JP2021534240A5 - - Google Patents

Info

Publication number
JP2021534240A5
JP2021534240A5 JP2021531468A JP2021531468A JP2021534240A5 JP 2021534240 A5 JP2021534240 A5 JP 2021534240A5 JP 2021531468 A JP2021531468 A JP 2021531468A JP 2021531468 A JP2021531468 A JP 2021531468A JP 2021534240 A5 JP2021534240 A5 JP 2021534240A5
Authority
JP
Japan
Prior art keywords
methyl
oxo
amino
dimethylamino
dihydropyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2021531468A
Other languages
English (en)
Japanese (ja)
Other versions
JP7433315B2 (ja
JP2021534240A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/045827 external-priority patent/WO2020033784A1/en
Publication of JP2021534240A publication Critical patent/JP2021534240A/ja
Publication of JP2021534240A5 publication Critical patent/JP2021534240A5/ja
Application granted granted Critical
Publication of JP7433315B2 publication Critical patent/JP7433315B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2021531468A 2018-08-10 2019-08-09 トランスグルタミナーゼ２（ｔｇ２）阻害剤 Active JP7433315B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862717697P 2018-08-10 2018-08-10
US62/717,697 2018-08-10
US201962845229P 2019-05-08 2019-05-08
US62/845,229 2019-05-08
PCT/US2019/045827 WO2020033784A1 (en) 2018-08-10 2019-08-09 Transglutaminase 2 (tg2) inhibitors

Publications (3)

Publication Number Publication Date
JP2021534240A JP2021534240A (ja) 2021-12-09
JP2021534240A5 true JP2021534240A5 (https=) 2022-08-18
JP7433315B2 JP7433315B2 (ja) 2024-02-19

Family

ID=69415167

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021531468A Active JP7433315B2 (ja) 2018-08-10 2019-08-09 トランスグルタミナーゼ２（ｔｇ２）阻害剤

Country Status (29)

Country Link
US (3) US12152026B2 (https=)
EP (2) EP3833348B1 (https=)
JP (1) JP7433315B2 (https=)
KR (1) KR102904276B1 (https=)
CN (1) CN112789040A (https=)
AU (1) AU2019318543B2 (https=)
BR (1) BR112021002532A2 (https=)
CL (1) CL2021000328A1 (https=)
CO (1) CO2021001472A2 (https=)
CY (1) CY1126147T1 (https=)
DK (1) DK3833348T3 (https=)
ES (2) ES3017786T3 (https=)
FI (1) FI3833348T3 (https=)
HR (1) HRP20230798T1 (https=)
HU (1) HUE062140T2 (https=)
IL (1) IL280719B2 (https=)
LT (1) LT3833348T (https=)
MX (1) MX2021001550A (https=)
MY (1) MY205622A (https=)
PH (1) PH12021500008A1 (https=)
PL (1) PL3833348T3 (https=)
PT (1) PT3833348T (https=)
RS (1) RS64464B1 (https=)
SG (1) SG11202100736PA (https=)
SI (1) SI3833348T1 (https=)
SM (1) SMT202300186T1 (https=)
TW (1) TWI825144B (https=)
UY (1) UY38333A (https=)
WO (1) WO2020033784A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11466017B2 (en) 2011-03-10 2022-10-11 Board Of Regents, The University Of Texas System Heterocyclic inhibitors of PTPN11
WO2017210134A1 (en) 2016-05-31 2017-12-07 Board Of Regents, University Of Texas System Heterocyclic inhibitors of ptpn11
MX2020011528A (es) 2018-05-02 2021-02-09 Navire Pharma Inc Inhibidores heterociclicos sustituidos de ptpn11.
KR20210018818A (ko) 2018-06-05 2021-02-18 에프. 호프만-라 로슈 아게 자가면역 질환의 치료를 위한 테트라하이드로-1H-피라지노[2,1-a]이소인돌릴퀴놀린 화합물
CN112601750B (zh) 2018-08-10 2023-10-31 纳维尔制药有限公司 Ptpn11（shp2）抑制剂
TWI825144B (zh) * 2018-08-10 2023-12-11 美商思達利醫藥公司 第二型轉麩醯胺酸酶(tg2)抑制劑
KR20220017917A (ko) 2019-05-08 2022-02-14 알리고스 테라퓨틱스 인코포레이티드 Thr-베타의 조절제 및 이의 사용 방법
SI4192814T1 (sl) * 2021-06-30 2025-02-28 Zedira Gmbh Zaviralci transglutaminaz
HRP20241589T1 (hr) * 2021-06-30 2025-01-31 Zedira Gmbh Inhibitori transglutaminaza
US20240300902A1 (en) * 2021-11-18 2024-09-12 Md Biolab Co., Ltd. Novel transglutaminase 2 inhibitor and use thereof
CN115611760A (zh) * 2022-10-13 2023-01-17 天津药明康德新药开发有限公司 一种适合规模化生产(s)-2-氨基-5-炔基己酸的化学合成方法
EP4653420A1 (en) * 2023-01-17 2025-11-26 Shenyang Haisco Pharmaceutical Co., Ltd. Method for preparing chiral amino alcohol pharmaceutical intermediates
CN116891413A (zh) * 2023-06-06 2023-10-17 山东东岳高分子材料有限公司 一种连续化制备2,4,5-三氟苯胺的方法
CN117024254B (zh) * 2023-08-10 2025-09-09 浙江大学衢州研究院 一种多氟苯酚的合成方法
WO2025153465A1 (en) 2024-01-15 2025-07-24 UCB Biopharma SRL Method for the treatment of fibrotic-related disorder associated to ibd

