JP2021518385A - エピネフリンのスプレー製剤 - Google Patents

エピネフリンのスプレー製剤 Download PDF

Info

Publication number
JP2021518385A
JP2021518385A JP2020550178A JP2020550178A JP2021518385A JP 2021518385 A JP2021518385 A JP 2021518385A JP 2020550178 A JP2020550178 A JP 2020550178A JP 2020550178 A JP2020550178 A JP 2020550178A JP 2021518385 A JP2021518385 A JP 2021518385A
Authority
JP
Japan
Prior art keywords
pharmaceutical spray
spray formulation
microns
pharmaceutical
epinephrine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2020550178A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021518385A5 (enExample
Inventor
スティーブン ハートマン，
スティーブン ハートマン，
ミシェル ローベル，
ミシェル ローベル，
マシュー ピー． ロベン，
マシュー ピー． ロベン，
ケネス エル． ドレチェン，
ケネス エル． ドレチェン，
マイケル メサ，
マイケル メサ，
Original Assignee
ブリン ファーマ， エルエルシー
ブリン ファーマ， エルエルシー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ブリン ファーマ， エルエルシー, ブリン ファーマ， エルエルシー filed Critical ブリン ファーマ， エルエルシー
Publication of JP2021518385A publication Critical patent/JP2021518385A/ja
Publication of JP2021518385A5 publication Critical patent/JP2021518385A5/ja
Priority to JP2023065124A priority Critical patent/JP2023085545A/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
    • A61M11/007—Syringe-type or piston-type sprayers or atomisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/08—Inhaling devices inserted into the nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3546—Range
    • A61M2205/3553—Range remote, e.g. between patient's home and doctor's office

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Anesthesiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Mechanical Engineering (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2020550178A 2018-03-19 2019-03-15 エピネフリンのスプレー製剤 Pending JP2021518385A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023065124A JP2023085545A (ja) 2018-03-19 2023-04-12 エピネフリンのスプレー製剤

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201862644834P 2018-03-19 2018-03-19
US62/644,834 2018-03-19
US201862663100P 2018-04-26 2018-04-26
US62/663,100 2018-04-26
US201862712678P 2018-07-31 2018-07-31
US62/712,678 2018-07-31
US201862747048P 2018-10-17 2018-10-17
US62/747,048 2018-10-17
US201962810261P 2019-02-25 2019-02-25
US62/810,261 2019-02-25
PCT/US2019/022557 WO2019182908A1 (en) 2018-03-19 2019-03-15 Epinephrine spray formulations

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023065124A Division JP2023085545A (ja) 2018-03-19 2023-04-12 エピネフリンのスプレー製剤

Publications (2)

Publication Number Publication Date
JP2021518385A true JP2021518385A (ja) 2021-08-02
JP2021518385A5 JP2021518385A5 (enExample) 2022-03-24

Family

ID=67903732

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020550178A Pending JP2021518385A (ja) 2018-03-19 2019-03-15 エピネフリンのスプレー製剤
JP2023065124A Pending JP2023085545A (ja) 2018-03-19 2023-04-12 エピネフリンのスプレー製剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023065124A Pending JP2023085545A (ja) 2018-03-19 2023-04-12 エピネフリンのスプレー製剤

Country Status (13)

Country Link
US (12) US20190282518A1 (enExample)
EP (2) EP3768250A4 (enExample)
JP (2) JP2021518385A (enExample)
KR (1) KR20200140830A (enExample)
CN (1) CN112153966A (enExample)
AU (2) AU2019239640B2 (enExample)
BR (1) BR112020018913A2 (enExample)
CA (1) CA3094147A1 (enExample)
IL (2) IL316152A (enExample)
MX (2) MX2020009602A (enExample)
PH (1) PH12020551427A1 (enExample)
SG (1) SG11202008811WA (enExample)
WO (2) WO2019182745A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024515159A (ja) * 2021-03-09 2024-04-05 アプター フランス エスアーエス 経鼻流体投与装置

