HUE058160T2 - Váltakozó elektromos mezõk alkalmazása a vér-agy gát permeabilitásának növelésére - Google Patents

Váltakozó elektromos mezõk alkalmazása a vér-agy gát permeabilitásának növelésére

Info

Publication number
HUE058160T2
HUE058160T2 HUE20212126A HUE20212126A HUE058160T2 HU E058160 T2 HUE058160 T2 HU E058160T2 HU E20212126 A HUE20212126 A HU E20212126A HU E20212126 A HUE20212126 A HU E20212126A HU E058160 T2 HUE058160 T2 HU E058160T2
Authority
HU
Hungary
Prior art keywords
permeability
blood
increase
application
electric fields
Prior art date
Application number
HUE20212126A
Other languages
English (en)
Hungarian (hu)
Inventor
Carsten Hagemann
Mario Lohr
Almuth F Kessler
Malgorzata Burek
Carola Forster
Catherine BRAMI
Hadas Sara Hershkovich
Tali VOLOSHIN-SELA
Original Assignee
Novocure Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novocure Gmbh filed Critical Novocure Gmbh
Publication of HUE058160T2 publication Critical patent/HUE058160T2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/37211—Means for communicating with stimulators
    • A61N1/37217—Means for communicating with stimulators characterised by the communication link, e.g. acoustic or tactile
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36002—Cancer treatment, e.g. tumour
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36017—External stimulators, e.g. with patch electrodes with leads or electrodes penetrating the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36025—External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/0007—Special media to be introduced, removed or treated introduced into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/05—General characteristics of the apparatus combined with other kinds of therapy
    • A61M2205/054—General characteristics of the apparatus combined with other kinds of therapy with electrotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0693—Brain, cerebrum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2250/00—Specially adapted for animals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hospice & Palliative Care (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Medical Informatics (AREA)
  • Oncology (AREA)
  • Psychology (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Developmental Disabilities (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biotechnology (AREA)
  • Psychiatry (AREA)
HUE20212126A 2018-08-23 2019-08-22 Váltakozó elektromos mezõk alkalmazása a vér-agy gát permeabilitásának növelésére HUE058160T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862722100P 2018-08-23 2018-08-23

Publications (1)

Publication Number Publication Date
HUE058160T2 true HUE058160T2 (hu) 2022-07-28

Family

ID=68104708

Family Applications (4)

Application Number Title Priority Date Filing Date
HUE20212126A HUE058160T2 (hu) 2018-08-23 2019-08-22 Váltakozó elektromos mezõk alkalmazása a vér-agy gát permeabilitásának növelésére
HUE21170598A HUE059062T2 (hu) 2018-08-23 2019-08-22 Váltakozó elektromos mezõk alkalmazása vér-agy gát permeabilitásának növelésére
HUE19780002A HUE056950T2 (hu) 2018-08-23 2019-08-22 Váltakozó elektromos mezõk alkalmazása a vér-agy gát permeabilitásának növelésére
HUE21170656A HUE073324T2 (hu) 2018-08-23 2019-08-22 Váltakozó elektromos mezõk használata a vér-agy gát permeabilitásának növelésére

Family Applications After (3)

Application Number Title Priority Date Filing Date
HUE21170598A HUE059062T2 (hu) 2018-08-23 2019-08-22 Váltakozó elektromos mezõk alkalmazása vér-agy gát permeabilitásának növelésére
HUE19780002A HUE056950T2 (hu) 2018-08-23 2019-08-22 Váltakozó elektromos mezõk alkalmazása a vér-agy gát permeabilitásának növelésére
HUE21170656A HUE073324T2 (hu) 2018-08-23 2019-08-22 Váltakozó elektromos mezõk használata a vér-agy gát permeabilitásának növelésére

Country Status (17)

