JP2021505197A5 - - Google Patents
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- JP2021505197A5 JP2021505197A5 JP2020550034A JP2020550034A JP2021505197A5 JP 2021505197 A5 JP2021505197 A5 JP 2021505197A5 JP 2020550034 A JP2020550034 A JP 2020550034A JP 2020550034 A JP2020550034 A JP 2020550034A JP 2021505197 A5 JP2021505197 A5 JP 2021505197A5
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- 101000789586 Bacillus subtilis (strain 168) UPF0702 transmembrane protein YkjA Proteins 0.000 claims 1
- 101000792624 Bacillus subtilis (strain 168) Uncharacterized protein YbxH Proteins 0.000 claims 1
- 101000790792 Bacillus subtilis (strain 168) Uncharacterized protein YckC Proteins 0.000 claims 1
- 101000819705 Bacillus subtilis (strain 168) Uncharacterized protein YlxR Proteins 0.000 claims 1
- 101000948218 Bacillus subtilis (strain 168) Uncharacterized protein YtxJ Proteins 0.000 claims 1
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024044541A JP2024075688A (ja) | 2017-12-05 | 2024-03-21 | 微生物感染を防ぐための方法および組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762594943P | 2017-12-05 | 2017-12-05 | |
| US62/594,943 | 2017-12-05 | ||
| PCT/US2018/063880 WO2019113096A1 (en) | 2017-12-05 | 2018-12-04 | Methods and compositions to prevent microbial infection |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024044541A Division JP2024075688A (ja) | 2017-12-05 | 2024-03-21 | 微生物感染を防ぐための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021505197A JP2021505197A (ja) | 2021-02-18 |
| JP2021505197A5 true JP2021505197A5 (https=) | 2022-01-11 |
| JP7460531B2 JP7460531B2 (ja) | 2024-04-02 |
Family
ID=66658442
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020550034A Active JP7460531B2 (ja) | 2017-12-05 | 2018-12-04 | 微生物感染を防ぐための方法および組成物 |
| JP2024044541A Pending JP2024075688A (ja) | 2017-12-05 | 2024-03-21 | 微生物感染を防ぐための方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024044541A Pending JP2024075688A (ja) | 2017-12-05 | 2024-03-21 | 微生物感染を防ぐための方法および組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US12163135B2 (https=) |
| EP (1) | EP3720458A4 (https=) |
| JP (2) | JP7460531B2 (https=) |
| CN (2) | CN119875972A (https=) |
| AU (2) | AU2018379996A1 (https=) |
| CA (1) | CA3084954A1 (https=) |
| MX (1) | MX2020005875A (https=) |
| PH (1) | PH12020550941A1 (https=) |
| WO (1) | WO2019113096A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104805066B (zh) * | 2015-05-18 | 2018-04-24 | 武汉菲吉乐科生物科技有限公司 | 一种葡萄球菌裂解酶及其应用 |
| TWI718402B (zh) * | 2018-08-16 | 2021-02-11 | 葡萄王生技股份有限公司 | 副乾酪乳酸桿菌gks6之活性物質、含其之組合物及其促進長壽之用途 |
| US20220211872A1 (en) * | 2019-05-15 | 2022-07-07 | Universidad De Granada | Gene therapy with the genes hokd and ldrb for cancer treatments |
| CA3146363A1 (en) * | 2019-07-08 | 2021-01-14 | BioPlx, Inc. | Live biotherapeutic compositions and methods |
| WO2021163223A1 (en) * | 2020-02-10 | 2021-08-19 | The Research Foundation For The State University Of New York | Using resilient systems inference for estimating hospital acquired infection prevention infrastructure performance |
| EP4110269A4 (en) * | 2020-02-28 | 2024-01-17 | Emory University | PENTAGALLOYL GLUCOSE FROM SCHINUS PLANTS AND METHOD OF USE |
