JP2021520777A5 - - Google Patents
Info
- Publication number
- JP2021520777A5 JP2021520777A5 JP2020551506A JP2020551506A JP2021520777A5 JP 2021520777 A5 JP2021520777 A5 JP 2021520777A5 JP 2020551506 A JP2020551506 A JP 2020551506A JP 2020551506 A JP2020551506 A JP 2020551506A JP 2021520777 A5 JP2021520777 A5 JP 2021520777A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- variable region
- chain variable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862649208P | 2018-03-28 | 2018-03-28 | |
| US62/649,208 | 2018-03-28 | ||
| US201862664662P | 2018-04-30 | 2018-04-30 | |
| US62/664,662 | 2018-04-30 | ||
| US201862703299P | 2018-07-25 | 2018-07-25 | |
| US62/703,299 | 2018-07-25 | ||
| PCT/IB2019/000358 WO2019186276A2 (en) | 2018-03-28 | 2019-03-27 | Antibody-based methods of detecting and treating alzheimer's disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021520777A JP2021520777A (ja) | 2021-08-26 |
| JP2021520777A5 true JP2021520777A5 (https=) | 2022-04-04 |
Family
ID=66999856
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020551506A Pending JP2021520777A (ja) | 2018-03-28 | 2019-03-27 | アルツハイマー病を検出および処置するための抗体に基づく方法 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP3774887A2 (https=) |
| JP (1) | JP2021520777A (https=) |
| KR (1) | KR20200144551A (https=) |
| CN (1) | CN112236452A (https=) |
| AU (1) | AU2019244481A1 (https=) |
| BR (1) | BR112020018868A2 (https=) |
| CA (1) | CA3095443A1 (https=) |
| IL (1) | IL277577A (https=) |
| MX (1) | MX2020009991A (https=) |
| RU (1) | RU2020135052A (https=) |
| SG (1) | SG11202008098TA (https=) |
| WO (1) | WO2019186276A2 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10501531B2 (en) | 2013-03-13 | 2019-12-10 | Prothena Biosciences Limited | Tau immunotherapy |
| MY198194A (en) | 2016-05-02 | 2023-08-09 | Prothena Biosciences Ltd | Antibodies Recognizing Tau |
| PT3452507T (pt) | 2016-05-02 | 2022-12-20 | Prothena Biosciences Ltd | Imunoterapia anti-tau |
| KR102784294B1 (ko) | 2017-05-02 | 2025-03-19 | 프로테나 바이오사이언시즈 리미티드 | 타우 인식 항체 |
| CN111201030B (zh) | 2017-07-25 | 2024-11-01 | 真和制药有限公司 | 通过阻断tim-3和其配体的相互作用治疗癌症 |
| WO2020160156A2 (en) | 2019-01-30 | 2020-08-06 | Immutics, Inc. | Anti-gal3 antibodies and uses thereof |
| JP7630834B2 (ja) | 2019-03-03 | 2025-02-18 | プロセナ バイオサイエンシーズ リミテッド | タウ認識抗体 |
| JP2022547513A (ja) | 2019-09-09 | 2022-11-14 | アクソン ニューロサイエンス エスエー | アルツハイマー病及び軽度認知障害のバイオマーカー及び治療 |
| EP4157338A4 (en) | 2020-05-26 | 2024-11-13 | TrueBinding, Inc. | METHOD FOR TREATING INFLAMMATORY DISEASES BY GALECTIN-3 BLOCKING |
| CN117043183A (zh) * | 2020-12-16 | 2023-11-10 | 沃雅戈治疗公司 | Tau结合化合物 |
| MX2023008317A (es) * | 2021-02-19 | 2023-07-24 | Eisai R&D Man Co Ltd | Anticuerpo anti tau fosforilada en la treonina 217 (pt217). |
| AU2022246660A1 (en) * | 2021-03-31 | 2023-10-12 | Washington University | Csf phosphorylated tau and amyloid beta profiles as biomarkers of tauopathies |
| CN117003863A (zh) * | 2022-04-28 | 2023-11-07 | 厦门大学 | 针对p-tau 217的抗体及其用途 |
| CN114778856B (zh) * | 2022-05-30 | 2023-03-17 | 苏州宇测生物科技有限公司 | 磷酸化tau蛋白检测试剂盒 |
| CN115078736B (zh) * | 2022-06-24 | 2025-03-25 | 佛山市观迪医疗器械有限公司 | 一种用于阿尔茨海默症的均相免疫检测试剂盒 |
| CN119836437A (zh) * | 2022-08-19 | 2025-04-15 | 舒泰神(加州)生物科技有限公司 | 特异性识别程序性细胞死亡1配体1的抗体及其用途 |
| CN117624351B (zh) * | 2023-11-24 | 2024-07-05 | 无锡傲锐东源生物科技有限公司 | 一种抗人磷酸化tau181兔单克隆抗体及其应用 |
| CN120118184A (zh) * | 2023-12-08 | 2025-06-10 | 深圳湾实验室 | 靶向Tau的特异性结合蛋白及其应用 |
| WO2025160022A1 (en) * | 2024-01-26 | 2025-07-31 | Beckman Coulter, Inc. | Detecting phosphorylated tau (p-tau) 217 using chemiluminescent dioxetane compounds |
