JP2024543497A5 - - Google Patents
Info
- Publication number
- JP2024543497A5 JP2024543497A5 JP2024528586A JP2024528586A JP2024543497A5 JP 2024543497 A5 JP2024543497 A5 JP 2024543497A5 JP 2024528586 A JP2024528586 A JP 2024528586A JP 2024528586 A JP2024528586 A JP 2024528586A JP 2024543497 A5 JP2024543497 A5 JP 2024543497A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- heterocycloalkyl
- cycloalkyl
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2021/130284 | 2021-11-12 | ||
| CN2021130284 | 2021-11-12 | ||
| CN2022123821 | 2022-10-08 | ||
| CNPCT/CN2022/123821 | 2022-10-08 | ||
| PCT/CN2022/131290 WO2023083285A1 (en) | 2021-11-12 | 2022-11-11 | Small molecule inhibitors of ubiquitin specific protease 1 (usp1) and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024543497A JP2024543497A (ja) | 2024-11-21 |
| JP2024543497A5 true JP2024543497A5 (enExample) | 2025-11-19 |
Family
ID=86335132
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024528586A Pending JP2024543497A (ja) | 2021-11-12 | 2022-11-11 | ユビキチン特異的プロテアーゼ１（ｕｓｐ１）の小分子阻害剤及びその使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20250066348A1 (enExample) |
| EP (1) | EP4430049A4 (enExample) |
| JP (1) | JP2024543497A (enExample) |
| KR (1) | KR20240117555A (enExample) |
| CN (1) | CN119173515A (enExample) |
| AU (1) | AU2022387669A1 (enExample) |
| CA (1) | CA3235603A1 (enExample) |
| CL (1) | CL2024001398A1 (enExample) |
| CO (1) | CO2024006278A2 (enExample) |
| CR (1) | CR20240190A (enExample) |
| DO (1) | DOP2024000081A (enExample) |
| GE (1) | GEAP202416531A (enExample) |
| IL (1) | IL312640A (enExample) |
| JO (1) | JOP20240095A1 (enExample) |
| MX (1) | MX2024005756A (enExample) |
| PE (1) | PE20241350A1 (enExample) |
| WO (1) | WO2023083285A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR127646A1 (es) | 2021-11-12 | 2024-02-14 | Insilico Medicine Ip Ltd | Inhibidores de molécula pequeña de proteasa 1 específica de ubiquitina (usp1) y usos de los mismos |
| EP4480479A4 (en) * | 2022-02-18 | 2026-02-11 | Xizang Haisco Pharmaceutical Co Ltd | PYRAZOLOPYRIDINE DERIVATIVE AND ITS APPLICATION IN MEDICINE |
| WO2024022266A1 (en) * | 2022-07-25 | 2024-02-01 | Guangdong Newopp Biopharmaceuticals Co., Ltd. | Heteroaryl compounds as inhibitors of usp1 |
| CN119522224A (zh) * | 2022-08-09 | 2025-02-25 | 上海济煜医药科技有限公司 | 含氮杂环化合物作为泛素-特异性蛋白酶1抑制剂的制备方法、应用及其用途 |
| KR20250069611A (ko) * | 2022-09-20 | 2025-05-19 | 치아타이 티안큉 파마수티컬 그룹 주식회사 | 유비키틴 특이적 프로테아제 저해제로서의 카르보닐 축합 복소환 유도체 |
| CN120603835A (zh) * | 2023-01-20 | 2025-09-05 | 杭州英创医药科技有限公司 | 作为usp1抑制剂的化合物 |
| EP4741386A1 (en) * | 2023-07-05 | 2026-05-13 | Jiangsu Yahong Meditech Co., Ltd. | Pyrimidine compound, preparation method therefor and medical use thereof |
| WO2025010245A1 (en) | 2023-07-06 | 2025-01-09 | Exelixis, Inc. | Fused pyrazole derivatives as usp1 inhibitors |
| CN121532384A (zh) * | 2023-07-14 | 2026-02-13 | 来凯制药(宁波)有限公司 | 嘧啶化合物及其作为usp1抑制剂的用途 |
| TW202530200A (zh) * | 2023-09-25 | 2025-08-01 | 大陸商上海濟煜醫藥科技有限公司 | 嗒𠯤酮類化合物作為泛素－特異性蛋白酶１抑制劑的製備方法、應用及其用途 |
