JP2021520849A5 - - Google Patents
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- Publication number
- JP2021520849A5 JP2021520849A5 JP2021504566A JP2021504566A JP2021520849A5 JP 2021520849 A5 JP2021520849 A5 JP 2021520849A5 JP 2021504566 A JP2021504566 A JP 2021504566A JP 2021504566 A JP2021504566 A JP 2021504566A JP 2021520849 A5 JP2021520849 A5 JP 2021520849A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- tumor antigen
- acid sequence
- seq
- population
- Prior art date
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024046768A JP2024069663A (ja) | 2018-04-13 | 2024-03-22 | 腫瘍特異的ｔ細胞受容体を得る方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2018/082947 | 2018-04-13 | ||
| PCT/CN2018/082947 WO2019196088A1 (en) | 2018-04-13 | 2018-04-13 | Methods of obtaining tumor-specific t cell receptors |
| PCT/CN2019/082408 WO2019196924A1 (en) | 2018-04-13 | 2019-04-12 | Methods of obtaining tumor-specific t cell receptors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024046768A Division JP2024069663A (ja) | 2018-04-13 | 2024-03-22 | 腫瘍特異的ｔ細胞受容体を得る方法 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021520849A JP2021520849A (ja) | 2021-08-26 |
| JP2021520849A5 true JP2021520849A5 (https=) | 2022-04-20 |
| JPWO2019196924A5 JPWO2019196924A5 (https=) | 2022-04-20 |
| JP7549826B2 JP7549826B2 (ja) | 2024-09-12 |
Family
ID=68163041
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021504566A Active JP7549826B2 (ja) | 2018-04-13 | 2019-04-12 | 腫瘍特異的ｔ細胞受容体を得る方法 |
| JP2024046768A Pending JP2024069663A (ja) | 2018-04-13 | 2024-03-22 | 腫瘍特異的ｔ細胞受容体を得る方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024046768A Pending JP2024069663A (ja) | 2018-04-13 | 2024-03-22 | 腫瘍特異的ｔ細胞受容体を得る方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (6) | US11390659B2 (https=) |
| EP (1) | EP3775168A4 (https=) |
| JP (2) | JP7549826B2 (https=) |
| KR (1) | KR102805266B1 (https=) |
| CN (4) | CN112534045A (https=) |
| TW (1) | TW202012619A (https=) |
| WO (2) | WO2019196088A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016145578A1 (en) | 2015-03-13 | 2016-09-22 | Syz Cell Therapy Co. | Methods of cancer treatment using activated t cells |
| WO2019183924A1 (en) | 2018-03-30 | 2019-10-03 | Syz Cell Therapy Co. | Improved multiple antigen specific cell therapy methods |
| WO2019196088A1 (en) | 2018-04-13 | 2019-10-17 | Syz Cell Therapy Co. | Methods of obtaining tumor-specific t cell receptors |
| WO2019196087A1 (en) | 2018-04-13 | 2019-10-17 | Syz Cell Therapy Co. | Methods of cancer treatment using tumor antigen-specific t cells |
| KR102543325B1 (ko) | 2018-08-13 | 2023-06-13 | 루트패스 제노믹스, 인크. | 쌍을 이룬 이분 면역수용체 폴리뉴클레오티드의 고처리량 클로닝 및 이의 적용 |
| SG11202110956RA (en) | 2019-04-05 | 2021-10-28 | Rootpath Genomics Inc | Compositions and methods for t-cell receptor gene assembly |
| AU2020283030A1 (en) * | 2019-05-31 | 2021-12-23 | Modernatx, Inc. | Expanded T cell assay |
| MX2022000667A (es) * | 2019-07-15 | 2022-07-21 | Neogene Therapeutics B V | Metodo para aislar genes tcr. |
| EP4061487A4 (en) * | 2019-11-19 | 2023-12-20 | Rootpath Genomics, Inc. | COMPOSITIONS AND METHODS FOR IDENTIFYING T CELL RECEPTOR |
| WO2021108500A1 (en) * | 2019-11-26 | 2021-06-03 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | T cell receptors targeting mutations in rna splicing factors |
| WO2021156404A2 (en) * | 2020-02-07 | 2021-08-12 | Isa Pharmaceuticals | Treatment of hpv-related diseases |
| CN111234005B (zh) * | 2020-03-13 | 2022-11-29 | 中国医学科学院皮肤病医院(中国医学科学院皮肤病研究所) | 氨苯砜药物超敏反应性t细胞受体及其用途 |
| WO2022063966A1 (en) * | 2020-09-24 | 2022-03-31 | Medigene Immunotherapies Gmbh | Prame specific t-cell receptors and uses thereof |
