JP2021511331A5 - - Google Patents

Info

Publication number
JP2021511331A5
JP2021511331A5 JP2020539814A JP2020539814A JP2021511331A5 JP 2021511331 A5 JP2021511331 A5 JP 2021511331A5 JP 2020539814 A JP2020539814 A JP 2020539814A JP 2020539814 A JP2020539814 A JP 2020539814A JP 2021511331 A5 JP2021511331 A5 JP 2021511331A5
Authority
JP
Japan
Prior art keywords
compound
pharmaceutically acceptable
substituted
acceptable salt
unsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2020539814A
Other languages
English (en)
Japanese (ja)
Other versions
JP7401439B2 (ja
JP2021511331A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/014344 external-priority patent/WO2019144041A1/en
Publication of JP2021511331A publication Critical patent/JP2021511331A/ja
Publication of JP2021511331A5 publication Critical patent/JP2021511331A5/ja
Priority to JP2023163639A priority Critical patent/JP2023169374A/ja
Application granted granted Critical
Publication of JP7401439B2 publication Critical patent/JP7401439B2/ja
Priority to JP2025065043A priority patent/JP2025106500A/ja
Priority to JP2026061251A priority patent/JP2026113610A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020539814A 2018-01-19 2019-01-18 心筋節阻害剤としてのジヒドロベンゾフランおよびインデンアナログ Active JP7401439B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2023163639A JP2023169374A (ja) 2018-01-19 2023-09-26 心筋節阻害剤としてのジヒドロベンゾフランおよびインデンアナログ
JP2025065043A JP2025106500A (ja) 2018-01-19 2025-04-10 心筋節阻害剤としてのジヒドロベンゾフランおよびインデンアナログ
JP2026061251A JP2026113610A (ja) 2018-01-19 2026-04-02 心筋節阻害剤としてのジヒドロベンゾフランおよびインデンアナログ

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862619643P 2018-01-19 2018-01-19
US62/619,643 2018-01-19
US201862745724P 2018-10-15 2018-10-15
US62/745,724 2018-10-15
PCT/US2019/014344 WO2019144041A1 (en) 2018-01-19 2019-01-18 Dihydrobenzofuran and inden analogs as cardiac sarcomere inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023163639A Division JP2023169374A (ja) 2018-01-19 2023-09-26 心筋節阻害剤としてのジヒドロベンゾフランおよびインデンアナログ

Publications (3)

Publication Number Publication Date
JP2021511331A JP2021511331A (ja) 2021-05-06
JP2021511331A5 true JP2021511331A5 (enExample) 2022-01-25
JP7401439B2 JP7401439B2 (ja) 2023-12-19

Family

ID=65324663

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2020539814A Active JP7401439B2 (ja) 2018-01-19 2019-01-18 心筋節阻害剤としてのジヒドロベンゾフランおよびインデンアナログ
JP2023163639A Withdrawn JP2023169374A (ja) 2018-01-19 2023-09-26 心筋節阻害剤としてのジヒドロベンゾフランおよびインデンアナログ
JP2025065043A Withdrawn JP2025106500A (ja) 2018-01-19 2025-04-10 心筋節阻害剤としてのジヒドロベンゾフランおよびインデンアナログ
JP2026061251A Pending JP2026113610A (ja) 2018-01-19 2026-04-02 心筋節阻害剤としてのジヒドロベンゾフランおよびインデンアナログ

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2023163639A Withdrawn JP2023169374A (ja) 2018-01-19 2023-09-26 心筋節阻害剤としてのジヒドロベンゾフランおよびインデンアナログ
JP2025065043A Withdrawn JP2025106500A (ja) 2018-01-19 2025-04-10 心筋節阻害剤としてのジヒドロベンゾフランおよびインデンアナログ
JP2026061251A Pending JP2026113610A (ja) 2018-01-19 2026-04-02 心筋節阻害剤としてのジヒドロベンゾフランおよびインデンアナログ

Country Status (32)