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019182745A1 (en) 2018-03-19 2019-09-26 Bryn Pharma, LLC Epinephrine spray formulations
WO2020039262A1 (en) * 2018-08-18 2020-02-27 Ftf Pharma Private Limited Pharmaceuticals solution for oral dosage
WO2021026330A1 (en) * 2019-08-06 2021-02-11 Bryn Pharma, LLC Methods, devices, and systems for administered epinephrine
CN121265577A (zh) 2020-05-18 2026-01-06 奥瑞克索股份公司 用于药物递送的药物组合物
WO2022046976A1 (en) 2020-08-26 2022-03-03 Amphastar Pharmaceuticals, Inc. An epinephrine injection formulation with very low epinephrine concentration and low impurities during its shelf-life
FR3115210B1 (fr) * 2020-10-20 2024-05-17 Aptar France Sas Dispositif de distribution de produit fluide
WO2022129069A1 (en) 2020-12-17 2022-06-23 Philip Morris Products S.A. Pharmaceutical composition comprising epinephrine for aerosol administration
JP2024515446A (ja) * 2021-03-23 2024-04-10 １２３２１７６ ビー．シー． リミテッド アナフィラキシーを処置するためのデバイス
US12661315B2 (en) 2021-06-10 2026-06-23 Belhaven BioPharma Inc. Dry powder formulations of epinephrine and associated methods
US12414916B2 (en) 2021-06-10 2025-09-16 Belhaven BioPharma Inc. Dry powder formulations of epinephrine and associated methods
US11617716B2 (en) 2021-06-10 2023-04-04 Belhaven BioPharma Inc. Dry powder formulations of epinephrine and associated methods
USD999384S1 (en) 2021-10-18 2023-09-19 Dbv Technologies Patch assembly
GB202117016D0 (en) 2021-11-25 2022-01-12 Orexo Ab New pharmaceutical device
TW202333658A (zh) 2021-11-25 2023-09-01 瑞典商奥瑞克索股份公司 包含腎上腺素之新穎醫藥組合物
US12005185B2 (en) 2021-12-17 2024-06-11 Belhaven BioPharma Inc. Medical counter measures including dry powder formulations and associated methods
KR20240167901A (ko) * 2022-04-01 2024-11-28 에날레어 테라퓨틱스 인크. 호흡 자극제 비강 제형
US20260108465A1 (en) 2024-10-21 2026-04-23 Belhaven BioPharma Inc. Compositions, devices, and methods for intranasal delivery of dry powder epinephrine

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005531570A (ja) * 2002-05-23 2005-10-20 ユーエムディー， インコーポレイテッド 貫粘膜薬物送達及び凍結保護のための組成物及び方法
JP2010509394A (ja) * 2006-11-15 2010-03-25 エスケー ホルディングス カンパニー リミテッド 経鼻抗けいれん医薬組成物
WO2014127018A1 (en) * 2013-02-12 2014-08-21 Ys Pharmtech Epinephrine formulations for medicinal products
JP2016515609A (ja) * 2013-04-02 2016-05-30 テミス メディケア リミティド ジエチレングリコールモノエチルエーテル又は他のアルキル誘導体を含む医薬活性成分の組成物
US20170216199A1 (en) * 2015-09-18 2017-08-03 Insys Development Company, Inc. Epinephrine spray formulations

