CN112074516A - Nlrp3调节剂 - Google Patents

Nlrp3调节剂 Download PDF

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Publication number
CN112074516A
CN112074516A CN201980027881.7A CN201980027881A CN112074516A CN 112074516 A CN112074516 A CN 112074516A CN 201980027881 A CN201980027881 A CN 201980027881A CN 112074516 A CN112074516 A CN 112074516A
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China
Prior art keywords
alkyl
substituted
independently selected
independently
cancer
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Pending
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CN201980027881.7A
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English (en)
Chinese (zh)
Inventor
张泳
A·V·加瓦伊
A·F·唐奈
S·古什
W·R·鲁什
P·西瓦普拉卡萨姆
S·P·塞茨
J·A·马克瓦尔德
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Innate Tumor Immunity Inc
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IFM Therapeutics Inc
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Application filed by IFM Therapeutics Inc filed Critical IFM Therapeutics Inc
Priority to CN202011468364.4A priority Critical patent/CN112521387B/zh
Publication of CN112074516A publication Critical patent/CN112074516A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
CN201980027881.7A 2018-04-25 2019-04-24 Nlrp3调节剂 Pending CN112074516A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202011468364.4A CN112521387B (zh) 2018-04-25 2019-04-24 Nlrp3调节剂

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862662240P 2018-04-25 2018-04-25
US62/662,240 2018-04-25
US201862764818P 2018-08-16 2018-08-16
US62/764,818 2018-08-16
US201962825044P 2019-03-28 2019-03-28
US62/825,044 2019-03-28
PCT/US2019/028823 WO2019209896A1 (en) 2018-04-25 2019-04-24 Nlrp3 modulators

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202011468364.4A Division CN112521387B (zh) 2018-04-25 2019-04-24 Nlrp3调节剂

Publications (1)

Publication Number Publication Date
CN112074516A true CN112074516A (zh) 2020-12-11

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN201980027881.7A Pending CN112074516A (zh) 2018-04-25 2019-04-24 Nlrp3调节剂
CN202011468364.4A Active CN112521387B (zh) 2018-04-25 2019-04-24 Nlrp3调节剂

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Country Link
US (1) US12037344B2 (https=)
EP (2) EP3784670B1 (https=)
JP (2) JP7351850B2 (https=)
KR (1) KR102711180B1 (https=)
CN (2) CN112074516A (https=)
AU (1) AU2019261582A1 (https=)
BR (1) BR112020021539A2 (https=)
CA (1) CA3097865A1 (https=)
CL (1) CL2020002719A1 (https=)
CO (2) CO2021006672A2 (https=)
ES (1) ES2971122T3 (https=)
IL (1) IL278173A (https=)
MX (1) MX2020011234A (https=)
NZ (1) NZ769136A (https=)
PE (1) PE20210160A1 (https=)
SG (1) SG11202010463TA (https=)
TW (1) TW202014420A (https=)
WO (1) WO2019209896A1 (https=)
ZA (1) ZA202007307B (https=)

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CN115244052A (zh) * 2020-01-10 2022-10-25 先天肿瘤免疫公司 Nlrp3调节剂
WO2021150613A1 (en) 2020-01-20 2021-07-29 Incyte Corporation Spiro compounds as inhibitors of kras
CA3179692A1 (en) * 2020-04-16 2021-10-21 Incyte Corporation Fused tricyclic kras inhibitors
MX2022013637A (es) 2020-04-30 2022-11-16 Janssen Pharmaceutica Nv Nuevos compuestos de triazinoindol.
US11739102B2 (en) 2020-05-13 2023-08-29 Incyte Corporation Fused pyrimidine compounds as KRAS inhibitors
US20230202989A1 (en) * 2020-05-28 2023-06-29 Janssen Pharmaceutica Nv Compounds
WO2022037631A1 (zh) * 2020-08-21 2022-02-24 浙江海正药业股份有限公司 杂环类衍生物及其制备方法和用途
US11999752B2 (en) 2020-08-28 2024-06-04 Incyte Corporation Vinyl imidazole compounds as inhibitors of KRAS
WO2022072783A1 (en) 2020-10-02 2022-04-07 Incyte Corporation Bicyclic dione compounds as inhibitors of kras
EP3984535A1 (en) * 2020-10-16 2022-04-20 Albert-Ludwigs-Universität Freiburg Nlrp3 activators for use in the treatment of infectious diseases or cancer by activating nlrp3 inflammasome
CR20230286A (es) * 2020-11-24 2023-08-24 Amgen Inc Inhibidores de prmt5 novedosos
CN114539095A (zh) * 2020-11-26 2022-05-27 乐凯化学材料有限公司 3-（4-羟基-3-甲氧基-苯基）-2-氰基-2-丙烯酸乙酯的制备方法
WO2022204112A1 (en) 2021-03-22 2022-09-29 Incyte Corporation Imidazole and triazole kras inhibitors
MX2024000357A (es) 2021-07-07 2024-02-12 Incyte Corp Compuestos triciclicos como inhibidores de homologo de oncogen viral de sarcoma de rata kirsten (kras).
US12600717B2 (en) 2021-07-14 2026-04-14 Incyte Corporation Tricyclic compounds as inhibitors of KRAS
CN117940120A (zh) * 2021-07-16 2024-04-26 戴纳立制药公司 化合物、组合物和方法
US12441742B2 (en) 2021-08-31 2025-10-14 Incyte Corporation Naphthyridine compounds as inhibitors of KRAS
WO2023049697A1 (en) 2021-09-21 2023-03-30 Incyte Corporation Hetero-tricyclic compounds as inhibitors of kras
CA3234375A1 (en) 2021-10-01 2023-04-06 Incyte Corporation Pyrazoloquinoline kras inhibitors
WO2023064857A1 (en) 2021-10-14 2023-04-20 Incyte Corporation Quinoline compounds as inhibitors of kras
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CA3097865A1 (en) 2019-10-31
IL278173A (en) 2020-11-30
JP2021522249A (ja) 2021-08-30
JP2024001030A (ja) 2024-01-09
EP4353235A3 (en) 2024-07-31
CN112521387A (zh) 2021-03-19
MX2020011234A (es) 2020-11-11
EP3784670B1 (en) 2023-11-29
PE20210160A1 (es) 2021-01-26
SG11202010463TA (en) 2020-11-27
AU2019261582A1 (en) 2020-11-12
US12037344B2 (en) 2024-07-16
TW202014420A (zh) 2020-04-16
BR112020021539A2 (pt) 2021-01-19
CO2021006672A2 (es) 2021-06-10
CL2020002719A1 (es) 2020-12-18
CO2020013155A2 (es) 2021-06-10
KR102711180B1 (ko) 2024-09-26
WO2019209896A1 (en) 2019-10-31
JP7660634B2 (ja) 2025-04-11
US20210267964A1 (en) 2021-09-02
ES2971122T3 (es) 2024-06-03
KR20210005106A (ko) 2021-01-13
ZA202007307B (en) 2023-01-25
JP7351850B2 (ja) 2023-09-27
EP4353235A2 (en) 2024-04-17
CN112521387B (zh) 2023-08-22
NZ769136A (en) 2024-04-26
EP3784670A1 (en) 2021-03-03

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