JP2019501222A5 - - Google Patents
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- JP2019501222A5 JP2019501222A5 JP2018554640A JP2018554640A JP2019501222A5 JP 2019501222 A5 JP2019501222 A5 JP 2019501222A5 JP 2018554640 A JP2018554640 A JP 2018554640A JP 2018554640 A JP2018554640 A JP 2018554640A JP 2019501222 A5 JP2019501222 A5 JP 2019501222A5
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- Japan
- Prior art keywords
- alkyl
- independently
- item
- methyl
- cyano
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- 0 C*[C@@]1COCC1 Chemical compound C*[C@@]1COCC1 0.000 description 13
- LVEIJLGSXRYDEY-UHFFFAOYSA-N CC(C)c1c[nH]nn1 Chemical compound CC(C)c1c[nH]nn1 LVEIJLGSXRYDEY-UHFFFAOYSA-N 0.000 description 1
- ZLVYAWVDOLLMSD-UHFFFAOYSA-N CN(C)CCN(C)c(c(NC(C=C)=O)c1)cc(OC)c1Nc1nc(-c(cc2)c(cc[nH]3)c3c2C(N)=O)ccn1 Chemical compound CN(C)CCN(C)c(c(NC(C=C)=O)c1)cc(OC)c1Nc1nc(-c(cc2)c(cc[nH]3)c3c2C(N)=O)ccn1 ZLVYAWVDOLLMSD-UHFFFAOYSA-N 0.000 description 1
- XFSTWIDWOQOLIQ-UHFFFAOYSA-N CN(C)CCN(C)c(c(NC(C=C)=O)c1)cc(OC)c1Nc1nc(-c2c(cc[n]3C)c3cc(C(N)=O)c2)ccn1 Chemical compound CN(C)CCN(C)c(c(NC(C=C)=O)c1)cc(OC)c1Nc1nc(-c2c(cc[n]3C)c3cc(C(N)=O)c2)ccn1 XFSTWIDWOQOLIQ-UHFFFAOYSA-N 0.000 description 1
- RHSWKSOLSABYHY-UHFFFAOYSA-N CN(C)CCN(C)c(cc(c(Nc(nc1)nc(-c2c(cc[n]3C)c3cc(C(N)=O)c2)c1Cl)c1)OC)c1NC(C=C)=O Chemical compound CN(C)CCN(C)c(cc(c(Nc(nc1)nc(-c2c(cc[n]3C)c3cc(C(N)=O)c2)c1Cl)c1)OC)c1NC(C=C)=O RHSWKSOLSABYHY-UHFFFAOYSA-N 0.000 description 1
- BSKHPKMHTQYZBB-UHFFFAOYSA-N Cc1ccccn1 Chemical compound Cc1ccccn1 BSKHPKMHTQYZBB-UHFFFAOYSA-N 0.000 description 1
- YBOQHGVVMRFVDJ-UHFFFAOYSA-N SC1COCC1 Chemical compound SC1COCC1 YBOQHGVVMRFVDJ-UHFFFAOYSA-N 0.000 description 1
- JRKNQYISGWCMNB-UHFFFAOYSA-N SCC1COCC1 Chemical compound SCC1COCC1 JRKNQYISGWCMNB-UHFFFAOYSA-N 0.000 description 1
- RMVRSNDYEFQCLF-UHFFFAOYSA-N Sc1ccccc1 Chemical compound Sc1ccccc1 RMVRSNDYEFQCLF-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662276221P | 2016-01-07 | 2016-01-07 | |
| US62/276,221 | 2016-01-07 | ||
| US201662399730P | 2016-09-26 | 2016-09-26 | |
| US62/399,730 | 2016-09-26 | ||
| PCT/US2017/012466 WO2017120429A1 (en) | 2016-01-07 | 2017-01-06 | Selective inhibitors of clinically important mutants of the egfr tyrosine kinase |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021029700A Division JP2021091703A (ja) | 2016-01-07 | 2021-02-26 | Ｅｇｆｒチロシンキナーゼの臨床的に重要な変異体の選択的阻害薬 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019501222A JP2019501222A (ja) | 2019-01-17 |