Country Link
US (4) US10836755B2 (enExample)
EP (2) EP3740481B9 (enExample)
JP (4) JP7401439B2 (enExample)
KR (1) KR102797441B1 (enExample)
CN (3) CN111757875B (enExample)
AU (2) AU2019208331C1 (enExample)
BR (1) BR112020014428A2 (enExample)
CA (2) CA3087283C (enExample)
CL (2) CL2020001871A1 (enExample)
CO (1) CO2020009225A2 (enExample)
DK (1) DK3740481T5 (enExample)
EC (1) ECSP20044709A (enExample)
ES (1) ES2986630T3 (enExample)
FI (2) FI3740481T3 (enExample)
HR (1) HRP20241014T2 (enExample)
HU (1) HUE067913T2 (enExample)
IL (1) IL276094B2 (enExample)
LT (2) LT3740481T (enExample)
MA (1) MA51620B1 (enExample)
MD (1) MD3740481T3 (enExample)
MX (2) MX2020007532A (enExample)
MY (1) MY203855A (enExample)
PH (1) PH12020551090A1 (enExample)
PL (1) PL3740481T3 (enExample)
PT (1) PT3740481T (enExample)
RS (1) RS66042B9 (enExample)
SG (1) SG11202006296YA (enExample)
SI (1) SI3740481T1 (enExample)
SM (1) SMT202400329T1 (enExample)
TW (2) TWI835770B (enExample)
UY (1) UY38057A (enExample)
WO (1) WO2019144041A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202006296YA (en) 2018-01-19 2020-08-28 Cytokinetics Inc Dihydrobenzofuran and inden analogs as cardiac sarcomere inhibitors
EP3814343B1 (en) * 2018-06-26 2023-01-11 Cytokinetics, Inc. Cardiac sarcomere inhibitors
JP7438148B2 (ja) * 2018-06-26 2024-02-26 サイトキネティックス， インコーポレイテッド 心臓サルコメア阻害剤
MA53491A (fr) 2018-08-31 2021-09-15 Cytokinetics Inc Inhibiteurs de sarcomes cardiaques
EP4446314A3 (en) * 2019-05-03 2025-03-12 Praxis Precision Medicines, Inc. Kcnt1 inhibitors and methods of use
LT3999180T (lt) * 2019-07-17 2024-08-26 Cytokinetics, Inc. (r)-n-(5-(5-etil-1,2,4-oksadiazol-3-il)-2,3-dihidro-1h-inden-1-il)-1-metil-1h-pirazol-4-karboksamido polimorfai
WO2021011808A1 (en) * 2019-07-17 2021-01-21 Cytokinetics, Inc. Cardiac sarcomere inhibitor oral formulations
MX2022000498A (es) * 2019-07-17 2022-02-03 Cytokinetics Inc Polimorfos de (r)-n-(5-(5-isopropil-1,2,4-oxadiazol-3-il)-2,3-dihi dro-1h-inden-1-il) -2-metil-2h- tetrazol-5-carboxamida.
KR20230079053A (ko) 2020-08-28 2023-06-05 미요카디아, 인크. 미오신 조절제를 이용한 치료 방법
CN112094253B (zh) * 2020-09-10 2023-01-10 株式会社大熊制药 用于制备sglt抑制剂中间体的合成方法
KR20240015622A (ko) 2021-03-04 2024-02-05 싸이토키네틱스, 인코포레이티드 심장 근절 억제제
EP4370116B1 (en) 2021-07-16 2025-01-15 Cytokinetics, Inc. Aficamten dosage regimens for treating obstructive hypertrophic cardiomyopathy
JP2024530111A (ja) 2021-08-03 2024-08-16 サイトキネティックス， インコーポレイテッド アフィカムテンを調製するための工程
CN119789856A (zh) 2022-04-26 2025-04-08 迈奥卡迪亚公司 施用肌球蛋白抑制剂的方法
US20240091203A1 (en) * 2022-07-20 2024-03-21 Cytokinetics, Incorporated Methods for treating non-obstructive hypertrophic cardiomyopathy
JP2025525913A (ja) 2022-08-04 2025-08-07 サイトキネティックス， インコーポレイテッド 閉塞性肥大型心筋症を治療するための方法
JP2025527504A (ja) 2022-08-18 2025-08-22 サイトキネティックス， インコーポレイテッド 骨格筋速筋型ミオシン阻害剤としてのインダン誘導体及びクマラン誘導体
WO2024134498A1 (en) 2022-12-22 2024-06-27 Assia Chemical Industries Ltd. Solid state forms of aficamten and process for preparation thereof
CN115894361A (zh) * 2022-12-28 2023-04-04 上海合全药业股份有限公司 一种钯催化合成1-乙酰基-6-氰基-四氢喹啉的方法
CN120712262A (zh) * 2023-03-02 2025-09-26 苏州科睿思制药有限公司 Aficamten的共晶及其制备方法和用途
CN122070481A (zh) 2023-11-01 2026-05-19 百时美施贵宝公司 基于蛋白质水平用肌球蛋白抑制剂进行治疗的方法
WO2025175141A1 (en) * 2024-02-16 2025-08-21 Cytokinetics, Incorporated Fast skeletal muscle myosin inhibitors
WO2025198687A1 (en) 2024-03-20 2025-09-25 Cytokinetics, Incorporated Methods for treating heart diseases
CN122301864A (zh) * 2024-12-31 2026-06-30 广东东阳光药业股份有限公司 取代的茚类化合物及其用途

