MX2020009602A - Formulaciones de pulverizacion de epinefrina. - Google Patents

Formulaciones de pulverizacion de epinefrina.

Info

Publication number
MX2020009602A
MX2020009602A MX2020009602A MX2020009602A MX2020009602A MX 2020009602 A MX2020009602 A MX 2020009602A MX 2020009602 A MX2020009602 A MX 2020009602A MX 2020009602 A MX2020009602 A MX 2020009602A MX 2020009602 A MX2020009602 A MX 2020009602A
Authority
MX
Mexico
Prior art keywords
spray formulations
epinephrine spray
epinephrine
formulations
subjects
Prior art date
Application number
MX2020009602A
Other languages
English (en)
Inventor
Steven Hartman
Michelle Lobel
Matthew P Robben
Kenneth L Dretchen
Michael Mesa
Original Assignee
Bryn Pharma Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bryn Pharma Llc filed Critical Bryn Pharma Llc
Publication of MX2020009602A publication Critical patent/MX2020009602A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
    • A61M11/007—Syringe-type or piston-type sprayers or atomisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/08—Inhaling devices inserted into the nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3546—Range
    • A61M2205/3553—Range remote, e.g. between patient's home and doctor's office

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Mechanical Engineering (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se proporcionan en la presente formulaciones de pulverización de epinefrina. También se proporcionan en la presente métodos para tratar anafilaxis al administrar formulaciones de pulverización de epinefrina a sujetos en necesidad de este tratamiento.
MX2020009602A 2018-03-19 2019-03-15 Formulaciones de pulverizacion de epinefrina. MX2020009602A (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201862644834P 2018-03-19 2018-03-19
US201862663100P 2018-04-26 2018-04-26
US201862712678P 2018-07-31 2018-07-31
US201862747048P 2018-10-17 2018-10-17
US201962810261P 2019-02-25 2019-02-25
PCT/US2019/022557 WO2019182908A1 (en) 2018-03-19 2019-03-15 Epinephrine spray formulations

Publications (1)

Publication Number Publication Date
MX2020009602A true MX2020009602A (es) 2021-01-08

Family

ID=67903732

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2020009602A MX2020009602A (es) 2018-03-19 2019-03-15 Formulaciones de pulverizacion de epinefrina.
MX2023007212A MX2023007212A (es) 2018-03-19 2020-09-15 Formulaciones de pulverizacion de epinefrina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2023007212A MX2023007212A (es) 2018-03-19 2020-09-15 Formulaciones de pulverizacion de epinefrina.

Country Status (13)

Country Link
US (12) US10688044B2 (es)
EP (2) EP3768250A4 (es)
JP (2) JP2021518385A (es)
KR (1) KR20200140830A (es)
CN (1) CN112153966A (es)
AU (1) AU2019239640A1 (es)
BR (1) BR112020018913A2 (es)
CA (1) CA3094147A1 (es)
IL (1) IL277417A (es)
MX (2) MX2020009602A (es)
PH (1) PH12020551427A1 (es)
SG (1) SG11202008811WA (es)
WO (2) WO2019182745A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019182745A1 (en) * 2018-03-19 2019-09-26 Bryn Pharma, LLC Epinephrine spray formulations
WO2021026330A1 (en) * 2019-08-06 2021-02-11 Bryn Pharma, LLC Methods, devices, and systems for administered epinephrine
ES2929818T3 (es) 2020-05-18 2022-12-02 Orexo Ab Nueva composición farmacéutica para la administración de fármacos
WO2022046976A1 (en) * 2020-08-26 2022-03-03 Amphastar Pharmaceuticals, Inc. An epinephrine injection formulation with very low epinephrine concentration and low impurities during its shelf-life
WO2022129069A1 (en) 2020-12-17 2022-06-23 Philip Morris Products S.A. Pharmaceutical composition comprising epinephrine for aerosol administration
FR3120534B1 (fr) * 2021-03-09 2023-06-30 Aptar France Sas Tête de distribution nasale de produit fluide et dispositif comportant une telle tête
US11617716B2 (en) * 2021-06-10 2023-04-04 Belhaven BioPharma Inc. Dry powder formulations of epinephrine and associated methods
EP4236921A1 (en) 2021-11-25 2023-09-06 Orexo AB Pharmaceutical composition comprising adrenaline
WO2023192602A2 (en) * 2022-04-01 2023-10-05 Enalare Therapeutics Inc. Respiratory stimulant nasal formulations