| CN119334929B (zh) * | 2024-11-19 | 2026-02-24 | 中元汇吉生物技术股份有限公司 | 一种提升磷酸化tau蛋白检测灵敏度的方法及其试剂盒 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4880935A (en) | 1986-07-11 | 1989-11-14 | Icrf (Patents) Limited | Heterobifunctional linking agents derived from N-succinimido-dithio-alpha methyl-methylene-benzoates |
| JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・2・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
| US5204244A (en) | 1987-10-27 | 1993-04-20 | Oncogen | Production of chimeric antibodies by homologous recombination |
| US5202238A (en) | 1987-10-27 | 1993-04-13 | Oncogen | Production of chimeric antibodies by homologous recombination |
| IL106992A (en) | 1988-02-11 | 1994-06-24 | Bristol Myers Squibb Co | Acylhydrazone derivatives of anthracycline and methods for their preparation |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US5112596A (en) | 1990-04-23 | 1992-05-12 | Alkermes, Inc. | Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability |
| US5268164A (en) | 1990-04-23 | 1993-12-07 | Alkermes, Inc. | Increasing blood-brain barrier permeability with permeabilizer peptides |
| US6797492B2 (en) | 1991-05-17 | 2004-09-28 | Merck & Co., Inc. | Method for reducing the immunogenicity of antibody variable domains |
| US5262522A (en) | 1991-11-22 | 1993-11-16 | Immunex Corporation | Receptor for oncostatin M and leukemia inhibitory factor |
| US5622929A (en) | 1992-01-23 | 1997-04-22 | Bristol-Myers Squibb Company | Thioether conjugates |
| ATE191853T1 (de) | 1992-07-27 | 2000-05-15 | Us Health | Zielgerichte liposome zur blut-hirne schranke |
| US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
| US5457035A (en) | 1993-07-23 | 1995-10-10 | Immunex Corporation | Cytokine which is a ligand for OX40 |
| CU22615A1 (es) | 1994-06-30 | 2000-02-10 | Centro Inmunologia Molecular | Procedimiento de obtención de anticuerpos monoclonales murinos menos inmunogénicos. anticuerpos monoclonales obtenidos |
| ES2434840T3 (es) | 1995-07-27 | 2013-12-17 | Genentech, Inc. | Formulación de proteína liofilizada isotónica estable |
| DK0871490T3 (da) | 1995-12-22 | 2003-07-07 | Bristol Myers Squibb Co | Forgrenede hydrazonlinkere |
| AU5508798A (en) * | 1996-11-19 | 1998-06-10 | Trustees Of The University Of Pennsylvania, The | Diagnostic and therapeutic reagents for alzheimer's disease |
| EP0983303B1 (en) | 1997-05-21 | 2006-03-08 | Biovation Limited | Method for the production of non-immunogenic proteins |
| US6514221B2 (en) | 2000-07-27 | 2003-02-04 | Brigham And Women's Hospital, Inc. | Blood-brain barrier opening |
| US20030083299A1 (en) | 2000-11-04 | 2003-05-01 | Ferguson Ian A. | Non-invasive delivery of polypeptides through the blood-brain barrier |
| DE10121982B4 (de) | 2001-05-05 | 2008-01-24 | Lts Lohmann Therapie-Systeme Ag | Nanopartikel aus Protein mit gekoppeltem Apolipoprotein E zur Überwindung der Blut-Hirn-Schranke und Verfahren zu ihrer Herstellung |
| US20060167227A1 (en) | 2002-07-12 | 2006-07-27 | Axon Neuroscience Forschungs-Und Entwicklungs Gmbh | Truncated tau proteins |
| JP4995423B2 (ja) | 2002-12-03 | 2012-08-08 | ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート | 物質を血液−脳関門を渡って輸送するための人工低密度リポタンパク質キャリア |
| AU2003292936A1 (en) | 2002-12-24 | 2004-07-22 | Neurochem (International) Limited | Therapeutic formulations for the treatment of beta-amyloid related diseases |
| EP2478912B1 (en) | 2003-11-06 | 2016-08-31 | Seattle Genetics, Inc. | Auristatin conjugates with anti-HER2 or anti-CD22 antibodies and their use in therapy |
| DK1791565T3 (en) | 2004-09-23 | 2016-08-01 | Genentech Inc | Cysteingensplejsede antibodies and conjugates |