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US633499A (en) 1899-06-29 1899-09-19 Oil Well Supply Co Coupling for pipes, tubes, or casings.
US6334997B1 (en) * 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
KR100477070B1 (ko) 1994-03-25 2006-04-21 이소테크니카 인코포레이티드 중수소화작용에의한의약품의효능강화법
US5919785A (en) 1996-04-03 1999-07-06 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
CA2470427C (en) 2001-12-21 2012-07-10 Cytokinetics, Incorporated Compositions and methods for treating heart failure
US20030158186A1 (en) 2001-12-21 2003-08-21 Fady Malik Compositions and methods for treating heart failure
WO2004000764A2 (en) * 2002-06-24 2003-12-31 Vivoquest, Inc. BENZO(b)FURAN DIMERS
US7399866B2 (en) * 2003-01-14 2008-07-15 Cytokinetics, Inc. Compounds, compositions, and methods
JP2006516288A (ja) 2003-01-21 2006-06-29 アーケミックス コーポレイション 眼の薬物療法において有用なアプタマー治療薬
WO2004086865A1 (en) 2003-03-27 2004-10-14 Cytokinetics, Inc. Compounds, compositions and methods
RU2006101541A (ru) * 2003-06-20 2006-06-10 Амген Инк. (US) Производные пиперазина и способ их применения
US7507735B2 (en) * 2004-06-17 2009-03-24 Cytokinetics, Inc. Compounds, compositions and methods
US20060173183A1 (en) * 2004-12-31 2006-08-03 Alantos Pharmaceuticals, Inc., Multicyclic bis-amide MMP inhibitors
CN101137414A (zh) * 2004-12-31 2008-03-05 欧兰拓制药股份有限公司 多环双酰胺mmp抑制剂
TW200718692A (en) 2005-04-22 2007-05-16 Wyeth Corp Dihydrobenzofuran derivatives and uses thereof
JP5463034B2 (ja) * 2005-05-20 2014-04-09 アラントス・フアーマシユーテイカルズ・ホールデイング・インコーポレイテツド ピリミジン若しくはトリアジン縮合二環式メタロプロテアーゼ阻害薬
WO2007078815A2 (en) 2005-12-16 2007-07-12 Cytokinetics, Inc. Certain chemical entities, compositions, and methods
RU2318818C1 (ru) 2006-04-12 2008-03-10 Общество С Ограниченной Ответственностью "Исследовательский Институт Химического Разнообразия" Азагетероциклы, комбинаторная библиотека, фокусированная библиотека, фармацевтическая композиция и способ получения (варианты)
SA08290245B1 (ar) 2007-04-23 2012-02-12 استرازينيكا ايه بي مشتقات كربو كساميد جديدة من -n (8-اريل رباعي هيدرو نفثالين غير متجانس- 2- يل) أو -n (5-اريل كرومان غير متجانس -3-يل) لعلاج الألم
US20090192168A1 (en) 2008-01-04 2009-07-30 Alex Muci Compounds, Compositions and Methods
US20110275673A1 (en) * 2008-09-19 2011-11-10 Yibin Xiang Inhibitors of sphingosine kinase 1
ES2459468T3 (es) 2009-05-15 2014-05-09 Novartis Ag Arilpiridinas como inhibidores de aldosterona sintasa
US8592426B2 (en) * 2011-01-24 2013-11-26 Hoffmann—La Roche Inc. Aryl-benzocycloalkyl amide derivatives
US8759380B2 (en) 2011-04-22 2014-06-24 Cytokinetics, Inc. Certain heterocycles, compositions thereof, and methods for their use
WO2013048928A1 (en) * 2011-09-27 2013-04-04 Bristol-Myers Squibb Company Pyrrolinone carboxamide compounds useful as endothelial lipase inhibitors
TWI576347B (zh) 2012-01-20 2017-04-01 艾克泰聯製藥有限公司 作為ｐ２ｘ受體拮抗劑之雜環醯胺衍生物
US9199945B2 (en) 2013-06-21 2015-12-01 MyoKardia, Inc. Cycloalkyl-substituted pyrimidinedione compounds
SMT202000071T1 (it) 2013-06-21 2020-03-13 Myokardia Inc Composti di pirimidinadione contro le condizioni cardiache
HRP20181109T1 (hr) 2013-12-11 2018-11-02 Biogen Ma Inc. Spojevi biarila korisni za liječenje ljudskih bolesti u onkologiji, neurologiji i imunologiji
WO2015142001A2 (ko) 2014-03-21 2015-09-24 충남대학교산학협력단 강심 활성을 갖는 화합물 및 이를 함유하는 심부전 예방 또는 치료용 약학적 조성물
