JP2021192835A5 - - Google Patents
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- JP2021192835A5 JP2021192835A5 JP2021150228A JP2021150228A JP2021192835A5 JP 2021192835 A5 JP2021192835 A5 JP 2021192835A5 JP 2021150228 A JP2021150228 A JP 2021150228A JP 2021150228 A JP2021150228 A JP 2021150228A JP 2021192835 A5 JP2021192835 A5 JP 2021192835A5
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025064456A JP2025106473A (ja) | 2018-08-23 | 2025-04-09 | 血液脳関門の透過性を向上させるための交流電界の使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862722100P | 2018-08-23 | 2018-08-23 | |
| US62/722,100 | 2018-08-23 | ||
| JP2020573539A JP6974671B2 (ja) | 2018-08-23 | 2019-08-22 | 血液脳関門の透過性を向上させるための交流電界の使用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020573539A Division JP6974671B2 (ja) | 2018-08-23 | 2019-08-22 | 血液脳関門の透過性を向上させるための交流電界の使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025064456A Division JP2025106473A (ja) | 2018-08-23 | 2025-04-09 | 血液脳関門の透過性を向上させるための交流電界の使用 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021192835A JP2021192835A (ja) | 2021-12-23 |
| JP2021192835A5 true JP2021192835A5 (https=) | 2022-08-30 |
| JP7667045B2 JP7667045B2 (ja) | 2025-04-22 |
| JP7667045B6 JP7667045B6 (ja) | 2025-06-05 |
Family
ID=68104708
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020573539A Active JP6974671B2 (ja) | 2018-08-23 | 2019-08-22 | 血液脳関門の透過性を向上させるための交流電界の使用 |
| JP2021007072A Active JP7233453B2 (ja) | 2018-08-23 | 2021-01-20 | 血液脳関門の透過性を向上させるための交流電界の使用 |
| JP2021150228A Active JP7667045B6 (ja) | 2018-08-23 | 2021-09-15 | 血液脳関門の透過性を向上させるための交流電界の使用 |
| JP2025064456A Pending JP2025106473A (ja) | 2018-08-23 | 2025-04-09 | 血液脳関門の透過性を向上させるための交流電界の使用 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020573539A Active JP6974671B2 (ja) | 2018-08-23 | 2019-08-22 | 血液脳関門の透過性を向上させるための交流電界の使用 |
| JP2021007072A Active JP7233453B2 (ja) | 2018-08-23 | 2021-01-20 | 血液脳関門の透過性を向上させるための交流電界の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025064456A Pending JP2025106473A (ja) | 2018-08-23 | 2025-04-09 | 血液脳関門の透過性を向上させるための交流電界の使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US11351349B2 (https=) |
| EP (6) | EP4609908A3 (https=) |
| JP (4) | JP6974671B2 (https=) |
| KR (3) | KR20250069692A (https=) |
| CN (6) | CN112469352B (https=) |
| AU (2) | AU2019324585C1 (https=) |
| BR (1) | BR112020025422A2 (https=) |
| CA (2) | CA3242209A1 (https=) |
| DK (4) | DK3892219T3 (https=) |
| ES (4) | ES2922576T3 (https=) |
| FI (1) | FI3878389T3 (https=) |
| HU (4) | HUE058160T2 (https=) |
| IL (2) | IL279466B2 (https=) |
| MX (5) | MX2020013519A (https=) |
| PL (4) | PL3878389T3 (https=) |
| SG (1) | SG11202012592WA (https=) |
| WO (1) | WO2020039390A1 (https=) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10779875B2 (en) | 2013-05-06 | 2020-09-22 | Novocure Gmbh | Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment |
