JP2021521104A5 - - Google Patents
Info
- Publication number
- JP2021521104A5 JP2021521104A5 JP2020554437A JP2020554437A JP2021521104A5 JP 2021521104 A5 JP2021521104 A5 JP 2021521104A5 JP 2020554437 A JP2020554437 A JP 2020554437A JP 2020554437 A JP2020554437 A JP 2020554437A JP 2021521104 A5 JP2021521104 A5 JP 2021521104A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- alkyl
- cycloalkyl
- pharmaceutically acceptable
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023190466A JP7720376B2 (ja) | 2018-04-06 | 2023-11-08 | 置換されたベンゾフラン、ベンゾピロール、ベンゾチオフェン、及び構造的に関連する補体阻害剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862654108P | 2018-04-06 | 2018-04-06 | |
| US62/654,108 | 2018-04-06 | ||
| PCT/US2019/026054 WO2019195720A1 (en) | 2018-04-06 | 2019-04-05 | Substituted benzofuran, benzopyrrole, benzothiophene, and structurally related complement inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023190466A Division JP7720376B2 (ja) | 2018-04-06 | 2023-11-08 | 置換されたベンゾフラン、ベンゾピロール、ベンゾチオフェン、及び構造的に関連する補体阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021521104A JP2021521104A (ja) | 2021-08-26 |
| JP2021521104A5 true JP2021521104A5 (enExample) | 2022-08-09 |
| JP7383635B2 JP7383635B2 (ja) | 2023-11-20 |
Family
ID=68101457
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020554437A Active JP7383635B2 (ja) | 2018-04-06 | 2019-04-05 | 置換されたベンゾフラン、ベンゾピロール、ベンゾチオフェン、及び構造的に関連する補体阻害剤 |
| JP2023190466A Active JP7720376B2 (ja) | 2018-04-06 | 2023-11-08 | 置換されたベンゾフラン、ベンゾピロール、ベンゾチオフェン、及び構造的に関連する補体阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023190466A Active JP7720376B2 (ja) | 2018-04-06 | 2023-11-08 | 置換されたベンゾフラン、ベンゾピロール、ベンゾチオフェン、及び構造的に関連する補体阻害剤 |
Country Status (34)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI873092B (zh) | 2018-04-06 | 2025-02-21 | 美商百歐克斯製藥公司 | 取代的苯并呋喃、苯并吡咯、苯并噻吩及結構相關的補體抑制劑 |
| CA3148119A1 (en) * | 2019-07-31 | 2021-02-04 | Biocryst Pharmaceuticals, Inc. | Dosing regimens for oral complement factor d inhibitors |
| TWI890699B (zh) * | 2019-10-09 | 2025-07-21 | 美商百歐克斯製藥公司 | 口服補體因子d抑制劑 |
| UY38912A (es) | 2019-10-09 | 2021-05-31 | Biocryst Pharm Inc | Inhibidores del factor d del complemento para administración oral |
| CN115362162A (zh) | 2020-02-20 | 2022-11-18 | 艾其林医药公司 | 用于治疗补体因子d介导的障碍的杂芳基化合物 |
| AR121715A1 (es) * | 2020-04-03 | 2022-06-29 | Biocryst Pharm Inc | Pirrolopirimidinaminas como inhibidores del sistema del complemento |
| WO2022060764A1 (en) * | 2020-09-18 | 2022-03-24 | Merck Sharp & Dohme Corp. | Modified benzofuran-carboxamides as glucosylceramide synthase inhibitors |
| TW202304890A (zh) * | 2021-04-14 | 2023-02-01 | 美商百歐克斯製藥公司 | Klk5雙環雜芳香族抑制劑 |
| WO2023066357A1 (zh) * | 2021-10-21 | 2023-04-27 | 江苏恒瑞医药股份有限公司 | 稠合环类化合物、其制备方法及其在医药上的应用 |
| AR129422A1 (es) * | 2022-05-25 | 2024-08-21 | Univ Leuven Kath | Nuevos derivados para tratar trastornos mediados por trpm3 |
| EP4622643A1 (en) * | 2022-11-22 | 2025-10-01 | Maze Therapeutics, Inc. | Inhibitors of solute carrier family 6a member 19 (slc6a19) and methods of use thereof |
| TW202434204A (zh) * | 2023-01-06 | 2024-09-01 | 美商百歐克斯製藥公司 | 用於治療補體介導之疾病之口服劑型及口服給藥方案 |
| KR102925481B1 (ko) * | 2023-09-05 | 2026-02-10 | 광주과학기술원 | 신규 화합물 및 이의 건선 치료 용도 |
| WO2025080823A1 (en) | 2023-10-11 | 2025-04-17 | Regeneron Pharmaceuticals, Inc. | Treatment of macular degeneration with complement factor d (cfd) inhibitors |
| CN119504834B (zh) * | 2024-11-21 | 2025-10-17 | 南开大学 | 一种以含硅基团为疏水标签的pd-l1蛋白降解剂及其制备方法、药物组合物和应用 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3377387A (en) | 1966-12-01 | 1968-04-09 | Purdue Research Foundation | Process for preparing nitro compounds by reacting organic amines with ozone |
| US4559157A (en) | 1983-04-21 | 1985-12-17 | Creative Products Resource Associates, Ltd. | Cosmetic applicator useful for skin moisturizing |
