JP2017509672A5 - - Google Patents
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- JP2017509672A5 JP2017509672A5 JP2016560467A JP2016560467A JP2017509672A5 JP 2017509672 A5 JP2017509672 A5 JP 2017509672A5 JP 2016560467 A JP2016560467 A JP 2016560467A JP 2016560467 A JP2016560467 A JP 2016560467A JP 2017509672 A5 JP2017509672 A5 JP 2017509672A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- compound
- salt
- medicament
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims description 13
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- 108010014258 Elastin Proteins 0.000 claims description 5
- 229920002549 elastin Polymers 0.000 claims description 5
- 206010042863 synovial sarcoma Diseases 0.000 claims description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- 230000002194 synthesizing effect Effects 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims 4
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- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 claims 2
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- VSNHCAURESNICA-NJFSPNSNSA-N 1-oxidanylurea Chemical compound N[14C](=O)NO VSNHCAURESNICA-NJFSPNSNSA-N 0.000 claims 1
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| JP2008537726A (ja) * | 2005-01-25 | 2008-09-25 | ホワイトヘッド インスティチュート フォー バイオメディカル リサーチ | 癌細胞を殺傷するためのエラスチンアナログおよびその使用 |
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| US8143222B2 (en) | 2007-10-22 | 2012-03-27 | Washington University | Modular platform for targeted therapeutic delivery |
| CN106459011B (zh) | 2014-04-01 | 2019-11-15 | 华盛顿大学 | 作为抗肿瘤化合物的σ-2受体配体药物缀合物、其合成方法及其用途 |
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2021
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