JP2021514618A5 - - Google Patents
Info
- Publication number
- JP2021514618A5 JP2021514618A5 JP2020543995A JP2020543995A JP2021514618A5 JP 2021514618 A5 JP2021514618 A5 JP 2021514618A5 JP 2020543995 A JP2020543995 A JP 2020543995A JP 2020543995 A JP2020543995 A JP 2020543995A JP 2021514618 A5 JP2021514618 A5 JP 2021514618A5
- Authority
- JP
- Japan
- Prior art keywords
- igm
- antibody
- variant
- amino acid
- constant region
- Prior art date
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023183845A JP2024016093A (ja) | 2018-03-01 | 2023-10-26 | ＩｇＭ血清半減期に影響を及ぼすＩｇＭ Ｆｃ及びＪ鎖の変異 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862637186P | 2018-03-01 | 2018-03-01 | |
| US62/637,186 | 2018-03-01 | ||
| PCT/US2019/020374 WO2019169314A1 (en) | 2018-03-01 | 2019-03-01 | IgM Fc AND J-CHAIN MUTATIONS THAT AFFECT IgM SERUM HALF-LIFE |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023183845A Division JP2024016093A (ja) | 2018-03-01 | 2023-10-26 | ＩｇＭ血清半減期に影響を及ぼすＩｇＭ Ｆｃ及びＪ鎖の変異 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021514618A JP2021514618A (ja) | 2021-06-17 |
| JP2021514618A5 true JP2021514618A5 (https=) | 2022-03-07 |
| JPWO2019169314A5 JPWO2019169314A5 (https=) | 2022-03-07 |
| JP7376490B2 JP7376490B2 (ja) | 2023-11-08 |
Family
ID=67805543
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020543995A Active JP7376490B2 (ja) | 2018-03-01 | 2019-03-01 | ＩｇＭ血清半減期に影響を及ぼすＩｇＭ Ｆｃ及びＪ鎖の変異 |
| JP2023183845A Pending JP2024016093A (ja) | 2018-03-01 | 2023-10-26 | ＩｇＭ血清半減期に影響を及ぼすＩｇＭ Ｆｃ及びＪ鎖の変異 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023183845A Pending JP2024016093A (ja) | 2018-03-01 | 2023-10-26 | ＩｇＭ血清半減期に影響を及ぼすＩｇＭ Ｆｃ及びＪ鎖の変異 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US10899835B2 (https=) |
| EP (1) | EP3758752A4 (https=) |
| JP (2) | JP7376490B2 (https=) |
| KR (1) | KR102745232B1 (https=) |
| CN (1) | CN111787951B (https=) |
| AU (2) | AU2019227984A1 (https=) |
| BR (1) | BR112020017296A2 (https=) |
| IL (1) | IL276590A (https=) |
| MX (1) | MX2020009069A (https=) |
| SG (1) | SG11202008343YA (https=) |
| WO (1) | WO2019169314A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017512208A (ja) | 2014-02-10 | 2017-05-18 | アイジーエム バイオサイエンス， インコーポレイテッド | ＩｇＡ多重特異性結合分子 |
| IL292311A (en) | 2014-04-03 | 2022-06-01 | Igm Biosciences Inc | J-chain qualified |
| PT3247728T (pt) | 2015-01-20 | 2020-07-16 | Igm Biosciences Inc | Moléculas de ligação do recetor da superfamília do fator de necrose tumoral (fnt) e utilização das mesmas |
| KR102357312B1 (ko) | 2015-03-04 | 2022-02-03 | 아이쥐엠 바이오사이언스 인코포레이티드 | Ｃｄ20 결합 분자 및 그의 용도 |
| WO2016154593A1 (en) | 2015-03-25 | 2016-09-29 | Igm Biosciences, Inc. | Multi-valent hepatitis b virus antigen binding molecules and uses thereof |
| WO2016168758A1 (en) | 2015-04-17 | 2016-10-20 | Igm Biosciences, Inc. | Multi-valent human immunodeficiency virus antigen binding molecules and uses thereof |
| EP3824903A1 (en) | 2015-09-30 | 2021-05-26 | IGM Biosciences Inc. | Binding molecules with modified j-chain |
