JP2021522249A5 - - Google Patents
Info
- Publication number
- JP2021522249A5 JP2021522249A5 JP2020559472A JP2020559472A JP2021522249A5 JP 2021522249 A5 JP2021522249 A5 JP 2021522249A5 JP 2020559472 A JP2020559472 A JP 2020559472A JP 2020559472 A JP2020559472 A JP 2020559472A JP 2021522249 A5 JP2021522249 A5 JP 2021522249A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- alkyl
- 4alkyl
- substituted
- nhs
- Prior art date
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023149057A JP7660634B2 (ja) | 2018-04-25 | 2023-09-14 | Ｎｌｒｐ３修飾因子 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862662240P | 2018-04-25 | 2018-04-25 | |
| US62/662,240 | 2018-04-25 | ||
| US201862764818P | 2018-08-16 | 2018-08-16 | |
| US62/764,818 | 2018-08-16 | ||
| US201962825044P | 2019-03-28 | 2019-03-28 | |
| US62/825,044 | 2019-03-28 | ||
| PCT/US2019/028823 WO2019209896A1 (en) | 2018-04-25 | 2019-04-24 | Nlrp3 modulators |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023149057A Division JP7660634B2 (ja) | 2018-04-25 | 2023-09-14 | Ｎｌｒｐ３修飾因子 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021522249A JP2021522249A (ja) | 2021-08-30 |
| JPWO2019209896A5 JPWO2019209896A5 (https=) | 2022-04-25 |
| JP2021522249A5 true JP2021522249A5 (https=) | 2022-04-25 |
| JP7351850B2 JP7351850B2 (ja) | 2023-09-27 |
Family
ID=66677224
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020559472A Active JP7351850B2 (ja) | 2018-04-25 | 2019-04-24 | Ｎｌｒｐ３修飾因子 |
| JP2023149057A Active JP7660634B2 (ja) | 2018-04-25 | 2023-09-14 | Ｎｌｒｐ３修飾因子 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023149057A Active JP7660634B2 (ja) | 2018-04-25 | 2023-09-14 | Ｎｌｒｐ３修飾因子 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US12037344B2 (https=) |
| EP (2) | EP3784670B1 (https=) |
| JP (2) | JP7351850B2 (https=) |
| KR (1) | KR102711180B1 (https=) |
| CN (2) | CN112074516A (https=) |
| AU (1) | AU2019261582A1 (https=) |
| BR (1) | BR112020021539A2 (https=) |
| CA (1) | CA3097865A1 (https=) |
| CL (1) | CL2020002719A1 (https=) |
| CO (2) | CO2021006672A2 (https=) |
| ES (1) | ES2971122T3 (https=) |
| IL (1) | IL278173A (https=) |
| MX (1) | MX2020011234A (https=) |
| NZ (1) | NZ769136A (https=) |
| PE (1) | PE20210160A1 (https=) |
| SG (1) | SG11202010463TA (https=) |
| TW (1) | TW202014420A (https=) |
| WO (1) | WO2019209896A1 (https=) |
| ZA (1) | ZA202007307B (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115244052A (zh) * | 2020-01-10 | 2022-10-25 | 先天肿瘤免疫公司 | Nlrp3调节剂 |
| WO2021150613A1 (en) | 2020-01-20 | 2021-07-29 | Incyte Corporation | Spiro compounds as inhibitors of kras |
| CA3179692A1 (en) * | 2020-04-16 | 2021-10-21 | Incyte Corporation | Fused tricyclic kras inhibitors |
| MX2022013637A (es) | 2020-04-30 | 2022-11-16 | Janssen Pharmaceutica Nv | Nuevos compuestos de triazinoindol. |
| US11739102B2 (en) | 2020-05-13 | 2023-08-29 | Incyte Corporation | Fused pyrimidine compounds as KRAS inhibitors |
| US20230202989A1 (en) * | 2020-05-28 | 2023-06-29 | Janssen Pharmaceutica Nv | Compounds |
| WO2022037631A1 (zh) * | 2020-08-21 | 2022-02-24 | 浙江海正药业股份有限公司 | 杂环类衍生物及其制备方法和用途 |
| US11999752B2 (en) | 2020-08-28 | 2024-06-04 | Incyte Corporation | Vinyl imidazole compounds as inhibitors of KRAS |
| WO2022072783A1 (en) | 2020-10-02 | 2022-04-07 | Incyte Corporation | Bicyclic dione compounds as inhibitors of kras |
| EP3984535A1 (en) * | 2020-10-16 | 2022-04-20 | Albert-Ludwigs-Universität Freiburg | Nlrp3 activators for use in the treatment of infectious diseases or cancer by activating nlrp3 inflammasome |
| CR20230286A (es) * | 2020-11-24 | 2023-08-24 | Amgen Inc | Inhibidores de prmt5 novedosos |
| CN114539095A (zh) * | 2020-11-26 | 2022-05-27 | 乐凯化学材料有限公司 | 3-（4-羟基-3-甲氧基-苯基）-2-氰基-2-丙烯酸乙酯的制备方法 |