| JP2019501222A5 true JP2019501222A5 (https=) | 2020-01-23 |
Family
ID=59274526
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018554640A Withdrawn JP2019501222A (ja) | 2016-01-07 | 2017-01-06 | Ｅｇｆｒチロシンキナーゼの臨床的に重要な変異体の選択的阻害薬 |
| JP2021029700A Ceased JP2021091703A (ja) | 2016-01-07 | 2021-02-26 | Ｅｇｆｒチロシンキナーゼの臨床的に重要な変異体の選択的阻害薬 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021029700A Ceased JP2021091703A (ja) | 2016-01-07 | 2021-02-26 | Ｅｇｆｒチロシンキナーゼの臨床的に重要な変異体の選択的阻害薬 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10435388B2 (https=) |
| EP (1) | EP3399968B8 (https=) |
| JP (2) | JP2019501222A (https=) |
| KR (1) | KR20180105161A (https=) |
| CN (1) | CN109328059B (https=) |
| TW (1) | TWI726968B (https=) |
| WO (1) | WO2017120429A1 (https=) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106117185B (zh) * | 2015-08-31 | 2017-11-07 | 广州必贝特医药技术有限公司 | 2,4‑二含氮基团取代嘧啶类化合物及其制备方法和应用 |
| TWI726968B (zh) | 2016-01-07 | 2021-05-11 | 開曼群島商Ｃｓ醫藥技術公司 | Egfr酪胺酸激酶之臨床重要突變體之選擇性抑制劑 |
| MX383920B (es) | 2016-05-26 | 2025-03-14 | Recurium Ip Holdings Llc | Compuestos inhibidores de egfr. |
| EP3492462B1 (en) | 2016-07-26 | 2023-08-30 | Shenzhen TargetRx, Inc. | Amino pyrimidine compound for inhibiting protein tyrosine kinase activity |
| WO2018049214A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
| CN115819417A (zh) | 2016-09-09 | 2023-03-21 | 因赛特公司 | 作为hpk1调节剂的吡唑并吡啶衍生物及其用于治疗癌症的用途 |
| JP7028900B2 (ja) * | 2017-06-13 | 2022-03-02 | ベイジン アダマドル バイオテクノロジー リミテッド ライアビリティ カンパニー | アミノピリミジン化合物、その調製方法、およびその使用 |
| CN111093645A (zh) * | 2017-07-05 | 2020-05-01 | Cs制药技术有限公司 | Egfr酪氨酸激酶的临床上重要的突变体的选择性抑制剂 |
| MY201038A (en) * | 2017-07-28 | 2024-01-31 | Yuhan Corp | Intermediates useful for the synthesis of a selective inhibitor against protein kinase and processes for preparing the same |
| WO2019023621A1 (en) | 2017-07-28 | 2019-01-31 | Yale University | ANTICANCER DRUGS AND METHODS OF MAKING AND USING THEM |
| JP6985764B2 (ja) * | 2017-08-30 | 2021-12-22 | 深▲チェン▼市塔吉瑞生物医薬有限公司Shenzhen TargetRx, Inc. | アミノピリミジン系化合物、この化合物を含む組成物およびそれらの使用 |
| CN109503573A (zh) * | 2017-09-14 | 2019-03-22 | 昆明圣加南生物科技有限公司 | 2-取代苯胺基嘧啶衍生物及其用途 |
| CN107827875B (zh) * | 2017-09-25 | 2021-07-09 | 文韬创新药物研究（北京）有限责任公司 | 一种苯并咪唑类衍生物作为周期蛋白依赖性激酶4/6抑制剂的应用 |
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| EP3755703B1 (en) | 2018-02-20 | 2022-05-04 | Incyte Corporation | N-(phenyl)-2-(phenyl)pyrimidine-4-carboxamide derivatives and related compounds as hpk1 inhibitors for treating cancer |
