BR112023001236A2 - Polimorfos de 5-aza-4'-tio-2-desoxicitidina - Google Patents

Polimorfos de 5-aza-4'-tio-2-desoxicitidina

Info

Publication number
BR112023001236A2
BR112023001236A2 BR112023001236A BR112023001236A BR112023001236A2 BR 112023001236 A2 BR112023001236 A2 BR 112023001236A2 BR 112023001236 A BR112023001236 A BR 112023001236A BR 112023001236 A BR112023001236 A BR 112023001236A BR 112023001236 A2 BR112023001236 A2 BR 112023001236A2
Authority
BR
Brazil
Prior art keywords
deoxycytidine
aza
thio
polymorphs
crystalline polymorphs
Prior art date
Application number
BR112023001236A
Other languages
English (en)
Inventor
J Suto Mark
Young Jung Doo
Soo Lee Jin
Cho Hyunyong
Original Assignee
Southern Res Inst
Pinotbio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Southern Res Inst, Pinotbio Inc filed Critical Southern Res Inst
Publication of BR112023001236A2 publication Critical patent/BR112023001236A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

POLIMORFOS DE 5-AZA-4’-TIO-2-DESOXICITIDINA. A presente divulgação fornece polimorfos cristalinos de 5-aza-4’-tio-2’-desoxicitidina. Os polimorfos cristalinos podem ser formulados em uma composição farmacêutica, opcionalmente em combinação com um agente quimioterapêutico adicional. Os polimorfos cristalinos são úteis para tratar várias doenças, incluindo cânceres de sangue, como síndrome mielodisplásica e leucemia. Um processo para preparar os polimorfos cristalinos de 5-aza-4’-tio-2’-desoxicitidina também é divulgado. Este resumo se destina a ser uma ferramenta de varredura para fins de pesquisa na técnica particular e não se destina a ser limitativo da presente invenção.
BR112023001236A 2020-07-23 2021-07-23 Polimorfos de 5-aza-4'-tio-2-desoxicitidina BR112023001236A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063055754P 2020-07-23 2020-07-23
PCT/US2021/043021 WO2022020747A1 (en) 2020-07-23 2021-07-23 Polymorophs of 5-aza-4'-thio-2-deoxycytidine

Publications (1)

Publication Number Publication Date
BR112023001236A2 true BR112023001236A2 (pt) 2023-04-04

Family

ID=79687860

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023001236A BR112023001236A2 (pt) 2020-07-23 2021-07-23 Polimorfos de 5-aza-4'-tio-2-desoxicitidina

Country Status (10)

Country Link
US (1) US11447472B2 (pt)
EP (1) EP4185583A1 (pt)
JP (1) JP2023535724A (pt)
KR (1) KR20230061354A (pt)
CN (1) CN115989229A (pt)
AU (1) AU2021314329A1 (pt)
BR (1) BR112023001236A2 (pt)
CA (1) CA3186696A1 (pt)
MX (1) MX2023000979A (pt)
WO (1) WO2022020747A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230123277A1 (en) * 2021-10-15 2023-04-20 Akirabio, Inc. Compositions comprising 2'-deoxycytidine analogs and use thereof for the treatment of sickle cell disease and thalassemia

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6020322A (en) 1993-11-09 2000-02-01 Pro-Neuron, Inc. Acyl deoxyribonucleoside derivatives and uses thereof
US5591722A (en) * 1989-09-15 1997-01-07 Southern Research Institute 2'-deoxy-4'-thioribonucleosides and their antiviral activity
US20060014949A1 (en) * 2004-07-13 2006-01-19 Supergen Inc. Compositions and formulations of decitabine polymorphs and methods of use thereof
BRPI0912717A2 (pt) 2008-05-15 2014-12-23 Celgene Corp Composição farmacêutica, e, uso de 5-azacitidina
US20110218170A1 (en) 2010-03-02 2011-09-08 Southern Research Institute Use of 2'-deoxy-4'-thiocytidine and its analogues as dna hypomethylating anticancer agents
WO2011109012A1 (en) 2010-03-02 2011-09-09 Southern Research Institute Use of 2'-deoxy-4'-thiocytidine and its analogues as dna hypomethylating anticancer agents
JP6310144B2 (ja) 2014-07-14 2018-04-18 ギリアード サイエンシーズ， インコーポレイテッド がんを処置するための組み合わせ
US20160312261A1 (en) 2015-04-24 2016-10-27 Plasmia Biotech, S.L. Enzymatic production of cytosinic nucleoside analogues
CA3040840A1 (en) 2016-10-17 2018-04-26 Daiichi Sankyo Company, Limited Combined use of mdm2 inhibitor and dna methyltransferase inhibitor for cancer treatment
EP3781584A4 (en) * 2018-04-19 2022-05-11 Southern Research Institute 4'-THIO-NUCLEOTIDE AND NUCLEOSIDE PRODRUGS FOR THE TREATMENT OF CANCER