| US10188851B2 (en) | 2015-10-28 | 2019-01-29 | Novocure Limited | TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements |
| US10821283B2 (en) | 2016-04-04 | 2020-11-03 | Novocure Gmbh | Reducing motility of cancer cells using tumor treating fields (TTFields) |
| JP6980706B2 (ja) | 2016-06-30 | 2021-12-15 | ノボキュア ゲーエムベーハー | 身体への腫瘍治療電場の長手方向伝達用のアレイ |
| EP3571503B1 (en) | 2017-01-19 | 2026-04-15 | Novocure GmbH | System for viewing cell cultures under a microscope whilst applying ttfields |
| CN114082099A (zh) * | 2018-07-03 | 2022-02-25 | 埃德温·阊 | 使用交变电场提高细胞膜通透性 |
| CA3103070C (en) | 2018-07-10 | 2024-01-09 | Novocure Gmbh | Inhibiting viral infection using alternating electric fields |
| JP6974671B2 (ja) * | 2018-08-23 | 2021-12-01 | ノボキュア ゲーエムベーハー | 血液脳関門の透過性を向上させるための交流電界の使用 |
| US11986647B2 (en) | 2018-09-07 | 2024-05-21 | Novocure Gmbh | Treating autoinflammatory and mitochondrial diseases using an alternating electric field |
| WO2020049482A1 (en) | 2018-09-07 | 2020-03-12 | Yaniv Alon | Treating autoimmune diseases using an alternating electric field to reduce the proliferation of t-cells |
| CN112930209B (zh) | 2018-10-15 | 2024-10-15 | 诺沃库勒有限责任公司 | 生成遍及大脑具有高均匀性的肿瘤治疗场(ttfields)的装置和方法 |
| JP7148722B2 (ja) | 2018-10-25 | 2022-10-05 | ゼーヴ・ボンゾン | 被験者の脊椎構造体に対する交番電界（例えばＴＴＦｉｅｌｄ）の送達 |
| WO2020104921A1 (en) | 2018-11-19 | 2020-05-28 | Novocure Gmbh | Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elements |
| CN113164745B (zh) | 2018-11-29 | 2024-04-26 | 诺沃库勒有限责任公司 | 用于递送TTField（肿瘤治疗场）的增强灵活性换能器阵列 |
| JP7246486B2 (ja) | 2019-01-08 | 2023-03-27 | ノボキュア ゲーエムベーハー | 腫瘍治療電場（ｔｔｆｉｅｌｄｓ）を使用した治療を計画するための異なるタイプの組織への画像のセグメンテーションの品質評価 |
| CN113573774B (zh) | 2019-02-26 | 2026-03-06 | 诺沃库勒有限责任公司 | 基于靶向癌细胞的电特性确定TTfield治疗的频率 |
| JP2022522936A (ja) | 2019-02-27 | 2022-04-21 | ノボキュア ゲーエムベーハー | 埋込可能な変換器アレイを使用した腫瘍治療電場（ｔｔｆｉｅｌｄｓ）の送達 |
| EP3988099B1 (en) | 2019-03-29 | 2023-06-07 | Novocure GmbH | Methods for restoring sensitivity to ttfields in ttfields-resistant cancer cells with ptger3 inhibitors |
| US11291837B2 (en) | 2019-04-17 | 2022-04-05 | Novocure Gmbh | Uploading data from an isolated system without compromising isolation |
| JP7472264B2 (ja) | 2019-07-31 | 2024-04-22 | ノボキュア ゲーエムベーハー | 頭蓋骨インプラントに埋め込まれた電極による腫瘍治療電場（ｔｔフィールド）の印加 |
| US12343336B2 (en) | 2019-08-05 | 2025-07-01 | Novocure Gmbh | Increasing cancer cells' sensitivity to tumor treating fields (TTFields) by inhibiting IL11 activity |
| JP2022545794A (ja) | 2019-08-30 | 2022-10-31 | ノボキュア ゲーエムベーハー | 頸部への腫瘍治療電界（ＴＴＦｉｅｌｄｓ）の印加 |
| EP4028052A1 (en) | 2019-09-10 | 2022-07-20 | Novocure GmbH | A method of reducing viability of cancer cells by applying alternating electric fields and administering checkpoint inhibitors to the cancer cells |
| JP7670721B6 (ja) | 2019-12-31 | 2025-06-06 | ノボキュア ゲーエムベーハー | 振幅調整およびチャネルの切り替え中のスパイクを防止する高電圧、高効率正弦波発生器 |
