CN112534045A - 获得肿瘤特异性t细胞受体的方法 - Google Patents
获得肿瘤特异性t细胞受体的方法 Download PDFInfo
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- CN112534045A CN112534045A CN201980025587.2A CN201980025587A CN112534045A CN 112534045 A CN112534045 A CN 112534045A CN 201980025587 A CN201980025587 A CN 201980025587A CN 112534045 A CN112534045 A CN 112534045A
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Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110295872.5A CN113185602B (zh) | 2018-04-13 | 2019-04-12 | 获得肿瘤特异性t细胞受体的方法 |
| CN202310140638.4A CN116003575A (zh) | 2018-04-13 | 2019-04-12 | 获得肿瘤特异性t细胞受体的方法 |
| CN202110295574.6A CN112979783B (zh) | 2018-04-13 | 2019-04-12 | 获得肿瘤特异性t细胞受体的方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2018/082947 | 2018-04-13 | ||
| PCT/CN2018/082947 WO2019196088A1 (en) | 2018-04-13 | 2018-04-13 | Methods of obtaining tumor-specific t cell receptors |
| PCT/CN2019/082408 WO2019196924A1 (en) | 2018-04-13 | 2019-04-12 | Methods of obtaining tumor-specific t cell receptors |
Related Child Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110295872.5A Division CN113185602B (zh) | 2018-04-13 | 2019-04-12 | 获得肿瘤特异性t细胞受体的方法 |
| CN202310140638.4A Division CN116003575A (zh) | 2018-04-13 | 2019-04-12 | 获得肿瘤特异性t细胞受体的方法 |
| CN202110295574.6A Division CN112979783B (zh) | 2018-04-13 | 2019-04-12 | 获得肿瘤特异性t细胞受体的方法 |
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| Publication Number | Publication Date |
|---|---|
| CN112534045A true CN112534045A (zh) | 2021-03-19 |
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Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980025587.2A Pending CN112534045A (zh) | 2018-04-13 | 2019-04-12 | 获得肿瘤特异性t细胞受体的方法 |
| CN202110295872.5A Active CN113185602B (zh) | 2018-04-13 | 2019-04-12 | 获得肿瘤特异性t细胞受体的方法 |
| CN202310140638.4A Pending CN116003575A (zh) | 2018-04-13 | 2019-04-12 | 获得肿瘤特异性t细胞受体的方法 |
| CN202110295574.6A Active CN112979783B (zh) | 2018-04-13 | 2019-04-12 | 获得肿瘤特异性t细胞受体的方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110295872.5A Active CN113185602B (zh) | 2018-04-13 | 2019-04-12 | 获得肿瘤特异性t细胞受体的方法 |
| CN202310140638.4A Pending CN116003575A (zh) | 2018-04-13 | 2019-04-12 | 获得肿瘤特异性t细胞受体的方法 |
| CN202110295574.6A Active CN112979783B (zh) | 2018-04-13 | 2019-04-12 | 获得肿瘤特异性t细胞受体的方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (6) | US11390659B2 (https=) |
| EP (1) | EP3775168A4 (https=) |
| JP (2) | JP7549826B2 (https=) |
| KR (1) | KR102805266B1 (https=) |
| CN (4) | CN112534045A (https=) |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016145578A1 (en) | 2015-03-13 | 2016-09-22 | Syz Cell Therapy Co. | Methods of cancer treatment using activated t cells |
| WO2019183924A1 (en) | 2018-03-30 | 2019-10-03 | Syz Cell Therapy Co. | Improved multiple antigen specific cell therapy methods |
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| SG11202110956RA (en) | 2019-04-05 | 2021-10-28 | Rootpath Genomics Inc | Compositions and methods for t-cell receptor gene assembly |
