JP2021532140A - Ｃｄ３３及びｃｄ３に結合する二重特異性抗体コンストラクトの長期投与 - Google Patents

Ｃｄ３３及びｃｄ３に結合する二重特異性抗体コンストラクトの長期投与 Download PDF

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JP2021532140A
JP2021532140A JP2021504257A JP2021504257A JP2021532140A JP 2021532140 A JP2021532140 A JP 2021532140A JP 2021504257 A JP2021504257 A JP 2021504257A JP 2021504257 A JP2021504257 A JP 2021504257A JP 2021532140 A JP2021532140 A JP 2021532140A
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bispecific antibody
dose
administration
antibody construct
days
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JP2021532140A5 (https=
JPWO2020025532A5 (https=
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ナゴルセン，ディルク
メータ，バクティ
クフェル，ペーター
キシェル，ローマン
カールドヤニディ，ソフィア・ケイ
Original Assignee
アムジェン リサーチ （ミュニック） ゲゼルシャフト ミット ベシュレンクテル ハフツング
アムジエン・インコーポレーテツド
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Publication of JP2021532140A publication Critical patent/JP2021532140A/ja
Publication of JP2021532140A5 publication Critical patent/JP2021532140A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
JP2021504257A 2018-07-30 2019-07-29 Ｃｄ３３及びｃｄ３に結合する二重特異性抗体コンストラクトの長期投与 Pending JP2021532140A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862712147P 2018-07-30 2018-07-30
US62/712,147 2018-07-30
PCT/EP2019/070343 WO2020025532A1 (en) 2018-07-30 2019-07-29 Prolonged administration of a bispecific antibody construct binding to cd33 and cd3

Publications (3)

Publication Number Publication Date
JP2021532140A true JP2021532140A (ja) 2021-11-25
JP2021532140A5 JP2021532140A5 (https=) 2022-07-25
JPWO2020025532A5 JPWO2020025532A5 (https=) 2022-07-25

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JP2021504257A Pending JP2021532140A (ja) 2018-07-30 2019-07-29 Ｃｄ３３及びｃｄ３に結合する二重特異性抗体コンストラクトの長期投与

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US (1) US20210301017A1 (https=)
EP (1) EP3830121A1 (https=)
JP (1) JP2021532140A (https=)
CN (1) CN112771075A (https=)
AU (1) AU2019313444A1 (https=)
CA (1) CA3107186A1 (https=)
IL (1) IL280275A (https=)
MA (1) MA53325A (https=)
MX (1) MX2021001221A (https=)
SG (1) SG11202100710TA (https=)
TW (1) TW202021616A (https=)
WO (1) WO2020025532A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021083467A1 (en) * 2019-10-28 2021-05-06 Y-Mabs Therapeutics, Inc. Administration of cd22, cd33 and/or tim-3 antibodies using ommaya reservoirs for the treatment of cns cancer or neurodegenerative diseases
WO2021183861A1 (en) 2020-03-12 2021-09-16 Amgen Inc. Method for treatment and prophylaxis of crs in patients comprising a combination of bispecifc antibodies binding to cds x cancer cell and tnfalpha or il-6 inhibitor
AU2021281554A1 (en) * 2020-05-29 2022-12-15 Amgen Inc. Adverse effects-mitigating administration of a bispecific antibody construct binding to CD33 and CD3
CN118221826B (zh) * 2024-04-25 2024-11-15 北京绿竹生物技术股份有限公司 一种结合人cd33和cd3的双特异性抗体

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013508439A (ja) * 2009-10-27 2013-03-07 マイクロメット アクチェンゲゼルシャフト ＣＤ１９ｘＣＤ３二重特異性抗体を投与するための投与計画
JP2016516056A (ja) * 2013-03-15 2016-06-02 アムジエン・インコーポレーテツド 二重特異性二価ｓｃＦｖ−Ｆｃ分子
JP2016536341A (ja) * 2013-09-13 2016-11-24 アムジエン・インコーポレーテツド 骨髄性白血病の治療におけるエピジェネティック因子ならびにｃｄ３３およびｃｄ３を標的化する二重特異性化合物の組み合わせ
WO2017004532A1 (en) * 2015-07-02 2017-01-05 Celgene Corporation Combination therapy for treatment of hematological cancers and solid tumors
WO2017182427A1 (en) * 2016-04-19 2017-10-26 Amgen Research (Munich) Gmbh Administration of a bispecific construct binding to cd33 and cd3 for use in a method for the treatment of myeloid leukemia

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