| MX2022006136A (es) | 2019-12-31 | 2022-06-17 | Novocure Gmbh | Matrices para suministrar campos de tratamiento de tumores (ttfields) con elementos de electrodos y sensores de temperatura accesibles individualmente. |
| US12121739B2 (en) | 2019-12-31 | 2024-10-22 | Novocure Gmbh | Methods, systems, and apparatuses for managing temperatures induced by alternating fields |
| WO2021198864A1 (en) | 2020-03-30 | 2021-10-07 | Novocure Gmbh | Intravenous / intra-spinal / intra-cavity / intraventricular delivery of ttfields (tumor treating fields) for treating cancer and metastases |
| MX2022010015A (es) * | 2020-04-24 | 2022-09-05 | Novocure Gmbh | Uso de campos electricos alternos para aumentar la permeabilidad de la barrera hematoencefalica. |
| US11818943B2 (en) | 2020-06-25 | 2023-11-14 | Novocure Gmbh | Fabricating organic light emitting diodes (OLEDs) using tubulin |
| WO2022064339A1 (en) | 2020-09-25 | 2022-03-31 | Novocure Gmbh | Varying the metallization area on individual electrode elements in a tumor treating fields (ttfields) system to maximize current without overheating |
| EP4251261A1 (en) | 2020-11-25 | 2023-10-04 | Novocure Gmbh | Increasing the efficacy of tumor treating fields (ttfields) by applying the ttfields at peak intensity less than half the time |
| WO2022130183A2 (en) * | 2020-12-17 | 2022-06-23 | Novocure Gmbh | Pyroelectric-based temperature sensing of transducer arrays for applying tumor treating fields (ttfields) |
| CN113008403B (zh) * | 2021-02-08 | 2022-08-12 | 清华大学 | 电场发生装置及测温电极装置 |
| US12397151B2 (en) | 2021-02-17 | 2025-08-26 | Novocure Gmbh | Arrays for delivering tumor treating fields (TTFields) with sets of electrode elements having individually adjustable active areas |
| JP2024509964A (ja) | 2021-03-12 | 2024-03-05 | ノボキュア ゲーエムベーハー | 交流電界を用いてマクロファージの表現型をスキューイングすることによる、疾患を処置する方法 |
| JP2024513854A (ja) | 2021-03-31 | 2024-03-27 | ノボキュア ゲーエムベーハー | 腫瘍治療電場（ＴＴＦｉｅｌｄｓ）システムの電極を使用したインピーダンス断層撮影法 |
| US20220323753A1 (en) * | 2021-04-08 | 2022-10-13 | Novocure Gmbh | Methods of Treating Neurodegenerative Disorders with Alternating Electric Fields |
| CN113509641A (zh) * | 2021-06-29 | 2021-10-19 | 北京康源嘉成生物科技有限公司 | 一种非药物且非侵入性开放血脑屏障的装置和方法 |
| US20230009366A1 (en) * | 2021-06-30 | 2023-01-12 | Novocure Gmbh | Using Alternating Electric Fields at Different Frequencies to Increase Permeability of the Blood Brain Barrier and also to Provide Other Benefits |
| KR20240027008A (ko) | 2021-06-30 | 2024-02-29 | 노보큐어 게엠베하 | 종양 치료 필드(ttfield)를 인가하기 위한 트랜스듀서 어레이에서 전류를 제한하기 위한 커패시터의 사용 |
| TW202322866A (zh) * | 2021-09-30 | 2023-06-16 | 瑞士商諾沃庫勒有限責任公司 | 使用交流電場治療患者時減少電感覺 |
| US12599765B2 (en) | 2021-12-14 | 2026-04-14 | Novocure Gmbh | Shifting of transducer array to reduce skin irritation |
| CN121371475A (zh) * | 2021-12-22 | 2026-01-23 | 江苏海莱新创医疗科技有限公司 | 胶质瘤治疗系统 |