| LU84979A1 (fr) | 1983-08-30 | 1985-04-24 | Oreal | Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux |
| LU86084A1 (fr) | 1985-09-20 | 1987-04-02 | Faco Sa | Apparei de massage electrique |
| US5102417A (en) | 1985-11-07 | 1992-04-07 | Expandable Grafts Partnership | Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft |
| US4800882A (en) | 1987-03-13 | 1989-01-31 | Cook Incorporated | Endovascular stent and delivery system |
| US4820508A (en) | 1987-06-23 | 1989-04-11 | Neutrogena Corporation | Skin protective composition |
| US4886062A (en) | 1987-10-19 | 1989-12-12 | Medtronic, Inc. | Intravascular radially expandable stent and method of implant |
| US4992478A (en) | 1988-04-04 | 1991-02-12 | Warner-Lambert Company | Antiinflammatory skin moisturizing composition and method of preparing same |
| US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| WO1990013332A1 (en) | 1989-05-11 | 1990-11-15 | Cedars-Sinai Medical Center | Stent with sustained drug delivery |
| WO1991012779A1 (en) | 1990-02-28 | 1991-09-05 | Medtronic, Inc. | Intralumenal drug eluting prosthesis |
| US5429634A (en) | 1993-09-09 | 1995-07-04 | Pdt Systems | Biogenic implant for drug delivery and method |
| US5419760A (en) | 1993-01-08 | 1995-05-30 | Pdt Systems, Inc. | Medicament dispensing stent for prevention of restenosis of a blood vessel |
| US6774278B1 (en) | 1995-06-07 | 2004-08-10 | Cook Incorporated | Coated implantable medical device |
| CA2348740A1 (en) | 1998-12-23 | 2000-07-06 | Ruth R. Wexler | Thrombin or factor xa inhibitors |
| CN100488947C (zh) | 1999-01-13 | 2009-05-20 | 杰南技术公司 | 丝氨酸蛋白酶抑制剂 |
| GB0016454D0 (en) | 2000-07-04 | 2000-08-23 | Hoffmann La Roche | Thienopyrrolidinones |
| US6770729B2 (en) | 2002-09-30 | 2004-08-03 | Medtronic Minimed, Inc. | Polymer compositions containing bioactive agents and methods for their use |
| ATE552245T1 (de) * | 2006-05-15 | 2012-04-15 | Merck Sharp & Dohme | Antidiabetische bicyclische verbindungen |
| JP2010502618A (ja) * | 2006-08-31 | 2010-01-28 | アリーナ ファーマシューティカルズ， インコーポレイテッド | セロトニン５−ｈｔ２ａ受容体のモジュレータとしてのベンゾフラン誘導体 |
| US9056874B2 (en) * | 2012-05-04 | 2015-06-16 | Novartis Ag | Complement pathway modulators and uses thereof |
| JP6180514B2 (ja) | 2012-05-04 | 2017-08-16 | ノバルティス アーゲー | 補体経路モジュレーターおよびその使用 |
| KR20160036568A (ko) * | 2013-07-18 | 2016-04-04 | 노파르티스 아게 | 보체 인자 d 억제제로서의 아미노메틸-비아릴 유도체 및 그의 용도 |
| MX2016002241A (es) | 2013-08-22 | 2016-05-31 | Hoffmann La Roche | Alcoholes de alquinilo y metodos de uso. |
| KR20160118368A (ko) | 2014-02-25 | 2016-10-11 | 아칠리온 파르마세우티칼스 인코포레이티드 | 보체 매개된 장애의 치료를 위한 에터 화합물 |
| WO2016088082A1 (en) * | 2014-12-05 | 2016-06-09 | Novartis Ag | Amidomethyl-biaryl derivatives complement factor d inhibitors and uses thereof |
| WO2017035415A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Alkyne compounds for treatment of immune and inflammatory disorders |
| TWI747873B (zh) * | 2016-02-01 | 2021-12-01 | 美商百歐克斯製藥公司 | 苯并吡唑化合物及其類似物 |
| WO2019057946A1 (en) | 2017-09-25 | 2019-03-28 | F. Hoffmann-La Roche Ag | MULTI-CYCLIC AROMATIC COMPOUNDS AS D-FACTOR INHIBITORS |
| TWI873092B (zh) | 2018-04-06 | 2025-02-21 | 美商百歐克斯製藥公司 | 取代的苯并呋喃、苯并吡咯、苯并噻吩及結構相關的補體抑制劑 |
| CA3148119A1 (en) | 2019-07-31 | 2021-02-04 | Biocryst Pharmaceuticals, Inc. | Dosing regimens for oral complement factor d inhibitors |
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2019
- 2019-04-03 TW TW108111855A patent/TWI873092B/zh active
- 2019-04-03 TW TW114101929A patent/TW202535858A/zh unknown
- 2019-04-05 SM SM20240528T patent/SMT202400528T1/it unknown
- 2019-04-05 DK DK19780738.1T patent/DK3687506T3/da active
- 2019-04-05 BR BR112020019183-3A patent/BR112020019183A2/pt unknown
- 2019-04-05 RS RS20211179A patent/RS62370B1/sr unknown
