CY1126147T1 - Αναστολεις της τρανσγλουταμινασης 2 (tg2) - Google Patents

Αναστολεις της τρανσγλουταμινασης 2 (tg2)

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Publication number
CY1126147T1
CY1126147T1 CY20231100392T CY231100392T CY1126147T1 CY 1126147 T1 CY1126147 T1 CY 1126147T1 CY 20231100392 T CY20231100392 T CY 20231100392T CY 231100392 T CY231100392 T CY 231100392T CY 1126147 T1 CY1126147 T1 CY 1126147T1
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Cyprus
Prior art keywords
inhibitors
transglutaminase
compounds
inhibition
benefit
Prior art date
Application number
CY20231100392T
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English (en)
Inventor
David Campbell
Justin Chapman
Mui Cheung
Thomas R. DIRAIMONDO
Sergio G. Duron
Original Assignee
Sitari Pharma, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sitari Pharma, Inc. filed Critical Sitari Pharma, Inc.
Publication of CY1126147T1 publication Critical patent/CY1126147T1/el

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
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  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)

Abstract

Στο παρόν περιγράφονται ενώσεις και φαρμακευτικές συνθέσεις που περιέχουν τέτοιες ενώσεις, οι οποίες αναστέλλουν την τρανσγλουταμινάση 2 (TG2). Επίσης περιγράφονται εδώ μέθοδοι για τη χρήση τέτοιων αναστολέων της TG2, μόνων ή σε συνδυασμό με άλλες ενώσεις, για την αντιμετώπιση νόσων ή καταστάσεων που θα μπορούσαν να ωφεληθούν από την αναστολή της TG2.
CY20231100392T 2018-08-10 2023-08-04 Αναστολεις της τρανσγλουταμινασης 2 (tg2) CY1126147T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862717697P 2018-08-10 2018-08-10
US201962845229P 2019-05-08 2019-05-08
PCT/US2019/045827 WO2020033784A1 (en) 2018-08-10 2019-08-09 Transglutaminase 2 (tg2) inhibitors

Publications (1)

Publication Number Publication Date
CY1126147T1 true CY1126147T1 (el) 2023-11-15

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ID=69415167

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CY20231100392T CY1126147T1 (el) 2018-08-10 2023-08-04 Αναστολεις της τρανσγλουταμινασης 2 (tg2)

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US (2) US20210163480A1 (el)
EP (2) EP4219460A1 (el)
JP (1) JP7433315B2 (el)
KR (1) KR20210044248A (el)
CN (1) CN112789040A (el)
AU (1) AU2019318543B2 (el)
BR (1) BR112021002532A2 (el)
CA (1) CA3109195A1 (el)
CL (1) CL2021000328A1 (el)
CO (1) CO2021001472A2 (el)
CY (1) CY1126147T1 (el)
DK (1) DK3833348T3 (el)
ES (1) ES2947438T3 (el)
FI (1) FI3833348T3 (el)
HR (1) HRP20230798T1 (el)
HU (1) HUE062140T2 (el)
IL (1) IL280719B2 (el)
LT (1) LT3833348T (el)
MX (1) MX2021001550A (el)
PH (1) PH12021500008A1 (el)
PL (1) PL3833348T3 (el)
PT (1) PT3833348T (el)
RS (1) RS64464B1 (el)
SG (1) SG11202100736PA (el)
SI (1) SI3833348T1 (el)
TW (1) TWI825144B (el)
UY (1) UY38333A (el)
WO (1) WO2020033784A1 (el)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11466017B2 (en) 2011-03-10 2022-10-11 Board Of Regents, The University Of Texas System Heterocyclic inhibitors of PTPN11
US10280171B2 (en) 2016-05-31 2019-05-07 Board Of Regents, The University Of Texas System Heterocyclic inhibitors of PTPN11
WO2019213318A1 (en) 2018-05-02 2019-11-07 Board Of Regents, The University Of Texas System Substituted heterocyclic inhibitors of ptpn11
KR20210043569A (ko) 2018-08-10 2021-04-21 나비레 파르마, 인코퍼레이티드 암 치료를 위한 ptpn11 (shp2) 저해제로서 6-(4-아미노-3-메틸-2-옥사-8-아자스피로[4.5]데칸-8-일)-3-(2,3-디클로로페닐)-2-메틸피리미딘-4(3h)-온 유도체 및 관련 화합물
TWI825144B (zh) * 2018-08-10 2023-12-11 美商思達利醫藥公司 第二型轉麩醯胺酸酶(tg2)抑制劑
IL309077A (en) * 2021-06-30 2024-02-01 Zedira Gmbh Transglutaminase inhibitors
WO2023090479A1 (ko) * 2021-11-18 2023-05-25 주식회사 엠디바이오팜 신규한 트랜스글루타미나제 2 억제제 및 이의 용도
CN115611760A (zh) * 2022-10-13 2023-01-17 天津药明康德新药开发有限公司 一种适合规模化生产(s)-2-氨基-5-炔基己酸的化学合成方法