| WO2023126842A1 (en) | 2021-12-29 | 2023-07-06 | Novocure Gmbh | Apparatus for reducing electrosensation using alternating electric fields with larger cathodes and smaller anodes |
| JP2024545019A (ja) | 2021-12-30 | 2024-12-05 | ノボキュア ゲーエムベーハー | 腫瘍治療フィールド（ｔｔｆｉｅｌｄ）を使用した治療のためのパラメータ値の選択 |
| CN114367060A (zh) * | 2022-01-13 | 2022-04-19 | 深圳大学 | 激光交变电场联合治疗仪 |
| IL314392A (en) | 2022-03-30 | 2024-09-01 | Novocure Gmbh | Reducing electrosensation whilst treating a subject using alternating electric fields by pairing transducer arrays together |
| CA3255022A1 (en) | 2022-03-30 | 2023-10-05 | Novocure Gmbh | USE OF INTERLACED COOLING PERIODS TO INCREASE THE MAXIMUM INTENSITY OF TUMOR TREATMENT FIELDS |
| WO2023242741A1 (en) | 2022-06-13 | 2023-12-21 | Novocure Gmbh | Systems and methods for increasing intestinal absorption of therapeutic agents |
| EP4514450A1 (en) | 2022-06-27 | 2025-03-05 | Novocure GmbH | Using a closed-loop technique to reduce electrosensation while treating a subject using alternating electric fields |
| US20240001111A1 (en) | 2022-06-30 | 2024-01-04 | Novocure Gmbh | Electrode Assembly for Applying Tumor Treating Fields (TTFields) that Includes a Plurality of Thermally Linked but Electrically Isolated Graphite Sheets |
| KR102637878B1 (ko) * | 2022-09-02 | 2024-02-19 | 주식회사 뉴로스피어 | 대뇌병변 산화철의 전자-펜톤효과를 이용한 전기장 대뇌자극치료기기 |
| JP2025532790A (ja) | 2022-09-30 | 2025-10-03 | ノボキュア ゲーエムベーハー | 電気感覚および／または皮膚刺激を軽減するための組成物、システム、および方法 |
| TW202430241A (zh) | 2022-09-30 | 2024-08-01 | 瑞士商諾沃庫勒有限責任公司 | 在使用交流電場治療受試者時藉由控制上升特性來降低電知覺 |
| US20240108892A1 (en) | 2022-09-30 | 2024-04-04 | Novocure Gmbh | Changing the Orientation of Tumor Treating Fields (TTFields) by Adjusting the Amplitudes of Two or More Electric Fields that Are All In-Phase with Each Other |
| EP4561680A1 (en) | 2022-09-30 | 2025-06-04 | Novocure Gmbh | Reducing electrosensation while treating a subject using alternating electric fields by deactivating selected electrode elements |
| EP4590389A1 (en) | 2022-12-27 | 2025-07-30 | Novocure GmbH | Multi-channel device for directional shaping of electric fields e.g., tumor treating fields (ttfields) |
| CN120417965A (zh) | 2022-12-28 | 2025-08-01 | 诺沃库勒有限责任公司 | 将电极元件定位在受试者身体上以提供更强的交变电场（例如，TTFields）而不会过热 |
| EP4642519A1 (en) | 2022-12-29 | 2025-11-05 | Novocure GmbH | Reducing electrosensation during application of alternating electric fields by ensuring that successive increases in amplitude occur during opposite phases of an ac waveform |
| TW202428320A (zh) | 2022-12-29 | 2024-07-16 | 瑞士商諾沃庫勒有限責任公司 | 透過增加波形的斜坡上升部分的步階數量減少使用交流電場治療受試者時的電感覺 |
| US12268863B2 (en) | 2023-02-06 | 2025-04-08 | Novocure Gmbh | Shiftable transducer array with anisotropic material layer |
| CN120659643A (zh) | 2023-02-10 | 2025-09-16 | 诺沃库勒有限责任公司 | 将各组电极阵列按顺序定位于非重叠位置处以减轻肿瘤治疗电场（TTFields）疗法期间的皮肤刺激 |
