JP2021534240A5 - - Google Patents
Info
- Publication number
- JP2021534240A5 JP2021534240A5 JP2021531468A JP2021531468A JP2021534240A5 JP 2021534240 A5 JP2021534240 A5 JP 2021534240A5 JP 2021531468 A JP2021531468 A JP 2021531468A JP 2021531468 A JP2021531468 A JP 2021531468A JP 2021534240 A5 JP2021534240 A5 JP 2021534240A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- oxo
- amino
- dimethylamino
- dihydropyridine
- Prior art date
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862717697P | 2018-08-10 | 2018-08-10 | |
| US62/717,697 | 2018-08-10 | ||
| US201962845229P | 2019-05-08 | 2019-05-08 | |
| US62/845,229 | 2019-05-08 | ||
| PCT/US2019/045827 WO2020033784A1 (en) | 2018-08-10 | 2019-08-09 | Transglutaminase 2 (tg2) inhibitors |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021534240A JP2021534240A (ja) | 2021-12-09 |
| JPWO2020033784A5 JPWO2020033784A5 (https=) | 2022-08-18 |
| JP2021534240A5 true JP2021534240A5 (https=) | 2022-08-18 |
| JP7433315B2 JP7433315B2 (ja) | 2024-02-19 |
Family
ID=69415167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021531468A Active JP7433315B2 (ja) | 2018-08-10 | 2019-08-09 | トランスグルタミナーゼ２（ｔｇ２）阻害剤 |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US12152026B2 (https=) |
| EP (2) | EP4219460B1 (https=) |
| JP (1) | JP7433315B2 (https=) |
| KR (1) | KR102904276B1 (https=) |
| CN (1) | CN112789040A (https=) |
| AU (1) | AU2019318543B2 (https=) |
| BR (1) | BR112021002532A2 (https=) |
| CL (1) | CL2021000328A1 (https=) |
| CO (1) | CO2021001472A2 (https=) |
| CY (1) | CY1126147T1 (https=) |
| DK (1) | DK3833348T3 (https=) |
| ES (2) | ES2947438T3 (https=) |
| FI (1) | FI3833348T3 (https=) |
| HR (1) | HRP20230798T1 (https=) |
| HU (1) | HUE062140T2 (https=) |
| IL (1) | IL280719B2 (https=) |
| LT (1) | LT3833348T (https=) |
| MX (1) | MX2021001550A (https=) |
| MY (1) | MY205622A (https=) |
| PH (1) | PH12021500008A1 (https=) |
| PL (1) | PL3833348T3 (https=) |
| PT (1) | PT3833348T (https=) |
| RS (1) | RS64464B1 (https=) |
| SG (1) | SG11202100736PA (https=) |
| SI (1) | SI3833348T1 (https=) |
| SM (1) | SMT202300186T1 (https=) |
| TW (1) | TWI825144B (https=) |
| UY (1) | UY38333A (https=) |
| WO (1) | WO2020033784A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11466017B2 (en) | 2011-03-10 | 2022-10-11 | Board Of Regents, The University Of Texas System | Heterocyclic inhibitors of PTPN11 |
| AU2017274199B2 (en) | 2016-05-31 | 2021-09-23 | Board Of Regents, The University Of Texas System | Heterocyclic inhibitors of PTPN11 |
| KR102611661B1 (ko) | 2018-05-02 | 2023-12-08 | 나비레 파르마, 인코퍼레이티드 | Ptpn11의 치환된 헤테로사이클릭 억제제 |
| EP3802539B1 (en) | 2018-06-05 | 2023-09-20 | F. Hoffmann-La Roche AG | Tetrahydro-1h-pyrazino[2,1-a]isoindolylquinoline compounds for the treatment of autoimmune disease |
| TWI825144B (zh) * | 2018-08-10 | 2023-12-11 | 美商思達利醫藥公司 | 第二型轉麩醯胺酸酶(tg2)抑制劑 |