Family Cites Families (166)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4959358A (en) 1983-06-06 1990-09-25 Beth Israel Hospital Assn. Drug administration
US20040002647A1 (en) 1991-10-18 2004-01-01 Ashvin Desai Gel injection treatment of body parts
FR2762589B1 (fr) 1997-04-28 1999-07-16 Sofab Flacon de distribution pour liquide, creme ou gel comportant un dispositif filtrant de l'air entrant
US5922341A (en) 1997-10-28 1999-07-13 Vivus, Incorporated Local administration of pharmacologically active agents to treat premature ejaculation
US20010053775A1 (en) 1998-01-30 2001-12-20 Matthias Seidel Nasal solutions
KR100288190B1 (ko) * 1998-02-09 2001-04-16 김용규 피록시캄 함유 알콜성 하이드로겔 조성물
DE19807922A1 (de) 1998-02-25 1999-08-26 Pfeiffer Erich Gmbh & Co Kg Spender für Medien
USD425195S (en) 1998-03-25 2000-05-16 Abbott Laboratories Combined pharmaceutical container and cap
DE19817417A1 (de) 1998-04-18 1999-10-21 Pfeiffer Erich Gmbh & Co Kg Spender für Medien, insbesondere Pulver
FR2779129B1 (fr) 1998-05-26 2000-08-18 Sofab Diffuseur de produits liquides sous forme d'aerosols
USD444227S1 (en) 1998-10-16 2001-06-26 Sofab Nasal applicator
EP1128858A1 (en) 1998-11-13 2001-09-05 Elan Pharma International Limited Drug delivery systems and methods
FR2793221B1 (fr) 1999-05-05 2001-07-27 Sofab Embout pour la distribution et la pulverisation de produits pharmaceutiques liquides
AU2249701A (en) 1999-11-12 2001-06-06 David Bernstein Methods for treating cardiac arrest or pulmonary hypertension and compositions for use therein comprising vasoactive intestinal polypeptide and cardiac device for electrical and chemical regulation and methods of use
AU3048501A (en) * 1999-11-18 2001-05-30 Natco Pharma Limited An improved pharmaceutical composition for treating male erectile dysfunction
DE19960459A1 (de) 1999-12-15 2001-06-21 Pfeiffer Erich Gmbh & Co Kg Spender für Medien
US6413499B1 (en) 2000-01-06 2002-07-02 Bryan M. Clay Methods and kits for maxillary dental anesthesia by means of a nasal deliverable anesthetic
US6348737B1 (en) 2000-03-02 2002-02-19 International Business Machines Corporation Metallic interlocking structure
US6284765B1 (en) 2000-04-27 2001-09-04 The University Of North Texas Health Science Center At Fort Worth (+) naloxone and epinephrine combination therapy
FR2809961B1 (fr) 2000-06-09 2004-12-03 Seppic Sa Utilisation d'ethers de sucres, comme adjuvants d'immunite dans les compositions vaccinales, compositions therapeutiques les renfermant et leur utilisation comme vaccins
US20070225379A1 (en) * 2001-08-03 2007-09-27 Carrara Dario Norberto R Transdermal delivery of systemically active central nervous system drugs
FR2817848B1 (fr) 2000-12-12 2003-03-07 Rexam Sofab Micropompe electronique
AU2002303425A1 (en) 2001-04-24 2002-11-05 Epigenesis Pharmaceuticals, Inc. Composition, formulations and kit for treatment of respiratory and lung disease with non-glucocorticoid steroids and/or ubiquinone and a bronchodilating agent
AU2002305236A1 (en) 2001-04-24 2002-11-05 Epigenesis Pharmaceuticals, Inc. Composition, formulations and kits for treatment of respiratory and lung disease with anti-sense oligonucleotides and a bronchodilating agent
US20030216329A1 (en) 2001-04-24 2003-11-20 Robinson Cynthia B. Composition, formulations & kit for treatment of respiratory & lung disease with dehydroepiandrosterone(s) steroid & an anti-muscarinic agent(s)
AU2002303427A1 (en) 2001-04-24 2002-11-05 East Carolina University Compositions and formulations with a non-glucocorticoid steroid and/or a ubiquinone and kit for treatment of respiratory and lung disease
US6708852B2 (en) 2001-08-20 2004-03-23 Alternative Packaging Solutions, L.P. Non-chemical aerosol dispenser
PL200833B1 (pl) 2001-09-21 2009-02-27 Pfeiffer Erich Gmbh & Co Kg Dozownik z pojemnikiem aplikowanego środka oraz pompka do dozownika
US7201296B2 (en) 2001-09-21 2007-04-10 Ing. Erich Pfeiffer Gmbh Dosing device with a pumping device
