JP2021530488A - 可溶性グアニル酸シクラーゼ活性化薬としてのアルコキシピラゾール - Google Patents
可溶性グアニル酸シクラーゼ活性化薬としてのアルコキシピラゾール Download PDFInfo
- Publication number
- JP2021530488A JP2021530488A JP2021500613A JP2021500613A JP2021530488A JP 2021530488 A JP2021530488 A JP 2021530488A JP 2021500613 A JP2021500613 A JP 2021500613A JP 2021500613 A JP2021500613 A JP 2021500613A JP 2021530488 A JP2021530488 A JP 2021530488A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- heterocyclyl
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 *C=CC(COc1c(*)c(*)c(*)cc1-c1cccc(N(C2O*)N=CC2C(O)=O)n1)=C(*)C1=C(*)/C=C/C(/*)=C/C=C1 Chemical compound *C=CC(COc1c(*)c(*)c(*)cc1-c1cccc(N(C2O*)N=CC2C(O)=O)n1)=C(*)C1=C(*)/C=C/C(/*)=C/C=C1 0.000 description 10
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024052193A JP2024095711A (ja) | 2018-07-12 | 2024-03-27 | 可溶性グアニル酸シクラーゼ活性化薬としてのアルコキシピラゾール |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862696887P | 2018-07-12 | 2018-07-12 | |
| US62/696,887 | 2018-07-12 | ||
| PCT/EP2019/068448 WO2020011804A1 (en) | 2018-07-12 | 2019-07-09 | Alkoxy pyrazoles as soluble guanylate cyclase activators |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024052193A Division JP2024095711A (ja) | 2018-07-12 | 2024-03-27 | 可溶性グアニル酸シクラーゼ活性化薬としてのアルコキシピラゾール |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021530488A true JP2021530488A (ja) | 2021-11-11 |
| JP2021530488A5 JP2021530488A5 (https=) | 2022-07-15 |
| JPWO2020011804A5 JPWO2020011804A5 (https=) | 2022-07-15 |
Family
ID=67314737
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021500613A Pending JP2021530488A (ja) | 2018-07-12 | 2019-07-09 | 可溶性グアニル酸シクラーゼ活性化薬としてのアルコキシピラゾール |
| JP2024052193A Pending JP2024095711A (ja) | 2018-07-12 | 2024-03-27 | 可溶性グアニル酸シクラーゼ活性化薬としてのアルコキシピラゾール |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024052193A Pending JP2024095711A (ja) | 2018-07-12 | 2024-03-27 | 可溶性グアニル酸シクラーゼ活性化薬としてのアルコキシピラゾール |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US11690848B2 (https=) |
| EP (1) | EP3820470B1 (https=) |
| JP (2) | JP2021530488A (https=) |
| KR (1) | KR20210032443A (https=) |
| CN (1) | CN112384214A (https=) |
| AU (1) | AU2019301887A1 (https=) |
| BR (1) | BR112020025670A2 (https=) |
| CA (1) | CA3103727A1 (https=) |
| CL (1) | CL2021000023A1 (https=) |
| EA (1) | EA202190193A1 (https=) |
| MA (1) | MA53118A (https=) |
| MX (1) | MX2021000405A (https=) |
| PH (1) | PH12021550075A1 (https=) |
| WO (1) | WO2020011804A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118900690A (zh) * | 2022-03-21 | 2024-11-05 | 勃林格殷格翰国际有限公司 | 用于治疗门脉高压的可溶性鸟苷酸环化酶活化剂 |
| WO2024097316A1 (en) | 2022-11-04 | 2024-05-10 | Boehringer Ingelheim International Gmbh | Soluble guanylate cyclase activators for treating systemic sclerosis |
| US20240199590A1 (en) | 2022-12-09 | 2024-06-20 | Boehringer Ingelheim International Gmbh | Solid forms of a sgc activator |
| WO2025036839A1 (en) * | 2023-08-16 | 2025-02-20 | Boehringer Ingelheim International Gmbh | Soluble guanylate cyclase activators for treating clinically significant portal hypertension and decompensated cirrhosis |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015527394A (ja) * | 2012-09-07 | 2015-09-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 可溶性グアニル酸シクラーゼ活性化因子としてのアルコキシピラゾール |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112018015718A2 (pt) * | 2016-02-01 | 2019-01-08 | Ironwood Pharmaceuticals Inc | utilização de estimuladores de sgc para o tratamento de esteato-hepatite não alcoólica (nash) |
| US10925876B2 (en) | 2016-05-18 | 2021-02-23 | Merck Sharp & Dohme Corp. | Methods for using triazolo-pyrazinyl soluble guanylate cyclase activators in fibrotic disorders |
-
2019
- 2019-07-09 EP EP19740509.5A patent/EP3820470B1/en active Active
- 2019-07-09 EA EA202190193A patent/EA202190193A1/ru unknown
- 2019-07-09 KR KR1020217004281A patent/KR20210032443A/ko not_active Ceased
- 2019-07-09 CN CN201980045881.XA patent/CN112384214A/zh active Pending