| CN121909194A (zh) * | 2023-09-26 | 2026-04-21 | 上海济煜医药科技股份有限公司 | 一类氮杂环胺类化合物作为泛素-特异性蛋白酶1抑制剂的制备方法、应用及其用途 |
| WO2025102016A1 (en) | 2023-11-10 | 2025-05-15 | Vrise Therapeutics, Inc. | Novel molecules as inhibitors of dna damage repair pathway |
| WO2025151705A1 (en) | 2024-01-10 | 2025-07-17 | Vrise Therapeutics, Inc. | Novel inhibitors of dna damage repair pathway |
| WO2025227060A1 (en) * | 2024-04-26 | 2025-10-30 | Insilico Medicine Ip Limited | Heterocyclic inhibitors of ubiquitin specific protease 1 (usp1) in combination with additional agents for use in the treatment of cancer |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3377493B1 (en) * | 2015-11-20 | 2020-04-08 | Forma Therapeutics, Inc. | Purinones as ubiquitin-specific protease 1 inhibitors |
| AU2019405925B2 (en) * | 2018-12-20 | 2025-07-03 | KSQ Therapeutics, Inc. | Substituted pyrazolopyrimidines and substituted purines and their use as ubiquitin-specific-processing protease 1 (USP1) inhibitors |
| US20230277533A1 (en) * | 2020-02-14 | 2023-09-07 | KSQ Therapeutics, Inc. | Therapeutic combinations comprising ubiquitin-specific-processing protease 1 (usp1) inhibitors and poly (adp-ribose) polymerase (parp) inhibitors |
| AU2021371305A1 (en) * | 2020-10-30 | 2023-06-15 | KSQ Therapeutics, Inc. | Solid state forms of substituted pyrazolopyrimidines and uses thereof |
| EP4291559A1 (en) * | 2021-02-15 | 2023-12-20 | Tango Therapeutics, Inc. | Pyrrolo[3,2-d]pyrimidine compounds and methods of use in the treatment of cancer |
| JP2024511996A (ja) * | 2021-03-17 | 2024-03-18 | タンゴ セラピューティクス， インコーポレイテッド | 抗がん剤としてのプリン誘導体 |
| WO2022199652A1 (en) * | 2021-03-24 | 2022-09-29 | Impact Therapeutics (Shanghai) , Inc | Five-membered heteroaryl-pyrimidine compounds as usp1 inhibitors and the use thereof |
| IL307157A (en) * | 2021-04-07 | 2023-11-01 | Forma Therapeutics Inc | Ubiquitin-specific protease 1 (USP1) inhibition |
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2022
- 2022-11-11 CN CN202280087722.8A patent/CN119173515A/zh active Pending
- 2022-11-11 CR CR20240190A patent/CR20240190A/es unknown
- 2022-11-11 AU AU2022387669A patent/AU2022387669A1/en active Pending
- 2022-11-11 IL IL312640A patent/IL312640A/en unknown
- 2022-11-11 EP EP22892078.1A patent/EP4430049A4/en active Pending
- 2022-11-11 JP JP2024528586A patent/JP2024543497A/ja active Pending
- 2022-11-11 CA CA3235603A patent/CA3235603A1/en active Pending
- 2022-11-11 US US18/708,686 patent/US20250066348A1/en active Pending
- 2022-11-11 MX MX2024005756A patent/MX2024005756A/es unknown
- 2022-11-11 GE GEAP202416531A patent/GEAP202416531A/en unknown
- 2022-11-11 WO PCT/CN2022/131290 patent/WO2023083285A1/en not_active Ceased
- 2022-11-11 PE PE2024001034A patent/PE20241350A1/es unknown
- 2022-11-11 KR KR1020247018880A patent/KR20240117555A/ko active Pending
-
2024
- 2024-04-24 JO JOJO/P/2024/0095A patent/JOP20240095A1/ar unknown
- 2024-05-09 CL CL2024001398A patent/CL2024001398A1/es unknown
- 2024-05-10 DO DO2024000081A patent/DOP2024000081A/es unknown
- 2024-05-17 CO CONC2024/0006278A patent/CO2024006278A2/es unknown