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US5052558A (en) 1987-12-23 1991-10-01 Entravision, Inc. Packaged pharmaceutical product
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GB9509271D0 (en) 1995-05-05 1995-06-28 Biopharm Res & Dev Ltd Blood clot stabilisation inhibitors
US7579313B2 (en) * 2003-11-18 2009-08-25 The Board Of Trustees Of The Leland Stanford Junior University Transglutaminase inhibitors and methods of use thereof
DE102006052755A1 (de) 2006-11-08 2008-05-15 N-Zyme Biotec Gmbh Michaelsysteme als Transglutaminaseinhibitoren
WO2012078519A2 (en) * 2010-12-06 2012-06-14 Numerate, Inc. 3-acylidene-2-oxoindole derivatives for inhibition of transglutaminase 2
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EP3290413B9 (en) * 2011-12-21 2020-04-29 ONO Pharmaceutical Co., Ltd. Pyridinone and pyrimidinone derivatives as factor xia inhibitors
EP2687511A1 (de) * 2012-07-17 2014-01-22 Zedira GmbH Pyridinonderivate als Gewebetransglutaminaseinhibitoren
KR101548789B1 (ko) 2012-12-21 2015-09-01 주식회사 엘지화학 케이블형 이차전지 및 이의 제조 방법
EP3342779A1 (en) * 2016-12-27 2018-07-04 Zedira GmbH Inhibitors of transglutaminases
TWI825144B (zh) * 2018-08-10 2023-12-11 美商思達利醫藥公司 第二型轉麩醯胺酸酶(tg2)抑制劑

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EP3833348A1 (en) 2021-06-16
HUE062140T2 (hu) 2023-09-28
CL2021000328A1 (es) 2021-08-27
SG11202100736PA (en) 2021-02-25
PL3833348T3 (pl) 2023-10-09
WO2020033784A1 (en) 2020-02-13
JP7433315B2 (ja) 2024-02-19
EP3833348B1 (en) 2023-05-31
TWI825144B (zh) 2023-12-11
US11548892B1 (en) 2023-01-10
UY38333A (es) 2020-05-29
IL280719B1 (en) 2023-07-01
PT3833348T (pt) 2023-06-29
SI3833348T1 (sl) 2023-08-31
IL280719B2 (en) 2023-11-01
IL280719A (en) 2021-03-25
TW202023553A (zh) 2020-07-01
BR112021002532A2 (pt) 2021-05-04
EP3833348A4 (en) 2021-06-30
ES2947438T3 (es) 2023-08-09
EP4219460A1 (en) 2023-08-02
RS64464B1 (sr) 2023-09-29
MX2021001550A (es) 2021-07-15
CN112789040A (zh) 2021-05-11
FI3833348T3 (fi) 2023-06-21
PH12021500008A1 (en) 2021-09-13
LT3833348T (lt) 2023-07-10
KR20210044248A (ko) 2021-04-22
CO2021001472A2 (es) 2021-03-08
AU2019318543A1 (en) 2021-03-11
DK3833348T3 (da) 2023-06-26
JP2021534240A (ja) 2021-12-09
US20210163480A1 (en) 2021-06-03
CA3109195A1 (en) 2020-02-13
HRP20230798T1 (hr) 2023-10-27
AU2019318543B2 (en) 2022-12-22

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