Country Link
US (5) US11351349B2 (https=)
EP (6) EP4609908A3 (https=)
JP (4) JP6974671B2 (https=)
KR (3) KR20250069692A (https=)
CN (6) CN112469352B (https=)
AU (2) AU2019324585C1 (https=)
BR (1) BR112020025422A2 (https=)
CA (2) CA3242209A1 (https=)
DK (4) DK3892219T3 (https=)
ES (4) ES2922576T3 (https=)
FI (1) FI3878389T3 (https=)
HU (4) HUE058160T2 (https=)
IL (2) IL279466B2 (https=)
MX (5) MX2020013519A (https=)
PL (4) PL3878389T3 (https=)
SG (1) SG11202012592WA (https=)
WO (1) WO2020039390A1 (https=)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10779875B2 (en) 2013-05-06 2020-09-22 Novocure Gmbh Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment
US10188851B2 (en) 2015-10-28 2019-01-29 Novocure Limited TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements
US10821283B2 (en) 2016-04-04 2020-11-03 Novocure Gmbh Reducing motility of cancer cells using tumor treating fields (TTFields)
JP6980706B2 (ja) 2016-06-30 2021-12-15 ノボキュア ゲーエムベーハー 身体への腫瘍治療電場の長手方向伝達用のアレイ
EP3571503B1 (en) 2017-01-19 2026-04-15 Novocure GmbH System for viewing cell cultures under a microscope whilst applying ttfields
CN114082099A (zh) * 2018-07-03 2022-02-25 埃德温·阊 使用交变电场提高细胞膜通透性
CA3103070C (en) 2018-07-10 2024-01-09 Novocure Gmbh Inhibiting viral infection using alternating electric fields
JP6974671B2 (ja) * 2018-08-23 2021-12-01 ノボキュア ゲーエムベーハー 血液脳関門の透過性を向上させるための交流電界の使用
US11986647B2 (en) 2018-09-07 2024-05-21 Novocure Gmbh Treating autoinflammatory and mitochondrial diseases using an alternating electric field
WO2020049482A1 (en) 2018-09-07 2020-03-12 Yaniv Alon Treating autoimmune diseases using an alternating electric field to reduce the proliferation of t-cells
CN112930209B (zh) 2018-10-15 2024-10-15 诺沃库勒有限责任公司 生成遍及大脑具有高均匀性的肿瘤治疗场(ttfields)的装置和方法
JP7148722B2 (ja) 2018-10-25 2022-10-05 ゼーヴ・ボンゾン 被験者の脊椎構造体に対する交番電界（例えばＴＴＦｉｅｌｄ）の送達
WO2020104921A1 (en) 2018-11-19 2020-05-28 Novocure Gmbh Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elements
CN113164745B (zh) 2018-11-29 2024-04-26 诺沃库勒有限责任公司 用于递送TTField（肿瘤治疗场）的增强灵活性换能器阵列
JP7246486B2 (ja) 2019-01-08 2023-03-27 ノボキュア ゲーエムベーハー 腫瘍治療電場（ｔｔｆｉｅｌｄｓ）を使用した治療を計画するための異なるタイプの組織への画像のセグメンテーションの品質評価
CN113573774B (zh) 2019-02-26 2026-03-06 诺沃库勒有限责任公司 基于靶向癌细胞的电特性确定TTfield治疗的频率
JP2022522936A (ja) 2019-02-27 2022-04-21 ノボキュア ゲーエムベーハー 埋込可能な変換器アレイを使用した腫瘍治療電場（ｔｔｆｉｅｌｄｓ）の送達
EP3988099B1 (en) 2019-03-29 2023-06-07 Novocure GmbH Methods for restoring sensitivity to ttfields in ttfields-resistant cancer cells with ptger3 inhibitors
US11291837B2 (en) 2019-04-17 2022-04-05 Novocure Gmbh Uploading data from an isolated system without compromising isolation
JP7472264B2 (ja) 2019-07-31 2024-04-22 ノボキュア ゲーエムベーハー 頭蓋骨インプラントに埋め込まれた電極による腫瘍治療電場（ｔｔフィールド）の印加
US12343336B2 (en) 2019-08-05 2025-07-01 Novocure Gmbh Increasing cancer cells' sensitivity to tumor treating fields (TTFields) by inhibiting IL11 activity
JP2022545794A (ja) 2019-08-30 2022-10-31 ノボキュア ゲーエムベーハー 頸部への腫瘍治療電界（ＴＴＦｉｅｌｄｓ）の印加
EP4028052A1 (en) 2019-09-10 2022-07-20 Novocure GmbH A method of reducing viability of cancer cells by applying alternating electric fields and administering checkpoint inhibitors to the cancer cells