| AU2020283030A1 (en) * | 2019-05-31 | 2021-12-23 | Modernatx, Inc. | Expanded T cell assay |
| MX2022000667A (es) * | 2019-07-15 | 2022-07-21 | Neogene Therapeutics B V | Metodo para aislar genes tcr. |
| EP4061487A4 (en) * | 2019-11-19 | 2023-12-20 | Rootpath Genomics, Inc. | COMPOSITIONS AND METHODS FOR IDENTIFYING T CELL RECEPTOR |
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| WO2021156404A2 (en) * | 2020-02-07 | 2021-08-12 | Isa Pharmaceuticals | Treatment of hpv-related diseases |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104593325A (zh) * | 2014-12-09 | 2015-05-06 | 深圳源正细胞医疗技术有限公司 | 诱导dc成熟并分泌高浓度促炎因子的方法 |
| CN107002038A (zh) * | 2014-09-17 | 2017-08-01 | 约翰·霍普金斯大学 | 用于识别、富集和/或扩增抗原特异性t细胞的试剂和方法 |
| CN107735492A (zh) * | 2015-03-13 | 2018-02-23 | 深圳源正细胞医疗技术有限公司 | 使用活化t细胞治疗癌的方法 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| CA2386270A1 (en) | 1999-10-15 | 2001-04-26 | University Of Massachusetts | Rna interference pathway genes as tools for targeted genetic interference |
| US6326193B1 (en) | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
| AU2001275474A1 (en) | 2000-06-12 | 2001-12-24 | Akkadix Corporation | Materials and methods for the control of nematodes |
| JP2004501631A (ja) | 2000-06-28 | 2004-01-22 | ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー | Pd−l2分子:新規pd−1リガンドおよびその使用 |
| CN1609197A (zh) * | 2003-10-17 | 2005-04-27 | 上海普泛生物科技有限公司 | 一种用于发现肿瘤特异性抗原和肿瘤特异性抗原决定簇的高产率逆反免疫法 |
| US20090304679A1 (en) * | 2004-05-27 | 2009-12-10 | Weidanz Jon A | Antibodies as T cell receptor mimics, methods of production and uses thereof |
| CN101155914B (zh) | 2005-04-08 | 2013-03-06 | 阿戈斯治疗公司 | 树状细胞组合物和方法 |
| EP1795599A1 (en) * | 2005-12-09 | 2007-06-13 | Schuler, Gerold, Prof. Dr. | Methods for generating antigen-specific effector T cells |
| CN101765607B (zh) * | 2007-05-31 | 2015-09-09 | 莱顿教学医院 | 侵润宫颈恶性肿瘤的t细胞所靶向的用于疫苗的hpv表位 |
| EP3375868A1 (en) | 2007-11-08 | 2018-09-19 | Dana Farber Cancer Institute, Inc. | Stimulation of anti-tumor immunity using dendritic cell/tumor cell fusions and anti-cd3/cd28 |
| HUE029914T2 (en) | 2008-04-03 | 2017-04-28 | Cb Biotechnologies Inc | Amplicon-saving multiplex polymerase chain reaction for amplification of multiple targets |
| EP2258719A1 (en) * | 2009-05-19 | 2010-12-08 | Max-Delbrück-Centrum für Molekulare Medizin (MDC) | Multiple target T cell receptor |
| EP4219759A3 (en) | 2010-05-06 | 2023-09-06 | Adaptive Biotechnologies Corporation | Monitoring health and disease status using clonotype profiles |
| ES2635335T3 (es) | 2010-09-20 | 2017-10-03 | Biontech Cell & Gene Therapies Gmbh | Receptores de células T específicos de antígeno y epítopos de células T |
| US9187534B2 (en) * | 2011-03-11 | 2015-11-17 | Universite De Geneve | Multi-epitopic vaccine |
| US9345770B2 (en) * | 2011-11-16 | 2016-05-24 | University of Pittsburgh—of the Commonwealth System of Higher Education | Immunogenic tumor associated stromal cell antigen peptides and methods of their use |
| JP6309209B2 (ja) * | 2013-05-31 | 2018-04-11 | 国立研究開発法人国立国際医療研究センター | 血管平滑筋細胞の増殖を抑制する血管内皮細胞の検出方法 |
