|
US5287386A
(en)
|
1991-03-27 |
1994-02-15 |
Thinking Machines Corporation |
Differential driver/receiver circuit
|
|
WO1994026290A1
(en)
*
|
1993-05-07 |
1994-11-24 |
Immunex Corporation |
Cytokine designated 4-1bb ligand and human receptor that binds thereto
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US6046048A
(en)
|
1996-01-09 |
2000-04-04 |
Genetech, Inc. |
Apo-2 ligand
|
|
US6740739B1
(en)
|
1998-01-15 |
2004-05-25 |
Genentech, Inc. |
Substitutional variants of APO-2 ligand
|
|
WO2001049318A1
(en)
|
2000-01-03 |
2001-07-12 |
Tr Associates, L.L.C. |
Novel chimeric proteins and methods for using the same
|
|
WO2001057252A2
(en)
|
2000-02-04 |
2001-08-09 |
Aeomica, Inc. |
Methods and apparatus for high-throughput detection and characterization of alternatively spliced genes
|
|
US6436703B1
(en)
|
2000-03-31 |
2002-08-20 |
Hyseq, Inc. |
Nucleic acids and polypeptides
|
|
ES2394018T3
(es)
|
2001-11-27 |
2013-01-15 |
Ucb Pharma S.A. |
Procedimientos para el diagnóstico y el tratamiento de cánceres derivados de células epiteliales
|
|
US7772188B2
(en)
|
2003-01-28 |
2010-08-10 |
Ironwood Pharmaceuticals, Inc. |
Methods and compositions for the treatment of gastrointestinal disorders
|
|
KR20050082389A
(ko)
|
2004-02-18 |
2005-08-23 |
메덱스젠 주식회사 |
직렬 연쇄체를 갖는 면역접합체를 포함하는 장기이식합병증 치료용 약제학적 조성물
|
|
US7142018B2
(en)
|
2004-06-08 |
2006-11-28 |
Transmeta Corporation |
Circuits and methods for detecting and assisting wire transitions
|
|
US7279925B1
(en)
|
2005-03-10 |
2007-10-09 |
Cypress Semiconductor Corp. |
Capacitive feedforward circuit, system, and method to reduce buffer propagation delay
|
|
JP2006345852A
(ja)
*
|
2005-06-16 |
2006-12-28 |
Virxsys Corp |
抗体複合体
|
|
EP3208612B1
(en)
|
2008-04-09 |
2019-09-18 |
Genentech, Inc. |
Compositions and methods for the treatment of immune related diseases
|
|
SG191698A1
(en)
|
2008-06-30 |
2013-07-31 |
Univ Pennsylvania |
Fn14/trail fusion proteins
|
|
WO2010098788A2
(en)
|
2008-08-25 |
2010-09-02 |
Amplimmune, Inc. |
Pd-i antagonists and methods for treating infectious disease
|
|
US20110237498A1
(en)
|
2008-12-19 |
2011-09-29 |
Novartis Ag |
Soluble polypeptides for use in treating autoimmune and inflammatory disorders
|
|
PL2995315T3
(pl)
|
2009-05-15 |
2024-04-22 |
University Health Network |
Kompozycje i sposoby leczenia nowotworów hematologicznych celujące w oddziaływanie sirp alfa-cd47
|
|
CA3083324A1
(en)
*
|
2010-03-05 |
2011-09-09 |
The Johns Hopkins University |
Compositions and methods for targeted immunomodulatory antibodies and fusion proteins
|
|
WO2012042480A1
(en)
|
2010-09-28 |
2012-04-05 |
Kahr Medical Ltd. |
Compositions and methods for treatment of hematological malignancies
|
|
US8675439B2
(en)
|
2011-10-12 |
2014-03-18 |
Taiwan Semiconductor Manufacturing Co., Ltd. |
Bit line voltage bias for low power memory design
|
|
US9926364B2
(en)
|
2011-11-03 |
2018-03-27 |
Argen-X N.V. |
Chimeric human-llama antigens and methods of use
|
|
SI2804617T1
(sl)
|
2012-01-17 |
2020-10-30 |
The Board Of Trustees Of The Leland Stanford Junior University |
Visokoafinitetni SIRP-alfa reagenti
|
|
US20140370012A1
(en)
|
2012-01-27 |
2014-12-18 |
Gliknik Inc. |
Fusion proteins comprising igg2 hinge domains
|
|
AU2013239366A1
(en)
|
2012-03-29 |
2014-10-16 |
Aurigene Discovery Technologies Limited |
Immunomodulating cyclic compounds from the BC loop of human PD1
|
|
CN110563850A
(zh)