| AU2019225799A1 (en) * | 2018-02-20 | 2020-07-09 | Dana-Farber Cancer Institute, Inc. | Pharmaceutical combinations of EGFR inhibitors and methods of use thereof |
| US20210085688A1 (en) * | 2018-02-20 | 2021-03-25 | Dana-Farber Cancer Institute, Inc. | Pharmaceutical combinations of egfr inhibitors and methods of use thereof |
| CN112839648B (zh) | 2018-06-07 | 2025-04-04 | 达萨玛治疗公司 | Sarm1抑制剂 |
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| CN110790749B (zh) * | 2018-08-03 | 2023-07-14 | 北京普祺医药科技股份有限公司 | 一种含氮杂环化合物、药物组合物以及其用途 |
| US10899755B2 (en) | 2018-08-08 | 2021-01-26 | Incyte Corporation | Benzothiazole compounds and uses thereof |
| CN110857292A (zh) * | 2018-08-22 | 2020-03-03 | 上海艾力斯医药科技有限公司 | 一种egfr激酶抑制剂及其制备方法和应用 |
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| CN113227073B (zh) * | 2019-01-05 | 2022-09-16 | 山东轩竹医药科技有限公司 | Egfr酪氨酸激酶的选择性抑制剂的盐及其晶型 |
| CN111410651B (zh) * | 2019-01-05 | 2021-06-04 | 山东轩竹医药科技有限公司 | 酪氨酸激酶抑制剂的盐及其晶型 |
| PT3943491T (pt) | 2019-03-19 | 2025-07-28 | Voronoi Inc | Derivado de heteroarilo, método para a produção do mesmo e composição farmacêutica que compreende o mesmo como componente eficaz |
| US12157730B2 (en) | 2019-03-19 | 2024-12-03 | Voronoi Inc. | Heteroaryl derivative, method for producing same, and pharmaceutical composition comprising same as effective component |
| CN111825658B (zh) * | 2019-04-18 | 2024-11-08 | 华东理工大学 | Egfr三突变抑制剂及其应用 |
| CN112174961A (zh) * | 2019-07-04 | 2021-01-05 | 微境生物医药科技(上海)有限公司 | 一类抑制egfr激酶的化合物及其制备方法和用途 |
| CA3145686C (en) * | 2019-07-26 | 2023-03-21 | Charles Z. Ding | Pyrimidine compound acting on egfr and erbb2 |
| BR112022002059A2 (pt) | 2019-08-06 | 2022-06-07 | Incyte Corp | Formas sólidas de um inibidor de hpk1 |
| TW202128670A (zh) * | 2019-11-26 | 2021-08-01 | 大陸商上海翰森生物醫藥科技有限公司 | 含氮多環類衍生物抑制劑、其製備方法和應用 |
| CN113045475A (zh) * | 2019-12-27 | 2021-06-29 | 上海泓博智源医药股份有限公司 | 一种5-溴-7-甲基吲哚的制备方法 |
| CN113493419A (zh) * | 2020-03-18 | 2021-10-12 | 南京药石科技股份有限公司 | Egfr酪氨酸激酶抑制剂及其用途 |
| WO2021243596A1 (en) * | 2020-06-03 | 2021-12-09 | InventisBio Co., Ltd. | Aminopyrimidine compounds, preparation methods and uses thereof |
| TWI912374B (zh) * | 2020-09-24 | 2026-01-21 | 大陸商廣州費米子科技有限責任公司 | 嘧啶基衍生物、其製備方法及其用途 |
| EP4225309A4 (en) * | 2020-10-12 | 2024-12-25 | Dana-Farber Cancer Institute, Inc. | COVALENT INHIBITORS OF EGFR AND METHODS OF USE THEREOF |
