105325QA (en) * 2018-11-30 2021-06-29 Epizyme Inc Methods of treating whsc1-overexpressing cancers by inhibiting setd2
WO2021032935A1 (en) * 2019-08-21 2021-02-25 Kalvista Pharmaceuticals Limited Enzyme inhibitors
IL293340A (en) 2019-12-02 2022-07-01 Storm Therapeutics Ltd Polyheterocyclic compounds as mettl3 inhibitors
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