DE10220557A1 (de) 2002-05-02 2003-11-13 Pfeiffer Erich Gmbh & Co Kg Spender zum Austrag fließfähiger Medien
US8163764B2 (en) 2002-04-26 2012-04-24 Asan Laboratories Company (Cayman) Limited Skincare methods
CA2487399A1 (en) 2002-06-12 2004-02-19 Epigenesis Pharmaceuticals, Inc. Combination of anti-muscarinic agents and non-glucocorticoid steroids
GB2389530B (en) * 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
EP1531794B1 (en) 2002-06-28 2017-05-10 Civitas Therapeutics, Inc. Inhalable epinephrine
JP2006501251A (ja) 2002-08-28 2006-01-12 ルピン・リミテッド スピンダス・トリフォリアトゥスから得られる抗痙攣薬活性を有するサポニンの混合物を含むハーブ抽出物
US20040045546A1 (en) 2002-09-05 2004-03-11 Peirce Management, Llc Pharmaceutical delivery system for oral inhalation through nebulization consisting of inert substrate impregnated with substance (S) to be solubilized or suspended prior to use
DE10306686A1 (de) 2003-02-12 2004-08-26 Ing. Erich Pfeiffer Gmbh Austragvorrichtung zur manuellen Erzeugung eines Volumenstroms
US9254294B2 (en) 2003-02-24 2016-02-09 Pharmaceutical Productions Inc. Transmucosal hormone delivery system
KR20120066688A (ko) 2003-02-24 2012-06-22 파마슈티칼 프로덕션스, 인크. 경점막 약물 전달 시스템
US7871607B2 (en) 2003-03-05 2011-01-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
EP2330213A1 (en) 2003-03-05 2011-06-08 Halozyme, Inc. Soluble hyaluronidase glycoprotein (sHASEGP), process for preparing the same, uses and pharmaceutical compositions comprising thereof
DE10323603A1 (de) 2003-05-20 2004-12-30 Ing. Erich Pfeiffer Gmbh Dosiervorrichtung mit einer Pumpeinrichtung
USD552231S1 (en) 2003-10-31 2007-10-02 Glaxo Group Limited Dispenser for dispensing a fluid into a nasal cavity
PL1768650T3 (pl) 2004-06-04 2009-01-30 Camurus Ab Ciekłe formulacje depot
EP1616629B1 (de) 2004-07-13 2014-04-02 Aptar Radolfzell GmbH Betätigungseinrichtung für einen Medienspender
US8048035B2 (en) 2004-08-06 2011-11-01 Meridian Medical Technologies, Inc. Automatic injector with needle cover
US7449012B2 (en) 2004-08-06 2008-11-11 Meridian Medical Technologies, Inc. Automatic injector
US20140162965A1 (en) 2004-08-25 2014-06-12 Aegis Therapeutics, Inc. Compositions for oral drug administration
US9895444B2 (en) 2004-08-25 2018-02-20 Aegis Therapeutics, Llc Compositions for drug administration
GB0425518D0 (en) 2004-11-19 2004-12-22 Clinical Designs Ltd Substance source
US7648482B2 (en) 2004-11-22 2010-01-19 Intelliject, Inc. Devices, systems, and methods for medicament delivery
GB2434548B (en) 2004-11-22 2009-04-08 Intelliject Inc Devices, systems, and methods for medicament delivery
US7648483B2 (en) 2004-11-22 2010-01-19 Intelliject, Inc. Devices, systems and methods for medicament delivery
US7947017B2 (en) 2004-11-22 2011-05-24 Intelliject, Inc. Devices, systems and methods for medicament delivery
US20110226646A1 (en) 2004-12-06 2011-09-22 Wyrick Ronald E Kits Containing Medicine Injection Devices And Containers
NZ554828A (en) 2004-12-06 2010-07-30 Washington Biotech Corp Medicine injection devices and methods
US7905352B2 (en) 2004-12-06 2011-03-15 Washington Biotech Corporation Kits containing medicine injection devices and containers
FR2880807B1 (fr) 2005-01-19 2007-04-13 Aguettant Sa Lab Composition pharmaceutique injectable
US9022980B2 (en) 2005-02-01 2015-05-05 Kaleo, Inc. Medical injector simulation device
US8231573B2 (en) 2005-02-01 2012-07-31 Intelliject, Inc. Medicament delivery device having an electronic circuit system
US8206360B2 (en) 2005-02-01 2012-06-26 Intelliject, Inc. Devices, systems and methods for medicament delivery
CA2762072C (en) 2005-02-01 2017-08-29 Intelliject, Inc. Devices, systems, and methods for medicament delivery
US7731686B2 (en) 2005-02-01 2010-06-08 Intelliject, Inc. Devices, systems and methods for medicament delivery
ATE383205T1 (de) 2005-02-22 2008-01-15 Pfeiffer Erich Gmbh & Co Kg Spender für medien sowie montageverfahren hierfür