| WO2022204112A1 (en) | 2021-03-22 | 2022-09-29 | Incyte Corporation | Imidazole and triazole kras inhibitors |
| MX2024000357A (es) | 2021-07-07 | 2024-02-12 | Incyte Corp | Compuestos triciclicos como inhibidores de homologo de oncogen viral de sarcoma de rata kirsten (kras). |
| US12600717B2 (en) | 2021-07-14 | 2026-04-14 | Incyte Corporation | Tricyclic compounds as inhibitors of KRAS |
| CN117940120A (zh) * | 2021-07-16 | 2024-04-26 | 戴纳立制药公司 | 化合物、组合物和方法 |
| US12441742B2 (en) | 2021-08-31 | 2025-10-14 | Incyte Corporation | Naphthyridine compounds as inhibitors of KRAS |
| WO2023049697A1 (en) | 2021-09-21 | 2023-03-30 | Incyte Corporation | Hetero-tricyclic compounds as inhibitors of kras |
| CA3234375A1 (en) | 2021-10-01 | 2023-04-06 | Incyte Corporation | Pyrazoloquinoline kras inhibitors |
| WO2023064857A1 (en) | 2021-10-14 | 2023-04-20 | Incyte Corporation | Quinoline compounds as inhibitors of kras |
| WO2025190317A1 (en) * | 2024-03-13 | 2025-09-18 | National Institute Of Biological Sciences, Beijing | Urea compounds as nlrp3 agonists |
| WO2026006603A1 (en) * | 2024-06-26 | 2026-01-02 | Wisconsin Alumni Research Foundation | Tlr7/tlr8 agonists for use in trifunctional radiopharmaceutical compounds |
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| US6110929A (en) * | 1998-07-28 | 2000-08-29 | 3M Innovative Properties Company | Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof |
| DK1141028T3 (da) | 1998-12-23 | 2010-05-25 | Pfizer | Humane monoklonale antistoffer til CTLA-4 |
| IL148079A0 (en) | 1999-08-24 | 2002-09-12 | Medarex Inc | Human ctla-4 antibodies and compositions containing the same |
| US7927613B2 (en) | 2002-02-15 | 2011-04-19 | University Of South Florida | Pharmaceutical co-crystal compositions |
| US20090075980A1 (en) | 2003-10-03 | 2009-03-19 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridines and Analogs Thereof |
| TW200526656A (en) | 2003-10-03 | 2005-08-16 | 3M Innovative Properties Co | Pyrazolopyridines and analogs thereof |
| US7544697B2 (en) | 2003-10-03 | 2009-06-09 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridines and analogs thereof |
| WO2006093514A2 (en) | 2004-06-18 | 2006-09-08 | 3M Innovative Properties Company | Aryl and arylalkylenyl substituted thiazoloquinolines and thiazolonaphthyridines |
| WO2006029223A2 (en) * | 2004-09-08 | 2006-03-16 | Children's Medical Center Corporation | Method for stimulating the immune response of newborns |
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| CN104356236B (zh) | 2005-07-01 | 2020-07-03 | E.R.施贵宝&圣斯有限责任公司 | 抗程序性死亡配体1(pd-l1)的人单克隆抗体 |
| HRP20131167T1 (hr) | 2007-06-18 | 2014-01-03 | Merck Sharp & Dohme B.V. | Antitijela za humani receptor programirane smrti pd-1 |
| US20110294799A1 (en) | 2007-08-14 | 2011-12-01 | Novartis Ag | Organic Compounds |
| EP2303890A4 (en) | 2008-06-19 | 2012-04-11 | Progenics Pharm Inc | INHIBITORS OF PHOSPHATIDYLINOSITE-3-KINASE |
| AU2009333580B2 (en) | 2008-12-09 | 2016-07-07 | Genentech, Inc. | Anti-PD-L1 antibodies and their use to enhance T-cell function |
| NZ628923A (en) | 2009-11-24 | 2016-02-26 | Medimmune Ltd | Targeted binding agents against b7-h1 |
| KR101970025B1 (ko) | 2011-04-20 | 2019-04-17 | 메디뮨 엘엘씨 | Ｂ7-ｈ1 및 ｐｄ-1과 결합하는 항체 및 다른 분자들 |
| EP2699572B1 (en) | 2011-04-21 | 2016-08-10 | Origenis GmbH | Heterocyclic compounds as kinase inhibitors |
| PT2573073E (pt) | 2011-09-26 | 2015-02-05 | Sanofi Sa | Derivados de pirazoloquinolinona, sua preparação e sua utilização terapêutica |
| HRP20201595T1 (hr) | 2011-11-28 | 2020-12-11 | Merck Patent Gmbh | Anti-pd-l1 protutijela i njihova uporaba |
| CN113967253A (zh) | 2012-05-15 | 2022-01-25 | 百时美施贵宝公司 | 通过破坏pd-1/pd-l1信号传输的免疫治疗 |
