JP2021520777A - アルツハイマー病を検出および処置するための抗体に基づく方法 - Google Patents

アルツハイマー病を検出および処置するための抗体に基づく方法 Download PDF

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JP2021520777A
JP2021520777A JP2020551506A JP2020551506A JP2021520777A JP 2021520777 A JP2021520777 A JP 2021520777A JP 2020551506 A JP2020551506 A JP 2020551506A JP 2020551506 A JP2020551506 A JP 2020551506A JP 2021520777 A JP2021520777 A JP 2021520777A
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seq
amino acid
acid sequence
chain variable
antibody
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JPWO2019186276A5 (https=
JP2021520777A5 (https=
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ヨゼフ ハネス，
ヨゼフ ハネス，
エヴァ コンツェコヴェ，
エヴァ コンツェコヴェ，
アンドレイ コヴァチ，
アンドレイ コヴァチ，
ノルベルト ジルカ，
ノルベルト ジルカ，
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アクソン ニューロサイエンス エスエー
アクソン ニューロサイエンス エスエー
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Publication of JP2021520777A publication Critical patent/JP2021520777A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
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  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2020551506A 2018-03-28 2019-03-27 アルツハイマー病を検出および処置するための抗体に基づく方法 Pending JP2021520777A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862649208P 2018-03-28 2018-03-28
US62/649,208 2018-03-28
US201862664662P 2018-04-30 2018-04-30
US62/664,662 2018-04-30
US201862703299P 2018-07-25 2018-07-25
US62/703,299 2018-07-25
PCT/IB2019/000358 WO2019186276A2 (en) 2018-03-28 2019-03-27 Antibody-based methods of detecting and treating alzheimer's disease

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JP2021520777A true JP2021520777A (ja) 2021-08-26
JPWO2019186276A5 JPWO2019186276A5 (https=) 2022-04-04
JP2021520777A5 JP2021520777A5 (https=) 2022-04-04

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EP (1) EP3774887A2 (https=)
JP (1) JP2021520777A (https=)
KR (1) KR20200144551A (https=)
CN (1) CN112236452A (https=)
AU (1) AU2019244481A1 (https=)
BR (1) BR112020018868A2 (https=)
CA (1) CA3095443A1 (https=)
IL (1) IL277577A (https=)
MX (1) MX2020009991A (https=)
RU (1) RU2020135052A (https=)
SG (1) SG11202008098TA (https=)
WO (1) WO2019186276A2 (https=)

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CN117003863A (zh) * 2022-04-28 2023-11-07 厦门大学 针对p-tau 217的抗体及其用途
CN114778856B (zh) * 2022-05-30 2023-03-17 苏州宇测生物科技有限公司 磷酸化tau蛋白检测试剂盒
CN115078736B (zh) * 2022-06-24 2025-03-25 佛山市观迪医疗器械有限公司 一种用于阿尔茨海默症的均相免疫检测试剂盒
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CN119334929B (zh) * 2024-11-19 2026-02-24 中元汇吉生物技术股份有限公司 一种提升磷酸化tau蛋白检测灵敏度的方法及其试剂盒

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EP3774887A2 (en) 2021-02-17
KR20200144551A (ko) 2020-12-29
CN112236452A (zh) 2021-01-15
IL277577A (en) 2020-11-30
AU2019244481A1 (en) 2020-10-01
WO2019186276A8 (en) 2020-10-15
WO2019186276A2 (en) 2019-10-03
SG11202008098TA (en) 2020-10-29
RU2020135052A (ru) 2022-04-29
BR112020018868A2 (pt) 2021-01-26
MX2020009991A (es) 2020-10-14
CA3095443A1 (en) 2019-10-03
WO2019186276A3 (en) 2020-02-27

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