FR2885887B1 (fr) 2005-05-20 2010-11-05 Rexam Dispensing Sys Pompe a pointeau pour la distribution de produit liquide
FR2885890B1 (fr) 2005-05-20 2007-07-20 Rexam Dispensing Systems Sas Dispositif pour la delivrance et l'admission d'un produit liquide
CA111438S (fr) 2005-05-23 2006-12-22 Rexam Dispensing Sys Pulvérisateur nasal
FR2887232B1 (fr) 2005-06-21 2010-11-05 Rexam Dispensing Sys Embout poussoir pour distributeur de produit liquide
US8367734B1 (en) * 2005-08-11 2013-02-05 Amphastar Pharmaceuticals Inc. Stable epinephrine suspension formulation with high inhalation delivery efficiency
US7771751B2 (en) 2005-08-31 2010-08-10 Abraxis Bioscience, Llc Compositions comprising poorly water soluble pharmaceutical agents and antimicrobial agents
US7416194B2 (en) 2005-09-19 2008-08-26 Target Brands, Inc. Shopping cart base
FR2892158B1 (fr) 2005-10-17 2011-10-21 Valois Sas Pompe de distribution de produit fluide
JP5116482B2 (ja) * 2005-11-14 2013-01-09 帝國製薬株式会社 イオントフォレーシス用製剤
US8906392B2 (en) 2005-12-16 2014-12-09 University Of Kansas Nanocluster compositions and methods
USD545218S1 (en) 2006-05-04 2007-06-26 Henkel Kommanditgesellschaft Auf Aktien Container with closing device
US20070286813A1 (en) 2006-06-09 2007-12-13 Toutounghi Camille Nasal formulation
USD551569S1 (en) 2006-06-12 2007-09-25 Alteco Inc. Combined container and cap
USD604166S1 (en) 2006-08-04 2009-11-17 Med-Systems, Inc. Device to wash nasal passages
US20080269347A1 (en) * 2006-09-28 2008-10-30 Azopharma, Inc. Epinephrine formulations
ES2652415T3 (es) 2006-12-26 2018-02-02 Shin Nippon Biomedical Laboratories, Ltd. Preparación para aplicación transnasal
EP2125075A2 (en) 2007-01-22 2009-12-02 Intelliject, Inc. Medical injector with compliance tracking and monitoring
FR2917651B1 (fr) 2007-06-20 2010-09-17 Rexam Dispensing Sys Pompe pour la distribution d'un produit liquide a amorcage ameliore
ES2493641T3 (es) 2007-06-28 2014-09-12 Cydex Pharmaceuticals, Inc. Administración nasal de soluciones acuosas de corticosteroides
WO2009097277A1 (en) 2008-02-01 2009-08-06 Trustees Of Boston University Cationic contrast agents and methods of use thereof
DE102008007198A1 (de) 2008-02-01 2009-08-13 Infectopharm Arzneimittel Und Consilium Gmbh Oral oder nasal applizierbare Epinephrin- haltige Zubereitungen mit verbesserten Eigenschaften
US20090202467A1 (en) 2008-02-08 2009-08-13 Bock Richard W Sclerotherapy for varicose veins
TWI395593B (zh) 2008-03-06 2013-05-11 Halozyme Inc 可活化的基質降解酵素之活體內暫時性控制
FR2929252B1 (fr) 2008-03-27 2012-02-03 Rexam Pharma La Verpilliere Dispositif de distribution de fluide comprenant une pompe
US8021344B2 (en) 2008-07-28 2011-09-20 Intelliject, Inc. Medicament delivery device configured to produce an audible output
USD623733S1 (en) 2008-12-08 2010-09-14 Valois S.A.S. Dispenser
FR2941933B1 (fr) 2009-02-06 2016-02-12 Rexam Pharma La Verpilliere Dispositif pour la delivrance d'un produit comportant une pompe, comprenant une partie fixe et une partie mobile.
US9101539B2 (en) 2009-05-15 2015-08-11 Shin Nippon Biomedical Laboratories, Ltd. Intranasal pharmaceutical compositions with improved pharmacokinetics
WO2010139752A2 (en) 2009-06-04 2010-12-09 Alk Ag Stabilised composition comprising at least one adrenergic compound
US8628805B2 (en) 2009-06-04 2014-01-14 Alk Ag Stabilized composition comprising at least one adrenergic compound
US8263581B2 (en) 2009-07-03 2012-09-11 Jdp Therapeutics, Inc. Non-sedating antihistamine injection formulations and methods of use thereof
DE102009037164B3 (de) 2009-08-03 2010-12-09 Ing. Erich Pfeiffer Gmbh Austragvorrichtung für flüssige Medien
AU2010302945B2 (en) 2009-10-01 2015-09-24 The University Of Sydney Therapy and prevention of problem drinking
FR2952042B1 (fr) 2009-11-03 2012-01-20 Valois Sas Dispositif de distribution de produit fluide.
USD627458S1 (en) 2009-12-16 2010-11-16 Water Pik, Inc. Vessel for sinus cavity rinse