Also Published As

Publication number Publication date
CA3186696A1 (en) 2022-01-27
CN115989229A (zh) 2023-04-18
US20220024903A1 (en) 2022-01-27
MX2023000979A (es) 2023-04-20
KR20230061354A (ko) 2023-05-08
AU2021314329A8 (en) 2023-03-09
AU2021314329A1 (en) 2023-02-23
JP2023535724A (ja) 2023-08-21
US11447472B2 (en) 2022-09-20
WO2022020747A8 (en) 2023-02-16
WO2022020747A1 (en) 2022-01-27
EP4185583A1 (en) 2023-05-31

Similar Documents

Publication Publication Date Title
BRPI0413452A (pt) composto, composição farmacêutica, kit, artigo de fabricação, e, métodos de inibir dpp-iv, terapêutico e de tratar um estado de doença, cáncer, distúrbios autoimunes, uma condição einfecção por hiv
PE20181045A1 (es) Compuestos utiles como inmunomoduladores
PE20080361A1 (es) Compuestos derivados de purina como activadores del receptor de adenosina a2a
TNSN07154A1 (en) Purine derivatives for use as adenosin a-2a receptor agonists
BR0206435A (pt) Composto, composição farmacêutica, métodos de tratar a angiogênese em um paciente, de tratar distúrbios relacionados com kdr e proliferativos em um mamìfero, uso de um composto, e, processo para preparar compostos
BR0316407A (pt) Derivados de nucleosìdeo antiviral
BR112017018643A2 (pt) "derivados de tetra-hidrotiazepina bicíclicos úteis, composição farmacêutica compreendendo os mesmos, seu uso, e método in vitro ou ex vivo para a produção de células imunes ativadas"
BR0009884A (pt) Processos e composições para a inibição da função das sequências de polinucleotìdeos
AR033344A1 (es) Compuestos derivados de benzofenonas como inhibidores de la transcriptasa inversa, su uso en la fabricacion de medicamentos, intermediarios y composiciones farmaceuticas
BRPI0606870A2 (pt) composto de indol e uso do mesmo
UY27834A1 (es) Compuestos de amidas de acido 3-amino-tieno(2,3-b) piiridino-2-carboxilico sustituido y procedimientos para prepararlos y sus usos.
BR112023001236A2 (pt) Polimorfos de 5-aza-4'-tio-2-desoxicitidina
BRPI0514289A (pt) compostos orgánicos
TNSN07268A1 (en) Purine derivatives acting as a2a receptor agonists
BR112022015002A2 (pt) Ligante de il-7r-alfa/gama/c, composto, composição farmacêutica, método para tratar uma doença em um paciente e ácido nucleico
ATE439829T1 (de) Gel oder lísung enthaltend dihydrotestosterone, deren herstellungsverfahren und verwendung
BR112022001324A2 (pt) Composto, composição farmacêutica e método para tratamento de uma doença mediada por p38 map quinase em um indivíduo necessitando do mesmo
BRPI0513932A (pt) derivados de indol-2-carboxamidina como antagonistas de receptores de nmda
BR112018072468A2 (pt) composto para uso como um inibidor de quinase, composto ou n-óxido, sal farmaceuticamente aceitável, solvato farmaceuticamente aceitável ou estereoisômero, método in vitro para inibir atividade de proteína quinase e composição farmacêutica
CH309924A (fr) Procédé pour la fabrication d'articles poreux sous forme de feuilles et article obtenu par ce procédé.
BR102015018528A8 (pt) Método para produzir uma pinça para um instrumento cirúrgico e instrumento eletrocirúrgico
PE20171348A1 (es) Compuestos de benzoxaborol 4-sustituidos y uso de los mismos
CL2021003594A1 (es) Derivados de 3,6-diamino-piridazin-3-ilo, composiciones farmacéuticas que los contienen y sus usos como agentes proapoptóticos.
GB1015793A (en) Preparation of substituted thiaxanthenes
BR112015015786A2 (pt) composição de polietileno reticulado, processo para preparar uma composição de polietileno reticulado, artigo manufaturado, tubo e método para produzir um tubo