| JP2026511465A (ja) | 2023-03-31 | 2026-04-14 | ノボキュア ゲーエムベーハー | 電場の振幅を徐々に増加させることによる、回転交流電場を使用して被験者を治療するときの電気感覚の低減 |
| WO2024201412A1 (en) | 2023-03-31 | 2024-10-03 | Novocure Gmbh | Microneedles to overcome contact resistance |
| CN121925295A (zh) | 2023-09-29 | 2026-04-24 | 诺沃库勒有限责任公司 | 使用振幅和频率的交错变化来改善用交变电场进行治疗期间的电感觉 |
| CN121925288A (zh) | 2023-09-29 | 2026-04-24 | 诺沃库勒有限责任公司 | 使用专用柔性电路来实现温度感测的用于肿瘤治疗电场（TTField）疗法的换能器阵列 |
| CN121925289A (zh) | 2023-09-29 | 2026-04-24 | 诺沃库勒有限责任公司 | 用于使用多部分电极组件施加电信号的装置 |
| CN121401600A (zh) * | 2023-12-26 | 2026-01-27 | 江苏海莱新创医疗科技有限公司 | 转接器、肿瘤电场治疗系统、电极片质量检测系统及电极片质量检测方法 |
| US20250213849A1 (en) | 2023-12-29 | 2025-07-03 | Novocure Gmbh | Electrode Assembly for Delivering Alternating Electric Fields (e.g., TTFields) with Peripherally-Positioned Temperature Sensors |
Family Cites Families (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2536459T3 (es) * | 1995-08-29 | 2015-05-25 | Nitto Denko Corporation | Microporación de piel humana para administración de fármacos y aplicaciones de supervisión |
| EP0869829A1 (en) * | 1995-11-21 | 1998-10-14 | LERNER, Eduard Naumovich | Device for enhanced delivery of biologically active substances and compounds in an organism |
| CN1206353A (zh) * | 1995-11-21 | 1999-01-27 | E·N·勒纳 | 提高有机体内生物活性物质和化合物释放的装置 |
| US6678553B2 (en) * | 1995-11-21 | 2004-01-13 | Intraabrain International Nv | Device for enhanced delivery of biologically active substances and compounds in an organism |
| WO1997018855A1 (en) * | 1995-11-21 | 1997-05-29 | Eduard Naumovich Lerner | Device for enhanced delivery of biologically active substances and compounds in an organism |
| US6678558B1 (en) | 1999-03-25 | 2004-01-13 | Genetronics, Inc. | Method and apparatus for reducing electroporation-mediated muscle reaction and pain response |
| US20030078499A1 (en) | 1999-08-12 | 2003-04-24 | Eppstein Jonathan A. | Microporation of tissue for delivery of bioactive agents |
| US7089054B2 (en) | 2002-10-02 | 2006-08-08 | Standen Ltd. | Apparatus and method for treating a tumor or the like |
| US8447395B2 (en) | 2000-02-17 | 2013-05-21 | Novocure Ltd | Treating bacteria with electric fields |
| US8175698B2 (en) | 2000-02-17 | 2012-05-08 | Novocure Ltd. | Treating bacteria with electric fields |
| US7805201B2 (en) | 2000-02-17 | 2010-09-28 | Standen Ltd. | Treating a tumor or the like with an electric field |
| US7016725B2 (en) | 2001-11-06 | 2006-03-21 | Standen Ltd. | Method and apparatus for destroying dividing cells |
| CN1416466A (zh) | 2000-02-17 | 2003-05-07 | 约朗姆·帕尔蒂 | 破坏正在分裂的细胞的方法和装置 |
| US7136699B2 (en) | 2002-10-02 | 2006-11-14 | Standen, Ltd. | Apparatus for destroying dividing cells |
| US7599746B2 (en) * | 2000-02-17 | 2009-10-06 | Standen Ltd | Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases |
| US7146210B2 (en) | 2000-02-17 | 2006-12-05 | Standen Ltd. | Apparatus and method for optimizing tumor treatment efficiency by electric fields |