USD629884S1 (en) 2009-12-16 2010-12-28 Water Pik, Inc. Powered irrigator for sinus cavity rinse
USD627057S1 (en) 2009-12-21 2010-11-09 Med-Systems, Inc. Device to wash nasal passages
US20120322884A1 (en) 2010-03-01 2012-12-20 University Of Manitoba Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine
US8978937B2 (en) 2010-05-05 2015-03-17 Conopco Inc. Actuator for an aerosol container
FR2961192B1 (fr) 2010-06-10 2012-07-27 Rexam Healthcare La Verpillier Dispositif de distribution de produit comprenant une pompe et un embout de distribution
FR2961191B1 (fr) 2010-06-10 2012-07-27 Rexam Healthcare La Verpillier Pompe pour la delivrance d'un produit, comportant un piston coulissant dans une chambre de dosage
CN103068400A (zh) 2010-06-25 2013-04-24 阿斯顿大学 具有脂类动员性质的糖蛋白及其治疗用途
CN102335125A (zh) 2010-07-16 2012-02-01 上海禾丰制药有限公司 盐酸肾上腺素注射液及其制剂工艺
CN103596560B (zh) 2010-11-09 2016-08-10 张洁 薄层和液体结合的透皮给药系统
SG193958A1 (en) * 2011-03-31 2013-11-29 Acorda Therapeutics Inc Intranasal benzodiazepine pharmaceutical compositions
TWI461214B (zh) 2011-06-13 2014-11-21 Univ Chang Gung Biodegradable water-sensitive glue, a drug delivery system as a carrier thereof, and a pharmaceutical composition for the treatment and / or prevention of eye diseases
AP2014007377A0 (en) 2011-06-21 2014-01-31 Christopher Stepanian Automatic mixing device and delivery system
US9555118B2 (en) 2011-12-05 2017-01-31 Camrus Ab Robust controlled-release peptide formulations
CN104010661B (zh) 2011-12-27 2017-06-06 千寿制药株式会社 含有二丁基羟基甲苯的制剂及二丁基羟基甲苯的稳定化方法
WO2013123033A1 (en) 2012-02-14 2013-08-22 The Board Of Trustees Of The Leland Stanford Junior University Dimethylarginine dimethylaminohydrolase inhibitors and methods of use thereof
US9149426B2 (en) 2012-02-15 2015-10-06 University Of Tennessee Research Foundation Nanoparticle composition and methods to make and use the same
EP2834642A1 (en) 2012-03-30 2015-02-11 Rigshospitalet Compounds capable of modulating/preserving endothelial integrity for use in prevention or treatment of acute traumatic coagulopathy and resuscitated cardiac arrest
US9789071B2 (en) 2012-06-27 2017-10-17 G2B Pharma, Inc. Intranasal formulation of epinephrine for the treatment of anaphylaxis
US20140006681A1 (en) 2012-06-29 2014-01-02 Broadcom Corporation Memory management in a virtualization environment
WO2015020982A2 (en) 2013-08-04 2015-02-12 Aquavit Pharmaceuticals, Inc. Direct application system and method for the delivery of bioactive compositions and formulations
US10980865B2 (en) 2012-08-10 2021-04-20 Aquavit Pharmaceuticals, Inc. Direct application system and method for the delivery of bioactive compositions and formulations
US20140086976A1 (en) 2012-08-20 2014-03-27 Aladar A. Szalay Compositions containing protein polymers and vaccinia virus, and methods of use thereof
US20140066881A1 (en) * 2012-08-31 2014-03-06 Zoll Medical Corporation Cardiac resuscitation methods and kits
ES2595252T3 (es) 2012-10-08 2016-12-28 Aptissen S.A. Formulación acuosa estéril inyectable a base de ácido hialurónico reticulado y de hidroxiapatita para uso terapéutico
AU2013328393A1 (en) 2012-10-08 2015-04-09 Wockhardt Limited Stable injectable pharmaceutical composition of epinephrine or salts thereof
AU2013329751B2 (en) 2012-10-08 2017-12-21 Anteis S.A. Injectable sterile aqueous formulation based on crosslinked hyaluronic acid and hydroxyapatite for aesthetic use
AU2013370281B2 (en) 2012-12-27 2017-09-07 Kaleo, Inc. Devices, systems and methods for locating and interacting with medicament delivery systems
KR101586789B1 (ko) 2012-12-28 2016-01-19 주식회사 종근당 양이온성 약리학적 활성물질의 서방성 지질 초기제제 및 이를 포함하는 약제학적 조성물
FR3002293B1 (fr) 2013-02-15 2015-04-10 Aptar France Sas Pompe a precompression amelioree.
ES2691319T3 (es) 2013-02-18 2018-11-26 Glenn Abrahmsohn Composiciones y métodos para aliviar el dolor sin adormecimiento
US9907910B2 (en) 2013-03-15 2018-03-06 Windgap Medical, Inc. Portable drug mixing and delivery device and associated methods