Family Cites Families (155)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4959358A (en) * 1983-06-06 1990-09-25 Beth Israel Hospital Assn. Drug administration
US20040002647A1 (en) 1991-10-18 2004-01-01 Ashvin Desai Gel injection treatment of body parts
FR2762589B1 (fr) 1997-04-28 1999-07-16 Sofab Flacon de distribution pour liquide, creme ou gel comportant un dispositif filtrant de l'air entrant
US5922341A (en) 1997-10-28 1999-07-13 Vivus, Incorporated Local administration of pharmacologically active agents to treat premature ejaculation
US20010053775A1 (en) 1998-01-30 2001-12-20 Matthias Seidel Nasal solutions
KR100288190B1 (ko) * 1998-02-09 2001-04-16 김용규 피록시캄 함유 알콜성 하이드로겔 조성물
DE19807922A1 (de) 1998-02-25 1999-08-26 Pfeiffer Erich Gmbh & Co Kg Spender für Medien
DE19817417A1 (de) 1998-04-18 1999-10-21 Pfeiffer Erich Gmbh & Co Kg Spender für Medien, insbesondere Pulver
FR2779129B1 (fr) 1998-05-26 2000-08-18 Sofab Diffuseur de produits liquides sous forme d'aerosols
WO2000029049A1 (en) 1998-11-13 2000-05-25 Elan Pharma International Limited Drug delivery systems and methods
FR2793221B1 (fr) 1999-05-05 2001-07-27 Sofab Embout pour la distribution et la pulverisation de produits pharmaceutiques liquides
AU2249701A (en) 1999-11-12 2001-06-06 David Bernstein Methods for treating cardiac arrest or pulmonary hypertension and compositions for use therein comprising vasoactive intestinal polypeptide and cardiac device for electrical and chemical regulation and methods of use
EP1237538A2 (en) * 1999-11-18 2002-09-11 Natco Pharma Limited An improved pharmaceutical composition for treating male erectile dysfunction
DE19960459A1 (de) 1999-12-15 2001-06-21 Pfeiffer Erich Gmbh & Co Kg Spender für Medien
US6413499B1 (en) * 2000-01-06 2002-07-02 Bryan M. Clay Methods and kits for maxillary dental anesthesia by means of a nasal deliverable anesthetic
US6348737B1 (en) 2000-03-02 2002-02-19 International Business Machines Corporation Metallic interlocking structure
US6284765B1 (en) 2000-04-27 2001-09-04 The University Of North Texas Health Science Center At Fort Worth (+) naloxone and epinephrine combination therapy
FR2809961B1 (fr) 2000-06-09 2004-12-03 Seppic Sa Utilisation d'ethers de sucres, comme adjuvants d'immunite dans les compositions vaccinales, compositions therapeutiques les renfermant et leur utilisation comme vaccins
US20070225379A1 (en) * 2001-08-03 2007-09-27 Carrara Dario Norberto R Transdermal delivery of systemically active central nervous system drugs
FR2817848B1 (fr) 2000-12-12 2003-03-07 Rexam Sofab Micropompe electronique
US20030216329A1 (en) 2001-04-24 2003-11-20 Robinson Cynthia B. Composition, formulations & kit for treatment of respiratory & lung disease with dehydroepiandrosterone(s) steroid & an anti-muscarinic agent(s)
AU2002305236A1 (en) 2001-04-24 2002-11-05 Epigenesis Pharmaceuticals, Inc. Composition, formulations and kits for treatment of respiratory and lung disease with anti-sense oligonucleotides and a bronchodilating agent
US20050070487A1 (en) 2001-04-24 2005-03-31 Nyce Jonathan W. Composition, formulations and kit for treatment of respiratory and lung disease with non-glucocorticoid steroids and/or ubiquinone and a bronchodilating agent