| LT3833670T (lt) | 2018-08-10 | 2024-06-25 | Navire Pharma, Inc. | 6-(4-amino-3-metil-2-oksa-8-azaspiro[4.5]dekan-8-il)-3-(2,3-dichlorfenil)-2-metilpirimidin-4(3h)-ono dariniai ir susiję junginiai kaip ptpn11 (shp2) inhibitoriai, skirti vėžiui gydyti |
| GEP20247637B (en) | 2019-05-08 | 2024-06-25 | Aligos Therapeutics Inc | Modulators of thr-b and methods of use thereof |
| AU2022301517A1 (en) * | 2021-06-30 | 2023-12-14 | Zedira Gmbh | Inhibitors of transglutaminases |
| KR20240028466A (ko) * | 2021-06-30 | 2024-03-05 | 제디라 게엠베하 | 트랜스글루타미나아제 억제제 |
| US20240300902A1 (en) * | 2021-11-18 | 2024-09-12 | Md Biolab Co., Ltd. | Novel transglutaminase 2 inhibitor and use thereof |
| CN115611760A (zh) * | 2022-10-13 | 2023-01-17 | 天津药明康德新药开发有限公司 | 一种适合规模化生产(s)-2-氨基-5-炔基己酸的化学合成方法 |
| EP4653420A1 (en) * | 2023-01-17 | 2025-11-26 | Shenyang Haisco Pharmaceutical Co., Ltd. | Method for preparing chiral amino alcohol pharmaceutical intermediates |
| CN116891413A (zh) * | 2023-06-06 | 2023-10-17 | 山东东岳高分子材料有限公司 | 一种连续化制备2,4,5-三氟苯胺的方法 |
| CN117024254B (zh) * | 2023-08-10 | 2025-09-09 | 浙江大学衢州研究院 | 一种多氟苯酚的合成方法 |
| WO2025153465A1 (en) | 2024-01-15 | 2025-07-24 | UCB Biopharma SRL | Method for the treatment of fibrotic-related disorder associated to ibd |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5033252A (en) | 1987-12-23 | 1991-07-23 | Entravision, Inc. | Method of packaging and sterilizing a pharmaceutical product |
| US5052558A (en) | 1987-12-23 | 1991-10-01 | Entravision, Inc. | Packaged pharmaceutical product |
| US5021440A (en) | 1989-07-31 | 1991-06-04 | Merck & Co., Inc. | Imidazole compounds and their use as transglutaminase inhibitors |
| US5323907A (en) | 1992-06-23 | 1994-06-28 | Multi-Comp, Inc. | Child resistant package assembly for dispensing pharmaceutical medications |
| GB9509271D0 (en) | 1995-05-05 | 1995-06-28 | Biopharm Res & Dev Ltd | Blood clot stabilisation inhibitors |
| US7579313B2 (en) | 2003-11-18 | 2009-08-25 | The Board Of Trustees Of The Leland Stanford Junior University | Transglutaminase inhibitors and methods of use thereof |
| WO2006060702A1 (en) | 2004-12-03 | 2006-06-08 | The Brigham And Women's Hospital, Inc. | Substitued 3,4-dihydrothieno [2,3-d] pyrmidines as tissue transglutaminase inhibitors |
| DE102006052755A1 (de) | 2006-11-08 | 2008-05-15 | N-Zyme Biotec Gmbh | Michaelsysteme als Transglutaminaseinhibitoren |
| WO2011127933A1 (en) | 2010-04-16 | 2011-10-20 | Nuevolution A/S | Bi-functional complexes and methods for making and using such complexes |
| WO2011151395A2 (en) | 2010-06-02 | 2011-12-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Transglutaminase 2 inhibitors for use in the prevention or treatment of rapidly progressive glomerulonephritis |
| WO2012078519A2 (en) | 2010-12-06 | 2012-06-14 | Numerate, Inc. | 3-acylidene-2-oxoindole derivatives for inhibition of transglutaminase 2 |
| US8889716B2 (en) | 2011-05-10 | 2014-11-18 | Chdi Foundation, Inc. | Transglutaminase TG2 inhibitors, pharmaceutical compositions, and methods of use thereof |