| CA3181274A1 (en) * | 2020-06-02 | 2021-12-09 | Dan Rouse | Methods for stable genomic integration in recombinant microorganisms |
| CN111926048B (zh) * | 2020-07-20 | 2023-09-26 | 广东省微生物研究所(广东省微生物分析检测中心) | 烯丙基硫醚在制备促进铜绿假单胞菌叶酸生物合成制剂中的应用 |
| WO2023023560A1 (en) * | 2021-08-17 | 2023-02-23 | Contrafect Corporation | New uses |
| US12535933B2 (en) | 2021-11-16 | 2026-01-27 | Benuka Health, Llc | Systems, methods and devices for aiding in the decolonization of bacteria |
| CN114015622A (zh) * | 2021-12-14 | 2022-02-08 | 塔里木大学 | 无乳链球菌培养基及其制备方法 |
| CN114214354A (zh) * | 2021-12-31 | 2022-03-22 | 天津科技大学 | 一种双载体表达体系及其构建方法与应用 |
| CN116617373A (zh) * | 2022-02-14 | 2023-08-22 | 菲吉乐科(南京)生物科技有限公司 | 一种高效葡萄球菌噬菌体粉剂及其制备方法 |
| CN116179654B (zh) * | 2022-12-30 | 2023-09-15 | 军事科学院军事医学研究院环境医学与作业医学研究所 | 一种检测水中镉离子的滚环扩增检测体系及其应用 |
| CN117106674B (zh) * | 2023-10-23 | 2024-03-08 | 新益(天津)生物科技有限责任公司 | 一株能够降低尿酸、修复女性私处微生态平衡的植物乳杆菌opb15和应用 |
| CN119055779B (zh) * | 2024-07-31 | 2025-11-21 | 中国科学技术大学 | 金黄色葡萄球菌毒素蛋白相关基因sa1833/sa1832在治疗金黄色葡萄球菌感染中的应用 |
Family Cites Families (139)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4133875A (en) | 1978-02-23 | 1979-01-09 | Forsyth Dental Infirmary For Children | Method of controlling dental caries with streptococcus mutans mutant strains |
| WO1987005932A1 (en) | 1986-03-26 | 1987-10-08 | Genexpress Aps | Biological containment |
| US4716032A (en) | 1983-08-03 | 1987-12-29 | Geoffrey J. Westfall | Aerosol spray composition for mastitis prevention |
| US4548807A (en) | 1983-08-03 | 1985-10-22 | Geoffrey J. Westfall | Mastitis prevention |
| DE69310339T2 (de) | 1993-02-19 | 1997-08-21 | Philippe Djian | Präparate, die Corneozyt Proteine enthalten |
| US5733540A (en) | 1995-03-08 | 1998-03-31 | Lee; Peter Poon-Hang | Protection from viral infection via colonization of mucosal membranes with genetically modified bacteria |
| US5607672A (en) | 1995-06-07 | 1997-03-04 | University Of Florida Research Foundation, Inc. | Replacement therapy for dental caries |
| CA2222761A1 (en) | 1995-06-07 | 1996-12-19 | Washington University | Recombinant bacterial system with environmentally limited viability |
| US6593114B1 (en) * | 1996-01-05 | 2003-07-15 | Human Genome Sciences, Inc. | Staphylococcus aureus polynucleotides and sequences |
| US6737248B2 (en) | 1996-01-05 | 2004-05-18 | Human Genome Sciences, Inc. | Staphylococcus aureus polynucleotides and sequences |
| GB9604045D0 (en) | 1996-02-26 | 1996-04-24 | Smithkline Beecham Plc | Novel compounds |
| AUPN880996A0 (en) | 1996-03-20 | 1996-04-18 | Arnott's Biscuits Limited | Selection and/or enhancement of resident microorganisms in the gastrointestinal tract |
| US6645506B1 (en) | 1997-04-18 | 2003-11-11 | Ganeden Biotech, Inc. | Topical compositions containing extracellular products of Pseudomonas lindbergii and Emu oil |
| AU766257C (en) | 1998-05-07 | 2004-06-03 | Universite Libre De Bruxelles | Cytotoxin-based biological containment |
| US6461607B1 (en) | 1998-08-24 | 2002-10-08 | Ganeden Biotech, Inc. | Probiotic, lactic acid-producing bacteria and uses thereof |
| CA2360865A1 (en) | 1999-02-03 | 2000-08-10 | Biogal Gyogyszergyar Rt. | Process for the preparation of pseudomonic acid a antibiotic by microbiological method |