| EP3356401B1 (en) | 2015-09-30 | 2020-06-24 | IGM Biosciences, Inc. | Binding molecules with modified j-chain |
| JP6979971B2 (ja) | 2016-05-09 | 2021-12-15 | アイジーエム バイオサイエンシズ インコーポレイテッド | 抗ｐｄ−ｌ１抗体 |
| US11401337B2 (en) | 2017-04-07 | 2022-08-02 | Igm Biosciences, Inc. | Modified human IgM constant regions for modulation of complement-dependent cytolysis effector function |
| CN111787951B (zh) | 2018-03-01 | 2025-06-17 | Igm生物科学股份有限公司 | 影响IgM血清半衰期的IgM Fc和J链突变 |
| MX2022001934A (es) | 2019-08-15 | 2022-03-11 | Igm Biosciences Inc | Moleculas de union multimericas inmunoestimuladoras. |
| WO2021034646A1 (en) * | 2019-08-17 | 2021-02-25 | Igm Biosciences, Inc. | Multimeric bispecific anti-cd123 binding molecules and uses thereof |
| CN114616031A (zh) * | 2019-09-19 | 2022-06-10 | Igm生物科学股份有限公司 | 对靶标密度高的细胞的选择性增强的多聚体抗体 |
| CN110669134A (zh) * | 2019-10-15 | 2020-01-10 | 广东菲鹏生物有限公司 | IgM-FC片段、IgM-FC抗体及制备方法和应用 |
| IL293739A (en) * | 2020-01-06 | 2022-08-01 | Igm Biosciences Inc | Highly sialic acid-modified multimeric binding compounds |
| BR112022021392A2 (pt) * | 2020-04-22 | 2022-12-06 | Igm Biosciences Inc | Moléculas de ligação multiméricas de agonista de pd-1 |
| JP2023526224A (ja) * | 2020-05-12 | 2023-06-21 | アイジーエム バイオサイエンシズ インコーポレイテッド | がんを治療するための、がん治療薬との組合せでの多量体抗ｄｒ５結合分子の使用 |
| US20220033851A1 (en) * | 2020-08-03 | 2022-02-03 | Roger B. Swartz | mRNA, episomal and genomic integrated lentiviral and gammaretroviral vector expression of dimeric immunoglobulin A and polymeric immunoglobulin A to Enable Mucosal and Hematological Based Immunity/Protection via Gene Therapy for Allergens, viruses, HIV, bacteria, pneumonia, infections, pathology associated proteins, systemic pathologies, cancer, toxins and unnatural viruses. CAR engineered and non-CAR engineered immune cell expression of dimeric immunoglobulin A and polymeric immunoglobulin A. |
| KR102450007B1 (ko) * | 2020-10-16 | 2022-10-04 | 주식회사 아이엠바이오로직스 | IgM 영역을 이용한 융합단백질 플랫폼 |
| JP2024508709A (ja) * | 2021-02-17 | 2024-02-28 | アイジーエム バイオサイエンシズ インコーポレイテッド | 抗ｃｄ１２３結合分子及びその使用法 |
| JP7751338B2 (ja) * | 2021-09-13 | 2025-10-08 | シェンヤン アイ インダストリー テクノロジー インスティテュート リミテッド | 抗ペリオスチンヒト化モノクローナル抗体及びその製造方法と応用 |
| WO2023064766A1 (en) * | 2021-10-11 | 2023-04-20 | Igm Biosciences, Inc. | Lateral flow device and uses thereof |
| WO2023196995A1 (en) | 2022-04-07 | 2023-10-12 | Repertoire Immune Medicines, Inc. | T cell receptor multimers and uses thereof |
| CA3248964A1 (en) * | 2022-04-15 | 2025-07-10 | Imbiologics Corp. | Fusion protein platform with an improved half-life |
| CN121405820A (zh) * | 2025-12-29 | 2026-01-27 | 江苏谱新生物医药有限公司 | 一种病毒包膜嵌合受体及其相关生物材料和应用 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4046354B2 (ja) * | 1996-03-18 | 2008-02-13 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 増大した半減期を有する免疫グロブリン様ドメイン |
| AU740918B2 (en) * | 1997-01-10 | 2001-11-15 | Plantibodies Corporation | Novel epithelial tissue targeting agent |
