SG11202008098TA - Antibody-based methods of detecting and treating alzheimer's disease - Google Patents
Antibody-based methods of detecting and treating alzheimer's diseaseInfo
- Publication number
- SG11202008098TA SG11202008098TA SG11202008098TA SG11202008098TA SG11202008098TA SG 11202008098T A SG11202008098T A SG 11202008098TA SG 11202008098T A SG11202008098T A SG 11202008098TA SG 11202008098T A SG11202008098T A SG 11202008098TA SG 11202008098T A SG11202008098T A SG 11202008098TA
- Authority
- SG
- Singapore
- Prior art keywords
- antibody
- disease
- detecting
- based methods
- treating alzheimer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862649208P | 2018-03-28 | 2018-03-28 | |
| US201862664662P | 2018-04-30 | 2018-04-30 | |
| US201862703299P | 2018-07-25 | 2018-07-25 | |
| PCT/IB2019/000358 WO2019186276A2 (en) | 2018-03-28 | 2019-03-27 | Antibody-based methods of detecting and treating alzheimer's disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202008098TA true SG11202008098TA (en) | 2020-10-29 |
Family
ID=66999856
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202008098TA SG11202008098TA (en) | 2018-03-28 | 2019-03-27 | Antibody-based methods of detecting and treating alzheimer's disease |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP3774887A2 (https=) |
| JP (1) | JP2021520777A (https=) |
| KR (1) | KR20200144551A (https=) |
| CN (1) | CN112236452A (https=) |
| AU (1) | AU2019244481A1 (https=) |
| BR (1) | BR112020018868A2 (https=) |
| CA (1) | CA3095443A1 (https=) |
| IL (1) | IL277577A (https=) |
| MX (1) | MX2020009991A (https=) |
| RU (1) | RU2020135052A (https=) |
| SG (1) | SG11202008098TA (https=) |
| WO (1) | WO2019186276A2 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10501531B2 (en) | 2013-03-13 | 2019-12-10 | Prothena Biosciences Limited | Tau immunotherapy |
| MY198194A (en) | 2016-05-02 | 2023-08-09 | Prothena Biosciences Ltd | Antibodies Recognizing Tau |
| PT3452507T (pt) | 2016-05-02 | 2022-12-20 | Prothena Biosciences Ltd | Imunoterapia anti-tau |
| KR102784294B1 (ko) | 2017-05-02 | 2025-03-19 | 프로테나 바이오사이언시즈 리미티드 | 타우 인식 항체 |
| CN111201030B (zh) | 2017-07-25 | 2024-11-01 | 真和制药有限公司 | 通过阻断tim-3和其配体的相互作用治疗癌症 |
| WO2020160156A2 (en) | 2019-01-30 | 2020-08-06 | Immutics, Inc. | Anti-gal3 antibodies and uses thereof |
| JP7630834B2 (ja) | 2019-03-03 | 2025-02-18 | プロセナ バイオサイエンシーズ リミテッド | タウ認識抗体 |
| JP2022547513A (ja) | 2019-09-09 | 2022-11-14 | アクソン ニューロサイエンス エスエー | アルツハイマー病及び軽度認知障害のバイオマーカー及び治療 |
| EP4157338A4 (en) | 2020-05-26 | 2024-11-13 | TrueBinding, Inc. | METHOD FOR TREATING INFLAMMATORY DISEASES BY GALECTIN-3 BLOCKING |
| CN117043183A (zh) * | 2020-12-16 | 2023-11-10 | 沃雅戈治疗公司 | Tau结合化合物 |
| MX2023008317A (es) * | 2021-02-19 | 2023-07-24 | Eisai R&D Man Co Ltd | Anticuerpo anti tau fosforilada en la treonina 217 (pt217). |
| AU2022246660A1 (en) * | 2021-03-31 | 2023-10-12 | Washington University | Csf phosphorylated tau and amyloid beta profiles as biomarkers of tauopathies |
| CN117003863A (zh) * | 2022-04-28 | 2023-11-07 | 厦门大学 | 针对p-tau 217的抗体及其用途 |
| CN114778856B (zh) * | 2022-05-30 | 2023-03-17 | 苏州宇测生物科技有限公司 | 磷酸化tau蛋白检测试剂盒 |
| CN115078736B (zh) * | 2022-06-24 | 2025-03-25 | 佛山市观迪医疗器械有限公司 | 一种用于阿尔茨海默症的均相免疫检测试剂盒 |
| CN119836437A (zh) * | 2022-08-19 | 2025-04-15 | 舒泰神(加州)生物科技有限公司 | 特异性识别程序性细胞死亡1配体1的抗体及其用途 |
| CN117624351B (zh) * | 2023-11-24 | 2024-07-05 | 无锡傲锐东源生物科技有限公司 | 一种抗人磷酸化tau181兔单克隆抗体及其应用 |
| CN120118184A (zh) * | 2023-12-08 | 2025-06-10 | 深圳湾实验室 | 靶向Tau的特异性结合蛋白及其应用 |
| WO2025160022A1 (en) * | 2024-01-26 | 2025-07-31 | Beckman Coulter, Inc. | Detecting phosphorylated tau (p-tau) 217 using chemiluminescent dioxetane compounds |