| US8012936B2 (en) | 2006-03-29 | 2011-09-06 | New York University | Tau fragments for immunotherapy |
| WO2008140639A2 (en) * | 2007-02-08 | 2008-11-20 | Oligomerix, Inc. | Biomarkers and assays for alzheimer's disease |
| US8093018B2 (en) * | 2008-05-20 | 2012-01-10 | Otsuka Pharmaceutical Co., Ltd. | Antibody identifying an antigen-bound antibody and an antigen-unbound antibody, and method for preparing the same |
| JP5599454B2 (ja) * | 2009-08-06 | 2014-10-01 | イムナス・ファーマ株式会社 | Aβオリゴマーに特異的に結合する抗体およびその利用 |
| ME03008B (me) * | 2011-09-19 | 2018-10-20 | Axon Neuroscience Se | Terapija na osnovu proteina i dijagnoza patologije u којој posreduje tau u alcнajмerovoj bolesti |
| MX350311B (es) * | 2011-12-20 | 2017-09-01 | Janssen Biotech Inc | Anticuerpos anti-phf-tau y sus usos. |
| US8853505B2 (en) * | 2012-02-27 | 2014-10-07 | Syngenta Participations Ag | Variety corn line AA2205 |
| US8980270B2 (en) * | 2013-01-18 | 2015-03-17 | Ipierian, Inc. | Methods of treating a tauopathy |
| CN107428820B (zh) | 2014-11-19 | 2022-03-22 | 阿克松神经系统科学公司 | 在阿尔茨海默氏病中的人源化tau抗体 |
| CA3013254A1 (en) * | 2016-02-05 | 2017-08-10 | Jiangsu Hengrui Medicine Co., Ltd. | Thrombin antibody, antigen-binding fragment and pharmaceutical use thereof |
-
2019
- 2019-03-27 SG SG11202008098TA patent/SG11202008098TA/en unknown
- 2019-03-27 RU RU2020135052A patent/RU2020135052A/ru unknown
- 2019-03-27 WO PCT/IB2019/000358 patent/WO2019186276A2/en not_active Ceased
- 2019-03-27 BR BR112020018868-9A patent/BR112020018868A2/pt not_active IP Right Cessation
- 2019-03-27 CN CN201980029711.2A patent/CN112236452A/zh active Pending
- 2019-03-27 EP EP19732436.1A patent/EP3774887A2/en not_active Withdrawn
- 2019-03-27 KR KR1020207030584A patent/KR20200144551A/ko not_active Withdrawn
- 2019-03-27 CA CA3095443A patent/CA3095443A1/en active Pending
- 2019-03-27 MX MX2020009991A patent/MX2020009991A/es unknown
- 2019-03-27 AU AU2019244481A patent/AU2019244481A1/en not_active Abandoned
- 2019-03-27 JP JP2020551506A patent/JP2021520777A/ja active Pending
-
2020
- 2020-09-24 IL IL277577A patent/IL277577A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021520777A5 (https=) | ||
| RU2020135052A (ru) | Способы выявления и лечения болезни альцгеймера на основе антител | |
| JP7837375B2 (ja) | ピログルタメートアミロイド-βに対する抗体及びその使用 | |
| JP7399096B2 (ja) | 神経変性を検出するためのアッセイ | |
| CA3051512A1 (en) | Cd47 antigen binding unit and uses thereof | |
| CA2806076A1 (en) | Anti-tumor antigen antibodies and methods of use | |
| RU2015142815A (ru) | Лечение рака с использованием антител, связывающихся с поверхностным grp78 | |
| CN116348769A (zh) | 用于检测tau蛋白病或淀粉样蛋白形成性疾病的基于血液的测定 | |
| JP2023052165A (ja) | H1.0k180me2抗体、その作製および使用の方法 | |
| CN110461874B (zh) | 抗gitr抗体、其抗原结合片段及其医药用途 | |
| US20230034474A1 (en) | Novel Molecules for Diagnosis | |
| US11009507B2 (en) | Methods and diagnostics for cancer detection and treatment monitoring | |
| KR101098186B1 (ko) | 피에이유에프(pauf) 특이적인 인간 단일클론항체, 이를 포함하는 암 치료용 조성물, 이를 이용하는 암의 진단방법 | |
| IL323614A (en) | Detection of autoantibodies against nr1 | |
| CN113527484B (zh) | 抗cd47单克隆抗体 | |
| CN116375874A (zh) | 一种cd33抗体及其应用 | |
| CN117178189A (zh) | 用于检测血浆和脑脊液中的神经丝轻链的方法 | |
| WO2021175191A1 (zh) | 抗tim-3抗体及其用途 | |
| KR102757524B1 (ko) | Cd47에 특이적인 인간화 항체 및 이를 포함하는 cd47 관련 질환의 예방 또는 치료용 약학적 조성물 | |
| CN115124620B (zh) | 一种能够激活nk细胞的抗体及其应用 | |
| WO2025037271A1 (en) | Plasma assay for detecting cns-derived tau peptides | |
| WO2026073156A1 (en) | Detection of autoantibodies against nr1 | |
| CN121464158A (zh) | 抗Claudin18.2抗体及其制备和使用方法 | |
| CN121152803A (zh) | Ceacam6结合抗体和其抗原结合片段 | |
| CN119874913A (zh) | 一种抗cd19的抗体及其应用 |