JP2021526130A - インスリンまたはインスリン類似体と組み合わせたグルコキナーゼ活性化薬の治療的使用 - Google Patents

インスリンまたはインスリン類似体と組み合わせたグルコキナーゼ活性化薬の治療的使用 Download PDF

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JP2021526130A
JP2021526130A JP2020563743A JP2020563743A JP2021526130A JP 2021526130 A JP2021526130 A JP 2021526130A JP 2020563743 A JP2020563743 A JP 2020563743A JP 2020563743 A JP2020563743 A JP 2020563743A JP 2021526130 A JP2021526130 A JP 2021526130A
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JP2021526130A5 (https=
JPWO2019241089A5 (https=
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フリーマン，ジェニファー・エル・アール
バルカース・ロペス，マリア・カーメン
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ブイティーブイ・セラピューティクス・エルエルシー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2020563743A 2018-06-12 2019-06-10 インスリンまたはインスリン類似体と組み合わせたグルコキナーゼ活性化薬の治療的使用 Pending JP2021526130A (ja)

Priority Applications (1)

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JP2024108379A JP2024150496A (ja) 2018-06-12 2024-07-04 インスリンまたはインスリン類似体と組み合わせたグルコキナーゼ活性化薬の治療的使用

Applications Claiming Priority (5)

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US201862683772P 2018-06-12 2018-06-12
US62/683,772 2018-06-12
US201962857753P 2019-06-05 2019-06-05
US62/857,753 2019-06-05
PCT/US2019/036227 WO2019241089A1 (en) 2018-06-12 2019-06-10 Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs

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JP2024108379A Division JP2024150496A (ja) 2018-06-12 2024-07-04 インスリンまたはインスリン類似体と組み合わせたグルコキナーゼ活性化薬の治療的使用

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JP2021526130A true JP2021526130A (ja) 2021-09-30
JP2021526130A5 JP2021526130A5 (https=) 2022-06-17
JPWO2019241089A5 JPWO2019241089A5 (https=) 2022-06-17

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JP2020563743A Pending JP2021526130A (ja) 2018-06-12 2019-06-10 インスリンまたはインスリン類似体と組み合わせたグルコキナーゼ活性化薬の治療的使用
JP2024108379A Pending JP2024150496A (ja) 2018-06-12 2024-07-04 インスリンまたはインスリン類似体と組み合わせたグルコキナーゼ活性化薬の治療的使用

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US (4) US10952993B2 (https=)
EP (2) EP3806852A1 (https=)
JP (2) JP2021526130A (https=)
KR (1) KR20210020866A (https=)
CN (3) CN112040945A (https=)
AU (2) AU2019287437A1 (https=)
CA (1) CA3093025A1 (https=)
MX (2) MX2020008905A (https=)
WO (1) WO2019241089A1 (https=)

Families Citing this family (3)

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CN112040945A (zh) 2018-06-12 2020-12-04 Vtv治疗有限责任公司 葡萄糖激酶激活剂与胰岛素或胰岛素类似物组合的治疗用途
US12391658B2 (en) 2020-02-18 2025-08-19 Vtv Therapeutics Llc Sulfoxide and sulfone glucokinase activators and methods of use thereof
CA3181722A1 (en) 2020-06-08 2021-12-16 Jing TENG Salts or co-crystals of {2-[3-cyclohexyl-3-(trans-4-propoxy-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008502658A (ja) * 2004-06-17 2008-01-31 ノボ　ノルディスク　アクティーゼルスカブ 肝臓選択的グルコキナーゼ活性化因子の使用
JP2013526608A (ja) * 2010-05-26 2013-06-24 トランステック ファーマ，インコーポレイティド グルコキナーゼ活性化因子と組み合わせたメトホルミンの使用、及びメトホルミン及びグルコキナーゼ活性化因子を含む組成物
JP2015517525A (ja) * 2012-05-17 2015-06-22 トランステック・ファーマ，エルエルシー 糖尿病治療のためのグルコキナーゼ活性化因子組成物

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