CN112236452A - 检测和治疗阿尔茨海默氏病的基于抗体的方法 - Google Patents

检测和治疗阿尔茨海默氏病的基于抗体的方法 Download PDF

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Publication number
CN112236452A
CN112236452A CN201980029711.2A CN201980029711A CN112236452A CN 112236452 A CN112236452 A CN 112236452A CN 201980029711 A CN201980029711 A CN 201980029711A CN 112236452 A CN112236452 A CN 112236452A
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seq
amino acid
acid sequence
antibody
variable region
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Chinese (zh)
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J.黑尼斯
E.康特塞科瓦
A.科瓦克
N.齐尔卡
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Axon Neuroscience SE
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

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  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Genetics & Genomics (AREA)
  • Public Health (AREA)
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  • Food Science & Technology (AREA)
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  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201980029711.2A 2018-03-28 2019-03-27 检测和治疗阿尔茨海默氏病的基于抗体的方法 Pending CN112236452A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862649208P 2018-03-28 2018-03-28
US62/649,208 2018-03-28
US201862664662P 2018-04-30 2018-04-30
US62/664,662 2018-04-30
US201862703299P 2018-07-25 2018-07-25
US62/703,299 2018-07-25
PCT/IB2019/000358 WO2019186276A2 (en) 2018-03-28 2019-03-27 Antibody-based methods of detecting and treating alzheimer's disease

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CN112236452A true CN112236452A (zh) 2021-01-15

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EP (1) EP3774887A2 (https=)
JP (1) JP2021520777A (https=)
KR (1) KR20200144551A (https=)
CN (1) CN112236452A (https=)
AU (1) AU2019244481A1 (https=)
BR (1) BR112020018868A2 (https=)
CA (1) CA3095443A1 (https=)
IL (1) IL277577A (https=)
MX (1) MX2020009991A (https=)
RU (1) RU2020135052A (https=)
SG (1) SG11202008098TA (https=)
WO (1) WO2019186276A2 (https=)

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CN115078736A (zh) * 2022-06-24 2022-09-20 佛山市观迪医疗器械有限公司 一种用于阿尔茨海默症的均相免疫检测试剂盒
WO2023206609A1 (zh) * 2022-04-28 2023-11-02 厦门大学 针对p-tau 217的抗体及其用途
CN117624351A (zh) * 2023-11-24 2024-03-01 无锡傲锐东源生物科技有限公司 一种抗人磷酸化tau181兔单克隆抗体及其应用
CN119334929A (zh) * 2024-11-19 2025-01-21 中元汇吉生物技术股份有限公司 一种提升磷酸化tau蛋白检测灵敏度的方法及其试剂盒

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AU2018308088B2 (en) 2017-07-25 2025-05-29 Truebinding, Inc. Treating cancer by blocking the interaction of TIM-3 and its ligand
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WO2022176959A1 (en) * 2021-02-19 2022-08-25 Eisai R&D Management Co., Ltd. Anti-pt217 tau antibody
CN117460954A (zh) * 2021-03-31 2024-01-26 华盛顿大学 作为tau蛋白病的生物标志物的CSF磷酸化tau和β-淀粉样蛋白概况
CN119836437A (zh) * 2022-08-19 2025-04-15 舒泰神(加州)生物科技有限公司 特异性识别程序性细胞死亡1配体1的抗体及其用途
CN120118184A (zh) * 2023-12-08 2025-06-10 深圳湾实验室 靶向Tau的特异性结合蛋白及其应用
WO2025160022A1 (en) * 2024-01-26 2025-07-31 Beckman Coulter, Inc. Detecting phosphorylated tau (p-tau) 217 using chemiluminescent dioxetane compounds

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Cited By (6)

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Publication number Priority date Publication date Assignee Title
WO2023206609A1 (zh) * 2022-04-28 2023-11-02 厦门大学 针对p-tau 217的抗体及其用途
CN114778856A (zh) * 2022-05-30 2022-07-22 苏州宇测生物科技有限公司 磷酸化tau蛋白检测试剂盒
CN115078736A (zh) * 2022-06-24 2022-09-20 佛山市观迪医疗器械有限公司 一种用于阿尔茨海默症的均相免疫检测试剂盒
CN117624351A (zh) * 2023-11-24 2024-03-01 无锡傲锐东源生物科技有限公司 一种抗人磷酸化tau181兔单克隆抗体及其应用
CN117624351B (zh) * 2023-11-24 2024-07-05 无锡傲锐东源生物科技有限公司 一种抗人磷酸化tau181兔单克隆抗体及其应用
CN119334929A (zh) * 2024-11-19 2025-01-21 中元汇吉生物技术股份有限公司 一种提升磷酸化tau蛋白检测灵敏度的方法及其试剂盒

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EP3774887A2 (en) 2021-02-17
KR20200144551A (ko) 2020-12-29
IL277577A (en) 2020-11-30
AU2019244481A1 (en) 2020-10-01
WO2019186276A8 (en) 2020-10-15
WO2019186276A2 (en) 2019-10-03
SG11202008098TA (en) 2020-10-29
RU2020135052A (ru) 2022-04-29
JP2021520777A (ja) 2021-08-26
BR112020018868A2 (pt) 2021-01-26
MX2020009991A (es) 2020-10-14
CA3095443A1 (en) 2019-10-03
WO2019186276A3 (en) 2020-02-27

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