WO2002085297A2 (en) 2001-04-24 2002-10-31 East Carolina University Compositions & formulations with a non-glucocorticoid steroid &/or a ubiquinone & kit for treatment of respiratory & lung disease
US6708852B2 (en) 2001-08-20 2004-03-23 Alternative Packaging Solutions, L.P. Non-chemical aerosol dispenser
US7201296B2 (en) 2001-09-21 2007-04-10 Ing. Erich Pfeiffer Gmbh Dosing device with a pumping device
JP4210215B2 (ja) 2001-09-21 2009-01-14 インジ エリッヒ プファイファ ゲーエムベーハ 媒体リザーバを備えた投与装置とこれのためのポンプ装置
DE10220557A1 (de) 2002-05-02 2003-11-13 Pfeiffer Erich Gmbh & Co Kg Spender zum Austrag fließfähiger Medien
US8163764B2 (en) 2002-04-26 2012-04-24 Asan Laboratories Company (Cayman) Limited Skincare methods
EP1509209A1 (en) * 2002-05-23 2005-03-02 UMD, Inc. Compositions and method for transmucosal drug delivery and cryoprotection
WO2004014293A2 (en) 2002-06-12 2004-02-19 Epigenesis Pharmaceuticals, Inc. Combination of anti-muscarinic agents and non-glucocorticoid steroids
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
ES2638987T3 (es) 2002-06-28 2017-10-25 Civitas Therapeutics, Inc. Epinefrina inhalable
EP1556062B1 (en) * 2002-08-28 2009-12-23 Lupin Limited Herbal extract comprising a mixture of saponins obtained from sapindus trifoliatus for anticonvulsant activity
US20040045546A1 (en) * 2002-09-05 2004-03-11 Peirce Management, Llc Pharmaceutical delivery system for oral inhalation through nebulization consisting of inert substrate impregnated with substance (S) to be solubilized or suspended prior to use
DE10306686A1 (de) 2003-02-12 2004-08-26 Ing. Erich Pfeiffer Gmbh Austragvorrichtung zur manuellen Erzeugung eines Volumenstroms
US9254294B2 (en) 2003-02-24 2016-02-09 Pharmaceutical Productions Inc. Transmucosal hormone delivery system
DK1599186T3 (da) 2003-02-24 2013-07-08 Pharmaceutical Productions Inc System til administration af transmukalt lægemiddel
US7871607B2 (en) 2003-03-05 2011-01-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
CN1942588B (zh) 2003-03-05 2013-06-12 海洋酶公司 可溶性透明质酸酶糖蛋白(sHASEGP)、制备它们的方法、它们的用途和包含它们的药物组合物
DE10323603A1 (de) 2003-05-20 2004-12-30 Ing. Erich Pfeiffer Gmbh Dosiervorrichtung mit einer Pumpeinrichtung
NZ551990A (en) 2004-06-04 2011-01-28 Camurus Ab Liquid depot formulations
EP1616629B1 (de) 2004-07-13 2014-04-02 Aptar Radolfzell GmbH Betätigungseinrichtung für einen Medienspender
US7449012B2 (en) 2004-08-06 2008-11-11 Meridian Medical Technologies, Inc. Automatic injector
US8048035B2 (en) 2004-08-06 2011-11-01 Meridian Medical Technologies, Inc. Automatic injector with needle cover
US9895444B2 (en) 2004-08-25 2018-02-20 Aegis Therapeutics, Llc Compositions for drug administration
US20140162965A1 (en) 2004-08-25 2014-06-12 Aegis Therapeutics, Inc. Compositions for oral drug administration
GB0425518D0 (en) 2004-11-19 2004-12-22 Clinical Designs Ltd Substance source
US7648482B2 (en) 2004-11-22 2010-01-19 Intelliject, Inc. Devices, systems, and methods for medicament delivery
WO2006057636A1 (en) 2004-11-22 2006-06-01 Intelliject, Llc Devices, systems, and methods for medicament delivery