| US6868289B2 (en) | 2002-10-02 | 2005-03-15 | Standen Ltd. | Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor |
| US6546290B1 (en) | 2000-04-12 | 2003-04-08 | Roamitron Holding S.A. | Method and apparatus for electromedical therapy |
| US6853858B2 (en) * | 2000-05-08 | 2005-02-08 | Brainsgate, Ltd. | Administration of anti-inflammatory drugs into the central nervous system |
| JP4311904B2 (ja) * | 2000-05-08 | 2009-08-12 | ブレインスゲート リミテッド | 血液脳関門及び脳血流の性質を改善するための翼口蓋神経節の刺激方法及び装置 |
| US7332313B2 (en) | 2001-06-05 | 2008-02-19 | Applied Biophysics, Inc. | Electrical wounding assay for cells in vitro |
| US6904322B2 (en) | 2002-02-15 | 2005-06-07 | Kalaco Scientific, Inc. | Transcranial electrostimulation apparatus and method |
| US20030171738A1 (en) | 2002-03-06 | 2003-09-11 | Konieczynski David D. | Convection-enhanced drug delivery device and method of use |
| AU2003299471A1 (en) | 2002-05-07 | 2004-05-13 | Kai Kroll | Method and device for treating concer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy |
| JP4995423B2 (ja) * | 2002-12-03 | 2012-08-08 | ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート | 物質を血液−脳関門を渡って輸送するための人工低密度リポタンパク質キャリア |
| US10912712B2 (en) | 2004-03-25 | 2021-02-09 | The Feinstein Institutes For Medical Research | Treatment of bleeding by non-invasive stimulation |
| DE602005020504D1 (de) * | 2004-12-07 | 2010-05-20 | Standen Ltd | Vivo über einen längeren zeitraum |
| CA2594231C (en) | 2004-12-27 | 2016-04-19 | Standen Ltd. | Treating a tumor or the like with electric fields at different orientations |
| US8788044B2 (en) | 2005-01-21 | 2014-07-22 | Michael Sasha John | Systems and methods for tissue stimulation in medical treatment |
| US20100049117A1 (en) | 2005-04-18 | 2010-02-25 | Pantec Biosolutions Ag | Microporator for Porating a Biological Membrane and Integrated Permeant Administering System |
| EP1937151A4 (en) * | 2005-09-19 | 2011-07-06 | Univ Columbia | Systems and methods for opening of the blood-brain barrier of a subject using ultrasound |
| CN101321555B (zh) * | 2005-10-03 | 2020-12-08 | 诺沃库勒有限责任公司 | 优化电场特征以增加电场在增殖细胞上的效果 |
| US8019414B2 (en) | 2006-04-05 | 2011-09-13 | Novocure Ltd. | Treating cancer using electromagnetic fields in combination with other treatment regimens |
| CN100515522C (zh) * | 2006-09-18 | 2009-07-22 | 郭国祯 | 促进药物透过血脑屏障的电磁脉冲辐照系统和方法 |
| CN102008782B (zh) * | 2006-11-08 | 2014-11-26 | 株式会社P·曼德 | 神经营养因子产生促进装置 |
| DK2167194T3 (en) | 2007-03-06 | 2017-06-19 | Novocure Ltd | TREATMENT OF CANCER USING ELECTROMAGNETIC FIELDS IN COMBINATION WITH PHOTODYNAMIC THERAPY |
| EP2183024B1 (en) * | 2007-08-14 | 2019-05-15 | Novocure Ltd. | Treating parasites with electric fields |
| US8715203B2 (en) | 2007-09-17 | 2014-05-06 | Novocure Limited | Composite electrode |