- 2019-07-09 MX MX2021000405A patent/MX2021000405A/es unknown
- 2019-07-09 WO PCT/EP2019/068448 patent/WO2020011804A1/en not_active Ceased
- 2019-07-09 CA CA3103727A patent/CA3103727A1/en active Pending
- 2019-07-09 US US17/258,759 patent/US11690848B2/en active Active
- 2019-07-09 JP JP2021500613A patent/JP2021530488A/ja active Pending
- 2019-07-09 AU AU2019301887A patent/AU2019301887A1/en not_active Abandoned
- 2019-07-09 MA MA053118A patent/MA53118A/fr unknown
- 2019-07-09 BR BR112020025670-6A patent/BR112020025670A2/pt not_active IP Right Cessation
-
2021
- 2021-01-06 CL CL2021000023A patent/CL2021000023A1/es unknown
- 2021-01-12 PH PH12021550075A patent/PH12021550075A1/en unknown
-
2024
- 2024-03-27 JP JP2024052193A patent/JP2024095711A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015527394A (ja) * | 2012-09-07 | 2015-09-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 可溶性グアニル酸シクラーゼ活性化因子としてのアルコキシピラゾール |
Non-Patent Citations (2)
| Title |
|---|
| FLORES-COSTA, ROGER ET AL., BRITISH JOURNAL OF PHARMACOLOGY, vol. 175, no. 6, JPN6023022255, March 2018 (2018-03-01), pages 953 - 967, ISSN: 0005356906 * |
| SCHWABL, PHILIPP ET AL., SCIETNTIFIC REPORTS, vol. 8:9372, JPN6023022254, 19 June 2018 (2018-06-19), pages 1 - 13, ISSN: 0005356907 * |
Also Published As
| Publication number | Publication date |
|---|---|
| MX2021000405A (es) | 2021-03-25 |
| CA3103727A1 (en) | 2020-01-16 |
| MA53118A (fr) | 2021-05-19 |
| KR20210032443A (ko) | 2021-03-24 |
| WO2020011804A1 (en) | 2020-01-16 |
| EA202190193A1 (ru) | 2021-06-16 |
| AU2019301887A1 (en) | 2021-01-07 |
| JP2024095711A (ja) | 2024-07-10 |
| US20210121473A1 (en) | 2021-04-29 |
| US11690848B2 (en) | 2023-07-04 |
| BR112020025670A2 (pt) | 2021-03-16 |
| CL2021000023A1 (es) | 2021-06-11 |
| CN112384214A (zh) | 2021-02-19 |
| PH12021550075A1 (en) | 2021-09-20 |
| EP3820470A1 (en) | 2021-05-19 |
| EP3820470B1 (en) | 2024-09-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2024095711A (ja) | 可溶性グアニル酸シクラーゼ活性化薬としてのアルコキシピラゾール | |
| JP6180420B2 (ja) | 増殖性疾患の治療のためのｈｓｐ９０阻害剤と組み合わせた２−カルボキサミドシクロアミノウレア誘導体 | |
| JPWO2003043655A1 (ja) | 頻尿の治療剤 | |
| JPWO2019074116A1 (ja) | Ａｘｌ阻害剤を有効成分として含む固形がん治療剤 | |
| HUP0301336A2 (hu) | Réztartalmú amin-oxidázok inhibitorai és alkalmazásuk gyógyszerkészítmények előállítására | |
| AU2017327383A1 (en) | Method of reducing thyroid-associated side effects | |
| US20240016791A1 (en) | Iloperidone metabolite for use in the treatment of psychiatric disorders | |
| KR20110093841A (ko) | 자가면역 질환의 치료를 위한 ｄｈｏｄｈ 억제제 및 메토트렉세이트를 포함하는 조합 요법 | |
| ES2972934T3 (es) | Combinación de sepetaprost y ripasudil para su uso en la profilaxis o tratamiento del glaucoma o hipertensión ocular | |
| WO2019124489A1 (ja) | セペタプロストとｅｐ２アゴニストとの組み合わせ医薬 | |
| JP5559696B2 (ja) | 糖尿病性腎症の治療剤 | |
| JP2023554354A (ja) | アルツハイマー病の処置のためのマシチニブ | |
| WO2021066136A1 (ja) | 筋ジストロフィー治療薬 | |
| EA042973B1 (ru) | Алкоксипиразолы в качестве активаторов растворимой гуанилатциклазы | |
| TW201806601A (zh) | σ受體配體在皰疹後遺疼痛中的用途 | |
| WO2025207099A1 (en) | Ppar-delta inhibitors for preventing post-operative atrial fibrillation | |
| JPH0653678B2 (ja) | アレルギ−性疾患治療剤 | |
| JPH03218313A (ja) | 脳細胞保護剤 | |
| WO2019124487A1 (ja) | オミデネパグの組合せ | |
| JPS61282358A (ja) | 治療用化合物 | |
| WO2018012634A1 (ja) | 不飽和複素５員環含有化合物を含有する肺高血圧症の予防又は治療剤 | |
| HK40029829B (en) | Combination of sepetaprost and ripasudil for use in the prophylaxis or treatment of glaucoma or ocular hypertension | |
| WO2006085688A1 (ja) | 神経因性疼痛治療剤 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20220707 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20220707 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20230601 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20230831 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20231127 |
|
| A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20240327 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20240404 |
|
| A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20240628 |