| US6417002B1 (en) * | 1999-02-11 | 2002-07-09 | Pharmacopeia, Inc. | Method for maintenance and selection of episomes |
| CA2430501A1 (en) | 2000-01-11 | 2001-07-19 | Intralytix, Inc. | Method for produce sanitation using bacteriophages |
| US6719991B2 (en) | 2000-06-09 | 2004-04-13 | Baylor College Of Medicine | Combination of antimicrobial agents and bacterial interference to coat medical devices |
| US6551828B1 (en) | 2000-06-28 | 2003-04-22 | Protemation, Inc. | Compositions and methods for generating expression vectors through site-specific recombination |
| AUPQ899700A0 (en) | 2000-07-25 | 2000-08-17 | Borody, Thomas Julius | Probiotic recolonisation therapy |
| AU2001286741A1 (en) * | 2000-08-25 | 2002-03-04 | Trustees Of Tufts College | Methods and compositions for potentiating antibiotic action against persistent/tolerant pathogenic microorganisms |
| EP1358479A4 (en) | 2000-09-25 | 2006-05-10 | Acuabiotec Llc | METHOD, SYSTEM AND COMPUTER PROGRAM PRODUCT FOR THE TECHNICAL MANAGEMENT AND BIO CONTROL OF DISEASES IN ANIMAL PRODUCTION SYSTEMS |
| US20020192741A1 (en) | 2000-09-28 | 2002-12-19 | Mckillip John L. | Selective medium for gram-positive bacteria |
| US6660262B2 (en) | 2001-09-28 | 2003-12-09 | Bovine Health Products, Inc. | Broad spectrum antimicrobial compound and treatment |
| EP1465990B1 (en) * | 2001-12-21 | 2011-07-13 | Biosynexus Incorporated | Truncated lysostaphin molecule with enhanced staphylolytic activity |
| US20040241150A1 (en) | 2002-12-19 | 2004-12-02 | Hargis Billy M. | Defined competitive exclusion cultures for food borne pathogens |
| US7482023B2 (en) | 2003-01-03 | 2009-01-27 | Sca Hygiene Products Ab | Hygiene tissue with lactic acid producing bacterial strains |
| ATE516024T1 (de) | 2004-05-14 | 2011-07-15 | Optimer Pharmaceuticals Inc | Behandlung von krankheiten im zusammenhang mit der anwendung von antibiotika |
| US8729013B2 (en) | 2004-08-26 | 2014-05-20 | The University Of Western Ontario | Methods of inhibiting staphylobactin-mediated iron uptake in S. aureus |
| US7627437B2 (en) | 2005-01-14 | 2009-12-01 | Idaho Research Foundation | Categorization of microbial communities |
| US20060257373A1 (en) | 2005-05-10 | 2006-11-16 | National Chung Hsing University | Antifungal formulation containing Streptomyces s.p.p., method for preparing the composition and relevant use |
| KR100844581B1 (ko) * | 2005-05-17 | 2008-07-09 | 주식회사 뉴젝스 | 혈청반응성 프로모터를 가진 리포터 아데노바이러스를 이용한 고속생리활성 물질의 검색 방법 |
| US8682619B2 (en) * | 2005-12-14 | 2014-03-25 | The Invention Science Fund I, Llc | Device including altered microorganisms, and methods and systems of use |
| US8852916B2 (en) | 2010-01-22 | 2014-10-07 | The Invention Science Fund I, Llc | Compositions and methods for therapeutic delivery with microorganisms |
| US20100260794A1 (en) | 2006-03-20 | 2010-10-14 | Vrije Universiteit Brussel | Live attenuated salmonella vaccine |
| US20080107699A1 (en) | 2006-10-25 | 2008-05-08 | Mark Spigelman | Method of using topical probiotics for the inhibition of surface contamination by a pathogenic microorganism and composition therefor |
| GB0624340D0 (en) | 2006-12-06 | 2007-01-17 | Nature Therapeutics Ltd | Antimicrobial composition |
