JP2021535164A5 - - Google Patents
Info
- Publication number
- JP2021535164A5 JP2021535164A5 JP2021511547A JP2021511547A JP2021535164A5 JP 2021535164 A5 JP2021535164 A5 JP 2021535164A5 JP 2021511547 A JP2021511547 A JP 2021511547A JP 2021511547 A JP2021511547 A JP 2021511547A JP 2021535164 A5 JP2021535164 A5 JP 2021535164A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- pharmaceutically acceptable
- acceptable salt
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024028682A JP7825650B2 (ja) | 2018-08-31 | 2024-02-28 | 心筋サルコメア阻害剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862726162P | 2018-08-31 | 2018-08-31 | |
| US62/726,162 | 2018-08-31 | ||
| PCT/US2019/049118 WO2020047447A1 (en) | 2018-08-31 | 2019-08-30 | Cardiac sarcomere inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024028682A Division JP7825650B2 (ja) | 2018-08-31 | 2024-02-28 | 心筋サルコメア阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021535164A JP2021535164A (ja) | 2021-12-16 |
| JP2021535164A5 true JP2021535164A5 (enExample) | 2022-10-18 |
| JP7447089B2 JP7447089B2 (ja) | 2024-03-11 |
Family
ID=67953902
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021511547A Active JP7447089B2 (ja) | 2018-08-31 | 2019-08-30 | 心筋サルコメア阻害剤 |
| JP2024028682A Active JP7825650B2 (ja) | 2018-08-31 | 2024-02-28 | 心筋サルコメア阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024028682A Active JP7825650B2 (ja) | 2018-08-31 | 2024-02-28 | 心筋サルコメア阻害剤 |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US11414424B2 (enExample) |
| EP (1) | EP3843842A1 (enExample) |
| JP (2) | JP7447089B2 (enExample) |
| CN (2) | CN112867539B (enExample) |
| AR (1) | AR116283A1 (enExample) |
| AU (1) | AU2019328556B2 (enExample) |
| BR (1) | BR112021003496A2 (enExample) |
| CA (1) | CA3110237A1 (enExample) |
| CL (1) | CL2021000481A1 (enExample) |
| CO (1) | CO2021003115A2 (enExample) |
| EA (1) | EA202190657A1 (enExample) |
| EC (1) | ECSP21016009A (enExample) |
| IL (2) | IL315709A (enExample) |
| MA (1) | MA53491A (enExample) |
| MX (1) | MX2021002199A (enExample) |
| NZ (1) | NZ773016A (enExample) |
| PH (1) | PH12021550400A1 (enExample) |
| SG (1) | SG11202101769YA (enExample) |
| TW (1) | TWI848972B (enExample) |
| UY (1) | UY38358A (enExample) |
| WO (1) | WO2020047447A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11202006296YA (en) | 2018-01-19 | 2020-08-28 | Cytokinetics Inc | Dihydrobenzofuran and inden analogs as cardiac sarcomere inhibitors |
| EP3814343B1 (en) | 2018-06-26 | 2023-01-11 | Cytokinetics, Inc. | Cardiac sarcomere inhibitors |
| JP7438148B2 (ja) | 2018-06-26 | 2024-02-26 | サイトキネティックス， インコーポレイテッド | 心臓サルコメア阻害剤 |
| US10981905B2 (en) | 2018-08-31 | 2021-04-20 | Xenon Pharmaceuticals Inc. | Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents |
| MA53491A (fr) | 2018-08-31 | 2021-09-15 | Cytokinetics Inc | Inhibiteurs de sarcomes cardiaques |
| CN116234546A (zh) * | 2020-03-11 | 2023-06-06 | 嘉兴优博生物技术有限公司 | Gpx4抑制剂、其药物组合物及它们在治疗gpx4介导的疾病中的用途 |
| KR20230079053A (ko) | 2020-08-28 | 2023-06-05 | 미요카디아, 인크. | 미오신 조절제를 이용한 치료 방법 |
| WO2022057849A1 (zh) * | 2020-09-17 | 2022-03-24 | 浙江海正药业股份有限公司 | 哌嗪类衍生物及其制备方法和用途 |
| EP4249474A4 (en) * | 2020-11-20 | 2024-04-17 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Triazine dione derivative, preparation method therefor and application thereof in medicine |
| KR20240015622A (ko) * | 2021-03-04 | 2024-02-05 | 싸이토키네틱스, 인코포레이티드 | 심장 근절 억제제 |
| CN119789856A (zh) | 2022-04-26 | 2025-04-08 | 迈奥卡迪亚公司 | 施用肌球蛋白抑制剂的方法 |