WO2006083876A2 (en) 2005-02-01 2006-08-10 Intelliject, Llc Devices, systems, and methods for medicament delivery
US7648483B2 (en) 2004-11-22 2010-01-19 Intelliject, Inc. Devices, systems and methods for medicament delivery
US7947017B2 (en) 2004-11-22 2011-05-24 Intelliject, Inc. Devices, systems and methods for medicament delivery
US20110226646A1 (en) 2004-12-06 2011-09-22 Wyrick Ronald E Kits Containing Medicine Injection Devices And Containers
US7905352B2 (en) 2004-12-06 2011-03-15 Washington Biotech Corporation Kits containing medicine injection devices and containers
US7297136B2 (en) 2004-12-06 2007-11-20 Wyrick Ronald E Medicine injection devices and methods
FR2880807B1 (fr) 2005-01-19 2007-04-13 Aguettant Sa Lab Composition pharmaceutique injectable
US8231573B2 (en) 2005-02-01 2012-07-31 Intelliject, Inc. Medicament delivery device having an electronic circuit system
US9022980B2 (en) 2005-02-01 2015-05-05 Kaleo, Inc. Medical injector simulation device
US8226610B2 (en) 2005-02-01 2012-07-24 Intelliject, Inc. Medical injector with compliance tracking and monitoring
US7731686B2 (en) 2005-02-01 2010-06-08 Intelliject, Inc. Devices, systems and methods for medicament delivery
US8206360B2 (en) 2005-02-01 2012-06-26 Intelliject, Inc. Devices, systems and methods for medicament delivery
EP1693115B1 (de) 2005-02-22 2008-01-09 Ing. Erich Pfeiffer GmbH Spender für Medien sowie Montageverfahren hierfür
FR2885887B1 (fr) 2005-05-20 2010-11-05 Rexam Dispensing Sys Pompe a pointeau pour la distribution de produit liquide
FR2885890B1 (fr) 2005-05-20 2007-07-20 Rexam Dispensing Systems Sas Dispositif pour la delivrance et l'admission d'un produit liquide
FR2887232B1 (fr) 2005-06-21 2010-11-05 Rexam Dispensing Sys Embout poussoir pour distributeur de produit liquide
US8367734B1 (en) * 2005-08-11 2013-02-05 Amphastar Pharmaceuticals Inc. Stable epinephrine suspension formulation with high inhalation delivery efficiency
PL3311805T3 (pl) 2005-08-31 2020-07-27 Abraxis Bioscience, Llc Kompozycje zawierające słabo rozpuszczalne w wodzie środki farmaceutyczne i środki przeciwdrobnoustrojowe
WO2011109340A1 (en) 2010-03-01 2011-09-09 Nova Southeastern University Epinephrine nanop articles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine
US7416194B2 (en) 2005-09-19 2008-08-26 Target Brands, Inc. Shopping cart base
FR2892158B1 (fr) 2005-10-17 2011-10-21 Valois Sas Pompe de distribution de produit fluide
WO2007055279A1 (ja) * 2005-11-14 2007-05-18 Teikoku Seiyaku Co., Ltd. イオントフォレーシス用製剤
US8906392B2 (en) 2005-12-16 2014-12-09 University Of Kansas Nanocluster compositions and methods
US20070286813A1 (en) 2006-06-09 2007-12-13 Toutounghi Camille Nasal formulation
US20080269347A1 (en) * 2006-09-28 2008-10-30 Azopharma, Inc. Epinephrine formulations
US7745430B2 (en) * 2006-11-15 2010-06-29 Sk Holdings Co., Ltd. Transnasal anticonvulsive pharmaceutical composition
EP2116264B1 (en) 2006-12-26 2017-09-27 Shin Nippon Biomedical Laboratories, Ltd. Preparation for transnasal application
FR2917651B1 (fr) 2007-06-20 2010-09-17 Rexam Dispensing Sys Pompe pour la distribution d'un produit liquide a amorcage ameliore
