JP2019501222A5 - - Google Patents
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- JP2019501222A5 JP2019501222A5 JP2018554640A JP2018554640A JP2019501222A5 JP 2019501222 A5 JP2019501222 A5 JP 2019501222A5 JP 2018554640 A JP2018554640 A JP 2018554640A JP 2018554640 A JP2018554640 A JP 2018554640A JP 2019501222 A5 JP2019501222 A5 JP 2019501222A5
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- 0 C*[C@@]1COCC1 Chemical compound C*[C@@]1COCC1 0.000 description 13
- LVEIJLGSXRYDEY-UHFFFAOYSA-N CC(C)c1c[nH]nn1 Chemical compound CC(C)c1c[nH]nn1 LVEIJLGSXRYDEY-UHFFFAOYSA-N 0.000 description 1
- ZLVYAWVDOLLMSD-UHFFFAOYSA-N CN(C)CCN(C)c(c(NC(C=C)=O)c1)cc(OC)c1Nc1nc(-c(cc2)c(cc[nH]3)c3c2C(N)=O)ccn1 Chemical compound CN(C)CCN(C)c(c(NC(C=C)=O)c1)cc(OC)c1Nc1nc(-c(cc2)c(cc[nH]3)c3c2C(N)=O)ccn1 ZLVYAWVDOLLMSD-UHFFFAOYSA-N 0.000 description 1
- XFSTWIDWOQOLIQ-UHFFFAOYSA-N CN(C)CCN(C)c(c(NC(C=C)=O)c1)cc(OC)c1Nc1nc(-c2c(cc[n]3C)c3cc(C(N)=O)c2)ccn1 Chemical compound CN(C)CCN(C)c(c(NC(C=C)=O)c1)cc(OC)c1Nc1nc(-c2c(cc[n]3C)c3cc(C(N)=O)c2)ccn1 XFSTWIDWOQOLIQ-UHFFFAOYSA-N 0.000 description 1
- RHSWKSOLSABYHY-UHFFFAOYSA-N CN(C)CCN(C)c(cc(c(Nc(nc1)nc(-c2c(cc[n]3C)c3cc(C(N)=O)c2)c1Cl)c1)OC)c1NC(C=C)=O Chemical compound CN(C)CCN(C)c(cc(c(Nc(nc1)nc(-c2c(cc[n]3C)c3cc(C(N)=O)c2)c1Cl)c1)OC)c1NC(C=C)=O RHSWKSOLSABYHY-UHFFFAOYSA-N 0.000 description 1
- BSKHPKMHTQYZBB-UHFFFAOYSA-N Cc1ccccn1 Chemical compound Cc1ccccn1 BSKHPKMHTQYZBB-UHFFFAOYSA-N 0.000 description 1
- YBOQHGVVMRFVDJ-UHFFFAOYSA-N SC1COCC1 Chemical compound SC1COCC1 YBOQHGVVMRFVDJ-UHFFFAOYSA-N 0.000 description 1
- JRKNQYISGWCMNB-UHFFFAOYSA-N SCC1COCC1 Chemical compound SCC1COCC1 JRKNQYISGWCMNB-UHFFFAOYSA-N 0.000 description 1
- RMVRSNDYEFQCLF-UHFFFAOYSA-N Sc1ccccc1 Chemical compound Sc1ccccc1 RMVRSNDYEFQCLF-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662276221P | 2016-01-07 | 2016-01-07 | |
| US62/276,221 | 2016-01-07 | ||
| US201662399730P | 2016-09-26 | 2016-09-26 | |
| US62/399,730 | 2016-09-26 | ||
| PCT/US2017/012466 WO2017120429A1 (en) | 2016-01-07 | 2017-01-06 | Selective inhibitors of clinically important mutants of the egfr tyrosine kinase |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021029700A Division JP2021091703A (ja) | 2016-01-07 | 2021-02-26 | Ｅｇｆｒチロシンキナーゼの臨床的に重要な変異体の選択的阻害薬 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019501222A JP2019501222A (ja) | 2019-01-17 |
| JP2019501222A5 true JP2019501222A5 (https=) | 2020-01-23 |
Family
ID=59274526
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018554640A Withdrawn JP2019501222A (ja) | 2016-01-07 | 2017-01-06 | Ｅｇｆｒチロシンキナーゼの臨床的に重要な変異体の選択的阻害薬 |
| JP2021029700A Ceased JP2021091703A (ja) | 2016-01-07 | 2021-02-26 | Ｅｇｆｒチロシンキナーゼの臨床的に重要な変異体の選択的阻害薬 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021029700A Ceased JP2021091703A (ja) | 2016-01-07 | 2021-02-26 | Ｅｇｆｒチロシンキナーゼの臨床的に重要な変異体の選択的阻害薬 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10435388B2 (https=) |
| EP (1) | EP3399968B8 (https=) |
| JP (2) | JP2019501222A (https=) |
| KR (1) | KR20180105161A (https=) |
| CN (1) | CN109328059B (https=) |
| TW (1) | TWI726968B (https=) |
| WO (1) | WO2017120429A1 (https=) |
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| UA125650C2 (uk) | 2016-09-09 | 2022-05-11 | Інсайт Корпорейшн | Регулятори нрk1 на основі похідних піразолопіридину та їх застосування для лікування раку |
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| ES2959967T3 (es) * | 2017-07-28 | 2024-02-29 | Yuhan Corp | Procedimiento de preparación deN-(5-(4-(4-formil-3-fenil-1h-pirazol-1-il)pirimidin-2-ilamino)-4-metoxi-2-morfolinofenil)acrilamida |
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| CN107827875B (zh) * | 2017-09-25 | 2021-07-09 | 文韬创新药物研究（北京）有限责任公司 | 一种苯并咪唑类衍生物作为周期蛋白依赖性激酶4/6抑制剂的应用 |
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| WO2017190637A1 (zh) | 2016-05-06 | 2017-11-09 | 深圳市塔吉瑞生物医药有限公司 | 用于抑制蛋白酪氨酸激酶活性的稠合嘧啶类化合物 |
| EP3454860B1 (en) | 2016-05-11 | 2025-09-17 | Beta Pharma, Inc. | 2-anilinopyrimidine derivatives as therapeutic agents for treatment of brain cancers |
| JP6740452B2 (ja) | 2016-07-26 | 2020-08-12 | 深▲セン▼市塔吉瑞生物医▲薬▼有限公司Ｓｈｅｎｚｈｅｎ ＴａｒｇｅｔＲｘ，Ｉｎｃ． | プロテインチロシンキナーゼの活性を阻害するためのアミノピリミジン系化合物 |
| CN111093645A (zh) | 2017-07-05 | 2020-05-01 | Cs制药技术有限公司 | Egfr酪氨酸激酶的临床上重要的突变体的选择性抑制剂 |
-
2017
- 2017-01-06 EP EP17736401.5A patent/EP3399968B8/en not_active Not-in-force
- 2017-01-06 TW TW106100545A patent/TWI726968B/zh not_active IP Right Cessation
- 2017-01-06 CN CN201780016875.2A patent/CN109328059B/zh active Active
- 2017-01-06 WO PCT/US2017/012466 patent/WO2017120429A1/en not_active Ceased
- 2017-01-06 KR KR1020187022731A patent/KR20180105161A/ko not_active Withdrawn
- 2017-01-06 US US16/068,559 patent/US10435388B2/en active Active
- 2017-01-06 JP JP2018554640A patent/JP2019501222A/ja not_active Withdrawn
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2021
- 2021-02-26 JP JP2021029700A patent/JP2021091703A/ja not_active Ceased
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