| CN119334929B (zh) * | 2024-11-19 | 2026-02-24 | 中元汇吉生物技术股份有限公司 | 一种提升磷酸化tau蛋白检测灵敏度的方法及其试剂盒 |
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| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4880935A (en) | 1986-07-11 | 1989-11-14 | Icrf (Patents) Limited | Heterobifunctional linking agents derived from N-succinimido-dithio-alpha methyl-methylene-benzoates |
| JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・2・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
| US5204244A (en) | 1987-10-27 | 1993-04-20 | Oncogen | Production of chimeric antibodies by homologous recombination |
| US5202238A (en) | 1987-10-27 | 1993-04-13 | Oncogen | Production of chimeric antibodies by homologous recombination |
| IL106992A (en) | 1988-02-11 | 1994-06-24 | Bristol Myers Squibb Co | Acylhydrazone derivatives of anthracycline and methods for their preparation |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
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| US5457035A (en) | 1993-07-23 | 1995-10-10 | Immunex Corporation | Cytokine which is a ligand for OX40 |
| CU22615A1 (es) | 1994-06-30 | 2000-02-10 | Centro Inmunologia Molecular | Procedimiento de obtención de anticuerpos monoclonales murinos menos inmunogénicos. anticuerpos monoclonales obtenidos |
| ES2434840T3 (es) | 1995-07-27 | 2013-12-17 | Genentech, Inc. | Formulación de proteína liofilizada isotónica estable |
| DK0871490T3 (da) | 1995-12-22 | 2003-07-07 | Bristol Myers Squibb Co | Forgrenede hydrazonlinkere |
| AU5508798A (en) * | 1996-11-19 | 1998-06-10 | Trustees Of The University Of Pennsylvania, The | Diagnostic and therapeutic reagents for alzheimer's disease |
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| US20060167227A1 (en) | 2002-07-12 | 2006-07-27 | Axon Neuroscience Forschungs-Und Entwicklungs Gmbh | Truncated tau proteins |
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| MX350311B (es) * | 2011-12-20 | 2017-09-01 | Janssen Biotech Inc | Anticuerpos anti-phf-tau y sus usos. |
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| CN107428820B (zh) | 2014-11-19 | 2022-03-22 | 阿克松神经系统科学公司 | 在阿尔茨海默氏病中的人源化tau抗体 |
| CA3013254A1 (en) * | 2016-02-05 | 2017-08-10 | Jiangsu Hengrui Medicine Co., Ltd. | Thrombin antibody, antigen-binding fragment and pharmaceutical use thereof |
-
2019
- 2019-03-27 SG SG11202008098TA patent/SG11202008098TA/en unknown
- 2019-03-27 RU RU2020135052A patent/RU2020135052A/ru unknown
- 2019-03-27 WO PCT/IB2019/000358 patent/WO2019186276A2/en not_active Ceased
- 2019-03-27 BR BR112020018868-9A patent/BR112020018868A2/pt not_active IP Right Cessation
- 2019-03-27 CN CN201980029711.2A patent/CN112236452A/zh active Pending
- 2019-03-27 EP EP19732436.1A patent/EP3774887A2/en not_active Withdrawn
- 2019-03-27 KR KR1020207030584A patent/KR20200144551A/ko not_active Withdrawn
- 2019-03-27 CA CA3095443A patent/CA3095443A1/en active Pending
- 2019-03-27 MX MX2020009991A patent/MX2020009991A/es unknown
- 2019-03-27 AU AU2019244481A patent/AU2019244481A1/en not_active Abandoned
- 2019-03-27 JP JP2020551506A patent/JP2021520777A/ja active Pending
-
2020
- 2020-09-24 IL IL277577A patent/IL277577A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2019244481A1 (en) | 2020-10-01 |
| WO2019186276A2 (en) | 2019-10-03 |
| CA3095443A1 (en) | 2019-10-03 |
| WO2019186276A8 (en) | 2020-10-15 |
| EP3774887A2 (en) | 2021-02-17 |
| MX2020009991A (es) | 2020-10-14 |
| WO2019186276A3 (en) | 2020-02-27 |
| BR112020018868A2 (pt) | 2021-01-26 |
| JP2021520777A (ja) | 2021-08-26 |
| KR20200144551A (ko) | 2020-12-29 |
| CN112236452A (zh) | 2021-01-15 |
| IL277577A (en) | 2020-11-30 |
| RU2020135052A (ru) | 2022-04-29 |
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