JP7419259B2 - 癌の治療のための４’－チオ－ヌクレオチドおよび－ヌクレオシドプロドラッグ - Google Patents
癌の治療のための４’－チオ－ヌクレオチドおよび－ヌクレオシドプロドラッグ Download PDFInfo
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- JP7419259B2 JP7419259B2 JP2020557913A JP2020557913A JP7419259B2 JP 7419259 B2 JP7419259 B2 JP 7419259B2 JP 2020557913 A JP2020557913 A JP 2020557913A JP 2020557913 A JP2020557913 A JP 2020557913A JP 7419259 B2 JP7419259 B2 JP 7419259B2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/12—Triazine radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/11—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
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- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
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| US201862660208P | 2018-04-19 | 2018-04-19 | |
| US62/660,208 | 2018-04-19 | ||
| PCT/US2019/028168 WO2019204637A1 (en) | 2018-04-19 | 2019-04-18 | 4'-thio-nucleotide and -nucleoside prodrugs for the treatment of cancer |
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| JP2021522197A JP2021522197A (ja) | 2021-08-30 |
| JP2021522197A5 JP2021522197A5 (enExample) | 2022-04-25 |
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| AU (2) | AU2019256465B2 (enExample) |
| CA (1) | CA3097003A1 (enExample) |
| WO (1) | WO2019204637A1 (enExample) |
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| CN113993521A (zh) | 2019-06-05 | 2022-01-28 | 南方研究院 | 基于噻拉滨和噻拉滨前药的治疗 |
| AU2021260964A1 (en) | 2020-04-23 | 2022-12-01 | Pinotbio, Inc. | Composition for treating blood cancer using 4'-thio-5-aza-2'-deoxycytidine and uses thereof |
| CN111393314A (zh) * | 2020-04-30 | 2020-07-10 | 安徽红杉生物医药科技有限公司 | 2-烷基-2-氨基丙酸酯盐酸盐的制备方法 |
| BR112023001236A2 (pt) * | 2020-07-23 | 2023-04-04 | Southern Res Inst | Polimorfos de 5-aza-4'-tio-2-desoxicitidina |
| WO2022031150A1 (ko) * | 2020-08-07 | 2022-02-10 | 주식회사 피노바이오 | 데옥시사이티딘계 항암제 및 실릴 에테르 함유 링커를 포함하는 접합체 및 이의 용도 |
| CN114685558A (zh) * | 2020-12-28 | 2022-07-01 | 尚科生物医药（上海）有限公司 | 一种瑞德西韦中间体的制备方法 |
| KR102891437B1 (ko) * | 2021-08-02 | 2025-11-26 | 주식회사 피노바이오 | 잘 설계된 다중 표적 억제제로 선정된 4'-티오-5-아자-2'-디옥시사이티딘의 의약 용도 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004018494A1 (ja) | 2002-08-22 | 2004-03-04 | Geneticlab Co., Ltd. | ４’−チオヌクレオチド |
| WO2016068341A1 (ja) | 2014-10-31 | 2016-05-06 | 富士フイルム株式会社 | チオヌクレオシド誘導体またはその塩および医薬組成物 |
| WO2016155593A1 (zh) | 2015-04-03 | 2016-10-06 | 四川科伦药物研究院有限公司 | 4'-硫代核苷的新型化合物及其制备方法、药物组合物和应用 |
| WO2016189055A1 (en) | 2015-05-27 | 2016-12-01 | Idenix Pharmaceuticals Llc | Nucleotides for the treatment of cancer |
| WO2019152459A1 (en) | 2018-02-01 | 2019-08-08 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Stereoselective synthesis and process for the manufacturing of 2'-deoxynucleosides |
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| US6020322A (en) * | 1993-11-09 | 2000-02-01 | Pro-Neuron, Inc. | Acyl deoxyribonucleoside derivatives and uses thereof |
| US5591722A (en) * | 1989-09-15 | 1997-01-07 | Southern Research Institute | 2'-deoxy-4'-thioribonucleosides and their antiviral activity |
| NZ509405A (en) * | 1998-07-23 | 2004-10-29 | Southern Res Inst | Preparation of 1-(4-thio-thioarabinofuranosyl) cytosine derivatives and their use as anticancer agents and DNA replication inhibitors |
| IL144032A0 (en) | 1999-01-13 | 2002-04-21 | Genentech Inc | Serine protease inhibitors |
| MX2010003261A (es) * | 2007-09-26 | 2010-08-18 | Sinai School Medicine | Analogos de azacitidina y usos de los mismos. |
| US20110218170A1 (en) * | 2010-03-02 | 2011-09-08 | Southern Research Institute | Use of 2'-deoxy-4'-thiocytidine and its analogues as dna hypomethylating anticancer agents |
| US9156874B2 (en) * | 2011-01-03 | 2015-10-13 | Nanjing Molecular Research, Inc. | Double-liver-targeting phosphoramidate and phosphonoamidate prodrugs |
| HRP20190572T1 (hr) * | 2012-08-13 | 2019-05-17 | Fujifilm Corporation | POSREDNIK ZA SINTEZU 1-(2-DEOKSI-2 FLUORO-4-TIO-beta-D-ARABINOFURANOZIL) CITOZINA, POSREDNIK ZA SINTEZU TIONUKLEOZIDA, I METODE ZA PROIZVODNJU OVIH POSREDNIKA |
| US20160312261A1 (en) * | 2015-04-24 | 2016-10-27 | Plasmia Biotech, S.L. | Enzymatic production of cytosinic nucleoside analogues |
| AU2021260964A1 (en) * | 2020-04-23 | 2022-12-01 | Pinotbio, Inc. | Composition for treating blood cancer using 4'-thio-5-aza-2'-deoxycytidine and uses thereof |
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| WO2016189055A1 (en) | 2015-05-27 | 2016-12-01 | Idenix Pharmaceuticals Llc | Nucleotides for the treatment of cancer |
| WO2019152459A1 (en) | 2018-02-01 | 2019-08-08 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Stereoselective synthesis and process for the manufacturing of 2'-deoxynucleosides |
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| AU2024278376A1 (en) | 2025-01-09 |
| AU2019256465B2 (en) | 2024-10-03 |
| KR20210005638A (ko) | 2021-01-14 |
| CN112513061B (zh) | 2025-01-24 |
| KR102810546B1 (ko) | 2025-05-20 |
| WO2019204637A1 (en) | 2019-10-24 |
| EP3781584A1 (en) | 2021-02-24 |
| AU2019256465A1 (en) | 2020-11-26 |
| US20210363170A1 (en) | 2021-11-25 |
| EP4209498A1 (en) | 2023-07-12 |
| JP2021522197A (ja) | 2021-08-30 |
| EP3781584A4 (en) | 2022-05-11 |
| CA3097003A1 (en) | 2019-10-24 |
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