ES2493641T3 (es) 2007-06-28 2014-09-12 Cydex Pharmaceuticals, Inc. Administración nasal de soluciones acuosas de corticosteroides
EP2247314A4 (en) 2008-02-01 2013-11-27 Univ Boston CATIONIC CONTRASTING AGENTS AND METHOD FOR THEIR USE
DE102008007198A1 (de) 2008-02-01 2009-08-13 Infectopharm Arzneimittel Und Consilium Gmbh Oral oder nasal applizierbare Epinephrin- haltige Zubereitungen mit verbesserten Eigenschaften
US20090202467A1 (en) 2008-02-08 2009-08-13 Bock Richard W Sclerotherapy for varicose veins
TWI395593B (zh) 2008-03-06 2013-05-11 Halozyme Inc 可活化的基質降解酵素之活體內暫時性控制
FR2929252B1 (fr) 2008-03-27 2012-02-03 Rexam Pharma La Verpilliere Dispositif de distribution de fluide comprenant une pompe
US8021344B2 (en) 2008-07-28 2011-09-20 Intelliject, Inc. Medicament delivery device configured to produce an audible output
FR2941933B1 (fr) 2009-02-06 2016-02-12 Rexam Pharma La Verpilliere Dispositif pour la delivrance d'un produit comportant une pompe, comprenant une partie fixe et une partie mobile.
WO2010131486A1 (en) 2009-05-15 2010-11-18 Shin Nippon Biomedical Laboratories, Ltd. Intranasal pharmaceutical compositions with improved pharmacokinetics
US8628805B2 (en) 2009-06-04 2014-01-14 Alk Ag Stabilized composition comprising at least one adrenergic compound
SI2437781T1 (sl) 2009-06-04 2013-12-31 Alk Ag Stabiliziran sestavek, ki obsega vsaj eno adrenergično spojino
US8263581B2 (en) 2009-07-03 2012-09-11 Jdp Therapeutics, Inc. Non-sedating antihistamine injection formulations and methods of use thereof
DE102009037164B3 (de) 2009-08-03 2010-12-09 Ing. Erich Pfeiffer Gmbh Austragvorrichtung für flüssige Medien
US9119805B2 (en) * 2009-10-01 2015-09-01 The University Of Sydney Therapy and prevention of problem drinking
FR2952042B1 (fr) 2009-11-03 2012-01-20 Valois Sas Dispositif de distribution de produit fluide.
US8978937B2 (en) 2010-05-05 2015-03-17 Conopco Inc. Actuator for an aerosol container
FR2961191B1 (fr) 2010-06-10 2012-07-27 Rexam Healthcare La Verpillier Pompe pour la delivrance d'un produit, comportant un piston coulissant dans une chambre de dosage
FR2961192B1 (fr) 2010-06-10 2012-07-27 Rexam Healthcare La Verpillier Dispositif de distribution de produit comprenant une pompe et un embout de distribution
US20130143797A1 (en) 2010-06-25 2013-06-06 Michael J. Tisdale Glycoproteins Having Lipid Mobilizing Properties an Therapeutic Uses Thereof
CN102335125A (zh) 2010-07-16 2012-02-01 上海禾丰制药有限公司 盐酸肾上腺素注射液及其制剂工艺
BR112013011594A2 (pt) 2010-11-09 2016-08-09 Jie Zhang sistemas de combinação de lâminas e líquidos para a liberação de medicamento dérmico
KR20140029426A (ko) * 2011-03-31 2014-03-10 아코르다 쎄라퓨틱스 인코포레이티드 비강내 벤조디아제핀 약제학적 조성물
TWI461214B (zh) 2011-06-13 2014-11-21 Univ Chang Gung Biodegradable water-sensitive glue, a drug delivery system as a carrier thereof, and a pharmaceutical composition for the treatment and / or prevention of eye diseases
CA2843227C (en) 2011-06-21 2019-08-13 Brent Buchine Automatic mixing device and delivery system
US9585959B2 (en) 2011-12-05 2017-03-07 Camurus Ab Robust controlled-release formulations