| CN119998292A (zh) | 2022-09-02 | 2025-05-13 | 赛特凯恩蒂克公司 | 5-(3,4-二氟苄基)-8-((1r,4r)-4-甲基环己基)-6,9-二氧代基-2,5,8-三氮杂螺[3.5]壬烷-2-甲醛的结晶形式 |
| CN122070481A (zh) | 2023-11-01 | 2026-05-19 | 百时美施贵宝公司 | 基于蛋白质水平用肌球蛋白抑制剂进行治疗的方法 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6334997B1 (en) | 1994-03-25 | 2002-01-01 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| KR100477070B1 (ko) | 1994-03-25 | 2006-04-21 | 이소테크니카 인코포레이티드 | 중수소화작용에의한의약품의효능강화법 |
| US5919785A (en) * | 1996-04-03 | 1999-07-06 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| KR100595926B1 (ko) | 1998-01-26 | 2006-07-05 | 웨인 웨스터만 | 수동 입력 통합 방법 및 장치 |
| US20030158186A1 (en) | 2001-12-21 | 2003-08-21 | Fady Malik | Compositions and methods for treating heart failure |
| US7399866B2 (en) | 2003-01-14 | 2008-07-15 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| US20070155713A1 (en) * | 2003-04-21 | 2007-07-05 | Rena Nishizawa | Nitrogen-containing heterocyclic compounds and use thereof |
| US7507735B2 (en) | 2004-06-17 | 2009-03-24 | Cytokinetics, Inc. | Compounds, compositions and methods |
| MX2007006230A (es) * | 2004-11-30 | 2007-07-25 | Amgen Inc | Quinolinas y analogos de quinazolinas y su uso como medicamentos para tratar cancer. |
| US20060173183A1 (en) | 2004-12-31 | 2006-08-03 | Alantos Pharmaceuticals, Inc., | Multicyclic bis-amide MMP inhibitors |
| WO2007078815A2 (en) | 2005-12-16 | 2007-07-12 | Cytokinetics, Inc. | Certain chemical entities, compositions, and methods |
| RU2318818C1 (ru) | 2006-04-12 | 2008-03-10 | Общество С Ограниченной Ответственностью "Исследовательский Институт Химического Разнообразия" | Азагетероциклы, комбинаторная библиотека, фокусированная библиотека, фармацевтическая композиция и способ получения (варианты) |
| US8592426B2 (en) | 2011-01-24 | 2013-11-26 | Hoffmann—La Roche Inc. | Aryl-benzocycloalkyl amide derivatives |
| US8759380B2 (en) | 2011-04-22 | 2014-06-24 | Cytokinetics, Inc. | Certain heterocycles, compositions thereof, and methods for their use |
| US9199945B2 (en) | 2013-06-21 | 2015-12-01 | MyoKardia, Inc. | Cycloalkyl-substituted pyrimidinedione compounds |
| SMT202000071T1 (it) | 2013-06-21 | 2020-03-13 | Myokardia Inc | Composti di pirimidinadione contro le condizioni cardiache |
| US9663516B2 (en) | 2014-12-18 | 2017-05-30 | MyoKardia, Inc. | Bicyclic-pyrimidinedione compounds |
| SG11201705928XA (en) | 2015-01-22 | 2017-08-30 | Myokardia Inc | 4-methylsulfonyl-substituted piperidine urea compounds for the treatment of dilated cardiomyopathy (dcm) |
| CN108430997B (zh) | 2015-12-17 | 2021-06-04 | 先正达参股股份有限公司 | 杀微生物的噁二唑衍生物 |
| US20190364899A1 (en) | 2015-12-18 | 2019-12-05 | Syngenta Participations Ag | Microbiocidal oxadiazole derivatives |
| EP3475275B1 (en) | 2016-06-23 | 2024-04-10 | Merck Sharp & Dohme LLC | 3-aryl and heteroaryl substituted 5-trifluoromethyl oxadiazoles as histone deacetylase 6 (hdac6) inhibitors |
| WO2018089433A1 (en) * | 2016-11-08 | 2018-05-17 | Navitor Pharmaceuticals, Inc. | PHENYL mTORC INHIBITORS AND USES THEREOF |
| SG11202006296YA (en) | 2018-01-19 | 2020-08-28 | Cytokinetics Inc | Dihydrobenzofuran and inden analogs as cardiac sarcomere inhibitors |
| US10710994B2 (en) | 2018-03-19 | 2020-07-14 | Genentech, Inc. | Oxadiazole transient receptor potential channel inhibitors |
| JP7438148B2 (ja) | 2018-06-26 | 2024-02-26 | サイトキネティックス， インコーポレイテッド | 心臓サルコメア阻害剤 |
| EP3814343B1 (en) | 2018-06-26 | 2023-01-11 | Cytokinetics, Inc. | Cardiac sarcomere inhibitors |