WO2014146060A1 (en) 2013-03-15 2014-09-18 Windgap Medical, Inc. Portable drug mixing and delivery system and method
US20150231334A1 (en) 2013-12-18 2015-08-20 Windgap Medical, Inc. Drug mixing and delivery system and method
FR3003481B1 (fr) 2013-03-19 2020-05-15 Aptar France Sas Dispositif de distribution de produit fluide.
EP3517122A1 (en) 2013-04-03 2019-07-31 Sanofi Treatment of diabetes mellitus by long-acting formulations of insulins
USD712535S1 (en) 2013-04-16 2014-09-02 Tiffany Du Two piece infant nasal aspirator
US20160220489A1 (en) 2013-09-03 2016-08-04 G2B Pharma Inc. Intranasal Formulation for the Treatment of Cardiopulmonary Resuscitation (CPR), Cardiac Life Support (CLS), Anaphylaxis and/or Anaphylactoid Reactions
BR112016007328A2 (pt) 2013-10-03 2017-08-01 Imprimis Pharmaceuticals Inc composições oftálmicas baseadas em epinefrina para administração intraocular e métodos para fabricar as mesmas
WO2015085373A1 (en) 2013-12-12 2015-06-18 Cellmid Limited Method of treatment of alopecia with monoterpenoids
WO2015095389A1 (en) 2013-12-18 2015-06-25 Aegis Therapeutics, Llc Compositions for drug administration
US20180000942A1 (en) 2013-12-18 2018-01-04 Aegis Therapeutics, Llc Compositions for drug administration
US9561177B2 (en) 2014-03-14 2017-02-07 Adapt Pharma Limited Nasal drug products and methods of their use
US9480644B2 (en) 2014-03-14 2016-11-01 Opiant Pharmaceuticals, Inc. Nasal drug products and methods of their use
CA2952622A1 (en) * 2014-06-16 2015-12-23 Loewi LLC Methods of anesthetizing nerve tissue in the trigeminal nerve pathway and medical uses thereof
FR3023188B1 (fr) 2014-07-04 2016-08-19 Aptar France Sas Dispositif de distribution de produit fluide.
FR3023189B1 (fr) 2014-07-04 2021-03-26 Aptar France Sas Dispositif de distribution de produit fluide.
KR101809908B1 (ko) 2014-07-21 2018-01-25 주식회사 종근당 5-알파환원효소억제제를 포함하는 조성물
US9283197B1 (en) 2014-08-15 2016-03-15 Jugal K. Taneja More potent and less toxic formulations of epinephrine and methods of medical use
US10039728B1 (en) 2014-08-15 2018-08-07 Jugal K. Taneja More potent and less toxic formulations of epinephrine and methods of medical use
JP6462859B2 (ja) 2014-08-18 2019-01-30 ウィンドギャップ メディカル， インコーポレイテッド 携帯型薬剤混合及び送達装置並びに関連の方法
FR3029810B1 (fr) 2014-12-16 2019-06-07 Aptar France Sas Dispositif de distribution de produit fluide.
CN107205938A (zh) 2014-12-18 2017-09-26 温德加普医疗股份有限公司 用于溶解或增溶治疗剂的方法和组合物
US9119876B1 (en) 2015-03-13 2015-09-01 Par Pharmaceutical, Inc. Epinephrine formulations
US11571384B2 (en) 2015-09-18 2023-02-07 Hikma Pharmaceuticals Usa Inc. Epinephrine spray formulations
US20170079907A1 (en) 2015-09-18 2017-03-23 Insys Development Company, Inc. Sublingual Epinephrine Spray
US11517525B2 (en) 2015-09-18 2022-12-06 Hikma Pharmaceuticals Usa Inc. Epinephrine spray formulations
WO2017094027A1 (en) 2015-12-01 2017-06-08 Cipla Limited Nasal spray assembly
ES2621877B1 (es) 2016-01-04 2018-05-04 Agencia Pública Empresarial Sanitaria Hospital De Poniente Solución para resección endoscópica
USD801830S1 (en) 2016-05-19 2017-11-07 Adhezion Biomedical, Llc Liquid dispenser
WO2017218918A1 (en) 2016-06-17 2017-12-21 Ys Pharmtech Stabilization of epinephrine formulations
FR3052690B1 (fr) 2016-06-20 2018-06-22 Aptar France Sas Dispositif de distribution de produit fluide.
CA3036553A1 (en) 2016-09-13 2018-03-22 Prothera Biologics, Inc. Methods for treating pulmonary disease using inter-alpha inhibitor proteins
EP3687475A4 (en) 2017-09-26 2021-07-28 YS Pharmtech STABILIZATION OF EPINEPHRIN FORMULATIONS
JP6941224B2 (ja) 2018-02-06 2021-09-29 イージス セラピューティクス，エルエルシー 疾患の処置のための鼻腔内エピネフリン製剤及び方法
WO2019182745A1 (en) 2018-03-19 2019-09-26 Bryn Pharma, LLC Epinephrine spray formulations
WO2021026330A1 (en) 2019-08-06 2021-02-11 Bryn Pharma, LLC Methods, devices, and systems for administered epinephrine
USD923776S1 (en) 2020-01-29 2021-06-29 Bryn Pharma, LLC Nasal spray device