CN104010661B (zh) * 2011-12-27 2017-06-06 千寿制药株式会社 含有二丁基羟基甲苯的制剂及二丁基羟基甲苯的稳定化方法
US9011882B2 (en) * 2012-02-14 2015-04-21 The Board Of Trustees Of The Leland Stanford Junior University Dimethylarginine dimethylaminohydrolase inhibitors and methods of use thereof
US9149426B2 (en) 2012-02-15 2015-10-06 University Of Tennessee Research Foundation Nanoparticle composition and methods to make and use the same
EP2834642A1 (en) 2012-03-30 2015-02-11 Rigshospitalet Compounds capable of modulating/preserving endothelial integrity for use in prevention or treatment of acute traumatic coagulopathy and resuscitated cardiac arrest
US9789071B2 (en) * 2012-06-27 2017-10-17 G2B Pharma, Inc. Intranasal formulation of epinephrine for the treatment of anaphylaxis
US10980865B2 (en) 2012-08-10 2021-04-20 Aquavit Pharmaceuticals, Inc. Direct application system and method for the delivery of bioactive compositions and formulations
WO2015020982A2 (en) 2013-08-04 2015-02-12 Aquavit Pharmaceuticals, Inc. Direct application system and method for the delivery of bioactive compositions and formulations
WO2014031693A1 (en) 2012-08-20 2014-02-27 Genelux Corporation Compositions containing protein polymers and vaccinia virus, and methods of use thereof
WO2014035473A1 (en) * 2012-08-31 2014-03-06 Zoll Medical Corporation Cardiac resuscitation methods and kits
CN104703587A (zh) 2012-10-08 2015-06-10 沃克哈特有限公司 肾上腺素及其盐的稳定的可注射药物组合物
JP6476120B2 (ja) 2012-10-08 2019-02-27 アプティッサン エス．アー．Ａｐｔｉｓｓｅｎ Ｓ．Ａ． 治療的使用のための架橋ヒアルロン酸及びハイドロキシアパタイトに基づく注入用無菌水性製剤
CN104703582B (zh) 2012-10-08 2017-11-24 安特易斯有限公司 用于化妆品的包含交联透明质酸和羟基磷灰石的注射用无菌水性制剂
GB2523512A (en) 2012-12-27 2015-08-26 Kaleo Inc Devices, systems and methods for locating and interacting with medicament delivery systems
KR101586789B1 (ko) 2012-12-28 2016-01-19 주식회사 종근당 양이온성 약리학적 활성물질의 서방성 지질 초기제제 및 이를 포함하는 약제학적 조성물
WO2014127015A1 (en) * 2013-02-12 2014-08-21 Ys Pharm Tech Epinephrine formulations for medicinal products
FR3002293B1 (fr) 2013-02-15 2015-04-10 Aptar France Sas Pompe a precompression amelioree.
AU2014217942B2 (en) 2013-02-18 2019-01-24 Glenn Abrahmsohn Compositions and methods for pain relief without numbness
US9907910B2 (en) 2013-03-15 2018-03-06 Windgap Medical, Inc. Portable drug mixing and delivery device and associated methods
AU2014232211B2 (en) 2013-03-15 2017-05-25 Windgap Medical, Inc. Portable drug mixing and delivery system and method
FR3003481B1 (fr) 2013-03-19 2020-05-15 Aptar France Sas Dispositif de distribution de produit fluide.
UA119324C2 (uk) * 2013-04-02 2019-06-10 Теміс Медікер Лімітед Композиції фармацевтично активних речовин, що містять моноетиловий ефір діетиленгліколю або інші алкільні похідні
MY181626A (en) 2013-04-03 2020-12-29 Sanofi Sa Treatment of diabetes mellitus by long-acting formulations of insulins
WO2015034822A1 (en) * 2013-09-03 2015-03-12 G2B Pharma Inc. Intranasal formulation for the treatment of cardiopulmonary resuscitation (cpr), cardiac life support (cls), anaphylaxis and/or anaphylactoid reactions
MX2016004257A (es) 2013-10-03 2016-08-17 Imprimis Pharmaceuticals Inc Composiciones oftalmicas basadas en epinefrina para la administracion intraocular y metodos para su frabricacion.