| US6045774A (en) * | 1997-01-10 | 2000-04-04 | Epicyte Pharmaceutical Inc. | J chain polypeptide targeting molecule linked to an imaging agent |
| US20050129616A1 (en) | 2001-05-25 | 2005-06-16 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to TRAIL receptors |
| US20040248299A1 (en) | 2002-12-27 | 2004-12-09 | Sumedha Jayasena | RNA interference |
| US20050014932A1 (en) | 2003-05-15 | 2005-01-20 | Iogenetics, Llc | Targeted biocides |
| CN101098889A (zh) | 2004-11-05 | 2008-01-02 | 盘林京有限公司 | 抗体导致的细胞膜损伤 |
| JP2008539753A (ja) * | 2005-05-09 | 2008-11-20 | グリクアート バイオテクノロジー アクチェンゲゼルシャフト | 修飾ｆｃ領域およびｆｃ受容体との結合変更を有する抗原結合分子 |
| US20110130324A1 (en) * | 2008-07-14 | 2011-06-02 | Uchicago Argonne, Llc | Methods for systematic control of protein stability |
| WO2011044368A1 (en) * | 2009-10-07 | 2011-04-14 | Macrogenics, Inc. | Fc region-containing polypeptides that exhibit improved effector function due to alterations of the extent of fucosylation, and methods for their use |
| TWI606064B (zh) | 2012-02-08 | 2017-11-21 | Ｉｇｍ生物科技公司 | 細胞死亡誘導分子（ｃｄｉｍ）結合蛋白類及彼等之用途 |
| MX367668B (es) * | 2013-03-15 | 2019-08-30 | Dana Farber Cancer Inst Inc | Anticuerpos neutralizadores de flavivirus y métodos de uso de los mismos. |
| JP6721505B2 (ja) | 2013-09-05 | 2020-07-15 | アイジーエム バイオサイエンシズ インコーポレイテッド | 定常領域が修飾された（ｃｏｎｓｔａｎｔ ｃｈａｉｎ ｍｏｄｉｆｉｅｄ）二重特異性五価及び六価Ｉｇ−Ｍ抗体 |
| JP2017512208A (ja) | 2014-02-10 | 2017-05-18 | アイジーエム バイオサイエンス， インコーポレイテッド | ＩｇＡ多重特異性結合分子 |
| IL292311A (en) | 2014-04-03 | 2022-06-01 | Igm Biosciences Inc | J-chain qualified |
| PT3247728T (pt) | 2015-01-20 | 2020-07-16 | Igm Biosciences Inc | Moléculas de ligação do recetor da superfamília do fator de necrose tumoral (fnt) e utilização das mesmas |
| KR102357312B1 (ko) | 2015-03-04 | 2022-02-03 | 아이쥐엠 바이오사이언스 인코포레이티드 | Ｃｄ20 결합 분자 및 그의 용도 |
| WO2016154593A1 (en) | 2015-03-25 | 2016-09-29 | Igm Biosciences, Inc. | Multi-valent hepatitis b virus antigen binding molecules and uses thereof |
| WO2016168758A1 (en) | 2015-04-17 | 2016-10-20 | Igm Biosciences, Inc. | Multi-valent human immunodeficiency virus antigen binding molecules and uses thereof |
| AU2016289525B2 (en) * | 2015-07-09 | 2022-02-03 | Dispensing Technologies B.V. | System for dosed dispensing of a fluid and method of manufacturing |
| EP3356401B1 (en) | 2015-09-30 | 2020-06-24 | IGM Biosciences, Inc. | Binding molecules with modified j-chain |
| EP3824903A1 (en) | 2015-09-30 | 2021-05-26 | IGM Biosciences Inc. | Binding molecules with modified j-chain |
| JP6979971B2 (ja) | 2016-05-09 | 2021-12-15 | アイジーエム バイオサイエンシズ インコーポレイテッド | 抗ｐｄ−ｌ１抗体 |
| JP2019530640A (ja) | 2016-07-20 | 2019-10-24 | アイジーエム バイオサイエンシズ インコーポレイテッド | 多量体ｏｘ４０結合分子及びその使用 |
| EP3496536A4 (en) | 2016-07-20 | 2020-02-12 | IGM Biosciences, Inc. | MULTIMERE CD40-BINDING MOLECULES AND USES THEREOF |
| EP3487298A4 (en) | 2016-07-20 | 2020-03-11 | IGM Biosciences, Inc. | MULTIMERE CD137 / 4-1BB-BINDING MOLECULES AND USES THEREOF |
| AU2017300647A1 (en) | 2016-07-20 | 2019-02-07 | Igm Biosciences, Inc. | Multimeric GITR binding molecules and uses thereof |