JP7670721B6 (ja) 2019-12-31 2025-06-06 ノボキュア ゲーエムベーハー 振幅調整およびチャネルの切り替え中のスパイクを防止する高電圧、高効率正弦波発生器
MX2022006136A (es) 2019-12-31 2022-06-17 Novocure Gmbh Matrices para suministrar campos de tratamiento de tumores (ttfields) con elementos de electrodos y sensores de temperatura accesibles individualmente.
US12121739B2 (en) 2019-12-31 2024-10-22 Novocure Gmbh Methods, systems, and apparatuses for managing temperatures induced by alternating fields
WO2021198864A1 (en) 2020-03-30 2021-10-07 Novocure Gmbh Intravenous / intra-spinal / intra-cavity / intraventricular delivery of ttfields (tumor treating fields) for treating cancer and metastases
MX2022010015A (es) * 2020-04-24 2022-09-05 Novocure Gmbh Uso de campos electricos alternos para aumentar la permeabilidad de la barrera hematoencefalica.
US11818943B2 (en) 2020-06-25 2023-11-14 Novocure Gmbh Fabricating organic light emitting diodes (OLEDs) using tubulin
WO2022064339A1 (en) 2020-09-25 2022-03-31 Novocure Gmbh Varying the metallization area on individual electrode elements in a tumor treating fields (ttfields) system to maximize current without overheating
EP4251261A1 (en) 2020-11-25 2023-10-04 Novocure Gmbh Increasing the efficacy of tumor treating fields (ttfields) by applying the ttfields at peak intensity less than half the time
WO2022130183A2 (en) * 2020-12-17 2022-06-23 Novocure Gmbh Pyroelectric-based temperature sensing of transducer arrays for applying tumor treating fields (ttfields)
CN113008403B (zh) * 2021-02-08 2022-08-12 清华大学 电场发生装置及测温电极装置
US12397151B2 (en) 2021-02-17 2025-08-26 Novocure Gmbh Arrays for delivering tumor treating fields (TTFields) with sets of electrode elements having individually adjustable active areas
JP2024509964A (ja) 2021-03-12 2024-03-05 ノボキュア ゲーエムベーハー 交流電界を用いてマクロファージの表現型をスキューイングすることによる、疾患を処置する方法
JP2024513854A (ja) 2021-03-31 2024-03-27 ノボキュア ゲーエムベーハー 腫瘍治療電場（ＴＴＦｉｅｌｄｓ）システムの電極を使用したインピーダンス断層撮影法
US20220323753A1 (en) * 2021-04-08 2022-10-13 Novocure Gmbh Methods of Treating Neurodegenerative Disorders with Alternating Electric Fields
CN113509641A (zh) * 2021-06-29 2021-10-19 北京康源嘉成生物科技有限公司 一种非药物且非侵入性开放血脑屏障的装置和方法
US20230009366A1 (en) * 2021-06-30 2023-01-12 Novocure Gmbh Using Alternating Electric Fields at Different Frequencies to Increase Permeability of the Blood Brain Barrier and also to Provide Other Benefits
KR20240027008A (ko) 2021-06-30 2024-02-29 노보큐어 게엠베하 종양 치료 필드(ttfield)를 인가하기 위한 트랜스듀서 어레이에서 전류를 제한하기 위한 커패시터의 사용
TW202322866A (zh) * 2021-09-30 2023-06-16 瑞士商諾沃庫勒有限責任公司 使用交流電場治療患者時減少電感覺
US12599765B2 (en) 2021-12-14 2026-04-14 Novocure Gmbh Shifting of transducer array to reduce skin irritation
CN121371475A (zh) * 2021-12-22 2026-01-23 江苏海莱新创医疗科技有限公司 胶质瘤治疗系统
WO2023126842A1 (en) 2021-12-29 2023-07-06 Novocure Gmbh Apparatus for reducing electrosensation using alternating electric fields with larger cathodes and smaller anodes
JP2024545019A (ja) 2021-12-30 2024-12-05 ノボキュア ゲーエムベーハー 腫瘍治療フィールド（ｔｔｆｉｅｌｄ）を使用した治療のためのパラメータ値の選択