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005531570A (ja) * 2002-05-23 2005-10-20 ユーエムディー， インコーポレイテッド 貫粘膜薬物送達及び凍結保護のための組成物及び方法
JP2010509394A (ja) * 2006-11-15 2010-03-25 エスケー ホルディングス カンパニー リミテッド 経鼻抗けいれん医薬組成物
WO2014127018A1 (en) * 2013-02-12 2014-08-21 Ys Pharmtech Epinephrine formulations for medicinal products
JP2016515609A (ja) * 2013-04-02 2016-05-30 テミス メディケア リミティド ジエチレングリコールモノエチルエーテル又は他のアルキル誘導体を含む医薬活性成分の組成物
US20170216199A1 (en) * 2015-09-18 2017-08-03 Insys Development Company, Inc. Epinephrine spray formulations

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ASIAN PAC J ALLERGY IMMUNOL., vol. 34, no. 1, JPN6023000893, 2016, pages 38 - 43, ISSN: 0005079966 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024515159A (ja) * 2021-03-09 2024-04-05 アプター フランス エスアーエス 経鼻流体投与装置

Also Published As

Publication number Publication date
IL277417A (en) 2020-11-30
US20200397722A1 (en) 2020-12-24
CN112153966A (zh) 2020-12-29
AU2019239640A1 (en) 2020-10-01
US11000489B2 (en) 2021-05-11
AU2025203305A1 (en) 2025-05-29
US20210093558A1 (en) 2021-04-01
US20210361594A1 (en) 2021-11-25
US20190282518A1 (en) 2019-09-19
MX2020009602A (es) 2021-01-08
MX2023007212A (es) 2023-06-29
US12150921B2 (en) 2024-11-26
JP2023085545A (ja) 2023-06-20
US20190282497A1 (en) 2019-09-19
EP3768250A4 (en) 2022-01-26
AU2019239640B2 (en) 2025-02-13
WO2019182745A1 (en) 2019-09-26
PH12020551427A1 (en) 2021-09-06
WO2019182908A1 (en) 2019-09-26
IL316152A (en) 2024-12-01
US12245995B2 (en) 2025-03-11
US11723884B2 (en) 2023-08-15
US20190254962A1 (en) 2019-08-22
US20230364036A1 (en) 2023-11-16
US20210346316A1 (en) 2021-11-11
US10688044B2 (en) 2020-06-23
EP4338804A3 (en) 2024-03-27
SG11202008811WA (en) 2020-10-29
US20210361595A1 (en) 2021-11-25
BR112020018913A2 (pt) 2020-12-29
US20190282496A1 (en) 2019-09-19
EP3768250A1 (en) 2021-01-27
US20200253866A1 (en) 2020-08-13
US12295921B2 (en) 2025-05-13
KR20200140830A (ko) 2020-12-16
US20200345629A1 (en) 2020-11-05
EP4338804A2 (en) 2024-03-20
US10925841B2 (en) 2021-02-23
CA3094147A1 (en) 2019-09-26

Similar Documents

Publication Publication Date Title
US12150921B2 (en) Epinephrine spray formulations
JP7621220B2 (ja) 疾患の処置のための鼻腔内エピネフリン製剤及び方法
EP2477634B1 (en) Non-sedating antihistamine injection formulations and methods of use thereof
US20180193332A1 (en) Low-temperature stable opioid antagonist solutions
WO2019142214A1 (en) Pharmaceutical composition comprising tiotropium for inhalation
US20170079907A1 (en) Sublingual Epinephrine Spray
WO2021026330A1 (en) Methods, devices, and systems for administered epinephrine
HK40107895A (en) Epinephrine spray formulations
EA045992B1 (ru) Составы эпинефрина в виде спрея
US20250262173A1 (en) Intranasal epinephrine formulations and methods of use
KR20200097311A (ko) 만성 폐쇄성 폐 질환의 급성 악화의 치료에서의 3-[5-아미노-4-(3-시아노벤조일)-피라졸-1-일]-n-시클로프로필-4-메틸벤즈아미드의 용도

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220315

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20220315

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20230111

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230112

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230412

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20230608

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20231010

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20231122

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20231208