| CN117957012A (zh) * | 2021-07-19 | 2024-04-30 | 得克萨斯州大学系统董事会 | 靶向fanci、rad51和pbk抗原的肽和经改造t细胞受体及使用方法 |
| EP4405464A4 (en) * | 2021-09-21 | 2025-12-03 | Univ Chicago | METHODS AND COMPOSITION USING PATIENT-DERIVED AUTOLOGOUS NEOANTIGENS FOR CANCER TREATMENT |
| CN116063511B (zh) * | 2021-09-30 | 2023-10-03 | 北京可瑞生物科技有限公司 | 抗原结合蛋白及其应用 |
| WO2023081655A1 (en) * | 2021-11-02 | 2023-05-11 | Fred Hutchinson Cancer Center | T cell immunotherapy for hematologic malignancies having an sf3b1 mutation |
| EP4493681A4 (en) * | 2022-03-17 | 2026-04-08 | Keshihua Nanjing Biotechnology Co Ltd | Tumor-Infiltrating Synthetic Lymphocytes (TILS) |
| CN119032110A (zh) * | 2022-04-07 | 2024-11-26 | 恺兴生命科技(上海)有限公司 | 嵌合多肽及其应用 |
| CN116063457A (zh) * | 2022-04-27 | 2023-05-05 | 恒瑞源正(广州)生物科技有限公司 | Mage-a1特异性t细胞受体及其用途 |
| WO2023220659A1 (en) * | 2022-05-10 | 2023-11-16 | Geneos Therapeutics, Inc. | Individualized cancer epitopes and methods of using the same |
| CN114920824B (zh) * | 2022-05-27 | 2023-12-05 | 重庆医科大学 | Tcr或其抗原结合片段及其应用 |
| CN121464154A (zh) * | 2023-07-07 | 2026-02-03 | 香港大学 | 趋同重组衍生的肝细胞癌特异性tcr及其应用 |
| CN117567595B (zh) * | 2024-01-17 | 2024-05-14 | 恒瑞源正(广州)生物科技有限公司 | Mage-a4特异性t细胞受体及其用途 |
| CN120518771A (zh) * | 2024-02-20 | 2025-08-22 | 上海信谱生物医药科技有限公司 | 一种识别kras突变的t细胞受体及其编码序列 |
| WO2025193663A2 (en) * | 2024-03-11 | 2025-09-18 | Affini-T Therapeutics, Inc. | Compositions and methods for treating neoplasia |
| CN119613530B (zh) * | 2024-12-13 | 2025-09-05 | 华中科技大学 | 一种靶向肝癌细胞甲胎蛋白抗原肽与hla-a24复合物的特异性tcr分子、tcr-t细胞及制备与应用 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| CA2386270A1 (en) | 1999-10-15 | 2001-04-26 | University Of Massachusetts | Rna interference pathway genes as tools for targeted genetic interference |
| US6326193B1 (en) | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
| AU2001275474A1 (en) | 2000-06-12 | 2001-12-24 | Akkadix Corporation | Materials and methods for the control of nematodes |
| JP2004501631A (ja) | 2000-06-28 | 2004-01-22 | ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー | Ｐｄ−ｌ２分子：新規ｐｄ−１リガンドおよびその使用 |
| CN1609197A (zh) * | 2003-10-17 | 2005-04-27 | 上海普泛生物科技有限公司 | 一种用于发现肿瘤特异性抗原和肿瘤特异性抗原决定簇的高产率逆反免疫法 |
| US20090304679A1 (en) * | 2004-05-27 | 2009-12-10 | Weidanz Jon A | Antibodies as T cell receptor mimics, methods of production and uses thereof |
| CN101155914B (zh) | 2005-04-08 | 2013-03-06 | 阿戈斯治疗公司 | 树状细胞组合物和方法 |
| EP1795599A1 (en) * | 2005-12-09 | 2007-06-13 | Schuler, Gerold, Prof. Dr. | Methods for generating antigen-specific effector T cells |
| CN101765607B (zh) * | 2007-05-31 | 2015-09-09 | 莱顿教学医院 | 侵润宫颈恶性肿瘤的t细胞所靶向的用于疫苗的hpv表位 |
| EP3375868A1 (en) | 2007-11-08 | 2018-09-19 | Dana Farber Cancer Institute, Inc. | Stimulation of anti-tumor immunity using dendritic cell/tumor cell fusions and anti-cd3/cd28 |
| HUE029914T2 (en) | 2008-04-03 | 2017-04-28 | Cb Biotechnologies Inc | Amplicon-saving multiplex polymerase chain reaction for amplification of multiple targets |
| EP2258719A1 (en) * | 2009-05-19 | 2010-12-08 | Max-Delbrück-Centrum für Molekulare Medizin (MDC) | Multiple target T cell receptor |
| EP4219759A3 (en) | 2010-05-06 | 2023-09-06 | Adaptive Biotechnologies Corporation | Monitoring health and disease status using clonotype profiles |
| ES2635335T3 (es) | 2010-09-20 | 2017-10-03 | Biontech Cell & Gene Therapies Gmbh | Receptores de células T específicos de antígeno y epítopos de células T |
| US9187534B2 (en) * | 2011-03-11 | 2015-11-17 | Universite De Geneve | Multi-epitopic vaccine |