US9663516B2 (en) 2014-12-18 2017-05-30 MyoKardia, Inc. Bicyclic-pyrimidinedione compounds
JP2018502137A (ja) * 2015-01-20 2018-01-25 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． 第ＸＩａ因子阻害剤
SG11201705928XA (en) 2015-01-22 2017-08-30 Myokardia Inc 4-methylsulfonyl-substituted piperidine urea compounds for the treatment of dilated cardiomyopathy (dcm)
CN105884752B (zh) * 2015-02-13 2018-08-31 山东轩竹医药科技有限公司 并环类回旋酶和拓扑异构酶iv抑制剂
US10501425B2 (en) 2015-10-02 2019-12-10 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
CN108430997B (zh) 2015-12-17 2021-06-04 先正达参股股份有限公司 杀微生物的噁二唑衍生物
US20190364899A1 (en) 2015-12-18 2019-12-05 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
CA3022432A1 (en) 2016-04-29 2017-11-02 Board Of Regents, The University Of Texas System Sigma receptor binders
EP3475275B1 (en) 2016-06-23 2024-04-10 Merck Sharp & Dohme LLC 3-aryl and heteroaryl substituted 5-trifluoromethyl oxadiazoles as histone deacetylase 6 (hdac6) inhibitors
SI3519416T1 (sl) 2016-09-27 2021-08-31 Merck Sharp & Dohme Corp. Derivati kromana, izokromana in dihidroizobenzofurana kot mGluR2-negativni alosterični modulatorji, sestavki in njihova uporaba
WO2018089433A1 (en) 2016-11-08 2018-05-17 Navitor Pharmaceuticals, Inc. PHENYL mTORC INHIBITORS AND USES THEREOF
JP2020023442A (ja) 2016-12-19 2020-02-13 住友化学株式会社 オキサジアゾール化合物及び植物病害防除方法
US20200000822A1 (en) 2017-02-23 2020-01-02 Board Of Regents, The University Of Texas System Methods of treatment for cancer, sterol homeostasis, and neurological diseases
CN110325517B (zh) 2017-02-28 2021-03-02 南京明德新药研发有限公司 螺环类化合物及其应用
IL322175A (en) 2017-08-04 2025-09-01 Myokardia Inc Treatment of hypertrophic cardiomyopathy (HCM) with pyrimidinedione compounds
SG11202006296YA (en) 2018-01-19 2020-08-28 Cytokinetics Inc Dihydrobenzofuran and inden analogs as cardiac sarcomere inhibitors
CR20200464A (es) 2018-03-08 2021-04-14 Incyte Corp Compuestos diólicos de aminopirazina como inhibidores de pi3k-y
US10710994B2 (en) 2018-03-19 2020-07-14 Genentech, Inc. Oxadiazole transient receptor potential channel inhibitors
EP3814343B1 (en) 2018-06-26 2023-01-11 Cytokinetics, Inc. Cardiac sarcomere inhibitors
JP7438148B2 (ja) 2018-06-26 2024-02-26 サイトキネティックス， インコーポレイテッド 心臓サルコメア阻害剤
MA53491A (fr) 2018-08-31 2021-09-15 Cytokinetics Inc Inhibiteurs de sarcomes cardiaques
US10981905B2 (en) 2018-08-31 2021-04-20 Xenon Pharmaceuticals Inc. Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents
MX2022000498A (es) 2019-07-17 2022-02-03 Cytokinetics Inc Polimorfos de (r)-n-(5-(5-isopropil-1,2,4-oxadiazol-3-il)-2,3-dihi dro-1h-inden-1-il) -2-metil-2h- tetrazol-5-carboxamida.
LT3999180T (lt) 2019-07-17 2024-08-26 Cytokinetics, Inc. (r)-n-(5-(5-etil-1,2,4-oksadiazol-3-il)-2,3-dihidro-1h-inden-1-il)-1-metil-1h-pirazol-4-karboksamido polimorfai
WO2021011808A1 (en) 2019-07-17 2021-01-21 Cytokinetics, Inc. Cardiac sarcomere inhibitor oral formulations
KR20230079053A (ko) 2020-08-28 2023-06-05 미요카디아, 인크. 미오신 조절제를 이용한 치료 방법
KR20240015622A (ko) 2021-03-04 2024-02-05 싸이토키네틱스, 인코포레이티드 심장 근절 억제제
EP4370116B1 (en) 2021-07-16 2025-01-15 Cytokinetics, Inc. Aficamten dosage regimens for treating obstructive hypertrophic cardiomyopathy
JP2024530111A (ja) 2021-08-03 2024-08-16 サイトキネティックス， インコーポレイテッド アフィカムテンを調製するための工程
CN119789856A (zh) 2022-04-26 2025-04-08 迈奥卡迪亚公司 施用肌球蛋白抑制剂的方法