|
2012-04-30 |
2019-12-13 |
比奥孔有限公司 |
靶向/免疫调节性融合蛋白及其制造方法
|
|
EP2730588A1
(en)
|
2012-11-12 |
2014-05-14 |
Intelectys |
Antibodies and fragments thereof raised against the alpha-3 domain of HLA-G protein, methods and means for their preparation, and uses thereof
|
|
CN104968364A
(zh)
|
2012-12-03 |
2015-10-07 |
百时美施贵宝公司 |
强化免疫调变性Fc融合蛋白的抗癌活性
|
|
WO2014106839A1
(en)
|
2013-01-01 |
2014-07-10 |
Kahr Medical Ltd. |
Stable form of signal converting protein fusion proteins, and methods of use and preparation thereof
|
|
US9873747B2
(en)
|
2013-01-31 |
2018-01-23 |
Thomas Jefferson University |
Fusion proteins that facilitate cancer cell destruction
|
|
WO2014180288A1
(zh)
|
2013-05-06 |
2014-11-13 |
中国药科大学 |
具有抑制肿瘤微环境血管再生和激活适应性免疫应答双功能的融合蛋白及其基因和应用
|
|
KR102314088B1
(ko)
|
2014-03-24 |
2021-10-15 |
이뮨원코 바이오파마슈티컬즈 (상하이) 컴퍼니 리미티드 |
새로운 이중 기능성의 재조합 융합 단백질, 이의 제조 방법 및 용도
|
|
US9546206B2
(en)
*
|
2014-08-08 |
2017-01-17 |
The Board Of Trustees Of The Leland Stanford Junior University |
High affinity PD-1 agents and methods of use
|
|
WO2016023001A1
(en)
|
2014-08-08 |
2016-02-11 |
The Board Of Trustees Of The Leland Stanford Junior University |
Multispecific high affinity pd-1 agents and methods of use
|
|
HUE046661T2
(hu)
|
2014-08-15 |
2020-03-30 |
Merck Patent Gmbh |
SIRP-alfa immunglobulin fúziós proteinek
|
|
EP3012271A1
(en)
|
2014-10-24 |
2016-04-27 |
Effimune |
Method and compositions for inducing differentiation of myeloid derived suppressor cell to treat cancer and infectious diseases
|
|
CR20170194A
(es)
*
|
2014-11-14 |
2017-07-10 |
Hoffmann La Roche |
Moleculas de unión a antígeno que comprenden un trímero de ligando de la familia de tnf
|
|
CN104403004B
(zh)
|
2014-11-24 |
2017-10-13 |
苏州丁孚靶点生物技术有限公司 |
抗体‑干扰素异二聚体的制备和用途
|
|
SI3227339T1
(sl)
|
2014-12-05 |
2022-02-28 |
Memorial Sloan-Kettering Cancer Center |
Himerni antigenski receptorji, ki ciljajo na receptor, povezan z G-proteinom, in njihova uporaba
|
|
US20180169183A1
(en)
|
2015-03-03 |
2018-06-21 |
Kahr Medical Ltd |
Dual signaling protein (dsp) fusion proteins, and methods of using thereof for treating diseases
|
|
WO2016156291A1
(en)
|
2015-03-31 |
2016-10-06 |
F. Hoffmann-La Roche Ag |
Antigen binding molecules comprising a trimeric tnf family ligand
|
|
CN106146670B
(zh)
|
2015-04-24 |
2019-01-15 |
宜明昂科生物医药技术（上海）有限公司 |
一种新的重组双功能融合蛋白及其制备和应用
|
|
CA2994935A1
(en)
|
2015-05-18 |
2016-11-24 |
Ab Initio Biotherapeutics, Inc. |
Sirp polypeptide compositions and methods of use
|
|
WO2017012770A1
(en)
|
2015-07-23 |
2017-01-26 |
Ratiopharm Gmbh |
Acid addition salts of filgotinib
|
|
AR105520A1
(es)
*
|
2015-07-30 |
2017-10-11 |
Macrogenics Inc |
Moléculas de unión a pd-1 y métodos de uso de las mismas
|
|
WO2017019846A1
(en)
|
2015-07-30 |
2017-02-02 |
Macrogenics, Inc. |
Pd-1-binding molecules and methods use thereof
|
|
WO2017027422A1
(en)
|
2015-08-07 |
2017-02-16 |
Alexo Therapeutics Inc. |
Constructs having a sirp-alpha domain or variant thereof
|
|
BR102016018074A2
(pt)
|
2015-08-07 |
2021-11-16 |
ALX Oncology Inc. |
Construção variante de sirp-alfa, seu método de preparação e seus usos, molécula de ácido nucleico, vetor, célula hospedeira, e composição farmacêutica
|
|
RU2766200C1
(ru)
*
|
2015-10-01 |
2022-02-09 |
Хит Байолоджикс, Инк. |
Композиции и способы для соединения внеклеточных доменов типа i и типа ii в качестве гетерологичных химерных белков
|
|
CN108430492B