| WO2009047365A1 (en) * | 2007-10-12 | 2009-04-16 | Capsulution Nanoscience Ag | Drug delivery system |
| DE102008018170B4 (de) | 2008-04-03 | 2010-05-12 | NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen | Mikrofluidisches System und Verfahren zum Aufbau und zur anschließenden Kultivierung sowie nachfolgender Untersuchung von komplexen Zellanordnungen |
| US9198733B2 (en) | 2008-04-29 | 2015-12-01 | Virginia Tech Intellectual Properties, Inc. | Treatment planning for electroporation-based therapies |
| US10245098B2 (en) | 2008-04-29 | 2019-04-02 | Virginia Tech Intellectual Properties, Inc. | Acute blood-brain barrier disruption using electrical energy based therapy |
| CN201205406Y (zh) * | 2008-05-06 | 2009-03-11 | 迟立广 | 中频交变电场理疗装置 |
| CN101318054B (zh) * | 2008-07-18 | 2012-01-25 | 圣太科医疗科技（上海）有限公司 | 微电场网引导的肝脏靶向性细胞内药物传递装置 |
| EP2153866A1 (en) * | 2008-08-14 | 2010-02-17 | Oncotherm Kft. | Portable radiofrequency hyperthermia device with flexible treatment electrode for electric field capacitive coupled energy transfer |
| WO2010118387A1 (en) | 2009-04-09 | 2010-10-14 | Virginia Tech Intellectual Properties, Inc. | Integration of very short electric pulses for minimally to noninvasive electroporation |
| WO2011025775A1 (en) | 2009-08-24 | 2011-03-03 | Alterman Ron L | Apparatus for trans-cerebral electrophoresis and methods of use thereof |
| CN101698121B (zh) * | 2009-10-23 | 2011-06-22 | 西安交通大学 | 促进药物透过血脑屏障的适型超声系统 |
| CN102100945A (zh) * | 2009-12-18 | 2011-06-22 | 重庆新大地电子有限公司 | 生物负电子保健治疗仪设备系统 |
| GB2479598B (en) * | 2010-04-16 | 2012-11-21 | Cancercure Technology As | Methods and systems for inducing hyperthermia |
| US20120310140A1 (en) | 2010-12-01 | 2012-12-06 | Spinal Modulation, Inc. | Directed delivery of agents to neural anatomy |
| CN202096600U (zh) * | 2011-04-09 | 2012-01-04 | 南宁市中新森泰科技有限公司 | 一种电位治疗仪 |
| CN102284132A (zh) * | 2011-06-30 | 2011-12-21 | 杭州电子科技大学 | 基于多针形电极的高压脉冲电场治疗装置 |
| US20150126964A1 (en) * | 2012-05-13 | 2015-05-07 | Corporation De L'ecole Polytechnique De Montreal | Drug delivery across the blood-brain barrier using magnetically heatable entities |
| US20120323214A1 (en) | 2012-05-16 | 2012-12-20 | Totada R Shantha | Alzheimer's disease treatment with multiple therapeutic agents delivered to the olfactory region through a special delivery catheter and iontophoresis |
| CN102836119A (zh) * | 2012-08-21 | 2012-12-26 | 中国人民解放军第三军医大学第二附属医院 | 微泡在制备用于联合诊断级超声作为提高肿瘤微血管通透性药物的用途 |
| ES2898374T3 (es) * | 2012-09-06 | 2022-03-07 | Covidien Lp | Sistema de tratamiento neurológico |
| WO2014066655A2 (en) * | 2012-10-25 | 2014-05-01 | Oncosec Medical Incorporation | Electroporation device |
| US9682066B2 (en) | 2012-12-04 | 2017-06-20 | University Of Cincinnati | Methods of treating primary brain tumors by administering letrozole |
| US9655669B2 (en) | 2013-05-06 | 2017-05-23 | Novocure Limited | Optimizing treatment using TTFields by changing the frequency during the course of long term tumor treatment |