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5052558A (en) 1987-12-23 1991-10-01 Entravision, Inc. Packaged pharmaceutical product
US5033252A (en) 1987-12-23 1991-07-23 Entravision, Inc. Method of packaging and sterilizing a pharmaceutical product
US5021440A (en) 1989-07-31 1991-06-04 Merck & Co., Inc. Imidazole compounds and their use as transglutaminase inhibitors
US5323907A (en) 1992-06-23 1994-06-28 Multi-Comp, Inc. Child resistant package assembly for dispensing pharmaceutical medications
GB9509271D0 (en) 1995-05-05 1995-06-28 Biopharm Res & Dev Ltd Blood clot stabilisation inhibitors
US7579313B2 (en) * 2003-11-18 2009-08-25 The Board Of Trustees Of The Leland Stanford Junior University Transglutaminase inhibitors and methods of use thereof
US20060183759A1 (en) 2004-12-03 2006-08-17 Stein Ross L Tissue transglutaminase inhibitors
DE102006052755A1 (de) * 2006-11-08 2008-05-15 N-Zyme Biotec Gmbh Michaelsysteme als Transglutaminaseinhibitoren
EP3540059A1 (en) 2010-04-16 2019-09-18 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
WO2011151395A2 (en) 2010-06-02 2011-12-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Transglutaminase 2 inhibitors for use in the prevention or treatment of rapidly progressive glomerulonephritis
WO2012078519A2 (en) * 2010-12-06 2012-06-14 Numerate, Inc. 3-acylidene-2-oxoindole derivatives for inhibition of transglutaminase 2
US8889716B2 (en) 2011-05-10 2014-11-18 Chdi Foundation, Inc. Transglutaminase TG2 inhibitors, pharmaceutical compositions, and methods of use thereof
US9732085B2 (en) 2011-12-21 2017-08-15 Ono Pharmaceutical Co., Ltd. Pyridinone and pyrimidinone derivatives as factor Xia
EP2687511A1 (de) * 2012-07-17 2014-01-22 Zedira GmbH Pyridinonderivate als Gewebetransglutaminaseinhibitoren
TW201418198A (zh) 2012-09-21 2014-05-16 Chdi Foundation Inc 轉麩醯胺酸酶ｔｇ２抑制劑，醫藥組成物及其使用方法
KR101548789B1 (ko) 2012-12-21 2015-09-01 주식회사 엘지화학 케이블형 이차전지 및 이의 제조 방법
BR112017014937A2 (pt) 2015-01-14 2018-03-13 Bristol-Myers Squibb Company dímeros de benzodiazepina ligados em ponte a heteroarileno, conjugados dos mesmos, e métodos de preparação e uso
EP3342779A1 (en) 2016-12-27 2018-07-04 Zedira GmbH Inhibitors of transglutaminases
TWI825144B (zh) * 2018-08-10 2023-12-11 美商思達利醫藥公司 第二型轉麩醯胺酸酶(tg2)抑制劑

Similar Documents

Publication Publication Date Title
JP2021534240A5 (https=)
US11591336B2 (en) Substituted pyrazolo[3,4-b]pyrazines as SHP2 phosphatase inhibitors
JP7687970B2 (ja) Ｉｒａｋ分解剤およびその使用
CA2780190C (en) Compounds and methods for kinase modulation, and indications therefor
KR102797536B1 (ko) PI3Kα 억제제 및 이의 사용 방법
JP7554672B2 (ja) Ｉｒａｋ分解剤およびそれらの使用
JP2009529047A5 (https=)
JP5911638B2 (ja) ベンゾチアゾール−６−イル酢酸誘導体およびｈｉｖ感染を処置するためのそれらの使用
JP2024503300A (ja) Ｉｒａｋ分解剤およびそれらの使用
JP5808793B2 (ja) キナーゼ調節のための化合物および方法、ならびにそれらの適応症
JP7479293B2 (ja) プテリジノン化合物およびその使用
RU2017106742A (ru) Комбинированная терапия для лечения парамиксовируса
JP2021001212A (ja) Ｂｔｋ阻害薬としての一級カルボキサミド類
TW202108141A (zh) Fgfr抑制劑及其使用方法
KR20200096522A (ko) 통합된 스트레스 경로의 조절제
PE20090370A1 (es) Derivados de heterociclo fusionado como inhibidores de quinasa
JP2022536540A (ja) アミノピリミジンアミドオートファジー阻害剤およびその使用方法
EP3601259A1 (en) Isoquinolines as inhibitors of hpk1
RU2013120966A (ru) ФУРО[3,2-d]ПИРИМИДИНОВЫЕ СОЕДИНЕНИЯ
JP2017524702A5 (https=)
JP2024045291A5 (https=)
JP2014518267A5 (https=)
JP6695353B2 (ja) Ｆｇｆｒ４阻害剤としてのホルミル化ｎ−複素環式誘導体
TW201822764A (zh) Syk抑制劑
JP2010505855A (ja) 新規なイミダゾチアゾール類およびイミダゾオキサゾール類