- 2019-04-05 EP EP19780738.1A patent/EP3687506B1/en active Active
- 2019-04-05 PL PL21183553.3T patent/PL3939658T3/pl unknown
- 2019-04-05 EP EP24203044.3A patent/EP4524133A3/en active Pending
- 2019-04-05 HU HUE19780738A patent/HUE055307T2/hu unknown
- 2019-04-05 RS RS20241292A patent/RS66185B1/sr unknown
- 2019-04-05 PL PL19780738T patent/PL3687506T3/pl unknown
- 2019-04-05 PT PT211835533T patent/PT3939658T/pt unknown
- 2019-04-05 AU AU2019247471A patent/AU2019247471B2/en active Active
- 2019-04-05 DK DK21183553.3T patent/DK3939658T3/da active
- 2019-04-05 HR HRP20241536TT patent/HRP20241536T1/hr unknown
- 2019-04-05 LT LTEPPCT/US2019/026054T patent/LT3687506T/lt unknown
- 2019-04-05 LT LTEP21183553.3T patent/LT3939658T/lt unknown
- 2019-04-05 MX MX2020010508A patent/MX2020010508A/es unknown
- 2019-04-05 SI SI201930099T patent/SI3687506T1/sl unknown
- 2019-04-05 MD MDE20201202T patent/MD3687506T2/ro unknown
- 2019-04-05 SG SG11202008972WA patent/SG11202008972WA/en unknown
- 2019-04-05 ES ES19780738T patent/ES2891123T3/es active Active
- 2019-04-05 AR ARP190100905A patent/AR115033A1/es unknown
- 2019-04-05 MD MDE20220940T patent/MD3939658T2/ro unknown
- 2019-04-05 MA MA57412A patent/MA57412B1/fr unknown
- 2019-04-05 KR KR1020207031889A patent/KR102936604B1/ko active Active
- 2019-04-05 PT PT197807381T patent/PT3687506T/pt unknown
- 2019-04-05 HU HUE21183553A patent/HUE069167T2/hu unknown
- 2019-04-05 MA MA51627A patent/MA51627B1/fr unknown
- 2019-04-05 EP EP21183553.3A patent/EP3939658B1/en active Active
- 2019-04-05 SM SM20210579T patent/SMT202100579T1/it unknown
- 2019-04-05 IL IL277787A patent/IL277787B2/en unknown
- 2019-04-05 PY PY201901927283A patent/PY1927283A/es unknown
- 2019-04-05 EA EA202092383A patent/EA202092383A1/ru unknown
- 2019-04-05 FI FIEP21183553.3T patent/FI3939658T3/fi active
- 2019-04-05 CN CN201980037403.4A patent/CN112272553B/zh active Active
- 2019-04-05 HR HRP20211405TT patent/HRP20211405T1/hr unknown
- 2019-04-05 JP JP2020554437A patent/JP7383635B2/ja active Active
- 2019-04-05 IL IL305879A patent/IL305879B2/en unknown
- 2019-04-05 SI SI201930860T patent/SI3939658T1/sl unknown
- 2019-04-05 WO PCT/US2019/026054 patent/WO2019195720A1/en not_active Ceased
- 2019-04-05 CN CN202311113144.3A patent/CN117164499A/zh active Pending
- 2019-04-05 ES ES21183553T patent/ES3000732T3/es active Active
- 2019-04-05 PE PE2020001534A patent/PE20210398A1/es unknown
- 2019-04-05 UY UY0001038174A patent/UY38174A/es active IP Right Grant
- 2019-07-15 US US16/511,642 patent/US11021458B2/en active Active
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2020
- 2020-09-29 PH PH12020551589A patent/PH12020551589A1/en unknown
- 2020-10-05 MX MX2022014817A patent/MX2022014817A/es unknown
- 2020-10-05 CL CL2020002578A patent/CL2020002578A1/es unknown
- 2020-11-05 CO CONC2020/0013840A patent/CO2020013840A2/es unknown
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2021
- 2021-02-05 US US17/168,574 patent/US11708347B2/en active Active
- 2021-03-16 US US17/202,965 patent/US11370774B2/en active Active
- 2021-09-21 CY CY20211100826T patent/CY1124510T1/el unknown
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2022
- 2022-04-27 US US17/730,438 patent/US11866418B2/en active Active
- 2022-04-27 US US17/730,463 patent/US12043610B2/en active Active
- 2022-11-29 CL CL2022003360A patent/CL2022003360A1/es unknown
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2023
- 2023-11-08 JP JP2023190466A patent/JP7720376B2/ja active Active
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2024
- 2024-01-08 US US18/407,053 patent/US20240294494A1/en active Pending
- 2024-09-17 AU AU2024219811A patent/AU2024219811A1/en active Pending
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2025
- 2025-12-08 US US19/412,163 patent/US20260092045A1/en active Pending