(zh)
|
2015-10-23 |
2022-05-03 |
阿珀吉科吉尼科斯股份公司 |
单链cd27受体激动剂蛋白
|
|
WO2017152132A1
(en)
|
2016-03-04 |
2017-09-08 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods of identifying and treating immune checkpoint inhibitor-responsive neoplasms
|
|
EP3433269B1
(en)
*
|
2016-03-23 |
2023-09-27 |
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) |
Fusion proteins of pd-1 and 4-1bb
|
|
MY209117A
(en)
*
|
2016-04-15 |
2025-06-23 |
Novartis Ag |
Compositions and methods for selective protein expression
|
|
EP3243832A1
(en)
|
2016-05-13 |
2017-11-15 |
F. Hoffmann-La Roche AG |
Antigen binding molecules comprising a tnf family ligand trimer and pd1 binding moiety
|
|
AR108468A1
(es)
|
2016-05-13 |
2018-08-22 |
Medimmune Llc |
POLIPÉPTIDOS DE FUSIÓN CD40L-Fc Y MÉTODOS DE USO DE LOS MISMOS
|
|
NZ748929A
(en)
|
2016-06-03 |
2025-11-28 |
Invectys |
Anti hla-g specific antibodies
|
|
CN107586342A
(zh)
|
2016-07-08 |
2018-01-16 |
生命序有限公司 |
重组免疫检查点受体及其应用
|
|
CN106267188B
(zh)
|
2016-08-15 |
2025-06-17 |
深圳大学 |
小分子免疫激动剂偶联pd-1抗体的新型抗体及其在抗肿瘤中的应用
|
|
CN107868791B
(zh)
|
2016-09-26 |
2021-11-23 |
阿思科力(苏州)生物科技有限公司 |
一种加强型Slit2 CAR-T和CAR-NK细胞制备方法和应用
|
|
HUE057559T2
(hu)
|
2016-11-02 |
2022-06-28 |
Jounce Therapeutics Inc |
PD-1 elleni antitestek és alkalmazásaik
|
|
TW201829463A
(zh)
|
2016-11-18 |
2018-08-16 |
瑞士商赫孚孟拉羅股份公司 |
抗hla-g抗體及其用途
|
|
WO2018114754A1
(en)
|
2016-12-19 |
2018-06-28 |
F. Hoffmann-La Roche Ag |
Combination therapy with targeted 4-1bb (cd137) agonists
|
|
LT3565579T
(lt)
|
2017-01-05 |
2023-09-11 |
Kahr Medical Ltd. |
Pd1-41bbl sulietas baltymas ir jo panaudojimo būdai
|
|
US11566060B2
(en)
|
2017-01-05 |
2023-01-31 |
Kahr Medical Ltd. |
PD1-CD70 fusion protein and methods of use thereof
|
|
WO2018127918A1
(en)
|
2017-01-05 |
2018-07-12 |
Kahr Medical Ltd. |
A sirp alpha-cd70 fusion protein and methods of use thereof
|
|
PT3565828T
(pt)
|
2017-01-05 |
2022-02-08 |
Kahr Medical Ltd |
Proteína de fusão sirp1 alfa-41bbl e seus métodos de utilização
|
|
CN107857819A
(zh)
|
2017-07-03 |
2018-03-30 |
江苏西迪尔生物技术有限公司 |
多功能融合蛋白及其应用
|
|
WO2019086499A1
(en)
|
2017-11-01 |
2019-05-09 |
F. Hoffmann-La Roche Ag |
Novel tnf family ligand trimer-containing antigen binding molecules
|
|
US12134638B2
(en)
|
2018-07-11 |
2024-11-05 |
Kahr Medical Ltd. |
SIRPalpha-4-1BBL variant fusion protein and methods of use thereof
|
|
KR20210044221A
(ko)
|
2018-07-11 |
2021-04-22 |
카 메디컬 리미티드 |
Pd1-4-1bbl 변이체 융합 단백질 및 이의 사용 방법
|
|
US20210301020A1
(en)
|
2018-07-24 |
2021-09-30 |
Amgen Inc. |
Combination of lilrb1/2 pathway inhibitors and pd-1 pathway inhibitors
|
|
CA3125748A1
(en)
|
2019-01-07 |
2020-07-16 |
Thomas Jefferson University |
Multi-functional fusion proteins and uses thereof
|
|
TWI760751B
(zh)
|
2019-05-29 |
2022-04-11 |
美商美國禮來大藥廠 |
Tigit及pd-1/tigit-結合分子
|
|
CN110128550B
(zh)
|
2019-05-30 |
2023-01-13 |
南京惟亚德生物医药有限公司 |
一种新型的同时阻断免疫检查点pd-l1和tigit的复制型溶瘤腺病毒和应用
|
|
US20220267409A1
(en)
|
2019-07-11 |
2022-08-25 |
Kahr Medical Ltd. |
Heterodimers and methods of use thereof
|
|
SE2050035A1
(en)
|
2020-01-16 |
2021-07-17 |
Holmbergs Safety System Holding Ab |
Belt buckle for a safety belt in a child restraint system
|
|
US20240076346A1
(en)
|
2021-01-13 |
2024-03-07 |
Kahr Medical Ltd. |
Type i membrane proteins heterodimers and methods of use thereof
|
|
IL313778A
(en)
|
2021-12-23 |
2024-08-01 |
Kahr Medical Ltd |
Lilrb polypeptides and uses thereof
|