| US11401337B2 (en) | 2017-04-07 | 2022-08-02 | Igm Biosciences, Inc. | Modified human IgM constant regions for modulation of complement-dependent cytolysis effector function |
| AU2019224136A1 (en) | 2018-02-26 | 2020-09-10 | Igm Biosciences, Inc. | Use of a multimeric anti-DR5 binding molecule in combination with a chemotherapeutic agent for treating cancer |
| CN111787951B (zh) | 2018-03-01 | 2025-06-17 | Igm生物科学股份有限公司 | 影响IgM血清半衰期的IgM Fc和J链突变 |
| KR20210083260A (ko) * | 2018-10-23 | 2021-07-06 | 아이쥐엠 바이오사이언스 인코포레이티드 | 다가 IgM- 및 IgA-Fc 기반 결합 분자 |
| US20220106398A1 (en) * | 2019-02-08 | 2022-04-07 | Igm Biosciences, Inc. | Anti-gitr antigen-binding domains and uses thereof |
-
2019
- 2019-03-01 CN CN201980016388.5A patent/CN111787951B/zh active Active
- 2019-03-01 AU AU2019227984A patent/AU2019227984A1/en not_active Abandoned
- 2019-03-01 BR BR112020017296-0A patent/BR112020017296A2/pt unknown
- 2019-03-01 KR KR1020207023441A patent/KR102745232B1/ko active Active
- 2019-03-01 WO PCT/US2019/020374 patent/WO2019169314A1/en not_active Ceased
- 2019-03-01 EP EP19760662.7A patent/EP3758752A4/en active Pending
- 2019-03-01 JP JP2020543995A patent/JP7376490B2/ja active Active
- 2019-03-01 MX MX2020009069A patent/MX2020009069A/es unknown
- 2019-03-01 SG SG11202008343YA patent/SG11202008343YA/en unknown
-
2020
- 2020-03-23 US US16/827,100 patent/US10899835B2/en active Active
- 2020-08-09 IL IL276590A patent/IL276590A/en unknown
- 2020-12-03 US US17/110,550 patent/US20210087273A1/en not_active Abandoned
-
2023
- 2023-10-26 JP JP2023183845A patent/JP2024016093A/ja active Pending
- 2023-12-29 US US18/400,974 patent/US20240124584A1/en active Pending
-
2025
- 2025-11-21 AU AU2025271120A patent/AU2025271120A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021514618A5 (https=) | ||
| JPWO2019169314A5 (https=) | ||
| JP7662516B2 (ja) | Ｐｄ－１標的化ｉｌ－１５／ｉｌ－１５ｒアルファｆｃ融合タンパク質およびその組み合わせ療法での使用 | |
| JP2020517287A5 (https=) | ||
| JP7209464B2 (ja) | ヒトインターロイキン－２に対する免疫刺激性モノクローナル抗体 | |
| JP2021533779A5 (https=) | ||
| JP2021159081A5 (https=) | ||
| JP2020500510A5 (https=) | ||
| CN106029694A (zh) | 治疗性肽 | |
| JP2018517431A5 (https=) | ||
| JP2016536322A5 (https=) | ||
| EP3221357A1 (en) | Common light chains and methods of use | |
| RU2017108203A (ru) | Слитые белки sirp-альфа с иммуноглобулином | |
| JP2017509335A5 (https=) | ||
| RU2018128215A (ru) | Антитела против mica | |
| JP2020519293A5 (https=) | ||
| JP2023525495A (ja) | 抗ｃｄ２６タンパク質及びそれらの使用法 | |
| JP2011526249A5 (https=) | ||
| RU2018104703A (ru) | Опухолеспецифичное антитело против egfr и его применение | |
| JP2018528786A5 (https=) | ||
| US20250206820A1 (en) | Ilt3 and cd3 binding agents and methods of use thereof | |
| EP3337825A1 (en) | Antibody or antibody fragment or non-ig scaffold binding to a binding region of an anti-n-methyl-d-aspartate (nmda) receptor antibody | |
| JP2017509323A5 (https=) | ||
| WO2022056197A1 (en) | Immune targeting molecules and uses thereof | |
| CN117120478A (zh) | 一种抗原结合分子 |