CN114367060A (zh) * 2022-01-13 2022-04-19 深圳大学 激光交变电场联合治疗仪
IL314392A (en) 2022-03-30 2024-09-01 Novocure Gmbh Reducing electrosensation whilst treating a subject using alternating electric fields by pairing transducer arrays together
CA3255022A1 (en) 2022-03-30 2023-10-05 Novocure Gmbh USE OF INTERLACED COOLING PERIODS TO INCREASE THE MAXIMUM INTENSITY OF TUMOR TREATMENT FIELDS
WO2023242741A1 (en) 2022-06-13 2023-12-21 Novocure Gmbh Systems and methods for increasing intestinal absorption of therapeutic agents
EP4514450A1 (en) 2022-06-27 2025-03-05 Novocure GmbH Using a closed-loop technique to reduce electrosensation while treating a subject using alternating electric fields
US20240001111A1 (en) 2022-06-30 2024-01-04 Novocure Gmbh Electrode Assembly for Applying Tumor Treating Fields (TTFields) that Includes a Plurality of Thermally Linked but Electrically Isolated Graphite Sheets
KR102637878B1 (ko) * 2022-09-02 2024-02-19 주식회사 뉴로스피어 대뇌병변 산화철의 전자-펜톤효과를 이용한 전기장 대뇌자극치료기기
JP2025532790A (ja) 2022-09-30 2025-10-03 ノボキュア ゲーエムベーハー 電気感覚および／または皮膚刺激を軽減するための組成物、システム、および方法
TW202430241A (zh) 2022-09-30 2024-08-01 瑞士商諾沃庫勒有限責任公司 在使用交流電場治療受試者時藉由控制上升特性來降低電知覺
US20240108892A1 (en) 2022-09-30 2024-04-04 Novocure Gmbh Changing the Orientation of Tumor Treating Fields (TTFields) by Adjusting the Amplitudes of Two or More Electric Fields that Are All In-Phase with Each Other
EP4561680A1 (en) 2022-09-30 2025-06-04 Novocure Gmbh Reducing electrosensation while treating a subject using alternating electric fields by deactivating selected electrode elements
EP4590389A1 (en) 2022-12-27 2025-07-30 Novocure GmbH Multi-channel device for directional shaping of electric fields e.g., tumor treating fields (ttfields)
CN120417965A (zh) 2022-12-28 2025-08-01 诺沃库勒有限责任公司 将电极元件定位在受试者身体上以提供更强的交变电场（例如，TTFields）而不会过热
EP4642519A1 (en) 2022-12-29 2025-11-05 Novocure GmbH Reducing electrosensation during application of alternating electric fields by ensuring that successive increases in amplitude occur during opposite phases of an ac waveform
TW202428320A (zh) 2022-12-29 2024-07-16 瑞士商諾沃庫勒有限責任公司 透過增加波形的斜坡上升部分的步階數量減少使用交流電場治療受試者時的電感覺
US12268863B2 (en) 2023-02-06 2025-04-08 Novocure Gmbh Shiftable transducer array with anisotropic material layer
CN120659643A (zh) 2023-02-10 2025-09-16 诺沃库勒有限责任公司 将各组电极阵列按顺序定位于非重叠位置处以减轻肿瘤治疗电场（TTFields）疗法期间的皮肤刺激
JP2026511465A (ja) 2023-03-31 2026-04-14 ノボキュア ゲーエムベーハー 電場の振幅を徐々に増加させることによる、回転交流電場を使用して被験者を治療するときの電気感覚の低減
WO2024201412A1 (en) 2023-03-31 2024-10-03 Novocure Gmbh Microneedles to overcome contact resistance
CN121925295A (zh) 2023-09-29 2026-04-24 诺沃库勒有限责任公司 使用振幅和频率的交错变化来改善用交变电场进行治疗期间的电感觉
CN121925288A (zh) 2023-09-29 2026-04-24 诺沃库勒有限责任公司 使用专用柔性电路来实现温度感测的用于肿瘤治疗电场（TTField）疗法的换能器阵列
CN121925289A (zh) 2023-09-29 2026-04-24 诺沃库勒有限责任公司 用于使用多部分电极组件施加电信号的装置
CN121401600A (zh) * 2023-12-26 2026-01-27 江苏海莱新创医疗科技有限公司 转接器、肿瘤电场治疗系统、电极片质量检测系统及电极片质量检测方法
US20250213849A1 (en) 2023-12-29 2025-07-03 Novocure Gmbh Electrode Assembly for Delivering Alternating Electric Fields (e.g., TTFields) with Peripherally-Positioned Temperature Sensors