| US10981905B2 (en) | 2018-08-31 | 2021-04-20 | Xenon Pharmaceuticals Inc. | Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents |
| MA53491A (fr) | 2018-08-31 | 2021-09-15 | Cytokinetics Inc | Inhibiteurs de sarcomes cardiaques |
| LT3999180T (lt) | 2019-07-17 | 2024-08-26 | Cytokinetics, Inc. | (r)-n-(5-(5-etil-1,2,4-oksadiazol-3-il)-2,3-dihidro-1h-inden-1-il)-1-metil-1h-pirazol-4-karboksamido polimorfai |
| WO2021011808A1 (en) | 2019-07-17 | 2021-01-21 | Cytokinetics, Inc. | Cardiac sarcomere inhibitor oral formulations |
| CA3157629A1 (en) | 2019-11-10 | 2021-05-14 | MyoKardia, Inc. | Methods of treatment with myosin modulator |
| KR20230079053A (ko) | 2020-08-28 | 2023-06-05 | 미요카디아, 인크. | 미오신 조절제를 이용한 치료 방법 |
| CN114456163B (zh) | 2020-11-09 | 2023-08-11 | 江苏恒瑞医药股份有限公司 | 四氢吡啶并嘧啶二酮类衍生物、其制备方法及其在医药上的应用 |
| CN114516843B (zh) | 2020-11-19 | 2024-10-22 | 江苏恒瑞医药股份有限公司 | 嘧啶二酮类衍生物、其制备方法及其在医药上的应用 |
| EP4249474A4 (en) | 2020-11-20 | 2024-04-17 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Triazine dione derivative, preparation method therefor and application thereof in medicine |
| CN116507621B (zh) | 2020-11-24 | 2025-10-17 | 江苏恒瑞医药股份有限公司 | 嘧啶二酮类衍生物、其制备方法及其在医药上的应用 |
| CN114539257B (zh) | 2020-11-24 | 2023-08-11 | 江苏恒瑞医药股份有限公司 | 嘧啶二酮类螺环衍生物、其制备方法及其在医药上的应用 |
| CN114539229B (zh) | 2020-11-24 | 2024-10-22 | 江苏恒瑞医药股份有限公司 | 嘧啶二酮类衍生物、其制备方法及其在医药上的应用 |
| KR20240015622A (ko) | 2021-03-04 | 2024-02-05 | 싸이토키네틱스, 인코포레이티드 | 심장 근절 억제제 |
| CN119998292A (zh) | 2022-09-02 | 2025-05-13 | 赛特凯恩蒂克公司 | 5-(3,4-二氟苄基)-8-((1r,4r)-4-甲基环己基)-6,9-二氧代基-2,5,8-三氮杂螺[3.5]壬烷-2-甲醛的结晶形式 |
-
2019
- 2019-08-30 MA MA053491A patent/MA53491A/fr unknown
- 2019-08-30 TW TW108131375A patent/TWI848972B/zh active
- 2019-08-30 CA CA3110237A patent/CA3110237A1/en active Pending
- 2019-08-30 CN CN201980068999.4A patent/CN112867539B/zh active Active
- 2019-08-30 SG SG11202101769YA patent/SG11202101769YA/en unknown
- 2019-08-30 BR BR112021003496-0A patent/BR112021003496A2/pt unknown
- 2019-08-30 MX MX2021002199A patent/MX2021002199A/es unknown
- 2019-08-30 EA EA202190657A patent/EA202190657A1/ru unknown
- 2019-08-30 UY UY0001038358A patent/UY38358A/es active IP Right Grant
- 2019-08-30 NZ NZ773016A patent/NZ773016A/en unknown
- 2019-08-30 IL IL315709A patent/IL315709A/en unknown
- 2019-08-30 IL IL281075A patent/IL281075B2/en unknown
- 2019-08-30 EP EP19768990.4A patent/EP3843842A1/en active Pending
- 2019-08-30 CN CN202410976837.3A patent/CN118955409A/zh active Pending
- 2019-08-30 US US16/557,281 patent/US11414424B2/en active Active
- 2019-08-30 JP JP2021511547A patent/JP7447089B2/ja active Active
- 2019-08-30 WO PCT/US2019/049118 patent/WO2020047447A1/en not_active Ceased
- 2019-08-30 AU AU2019328556A patent/AU2019328556B2/en active Active
- 2019-08-30 AR ARP190102477A patent/AR116283A1/es unknown
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2021
- 2021-02-25 CL CL2021000481A patent/CL2021000481A1/es unknown
- 2021-02-26 PH PH12021550400A patent/PH12021550400A1/en unknown
- 2021-03-09 EC ECSENADI202116009A patent/ECSP21016009A/es unknown
- 2021-03-10 CO CONC2021/0003115A patent/CO2021003115A2/es unknown
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2022
- 2022-05-04 US US17/736,895 patent/US11952381B2/en active Active
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2024
- 2024-02-26 US US18/587,730 patent/US12275741B2/en active Active
- 2024-02-28 JP JP2024028682A patent/JP7825650B2/ja active Active
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2025
- 2025-01-08 US US19/014,118 patent/US20250276976A1/en active Pending