| CA2673195C (en) | 2006-12-22 | 2012-05-29 | Bio-K Plus International Inc. | Growth inhibition and elimination of methicillin-resistant staphylococcus aureus by lactic acid bacteria |
| CA2672640A1 (en) | 2006-12-22 | 2008-07-03 | Francois-Marie Luquet | Growth inhibition of microorganisms by lactic acid bacteria |
| WO2009030040A1 (en) | 2007-09-05 | 2009-03-12 | Institut National De La Recherche Scientifique | Antimicrobial activity of bacteriocin-producing lactic acid bacteria |
| US20110008303A1 (en) | 2008-03-17 | 2011-01-13 | Cedars-Sinai Medical Center | Methods for treatment and prevention of mrsa/mssa |
| MX353908B (es) | 2008-06-13 | 2018-02-02 | Oragenics Inc | Uso de bacteria productora de peroxido de hidrogeno para blanquear dientes. |
| WO2009152298A1 (en) | 2008-06-13 | 2009-12-17 | Zeus Scientific, Inc. | Methods, compositions and and diagnostic kits for the detection and treatment for staphylococcal nasal decolonization using achromopeptidase |
| US9700611B2 (en) | 2008-06-23 | 2017-07-11 | Mississippi State University | Live attenuated catfish vaccine and method of making |
| KR101631335B1 (ko) | 2008-08-01 | 2016-06-16 | 온딘 인터내셔널 리미티드. | Mrsa 치료용 조성물 및 방법 |
| EP2337569A4 (en) | 2008-09-25 | 2013-04-03 | Univ New York | COMPOSITIONS AND METHODS FOR CHARACTERIZING AND RESTORING THE STOMACH DARM, SKIN AND NOSE MICROBIOTA |
| WO2010123599A2 (en) | 2009-01-23 | 2010-10-28 | The Board Of Trustees Of The University Of Illinois | Anti-bacterial compositions and methods including targeting virulence factors of staphylococcus aureus |
| US9464284B2 (en) | 2009-03-09 | 2016-10-11 | Bioatla, Llc | Mirac proteins |
| GB0909909D0 (en) | 2009-06-09 | 2009-07-22 | Chrisal Nv | Microcapsules containing microrgnisms |
| WO2011005756A1 (en) | 2009-07-06 | 2011-01-13 | Puretech Ventures, Llc | Delivery of agents targeted to microbiota niches |
| WO2011082218A1 (en) | 2009-12-31 | 2011-07-07 | Ira Milton Trachtman | Compositions and method for treatment and prophylaxis of inflammatory bowel disease |
| WO2011085367A2 (en) | 2010-01-11 | 2011-07-14 | Oragenics, Inc. | Non-replicating microorganisms as post-biotics |
| WO2013052174A2 (en) | 2011-06-06 | 2013-04-11 | The Trustees Of The University Of Pennsylvania | Methods for preventing and treating staphylococcus aureus colonization, infection, and disease |
| US9107938B2 (en) | 2010-09-30 | 2015-08-18 | The Board Of Trustees Of The University Of Arkansas | Methods of selecting and using therapeutic and prophylactic probiotic cultures to reduce bacterial pathogen loads |
| MX340019B (es) | 2010-11-23 | 2016-06-22 | Pantheryx Inc | Composiciones y metodos para el tratamiento en aplicaciones clinicas de amplio espectro, no diferenciadas o combinadas. |
| US10010568B2 (en) | 2011-02-04 | 2018-07-03 | Katherine Rose Kovarik | Method and system for reducing the likelihood of a spirochetes infection in a human being |
| US10111913B2 (en) | 2011-02-04 | 2018-10-30 | Joseph E. Kovarik | Method of reducing the likelihood of skin cancer in an individual human being |
| US10314865B2 (en) | 2011-02-04 | 2019-06-11 | Katherine Rose Kovarik | Method and system for treating cancer and other age-related diseases by extending the healthspan of a human |