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2536459T3 (es) * 1995-08-29 2015-05-25 Nitto Denko Corporation Microporación de piel humana para administración de fármacos y aplicaciones de supervisión
EP0869829A1 (en) * 1995-11-21 1998-10-14 LERNER, Eduard Naumovich Device for enhanced delivery of biologically active substances and compounds in an organism
CN1206353A (zh) * 1995-11-21 1999-01-27 E·N·勒纳 提高有机体内生物活性物质和化合物释放的装置
US6678553B2 (en) * 1995-11-21 2004-01-13 Intraabrain International Nv Device for enhanced delivery of biologically active substances and compounds in an organism
WO1997018855A1 (en) * 1995-11-21 1997-05-29 Eduard Naumovich Lerner Device for enhanced delivery of biologically active substances and compounds in an organism
US6678558B1 (en) 1999-03-25 2004-01-13 Genetronics, Inc. Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
US20030078499A1 (en) 1999-08-12 2003-04-24 Eppstein Jonathan A. Microporation of tissue for delivery of bioactive agents
US7089054B2 (en) 2002-10-02 2006-08-08 Standen Ltd. Apparatus and method for treating a tumor or the like
US8447395B2 (en) 2000-02-17 2013-05-21 Novocure Ltd Treating bacteria with electric fields
US8175698B2 (en) 2000-02-17 2012-05-08 Novocure Ltd. Treating bacteria with electric fields
US7805201B2 (en) 2000-02-17 2010-09-28 Standen Ltd. Treating a tumor or the like with an electric field
US7016725B2 (en) 2001-11-06 2006-03-21 Standen Ltd. Method and apparatus for destroying dividing cells
CN1416466A (zh) 2000-02-17 2003-05-07 约朗姆·帕尔蒂 破坏正在分裂的细胞的方法和装置
US7136699B2 (en) 2002-10-02 2006-11-14 Standen, Ltd. Apparatus for destroying dividing cells
US7599746B2 (en) * 2000-02-17 2009-10-06 Standen Ltd Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases
US7146210B2 (en) 2000-02-17 2006-12-05 Standen Ltd. Apparatus and method for optimizing tumor treatment efficiency by electric fields
US6868289B2 (en) 2002-10-02 2005-03-15 Standen Ltd. Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor
US6546290B1 (en) 2000-04-12 2003-04-08 Roamitron Holding S.A. Method and apparatus for electromedical therapy
US6853858B2 (en) * 2000-05-08 2005-02-08 Brainsgate, Ltd. Administration of anti-inflammatory drugs into the central nervous system
JP4311904B2 (ja) * 2000-05-08 2009-08-12 ブレインスゲート リミテッド 血液脳関門及び脳血流の性質を改善するための翼口蓋神経節の刺激方法及び装置
US7332313B2 (en) 2001-06-05 2008-02-19 Applied Biophysics, Inc. Electrical wounding assay for cells in vitro
US6904322B2 (en) 2002-02-15 2005-06-07 Kalaco Scientific, Inc. Transcranial electrostimulation apparatus and method
US20030171738A1 (en) 2002-03-06 2003-09-11 Konieczynski David D. Convection-enhanced drug delivery device and method of use
AU2003299471A1 (en) 2002-05-07 2004-05-13 Kai Kroll Method and device for treating concer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy
JP4995423B2 (ja) * 2002-12-03 2012-08-08 ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート 物質を血液−脳関門を渡って輸送するための人工低密度リポタンパク質キャリア
US10912712B2 (en) 2004-03-25 2021-02-09 The Feinstein Institutes For Medical Research Treatment of bleeding by non-invasive stimulation
DE602005020504D1 (de) * 2004-12-07 2010-05-20 Standen Ltd Vivo über einen längeren zeitraum