| US9345770B2 (en) * | 2011-11-16 | 2016-05-24 | University of Pittsburgh—of the Commonwealth System of Higher Education | Immunogenic tumor associated stromal cell antigen peptides and methods of their use |
| JP6309209B2 (ja) * | 2013-05-31 | 2018-04-11 | 国立研究開発法人国立国際医療研究センター | 血管平滑筋細胞の増殖を抑制する血管内皮細胞の検出方法 |
| JP6616295B2 (ja) | 2013-07-15 | 2019-12-04 | アメリカ合衆国 | 抗ヒトパピローマウイルス抗原ｔ細胞の調製方法 |
| CN110511960B (zh) | 2013-07-15 | 2023-05-23 | 美国卫生和人力服务部 | 抗人乳头瘤病毒16 e6 t细胞受体 |
| CN107002038B (zh) * | 2014-09-17 | 2021-10-15 | 约翰·霍普金斯大学 | 用于识别、富集和/或扩增抗原特异性t细胞的试剂和方法 |
| CN104593325A (zh) * | 2014-12-09 | 2015-05-06 | 深圳源正细胞医疗技术有限公司 | 诱导dc成熟并分泌高浓度促炎因子的方法 |
| WO2016145578A1 (en) | 2015-03-13 | 2016-09-22 | Syz Cell Therapy Co. | Methods of cancer treatment using activated t cells |
| SG11201707540QA (en) * | 2015-03-16 | 2017-10-30 | Max-Delbrück-Centrum Für Molekulare Medizin In Der Helmholtz-Gemeinschaft | Method of detecting new immunogenic t cell epitopes and isolating new antigen-specific t cell receptors by means of an mhc cell library |
| US20180171294A1 (en) | 2015-03-26 | 2018-06-21 | The Trustees Of The University Of Pennsylvania | In vitro artificial lymph node method for sensitization and expansion of t cells for therapy and epitope mapping |
| GB201604492D0 (en) | 2016-03-16 | 2016-04-27 | Immatics Biotechnologies Gmbh | Transfected t-cells and t-cell receptors for use in immunotherapy against cancers |
| US20170319638A1 (en) * | 2016-05-06 | 2017-11-09 | Virttu Biologics Limited | Treatment of cancer |
| AU2017276498A1 (en) | 2016-06-10 | 2019-01-03 | Io Biotech Aps | CALR and JAK2 vaccine compositions |
| US9642906B2 (en) * | 2016-09-16 | 2017-05-09 | Baylor College Of Medicine | Generation of HPV-specific T-cells |
| CN106645677B (zh) | 2016-11-15 | 2019-08-09 | 恒瑞源正（上海）生物科技有限公司 | 体外检测肿瘤新生抗原特异性t细胞的方法、试剂盒以及肿瘤疫苗 |
| HUE058957T2 (hu) * | 2016-12-08 | 2022-10-28 | Immatics Biotechnologies Gmbh | Új T-sejt receptorok és velük végzett immunterápia |
| WO2019183924A1 (en) | 2018-03-30 | 2019-10-03 | Syz Cell Therapy Co. | Improved multiple antigen specific cell therapy methods |
| WO2019196087A1 (en) | 2018-04-13 | 2019-10-17 | Syz Cell Therapy Co. | Methods of cancer treatment using tumor antigen-specific t cells |
| WO2019196088A1 (en) | 2018-04-13 | 2019-10-17 | Syz Cell Therapy Co. | Methods of obtaining tumor-specific t cell receptors |
-
2018
- 2018-04-13 WO PCT/CN2018/082947 patent/WO2019196088A1/en not_active Ceased
-
2019
- 2019-04-12 KR KR1020207032466A patent/KR102805266B1/ko active Active
- 2019-04-12 EP EP19785434.2A patent/EP3775168A4/en active Pending
- 2019-04-12 TW TW108112961A patent/TW202012619A/zh unknown
- 2019-04-12 JP JP2021504566A patent/JP7549826B2/ja active Active
- 2019-04-12 US US17/047,059 patent/US11390659B2/en active Active
- 2019-04-12 CN CN201980025587.2A patent/CN112534045A/zh active Pending
- 2019-04-12 CN CN202110295872.5A patent/CN113185602B/zh active Active
- 2019-04-12 CN CN202310140638.4A patent/CN116003575A/zh active Pending
- 2019-04-12 CN CN202110295574.6A patent/CN112979783B/zh active Active
- 2019-04-12 WO PCT/CN2019/082408 patent/WO2019196924A1/en not_active Ceased
-
2022
- 2022-06-17 US US17/843,912 patent/US20230023834A1/en active Pending
- 2022-06-17 US US17/843,920 patent/US20230212253A1/en active Pending
- 2022-06-17 US US17/843,916 patent/US12358967B2/en active Active
- 2022-06-17 US US17/843,917 patent/US20220403000A1/en active Pending
-
2023
- 2023-10-11 US US18/485,248 patent/US20240052010A1/en active Pending
-
2024
- 2024-03-22 JP JP2024046768A patent/JP2024069663A/ja active Pending
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