JP2021522197A5 - - Google Patents
Info
- Publication number
- JP2021522197A5 JP2021522197A5 JP2020557913A JP2020557913A JP2021522197A5 JP 2021522197 A5 JP2021522197 A5 JP 2021522197A5 JP 2020557913 A JP2020557913 A JP 2020557913A JP 2020557913 A JP2020557913 A JP 2020557913A JP 2021522197 A5 JP2021522197 A5 JP 2021522197A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cancer
- present
- structure represented
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862660208P | 2018-04-19 | 2018-04-19 | |
| US62/660,208 | 2018-04-19 | ||
| PCT/US2019/028168 WO2019204637A1 (en) | 2018-04-19 | 2019-04-18 | 4'-thio-nucleotide and -nucleoside prodrugs for the treatment of cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021522197A JP2021522197A (ja) | 2021-08-30 |
| JP2021522197A5 true JP2021522197A5 (enExample) | 2022-04-25 |
| JP7419259B2 JP7419259B2 (ja) | 2024-01-22 |
Family
ID=68239059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020557913A Active JP7419259B2 (ja) | 2018-04-19 | 2019-04-18 | 癌の治療のための４’－チオ－ヌクレオチドおよび－ヌクレオシドプロドラッグ |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20210363170A1 (enExample) |
| EP (2) | EP4209498A1 (enExample) |
| JP (1) | JP7419259B2 (enExample) |
| KR (1) | KR102810546B1 (enExample) |
| CN (1) | CN112513061B (enExample) |
| AU (2) | AU2019256465B2 (enExample) |
| CA (1) | CA3097003A1 (enExample) |
| WO (1) | WO2019204637A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113993521A (zh) | 2019-06-05 | 2022-01-28 | 南方研究院 | 基于噻拉滨和噻拉滨前药的治疗 |
| AU2021260964A1 (en) | 2020-04-23 | 2022-12-01 | Pinotbio, Inc. | Composition for treating blood cancer using 4'-thio-5-aza-2'-deoxycytidine and uses thereof |
| CN111393314A (zh) * | 2020-04-30 | 2020-07-10 | 安徽红杉生物医药科技有限公司 | 2-烷基-2-氨基丙酸酯盐酸盐的制备方法 |
| BR112023001236A2 (pt) * | 2020-07-23 | 2023-04-04 | Southern Res Inst | Polimorfos de 5-aza-4'-tio-2-desoxicitidina |
| WO2022031150A1 (ko) * | 2020-08-07 | 2022-02-10 | 주식회사 피노바이오 | 데옥시사이티딘계 항암제 및 실릴 에테르 함유 링커를 포함하는 접합체 및 이의 용도 |
| CN114685558A (zh) * | 2020-12-28 | 2022-07-01 | 尚科生物医药（上海）有限公司 | 一种瑞德西韦中间体的制备方法 |
| KR102891437B1 (ko) * | 2021-08-02 | 2025-11-26 | 주식회사 피노바이오 | 잘 설계된 다중 표적 억제제로 선정된 4'-티오-5-아자-2'-디옥시사이티딘의 의약 용도 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6020322A (en) * | 1993-11-09 | 2000-02-01 | Pro-Neuron, Inc. | Acyl deoxyribonucleoside derivatives and uses thereof |
| US5591722A (en) * | 1989-09-15 | 1997-01-07 | Southern Research Institute | 2'-deoxy-4'-thioribonucleosides and their antiviral activity |
| NZ509405A (en) * | 1998-07-23 | 2004-10-29 | Southern Res Inst | Preparation of 1-(4-thio-thioarabinofuranosyl) cytosine derivatives and their use as anticancer agents and DNA replication inhibitors |
| IL144032A0 (en) | 1999-01-13 | 2002-04-21 | Genentech Inc | Serine protease inhibitors |
| US20060127990A1 (en) * | 2002-08-22 | 2006-06-15 | Geneticlab Co., Ltd | 4'-thionucleotide |
| MX2010003261A (es) * | 2007-09-26 | 2010-08-18 | Sinai School Medicine | Analogos de azacitidina y usos de los mismos. |
| US20110218170A1 (en) * | 2010-03-02 | 2011-09-08 | Southern Research Institute | Use of 2'-deoxy-4'-thiocytidine and its analogues as dna hypomethylating anticancer agents |
| US9156874B2 (en) * | 2011-01-03 | 2015-10-13 | Nanjing Molecular Research, Inc. | Double-liver-targeting phosphoramidate and phosphonoamidate prodrugs |
| HRP20190572T1 (hr) * | 2012-08-13 | 2019-05-17 | Fujifilm Corporation | POSREDNIK ZA SINTEZU 1-(2-DEOKSI-2 FLUORO-4-TIO-beta-D-ARABINOFURANOZIL) CITOZINA, POSREDNIK ZA SINTEZU TIONUKLEOZIDA, I METODE ZA PROIZVODNJU OVIH POSREDNIKA |
| TWI678373B (zh) | 2014-10-31 | 2019-12-01 | 日商富士軟片股份有限公司 | 硫代核苷衍生物或其鹽及醫藥組合物 |
| CN106661077B (zh) | 2015-04-03 | 2019-02-12 | 四川科伦博泰生物医药股份有限公司 | 4’-硫代核苷的新型化合物及其制备方法、药物组合物和应用 |
| US20160312261A1 (en) * | 2015-04-24 | 2016-10-27 | Plasmia Biotech, S.L. | Enzymatic production of cytosinic nucleoside analogues |
| EP3303361A1 (en) * | 2015-05-27 | 2018-04-11 | Idenix Pharmaceuticals LLC | Nucleotides for the treatment of cancer |
| JP7425734B2 (ja) | 2018-02-01 | 2024-01-31 | ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ | ２’－デオキシヌクレオシドを製造するための立体選択的合成およびプロセス |
| AU2021260964A1 (en) * | 2020-04-23 | 2022-12-01 | Pinotbio, Inc. | Composition for treating blood cancer using 4'-thio-5-aza-2'-deoxycytidine and uses thereof |
-
2019
- 2019-04-18 US US17/045,986 patent/US20210363170A1/en not_active Abandoned
- 2019-04-18 CN CN201980037108.9A patent/CN112513061B/zh active Active
- 2019-04-18 AU AU2019256465A patent/AU2019256465B2/en active Active
- 2019-04-18 EP EP22204903.3A patent/EP4209498A1/en active Pending
- 2019-04-18 KR KR1020207033020A patent/KR102810546B1/ko active Active
- 2019-04-18 WO PCT/US2019/028168 patent/WO2019204637A1/en not_active Ceased
- 2019-04-18 EP EP19789422.3A patent/EP3781584A4/en not_active Withdrawn
- 2019-04-18 JP JP2020557913A patent/JP7419259B2/ja active Active
- 2019-04-18 CA CA3097003A patent/CA3097003A1/en active Pending
-
2024
- 2024-12-13 AU AU2024278376A patent/AU2024278376A1/en not_active Abandoned
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