CA2594231C (en) 2004-12-27 2016-04-19 Standen Ltd. Treating a tumor or the like with electric fields at different orientations
US8788044B2 (en) 2005-01-21 2014-07-22 Michael Sasha John Systems and methods for tissue stimulation in medical treatment
US20100049117A1 (en) 2005-04-18 2010-02-25 Pantec Biosolutions Ag Microporator for Porating a Biological Membrane and Integrated Permeant Administering System
EP1937151A4 (en) * 2005-09-19 2011-07-06 Univ Columbia Systems and methods for opening of the blood-brain barrier of a subject using ultrasound
CN101321555B (zh) * 2005-10-03 2020-12-08 诺沃库勒有限责任公司 优化电场特征以增加电场在增殖细胞上的效果
US8019414B2 (en) 2006-04-05 2011-09-13 Novocure Ltd. Treating cancer using electromagnetic fields in combination with other treatment regimens
CN100515522C (zh) * 2006-09-18 2009-07-22 郭国祯 促进药物透过血脑屏障的电磁脉冲辐照系统和方法
CN102008782B (zh) * 2006-11-08 2014-11-26 株式会社P·曼德 神经营养因子产生促进装置
DK2167194T3 (en) 2007-03-06 2017-06-19 Novocure Ltd TREATMENT OF CANCER USING ELECTROMAGNETIC FIELDS IN COMBINATION WITH PHOTODYNAMIC THERAPY
EP2183024B1 (en) * 2007-08-14 2019-05-15 Novocure Ltd. Treating parasites with electric fields
US8715203B2 (en) 2007-09-17 2014-05-06 Novocure Limited Composite electrode
WO2009047365A1 (en) * 2007-10-12 2009-04-16 Capsulution Nanoscience Ag Drug delivery system
DE102008018170B4 (de) 2008-04-03 2010-05-12 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen Mikrofluidisches System und Verfahren zum Aufbau und zur anschließenden Kultivierung sowie nachfolgender Untersuchung von komplexen Zellanordnungen
US9198733B2 (en) 2008-04-29 2015-12-01 Virginia Tech Intellectual Properties, Inc. Treatment planning for electroporation-based therapies
US10245098B2 (en) 2008-04-29 2019-04-02 Virginia Tech Intellectual Properties, Inc. Acute blood-brain barrier disruption using electrical energy based therapy
CN201205406Y (zh) * 2008-05-06 2009-03-11 迟立广 中频交变电场理疗装置
CN101318054B (zh) * 2008-07-18 2012-01-25 圣太科医疗科技（上海）有限公司 微电场网引导的肝脏靶向性细胞内药物传递装置
EP2153866A1 (en) * 2008-08-14 2010-02-17 Oncotherm Kft. Portable radiofrequency hyperthermia device with flexible treatment electrode for electric field capacitive coupled energy transfer
WO2010118387A1 (en) 2009-04-09 2010-10-14 Virginia Tech Intellectual Properties, Inc. Integration of very short electric pulses for minimally to noninvasive electroporation
WO2011025775A1 (en) 2009-08-24 2011-03-03 Alterman Ron L Apparatus for trans-cerebral electrophoresis and methods of use thereof
CN101698121B (zh) * 2009-10-23 2011-06-22 西安交通大学 促进药物透过血脑屏障的适型超声系统
CN102100945A (zh) * 2009-12-18 2011-06-22 重庆新大地电子有限公司 生物负电子保健治疗仪设备系统
GB2479598B (en) * 2010-04-16 2012-11-21 Cancercure Technology As Methods and systems for inducing hyperthermia
US20120310140A1 (en) 2010-12-01 2012-12-06 Spinal Modulation, Inc. Directed delivery of agents to neural anatomy
CN202096600U (zh) * 2011-04-09 2012-01-04 南宁市中新森泰科技有限公司 一种电位治疗仪
CN102284132A (zh) * 2011-06-30 2011-12-21 杭州电子科技大学 基于多针形电极的高压脉冲电场治疗装置
US20150126964A1 (en) * 2012-05-13 2015-05-07 Corporation De L'ecole Polytechnique De Montreal Drug delivery across the blood-brain barrier using magnetically heatable entities