Similar Documents

Publication Publication Date Title
JP2021529185A5 (enExample)
IL276094B2 (en) Dihydrobezofuran and indan analogues as cardiac sarcomere inhibitors
JP2021535164A5 (enExample)
JP2024508526A5 (enExample)
JP2021529746A5 (enExample)
CN115244056A (zh) 稠合咪唑类衍生物、其制备方法及其在医药上的应用
EP2639229B1 (en) Thiazole Derivative and use thereof as VAP-1 Inhibitor
JP2022508203A5 (enExample)
JP2002529532A5 (enExample)
JP2022540668A5 (enExample)
CA2498559A1 (en) Indole derivatives or benzimidazole derivatives for modulating i.kappa.b kinase
WO2009145360A1 (en) Benzene or thiophene derivative and use thereof as vap-1 inhibitor
JP2018531982A5 (enExample)
JP2012505891A5 (enExample)
JP2021517164A5 (enExample)
JP2022542803A5 (enExample)
JP2018521119A5 (enExample)
TW201031645A (en) Thiadiazole and oxadiazole derivatives, preparation thereof and therapeutic use thereof
JPS59118783A (ja) 新規の置換された１，４−ジヒドロピリジン、その製造法及びこれを診断剤として使用する方法
KR101726819B1 (ko) Gpr119 작용 활성을 갖는 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 약제학적 조성물
JP2020527149A5 (enExample)
CN106459026B (zh) 制备pde10抑制剂的方法和中间体
JP2007519640A5 (enExample)
WO2012124311A1 (ja) 新規なフェニルピリジン誘導体及びこれを含有する医薬
JPWO2011024468A1 (ja) 新規なスルホンアミド誘導体及びこれを含有する医薬