| RU2630677C2 (ru) | 2011-12-21 | 2017-09-12 | Оно Фармасьютикал Ко., Лтд. | Соединения |
| EP2687511A1 (de) * | 2012-07-17 | 2014-01-22 | Zedira GmbH | Pyridinonderivate als Gewebetransglutaminaseinhibitoren |
| TW201418198A (zh) | 2012-09-21 | 2014-05-16 | Chdi Foundation Inc | 轉麩醯胺酸酶ｔｇ２抑制劑，醫藥組成物及其使用方法 |
| KR101548789B1 (ko) | 2012-12-21 | 2015-09-01 | 주식회사 엘지화학 | 케이블형 이차전지 및 이의 제조 방법 |
| JP6676058B2 (ja) | 2015-01-14 | 2020-04-08 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | ヘテロアリーレン架橋したベンゾジアゼピン二量体、そのコンジュゲート、ならびに製造および使用方法 |
| EP3342779A1 (en) * | 2016-12-27 | 2018-07-04 | Zedira GmbH | Inhibitors of transglutaminases |
| TWI825144B (zh) * | 2018-08-10 | 2023-12-11 | 美商思達利醫藥公司 | 第二型轉麩醯胺酸酶(tg2)抑制劑 |
-
2019
- 2019-08-08 TW TW108128272A patent/TWI825144B/zh active
- 2019-08-09 WO PCT/US2019/045827 patent/WO2020033784A1/en not_active Ceased
- 2019-08-09 UY UY0001038333A patent/UY38333A/es not_active Application Discontinuation
- 2019-08-09 KR KR1020217006925A patent/KR102904276B1/ko active Active
- 2019-08-09 ES ES19846381T patent/ES2947438T3/es active Active
- 2019-08-09 IL IL280719A patent/IL280719B2/en unknown
- 2019-08-09 PL PL19846381.2T patent/PL3833348T3/pl unknown
- 2019-08-09 SI SI201930559T patent/SI3833348T1/sl unknown
- 2019-08-09 EP EP23174889.8A patent/EP4219460B1/en active Active
- 2019-08-09 US US17/267,110 patent/US12152026B2/en active Active
- 2019-08-09 SM SM20230186T patent/SMT202300186T1/it unknown
- 2019-08-09 BR BR112021002532-4A patent/BR112021002532A2/pt unknown
- 2019-08-09 RS RS20230613A patent/RS64464B1/sr unknown
- 2019-08-09 DK DK19846381.2T patent/DK3833348T3/da active
- 2019-08-09 LT LTEPPCT/US2019/045827T patent/LT3833348T/lt unknown
- 2019-08-09 EP EP19846381.2A patent/EP3833348B1/en active Active
- 2019-08-09 HR HRP20230798TT patent/HRP20230798T1/hr unknown
- 2019-08-09 MY MYPI2021000686A patent/MY205622A/en unknown
- 2019-08-09 JP JP2021531468A patent/JP7433315B2/ja active Active
- 2019-08-09 CN CN201980065467.5A patent/CN112789040A/zh active Pending
- 2019-08-09 SG SG11202100736PA patent/SG11202100736PA/en unknown
- 2019-08-09 MX MX2021001550A patent/MX2021001550A/es unknown
- 2019-08-09 ES ES23174889T patent/ES3017786T3/es active Active
- 2019-08-09 PT PT198463812T patent/PT3833348T/pt unknown
- 2019-08-09 AU AU2019318543A patent/AU2019318543B2/en active Active
- 2019-08-09 FI FIEP19846381.2T patent/FI3833348T3/fi active
- 2019-08-09 HU HUE19846381A patent/HUE062140T2/hu unknown
-
2021
- 2021-01-27 PH PH12021500008A patent/PH12021500008A1/en unknown
- 2021-02-08 CL CL2021000328A patent/CL2021000328A1/es unknown
- 2021-02-09 CO CONC2021/0001472A patent/CO2021001472A2/es unknown
-
2022
- 2022-05-20 US US17/749,335 patent/US11548892B1/en active Active
-
2023
- 2023-08-04 CY CY20231100392T patent/CY1126147T1/el unknown
-
2024
- 2024-09-06 US US18/826,431 patent/US20250011324A1/en active Pending
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