US20120323214A1 (en) 2012-05-16 2012-12-20 Totada R Shantha Alzheimer's disease treatment with multiple therapeutic agents delivered to the olfactory region through a special delivery catheter and iontophoresis
CN102836119A (zh) * 2012-08-21 2012-12-26 中国人民解放军第三军医大学第二附属医院 微泡在制备用于联合诊断级超声作为提高肿瘤微血管通透性药物的用途
ES2898374T3 (es) * 2012-09-06 2022-03-07 Covidien Lp Sistema de tratamiento neurológico
WO2014066655A2 (en) * 2012-10-25 2014-05-01 Oncosec Medical Incorporation Electroporation device
US9682066B2 (en) 2012-12-04 2017-06-20 University Of Cincinnati Methods of treating primary brain tumors by administering letrozole
US9655669B2 (en) 2013-05-06 2017-05-23 Novocure Limited Optimizing treatment using TTFields by changing the frequency during the course of long term tumor treatment
US10779875B2 (en) 2013-05-06 2020-09-22 Novocure Gmbh Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment
US10556121B2 (en) * 2015-02-20 2020-02-11 Endonovo Therapeutics, Inc. Method and apparatus for electromagnetic treatment of multiple sclerosis
HK1254629A1 (zh) 2015-04-10 2019-07-26 安吉戴尼克公司 使用热控电极进行不可逆电穿孔的系统和方法
EP3307378B1 (en) 2015-05-14 2024-06-26 London Health Sciences Centre Research Inc. Intratumoral modulation therapy
CN106333926A (zh) * 2015-07-10 2017-01-18 复旦大学 一种稳定性多肽介导跨屏障膜的脑部肿瘤多重靶向递药系统
US9910453B2 (en) 2015-09-25 2018-03-06 Novocure Limited High voltage, high efficiency sine wave generator with pre-set frequency and adjustable amplitude
US10188851B2 (en) 2015-10-28 2019-01-29 Novocure Limited TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements
US10821283B2 (en) * 2016-04-04 2020-11-03 Novocure Gmbh Reducing motility of cancer cells using tumor treating fields (TTFields)
JP6980706B2 (ja) 2016-06-30 2021-12-15 ノボキュア ゲーエムベーハー 身体への腫瘍治療電場の長手方向伝達用のアレイ
US20180008708A1 (en) * 2016-07-10 2018-01-11 Novocure Limited Synchronizing Tumor Cells to the G2/M Phase Using TTFields Combined with Taxane or Other Anti-Microtubule Agents
ES2959582T3 (es) 2016-08-18 2024-02-27 Novocure Gmbh Medición de temperatura en diversos conjuntos para aplicar campos de tratamiento de tumores
WO2018109691A2 (en) 2016-12-13 2018-06-21 Zeev Bomzon Treating patients with ttfields with the electrode positions optimized using deformable templates
EP3571503B1 (en) 2017-01-19 2026-04-15 Novocure GmbH System for viewing cell cultures under a microscope whilst applying ttfields
CN207462466U (zh) * 2017-02-08 2018-06-08 中国人民解放军总医院 一种脑部电磁理疗设备
WO2019175871A1 (en) * 2018-03-12 2019-09-19 Tel Hashomer Medical Research, Infrastructure And Services Ltd. Method for changing brain barrier permeability
US10953209B2 (en) 2018-03-28 2021-03-23 Board Of Regents Of The University Of Texas System Treating tumors using TTFields combined with a PARP inhibitor
JP7139448B2 (ja) 2018-04-09 2022-09-20 ノボキュア ゲーエムベーハー ＴＴＦｉｅｌｄｓ及びオーロラキナーゼ阻害剤による腫瘍の治療
PL3775956T3 (pl) 2018-04-10 2022-10-10 Novocure Gmbh Szacunki przewodności ac o niskiej częstotliwości (< 1 mhz) pozyskane z dwóch obrazów mri o różnych czasach repetycji
CN114082099A (zh) 2018-07-03 2022-02-25 埃德温·阊 使用交变电场提高细胞膜通透性
CA3103070C (en) 2018-07-10 2024-01-09 Novocure Gmbh Inhibiting viral infection using alternating electric fields
JP6974671B2 (ja) * 2018-08-23 2021-12-01 ノボキュア ゲーエムベーハー 血液脳関門の透過性を向上させるための交流電界の使用