| US9140698B2 (en) | 2011-04-06 | 2015-09-22 | The Board Of Regents Of The University Of Texas System | Modulating bacterial MAM polypeptides in pathogenic disease |
| PL2704704T3 (pl) | 2011-05-03 | 2019-04-30 | Dupont Nutrition Biosci Aps | Bakterie probiotyczne do miejscowego leczenia zaburzeń skóry |
| MX357938B (es) | 2011-06-19 | 2018-07-31 | Univ New York | Metodos para tratar y prevenir infecciones por staphylococcus aureus y afecciones asociadas. |
| EP2726599B1 (en) | 2011-06-30 | 2018-04-18 | ExxonMobil Research and Engineering Company | Regulation of toxin and antitoxin genes for biological containment |
| US20140219995A1 (en) | 2011-07-13 | 2014-08-07 | Microbiotix, Inc. | Inhibitors of bacterial type iii secretion system |
| CN102887952A (zh) | 2011-07-21 | 2013-01-23 | 广州瑞博奥生物科技有限公司 | 具有双重结合活性的抗MRSA-PBP 2a的单克隆抗体 |
| CN103998056B (zh) | 2011-07-22 | 2017-09-12 | 诺瓦蒂格姆疗法有限公司 | 用于接种抗金黄色葡萄球菌疫苗的方法和组合物 |
| WO2013050590A1 (en) * | 2011-10-07 | 2013-04-11 | Universite De Rennes 1 | Spra1 antimicrobial peptides and uses thereof |
| CN104105470A (zh) | 2012-02-14 | 2014-10-15 | 宝洁公司 | 皮肤共生益生元剂和包含其的组合物的局部使用 |
| EP2822582B1 (en) | 2012-03-05 | 2017-09-13 | University of Maryland, Baltimore | Multivalent vaccine protection from staphylococcus aureus infection |
| GB201206599D0 (en) | 2012-04-13 | 2012-05-30 | Univ Manchester | Probiotic bacteria |
| EP2841101B1 (en) | 2012-04-26 | 2019-08-07 | University Of Chicago | Compositions and methods related to antibodies that neutralize coagulase activity during staphylococcus aureus disease |
| EP3241902B1 (en) * | 2012-05-25 | 2018-02-28 | The Regents of The University of California | Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription |
| US8906668B2 (en) | 2012-11-23 | 2014-12-09 | Seres Health, Inc. | Synergistic bacterial compositions and methods of production and use thereof |
| WO2014107619A1 (en) | 2013-01-04 | 2014-07-10 | Second Genome, Inc. | Microbiome modulation index |
| CA2899925A1 (en) | 2013-02-04 | 2014-08-07 | Seres Therapeutics, Inc. | Compositions and methods for inhibition of pathogenic bacterial growth |
| US10660943B2 (en) | 2013-02-07 | 2020-05-26 | The Rockefeller University | Sequence specific antimicrobials |
| US10413577B2 (en) | 2013-02-22 | 2019-09-17 | The Regents Of The University Of California | Compositions and methods for promoting growth of beneficial microbes to treat or prevent disease or prolong life |
| US20140256582A1 (en) | 2013-03-05 | 2014-09-11 | Intelligent Medical Devices, Inc. | Optimized probes and primers and methods of using same for the detection, screening, isolation and sequencing of mrsa, mssa, staphylococcus markers, and the antibiotic resistance gene mec a |
| WO2014159287A1 (en) | 2013-03-14 | 2014-10-02 | Second Genome, Inc. | Microbial ecology shift assay |
| US9101597B2 (en) | 2013-03-14 | 2015-08-11 | The Administration Of The Tulane Educational Fund | Immunoprotective primary mesenchymal stem cells and methods |
| EP2967077A4 (en) | 2013-03-15 | 2016-09-14 | Seres Therapeutics Inc | NETWORK-BASED MICROBIAL COMPOSITIONS AND METHOD |