WO2015085373A1 (en) * 2013-12-12 2015-06-18 Cellmid Limited Method of treatment of alopecia with monoterpenoids
US20180000942A1 (en) 2013-12-18 2018-01-04 Aegis Therapeutics, Llc Compositions for drug administration
JP2017503017A (ja) 2013-12-18 2017-01-26 ウィンドギャップ メディカル， インコーポレイテッド 薬物混合および送達システムならびに方法
WO2015095389A1 (en) 2013-12-18 2015-06-25 Aegis Therapeutics, Llc Compositions for drug administration
US9561177B2 (en) * 2014-03-14 2017-02-07 Adapt Pharma Limited Nasal drug products and methods of their use
US20150359738A1 (en) * 2014-06-16 2015-12-17 Loewi LLC Methods of Anesthetizing Nerve Tissue in the Trigeminal Nerve Pathway and Medical Uses Thereof
FR3023189B1 (fr) 2014-07-04 2021-03-26 Aptar France Sas Dispositif de distribution de produit fluide.
FR3023188B1 (fr) 2014-07-04 2016-08-19 Aptar France Sas Dispositif de distribution de produit fluide.
KR101809908B1 (ko) 2014-07-21 2018-01-25 주식회사 종근당 5-알파환원효소억제제를 포함하는 조성물
US10039728B1 (en) 2014-08-15 2018-08-07 Jugal K. Taneja More potent and less toxic formulations of epinephrine and methods of medical use
US9283197B1 (en) 2014-08-15 2016-03-15 Jugal K. Taneja More potent and less toxic formulations of epinephrine and methods of medical use
JP6456479B2 (ja) 2014-08-18 2019-01-23 ウィンドギャップ メディカル， インコーポレイテッド 携帯型薬剤混合及び送達装置並びに関連の方法
FR3029810B1 (fr) 2014-12-16 2019-06-07 Aptar France Sas Dispositif de distribution de produit fluide.
AU2015364280A1 (en) 2014-12-18 2017-07-06 Windgap Medical, Inc. Method and compositions for dissolving or solubilizing therapeutic agents
US9119876B1 (en) 2015-03-13 2015-09-01 Par Pharmaceutical, Inc. Epinephrine formulations
US10039710B2 (en) * 2015-09-18 2018-08-07 Insys Development Company, Inc. Epinephrine spray formulations
US20170079907A1 (en) * 2015-09-18 2017-03-23 Insys Development Company, Inc. Sublingual Epinephrine Spray
US11571384B2 (en) 2015-09-18 2023-02-07 Hikma Pharmaceuticals Usa Inc. Epinephrine spray formulations
US11517525B2 (en) 2015-09-18 2022-12-06 Hikma Pharmaceuticals Usa Inc. Epinephrine spray formulations
US10940274B2 (en) * 2015-12-01 2021-03-09 Cipla Limited Nasal spray assembly
ES2621877B1 (es) 2016-01-04 2018-05-04 Agencia Pública Empresarial Sanitaria Hospital De Poniente Solución para resección endoscópica
US20190350881A1 (en) * 2016-06-17 2019-11-21 Ys Pharmtech Stabilization of epinephrine formulations
FR3052690B1 (fr) 2016-06-20 2018-06-22 Aptar France Sas Dispositif de distribution de produit fluide.
US20190269765A1 (en) 2016-09-13 2019-09-05 Prothera Biologics, Inc. Methods for treating pulmonary disease using inter-alpha inhibitor proteins
US11925608B2 (en) 2017-09-26 2024-03-12 Ys Pharmtech Stabilization of epinephrine formulations
JP6941224B2 (ja) 2018-02-06 2021-09-29 イージス セラピューティクス，エルエルシー 疾患の処置のための鼻腔内エピネフリン製剤及び方法
WO2019182745A1 (en) 2018-03-19 2019-09-26 Bryn Pharma, LLC Epinephrine spray formulations
WO2021026330A1 (en) 2019-08-06 2021-02-11 Bryn Pharma, LLC Methods, devices, and systems for administered epinephrine

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