| US12064421B2 (en) | 2020-11-02 | 2024-08-20 | Boehringer Ingelheim International Gmbh | Substituted 1H-pyrazolo[4,3-c]pyridines and derivatives as EGFR inhibitors |
| CN114539269B (zh) * | 2020-11-19 | 2023-04-28 | 上海医药工业研究院有限公司 | 一种含氮大环化合物、其制备方法及其应用 |
| WO2022115753A1 (en) * | 2020-11-30 | 2022-06-02 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Merged scaffold taf1 inhibitors |
| CN115867539B (zh) * | 2020-12-02 | 2025-07-22 | 上海和誉生物医药科技有限公司 | 2,3-二氢-1H-吡咯并[3,2-b]吡啶衍生物、其制备方法和应用 |
| AR126196A1 (es) * | 2021-06-23 | 2023-09-27 | Blueprint Medicines Corp | Proceso para preparar inhibidores de egfr |
| JP2024523506A (ja) * | 2021-06-23 | 2024-06-28 | ブループリント メディシンズ コーポレイション | 上皮成長因子受容体阻害剤の塩及び結晶形態 |
| CN115701429B (zh) * | 2021-08-02 | 2024-03-12 | 上海和誉生物医药科技有限公司 | 4-(1h-吲哚-1-基)嘧啶-2-氨基衍生物及其制备方法和应用 |
| JP7734995B2 (ja) * | 2021-08-06 | 2025-09-08 | 上海和誉生物医薬科技有限公司 | ピリミジンまたはピリジン誘導体およびその製造方法ならびに薬学上の応用 |
| CN115703760B (zh) * | 2021-08-11 | 2024-05-31 | 山东大学 | 2,4-二取代嘧啶类细胞周期蛋白依赖性激酶酶抑制剂及其制备方法和应用 |
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| WO2026047630A1 (en) * | 2024-08-31 | 2026-03-05 | Hetero Labs Limited | Heterocyclic compounds as egfr inhibitors |
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| TWI726968B (zh) | 2016-01-07 | 2021-05-11 | 開曼群島商Ｃｓ醫藥技術公司 | Egfr酪胺酸激酶之臨床重要突變體之選擇性抑制劑 |
| CN106279160B (zh) | 2016-03-18 | 2017-09-26 | 海南越康生物医药有限公司 | N‑苯基‑2‑氨基嘧啶类化合物制备方法和用途 |
| WO2017190637A1 (zh) | 2016-05-06 | 2017-11-09 | 深圳市塔吉瑞生物医药有限公司 | 用于抑制蛋白酪氨酸激酶活性的稠合嘧啶类化合物 |
| CN119970741A (zh) | 2016-05-11 | 2025-05-13 | 贝达医药公司 | 作为用于治疗脑癌之治疗剂的2-苯胺基嘧啶衍生物 |
| EP3492462B1 (en) | 2016-07-26 | 2023-08-30 | Shenzhen TargetRx, Inc. | Amino pyrimidine compound for inhibiting protein tyrosine kinase activity |
| CN111093645A (zh) | 2017-07-05 | 2020-05-01 | Cs制药技术有限公司 | Egfr酪氨酸激酶的临床上重要的突变体的选择性抑制剂 |
-
2017
- 2017-01-06 TW TW106100545A patent/TWI726968B/zh not_active IP Right Cessation
- 2017-01-06 CN CN201780016875.2A patent/CN109328059B/zh active Active
- 2017-01-06 JP JP2018554640A patent/JP2019501222A/ja not_active Withdrawn
- 2017-01-06 KR KR1020187022731A patent/KR20180105161A/ko not_active Withdrawn
- 2017-01-06 EP EP17736401.5A patent/EP3399968B8/en not_active Not-in-force
- 2017-01-06 US US16/068,559 patent/US10435388B2/en active Active
- 2017-01-06 WO PCT/US2017/012466 patent/WO2017120429A1/en not_active Ceased
-
2021
- 2021-02-26 JP JP2021029700A patent/JP2021091703A/ja not_active Ceased
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