| US9511100B2 (en) | 2013-06-05 | 2016-12-06 | Rebiotix, Inc. | Microbiota restoration therapy (MRT), compositions and methods of manufacture |
| WO2014205127A2 (en) | 2013-06-18 | 2014-12-24 | New York University | Cellular factors involved in the cytotoxicity of staphylococcus aureus leukocidins: novel therapeutic targets |
| WO2015024855A1 (en) | 2013-08-19 | 2015-02-26 | Syngulon Sa | Controlled growth of microorganisms |
| US9834775B2 (en) | 2013-09-27 | 2017-12-05 | President And Fellows Of Harvard College | Recombinant cells and organisms having persistent nonstandard amino acid dependence and methods of making them |
| US10058576B2 (en) | 2013-10-03 | 2018-08-28 | The Trustees Of The University Of Pennsylvania | Compositions and methods comprising a defined microbiome and methods of use thereof |
| US10752906B2 (en) | 2013-11-05 | 2020-08-25 | President And Fellows Of Harvard College | Precise microbiota engineering at the cellular level |
| EP3074027B1 (en) | 2013-11-25 | 2024-12-18 | Seres Therapeutics, Inc. | Synergistic bacterial compositions and methods of production and use thereof |
| MX2016007533A (es) | 2013-12-09 | 2016-12-14 | Univ New York | Composiciones y metodos para el suministro fagocitico de agentes anti-estafilococicos. |
| WO2015106175A1 (en) | 2014-01-10 | 2015-07-16 | The Regents Of The University Of California | Skin probiotic |
| KR102607213B1 (ko) | 2014-04-15 | 2023-11-30 | 에이오바이오미 엘엘씨 | 암모니아-산화 니트로소모나스 유트로파 균주 d23 |
| US20170081707A1 (en) | 2014-05-06 | 2017-03-23 | Phylagen, Inc. | Monitoring and managing a facility microbiome |
| EP3139939B1 (en) | 2014-05-07 | 2023-09-06 | The Regents of The University of California | Compositions and methods for treating skin and mucous membrane diseases |
| US10702558B2 (en) | 2014-05-30 | 2020-07-07 | Azitra Inc | Therapeutic treatment of skin disease with recombinant commensal skin microorganisms |
| JP2017519035A (ja) | 2014-06-27 | 2017-07-13 | ケーン バイオテク インコーポレーテッド | 抗微生物性−抗バイオフィルム性組成物及び該組成物のパーソナルケア製品のための使用 |
| US9760676B2 (en) | 2014-10-21 | 2017-09-12 | uBiome, Inc. | Method and system for microbiome-derived diagnostics and therapeutics for endocrine system conditions |
| EP3212661A1 (en) * | 2014-10-31 | 2017-09-06 | INSERM - Institut National de la Santé et de la Recherche Médicale | Cyclic antimicrobial pseudopeptides and uses thereof |
| SG10201903823QA (en) | 2014-10-31 | 2019-05-30 | Whole Biome Inc | Methods and compositions relating to microbial treatment and diagnosis of disorders |
| US9688967B2 (en) | 2014-12-05 | 2017-06-27 | Synlogic, Inc. | Bacteria engineered to treat diseases associated with hyperammonemia |
| SG11201704543XA (en) * | 2014-12-05 | 2017-07-28 | Synlogic Inc | Bacteria engineered to treat diseases associated with hyperammonemia |
| US10610546B2 (en) | 2015-05-13 | 2020-04-07 | Synlogic Operating Company Inc. | Bacteria engineered to reduce hyperphenylalaninemia |
| US20160206666A1 (en) | 2014-12-22 | 2016-07-21 | Synlogic, Inc. | Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tighten gut mucosal barrier |
| EP3064072A1 (en) | 2015-02-11 | 2016-09-07 | AB-Biotics S.A. | Probiotic lactobacillus strains for use in treating urinary tract infections |