| JP6616295B2 (ja) | 2013-07-15 | 2019-12-04 | アメリカ合衆国 | 抗ヒトパピローマウイルス抗原t細胞の調製方法 |
| CN110511960B (zh) | 2013-07-15 | 2023-05-23 | 美国卫生和人力服务部 | 抗人乳头瘤病毒16 e6 t细胞受体 |
| SG11201707540QA (en) * | 2015-03-16 | 2017-10-30 | Max-Delbrück-Centrum Für Molekulare Medizin In Der Helmholtz-Gemeinschaft | Method of detecting new immunogenic t cell epitopes and isolating new antigen-specific t cell receptors by means of an mhc cell library |
| US20180171294A1 (en) | 2015-03-26 | 2018-06-21 | The Trustees Of The University Of Pennsylvania | In vitro artificial lymph node method for sensitization and expansion of t cells for therapy and epitope mapping |
| GB201604492D0 (en) | 2016-03-16 | 2016-04-27 | Immatics Biotechnologies Gmbh | Transfected t-cells and t-cell receptors for use in immunotherapy against cancers |
| US20170319638A1 (en) * | 2016-05-06 | 2017-11-09 | Virttu Biologics Limited | Treatment of cancer |
| AU2017276498A1 (en) | 2016-06-10 | 2019-01-03 | Io Biotech Aps | CALR and JAK2 vaccine compositions |
| US9642906B2 (en) * | 2016-09-16 | 2017-05-09 | Baylor College Of Medicine | Generation of HPV-specific T-cells |
| CN106645677B (zh) | 2016-11-15 | 2019-08-09 | 恒瑞源正(上海)生物科技有限公司 | 体外检测肿瘤新生抗原特异性t细胞的方法、试剂盒以及肿瘤疫苗 |
| HUE058957T2 (hu) * | 2016-12-08 | 2022-10-28 | Immatics Biotechnologies Gmbh | Új T-sejt receptorok és velük végzett immunterápia |
| WO2019183924A1 (en) | 2018-03-30 | 2019-10-03 | Syz Cell Therapy Co. | Improved multiple antigen specific cell therapy methods |
| WO2019196087A1 (en) | 2018-04-13 | 2019-10-17 | Syz Cell Therapy Co. | Methods of cancer treatment using tumor antigen-specific t cells |
| WO2019196088A1 (en) | 2018-04-13 | 2019-10-17 | Syz Cell Therapy Co. | Methods of obtaining tumor-specific t cell receptors |
-
2018
- 2018-04-13 WO PCT/CN2018/082947 patent/WO2019196088A1/en not_active Ceased
-
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- 2019-04-12 KR KR1020207032466A patent/KR102805266B1/ko active Active
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-
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- 2024-03-22 JP JP2024046768A patent/JP2024069663A/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107002038A (zh) * | 2014-09-17 | 2017-08-01 | 约翰·霍普金斯大学 | 用于识别、富集和/或扩增抗原特异性t细胞的试剂和方法 |
| CN104593325A (zh) * | 2014-12-09 | 2015-05-06 | 深圳源正细胞医疗技术有限公司 | 诱导dc成熟并分泌高浓度促炎因子的方法 |
| CN107735492A (zh) * | 2015-03-13 | 2018-02-23 | 深圳源正细胞医疗技术有限公司 | 使用活化t细胞治疗癌的方法 |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116063457A (zh) * | 2022-04-27 | 2023-05-05 | 恒瑞源正(广州)生物科技有限公司 | Mage-a1特异性t细胞受体及其用途 |
| CN116063458A (zh) * | 2022-04-27 | 2023-05-05 | 恒瑞源正(广州)生物科技有限公司 | Mage-a1特异性t细胞受体及其用途 |
| WO2025176000A1 (zh) * | 2024-02-20 | 2025-08-28 | 上海信谱生物医药科技有限公司 | 一种识别kras突变的t细胞受体及其编码序列 |
| CN119613530A (zh) * | 2024-12-13 | 2025-03-14 | 华中科技大学 | 一种靶向肝癌细胞甲胎蛋白抗原肽与hla-a24复合物的特异性tcr分子、tcr-t细胞及制备与应用 |
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| EP3775168A4 (en) | 2022-04-20 |
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