| US10779875B2 (en) | 2013-05-06 | 2020-09-22 | Novocure Gmbh | Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment |
| US10556121B2 (en) * | 2015-02-20 | 2020-02-11 | Endonovo Therapeutics, Inc. | Method and apparatus for electromagnetic treatment of multiple sclerosis |
| HK1254629A1 (zh) | 2015-04-10 | 2019-07-26 | 安吉戴尼克公司 | 使用热控电极进行不可逆电穿孔的系统和方法 |
| EP3307378B1 (en) | 2015-05-14 | 2024-06-26 | London Health Sciences Centre Research Inc. | Intratumoral modulation therapy |
| CN106333926A (zh) * | 2015-07-10 | 2017-01-18 | 复旦大学 | 一种稳定性多肽介导跨屏障膜的脑部肿瘤多重靶向递药系统 |
| US9910453B2 (en) | 2015-09-25 | 2018-03-06 | Novocure Limited | High voltage, high efficiency sine wave generator with pre-set frequency and adjustable amplitude |
| US10188851B2 (en) | 2015-10-28 | 2019-01-29 | Novocure Limited | TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements |
| US10821283B2 (en) * | 2016-04-04 | 2020-11-03 | Novocure Gmbh | Reducing motility of cancer cells using tumor treating fields (TTFields) |
| JP6980706B2 (ja) | 2016-06-30 | 2021-12-15 | ノボキュア ゲーエムベーハー | 身体への腫瘍治療電場の長手方向伝達用のアレイ |
| US20180008708A1 (en) * | 2016-07-10 | 2018-01-11 | Novocure Limited | Synchronizing Tumor Cells to the G2/M Phase Using TTFields Combined with Taxane or Other Anti-Microtubule Agents |
| ES2959582T3 (es) | 2016-08-18 | 2024-02-27 | Novocure Gmbh | Medición de temperatura en diversos conjuntos para aplicar campos de tratamiento de tumores |
| WO2018109691A2 (en) | 2016-12-13 | 2018-06-21 | Zeev Bomzon | Treating patients with ttfields with the electrode positions optimized using deformable templates |
| EP3571503B1 (en) | 2017-01-19 | 2026-04-15 | Novocure GmbH | System for viewing cell cultures under a microscope whilst applying ttfields |
| CN207462466U (zh) * | 2017-02-08 | 2018-06-08 | 中国人民解放军总医院 | 一种脑部电磁理疗设备 |
| WO2019175871A1 (en) * | 2018-03-12 | 2019-09-19 | Tel Hashomer Medical Research, Infrastructure And Services Ltd. | Method for changing brain barrier permeability |
| US10953209B2 (en) | 2018-03-28 | 2021-03-23 | Board Of Regents Of The University Of Texas System | Treating tumors using TTFields combined with a PARP inhibitor |
| JP7139448B2 (ja) | 2018-04-09 | 2022-09-20 | ノボキュア ゲーエムベーハー | ＴＴＦｉｅｌｄｓ及びオーロラキナーゼ阻害剤による腫瘍の治療 |
| PL3775956T3 (pl) | 2018-04-10 | 2022-10-10 | Novocure Gmbh | Szacunki przewodności ac o niskiej częstotliwości (< 1 mhz) pozyskane z dwóch obrazów mri o różnych czasach repetycji |
| CN114082099A (zh) | 2018-07-03 | 2022-02-25 | 埃德温·阊 | 使用交变电场提高细胞膜通透性 |
| CA3103070C (en) | 2018-07-10 | 2024-01-09 | Novocure Gmbh | Inhibiting viral infection using alternating electric fields |
| JP6974671B2 (ja) * | 2018-08-23 | 2021-12-01 | ノボキュア ゲーエムベーハー | 血液脳関門の透過性を向上させるための交流電界の使用 |
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