| BR112017018656B1 (pt) | 2015-03-02 | 2021-11-30 | Synlogic, Inc | Bactéria geneticamente modificada, composição farmaceuticamente aceitável compreendendo a dita bactéria e uso da dita composição para tratar ou prevenir uma doença ou condição associada à inflamação intestinal e/ou função da barreira intestinal comprometida |
| EP3285872A4 (en) | 2015-04-20 | 2019-02-20 | S-Biomedic NV | METHOD AND COMPOSITIONS FOR CHANGING THE COMPOSITION OF SKIN MICROBIOMA WITH COMPLEX MIXTURES OF BACTERIAL BARS |
| US11406671B2 (en) | 2015-04-24 | 2022-08-09 | The Translational Genomics Research Institute | Compositions and methods for augmenting the nasal microbiome |
| CN107667173A (zh) | 2015-05-06 | 2018-02-06 | 斯尼普技术有限公司 | 改变微生物种群和改善微生物群 |
| EP3294757B1 (en) | 2015-05-13 | 2023-12-27 | Synlogic Operating Company, Inc. | Bacteria engineered to treat a disease or disorder |
| AU2016274311A1 (en) | 2015-06-10 | 2018-01-18 | Synlogic Operating Company, Inc. | Bacteria engineered to treat diseases associated with hyperammonemia |
| CA3012607A1 (en) | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Crispr enzymes and systems |
| WO2016210373A2 (en) * | 2015-06-24 | 2016-12-29 | Synlogic, Inc. | Recombinant bacteria engineered for biosafety, pharmaceutical compositions, and methods of use thereof |
| WO2016210384A2 (en) | 2015-06-25 | 2016-12-29 | Synlogic, Inc. | Bacteria engineered to treat metabolic diseases |
| US20170058282A1 (en) * | 2015-07-09 | 2017-03-02 | Massachusetts Institute Of Technology | Genetically engineered sensors for in vivo detection of bleeding |
| EP3328988A1 (en) | 2015-07-31 | 2018-06-06 | Synlogic, Inc. | Bacteria engineered to treat disorders involving propionate catabolism |
| WO2017059245A2 (en) | 2015-09-30 | 2017-04-06 | Trustees Of Boston University | Deadman and passcode microbial kill switches |
| BR112018008358A2 (pt) | 2015-10-26 | 2019-04-24 | Crestovo Holdings Llc | ?composições e métodos para terapia relacionada à microbiota fecal? |
| WO2017091753A1 (en) | 2015-11-25 | 2017-06-01 | Memorial Sloan-Kettering Cancer Center | Methods and compositions for reducing vancomycin-resistant enterococci infection or colonization |
| RU2662310C9 (ru) | 2015-12-04 | 2018-09-21 | Виктор Вениаминович Тец | Средство (варианты) и способы восстановления микрофлоры |
| LT6463B (lt) | 2015-12-10 | 2017-10-10 | Uab "Probiosanus" | Probiotinių bakterijų (pb) gyvybingumo ir stabilumo padidinimas detergentų turinčiuose asmens higienos ir buities priežiūros produktuose |
| GB201522153D0 (en) | 2015-12-15 | 2016-01-27 | Univ Southampton | Meningococcal infection and modified neisseria lactamica |
| US11542466B2 (en) | 2015-12-22 | 2023-01-03 | North Carolina State University | Methods and compositions for delivery of CRISPR based antimicrobials |
| WO2017123676A1 (en) | 2016-01-11 | 2017-07-20 | Synlogic, Inc. | Recombinant bacteria engineered to treat diseases and disorders associated with amino acid metabolism and methods of use thereof |
| US10689644B2 (en) | 2016-03-17 | 2020-06-23 | Duke University | Systems and methods for genetic analysis of intractable microbes |