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| JP6742903B2 (ja) | 2013-05-02 | 2020-08-19 | アナプティスバイオ インコーポレイティッド | プログラム死−１（ｐｄ−１）に対する抗体 |
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| MY184154A (en) | 2013-12-12 | 2021-03-23 | Shanghai hengrui pharmaceutical co ltd | Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof |
| WO2015095780A1 (en) | 2013-12-20 | 2015-06-25 | The University Of Kansas | Toll-like receptor 8 agonists |
| TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對ｐｄ-１的人類抗體 |
| SG10201900002QA (en) | 2014-01-24 | 2019-02-27 | Dana Farber Cancer Institue Inc | Antibody molecules to pd-1 and uses thereof |
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| CN112587672A (zh) | 2014-09-01 | 2021-04-02 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-pd-l1结合物 |
| CN108112254B (zh) | 2015-03-13 | 2022-01-28 | 西托姆克斯治疗公司 | 抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法 |
| MA44594B1 (fr) | 2015-05-29 | 2020-09-30 | Memorial Sloan Kettering Cancer Center | Anticorps anti-ctla-4 et méthodes d'utilisation de ceux-ci |
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| WO2017024465A1 (en) | 2015-08-10 | 2017-02-16 | Innovent Biologics (Suzhou) Co., Ltd. | Pd-1 antibodies |
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| CN114605548A (zh) | 2015-09-01 | 2022-06-10 | 艾吉纳斯公司 | 抗-pd-1抗体及其使用方法 |
| CN105523955B (zh) * | 2015-12-14 | 2018-08-17 | 北京嘉林药业股份有限公司 | 化合物及其在制备药物中的用途 |
| CN106943596A (zh) | 2016-01-07 | 2017-07-14 | 博笛生物科技（北京）有限公司 | 用于治疗肿瘤的抗-cd20组合 |
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| WO2017132827A1 (en) | 2016-02-02 | 2017-08-10 | Innovent Biologics (Suzhou) Co., Ltd. | Pd-1 antibodies |
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| TWI674261B (zh) | 2017-02-17 | 2019-10-11 | 美商英能腫瘤免疫股份有限公司 | Nlrp3 調節劑 |
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| MX2020011275A (es) | 2018-04-25 | 2020-11-13 | Bayer Ag | Novedosos compuestos de heteroaril-triazol y hetroaril[-]tetrazol como plaguicidas. |
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2019
- 2019-04-24 PE PE2020001652A patent/PE20210160A1/es unknown
- 2019-04-24 AU AU2019261582A patent/AU2019261582A1/en not_active Abandoned
- 2019-04-24 SG SG11202010463TA patent/SG11202010463TA/en unknown
- 2019-04-24 KR KR1020207033384A patent/KR102711180B1/ko active Active
- 2019-04-24 US US17/049,612 patent/US12037344B2/en active Active
- 2019-04-24 CN CN201980027881.7A patent/CN112074516A/zh active Pending
- 2019-04-24 EP EP19727780.9A patent/EP3784670B1/en active Active
- 2019-04-24 NZ NZ769136A patent/NZ769136A/en unknown
- 2019-04-24 JP JP2020559472A patent/JP7351850B2/ja active Active
- 2019-04-24 BR BR112020021539-2A patent/BR112020021539A2/pt not_active IP Right Cessation
- 2019-04-24 CN CN202011468364.4A patent/CN112521387B/zh active Active
- 2019-04-24 CA CA3097865A patent/CA3097865A1/en active Pending
- 2019-04-24 MX MX2020011234A patent/MX2020011234A/es unknown
- 2019-04-24 WO PCT/US2019/028823 patent/WO2019209896A1/en not_active Ceased
- 2019-04-24 EP EP23211253.2A patent/EP4353235A3/en active Pending
- 2019-04-24 ES ES19727780T patent/ES2971122T3/es active Active
- 2019-04-25 TW TW108114491A patent/TW202014420A/zh unknown
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2020
- 2020-10-20 IL IL278173A patent/IL278173A/en unknown
- 2020-10-21 CL CL2020002719A patent/CL2020002719A1/es unknown
- 2020-10-21 CO CONC2021/0006672A patent/CO2021006672A2/es unknown
- 2020-10-21 CO CONC2020/0013155A patent/CO2020013155A2/es unknown
- 2020-11-24 ZA ZA2020/07307A patent/ZA202007307B/en unknown
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2023
- 2023-09-14 JP JP2023149057A patent/JP7660634B2/ja active Active