| WO2017184601A1 (en) | 2016-04-19 | 2017-10-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Use of gram negative species to treat atopic dermatitis |
| CN110545828A (zh) | 2016-04-19 | 2019-12-06 | 基因组研究有限公司 | 细菌疗法 |
| EP3448398A4 (en) | 2016-04-21 | 2019-12-18 | Naked Biome, Inc. | COMPOSITIONS AND METHODS FOR TREATING SKIN DISEASES |
| CN109803534A (zh) | 2016-06-01 | 2019-05-24 | 克雷斯顿沃控股公司 | 用于治疗炎性肠病(ibd)和其他疾病的组合物和方法 |
| WO2017220708A1 (en) | 2016-06-22 | 2017-12-28 | Prodigest Bvba | Microbial carotenoids affecting gut microbial composition |
| WO2018049556A1 (en) | 2016-09-13 | 2018-03-22 | The Procter & Gamble Company | Methods of increasing microbial diversity of a skin microbiota |
| EA201990599A1 (ru) | 2016-09-27 | 2019-10-31 | Способ и система для получения и секвенирования библиотеки на основе crispr | |
| US11571446B2 (en) | 2016-11-18 | 2023-02-07 | Sanford Bumham Prebys Medical Discovery Institute | Gut microbiota and treatment of cancer |
| US11674128B2 (en) | 2016-12-12 | 2023-06-13 | Tsinghua University | Engineering of a minimal SaCas9 CRISPR/Cas system for gene editing and transcriptional regulation optimized by enhanced guide RNA |
| WO2018112194A1 (en) | 2016-12-15 | 2018-06-21 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for modulating growth of a genetically modified gut bacterial cell |
| WO2018109018A1 (fr) | 2016-12-16 | 2018-06-21 | Nestle Skin Health Sa | Capsule comprenant un microorganisme probiotique pour utilisation dans un dispositif de production et de distribution de compositions |
| EP3358015A1 (en) | 2017-02-03 | 2018-08-08 | Eligo Bioscience | Optimized vector for delivery in microbial populations |
| US20200268813A1 (en) | 2017-02-15 | 2020-08-27 | President And Fellows Of Harvard College | Modulation of host immune cell populations using gut microbiota |
| US20180250222A1 (en) | 2017-02-27 | 2018-09-06 | Continuum Group Llc | Sunscreen |
| WO2018182515A1 (en) | 2017-03-27 | 2018-10-04 | Agency For Science, Technology And Research | Methods of modifying fungi and uses thereof |
| JP2020516318A (ja) | 2017-04-17 | 2020-06-11 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 操作された共生細菌及び使用方法 |
-
2018
- 2018-12-04 JP JP2020550034A patent/JP7460531B2/ja active Active
- 2018-12-04 CN CN202510007125.5A patent/CN119875972A/zh active Pending
- 2018-12-04 US US16/209,706 patent/US12163135B2/en active Active
- 2018-12-04 EP EP18886851.7A patent/EP3720458A4/en active Pending
- 2018-12-04 AU AU2018379996A patent/AU2018379996A1/en not_active Abandoned
- 2018-12-04 CN CN201880088486.5A patent/CN111918960B/zh active Active
- 2018-12-04 MX MX2020005875A patent/MX2020005875A/es unknown
- 2018-12-04 CA CA3084954A patent/CA3084954A1/en active Pending
- 2018-12-04 WO PCT/US2018/063880 patent/WO2019113096A1/en not_active Ceased
-
2020
- 2020-06-05 PH PH12020550941A patent/PH12020550941A1/en unknown
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2024
- 2024-03-21 JP JP2024044541A patent/JP2024075688A/ja active Pending
- 2024-12-09 US US18/973,546 patent/US20250346910A1/en active Pending
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2025
- 2025-09-18 AU AU2025234199A patent/AU2025234199A1/en active Pending
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