Also Published As

Publication number Publication date
EP3773291B1 (en) 2021-10-27
KR20210071964A (ko) 2021-06-16
KR20250069692A (ko) 2025-05-19
SG11202012592WA (en) 2021-01-28
ES3043508T3 (en) 2025-11-25
CA3100817A1 (en) 2020-02-27
CN113908433A (zh) 2022-01-11
PL3878389T3 (pl) 2025-12-22
DK3892219T3 (da) 2022-06-27
CN113908432A (zh) 2022-01-11
EP3895643B1 (en) 2023-10-11
KR20240042240A (ko) 2024-04-01
ES2922576T3 (es) 2022-09-16
PL3773291T3 (pl) 2022-01-31
NZ770867A (en) 2023-11-24
IL279466B2 (en) 2025-09-01
IL279466A (en) 2021-01-31
EP3892219A1 (en) 2021-10-13
CA3100817C (en) 2025-04-01
CN113908430B (zh) 2026-04-28
CN112469352A (zh) 2021-03-09
EP3892219B1 (en) 2022-06-01
FI3878389T3 (fi) 2025-09-16
JP2021192835A (ja) 2021-12-23
US12290654B2 (en) 2025-05-06
MX2024015911A (es) 2025-02-10
EP3895643A1 (en) 2021-10-20
AU2019324585A1 (en) 2021-01-14
HUE073324T2 (hu) 2026-01-28
CN112469352B (zh) 2021-10-08
AU2019324585C1 (en) 2023-04-27
MX2024015910A (es) 2025-02-10
EP3773291A1 (en) 2021-02-17
JP7667045B6 (ja) 2025-06-05
DK3878389T3 (da) 2025-09-01
EP3804648B1 (en) 2022-01-19
CN112618956A (zh) 2021-04-09
CN113908430A (zh) 2022-01-11
CA3242209A1 (en) 2020-02-27
EP4609908A3 (en) 2025-10-01
AU2022268405A1 (en) 2023-01-05
JP2021522957A (ja) 2021-09-02
US10967167B2 (en) 2021-04-06
DK3804648T3 (da) 2022-04-11
BR112020025422A2 (pt) 2021-03-16
EP3878389A1 (en) 2021-09-15
ES2898090T3 (es) 2022-03-03
JP2025106473A (ja) 2025-07-15
EP3804648A1 (en) 2021-04-14
MX2024015920A (es) 2025-02-10
HUE059062T2 (hu) 2022-10-28
JP7233453B2 (ja) 2023-03-06
US11400269B2 (en) 2022-08-02
CN112618956B (zh) 2025-06-27
US20220265982A1 (en) 2022-08-25
EP4609908A2 (en) 2025-09-03
CN113908431B (zh) 2026-02-27
MX2020013519A (es) 2021-05-12
JP6974671B2 (ja) 2021-12-01
JP2021106879A (ja) 2021-07-29
JP7667045B2 (ja) 2025-04-22
US20200061360A1 (en) 2020-02-27
IL319986A (en) 2025-06-01
US20200061361A1 (en) 2020-02-27
US11351349B2 (en) 2022-06-07
AU2019324585B2 (en) 2022-12-08
CN113908431A (zh) 2022-01-11
WO2020039390A1 (en) 2020-02-27
CN113908433B (zh) 2025-12-19
PL3804648T3 (pl) 2022-06-06
HUE056950T2 (hu) 2022-03-28
DK3773291T3 (da) 2021-11-15
EP3895643C0 (en) 2023-10-11
IL279466B1 (en) 2025-05-01
MX2024015909A (es) 2025-02-10
EP3878389B1 (en) 2025-08-06
AU2022268405B2 (en) 2024-08-15
US20200269037A1 (en) 2020-08-27
ES2911526T3 (es) 2022-05-19
KR102805022B1 (ko) 2025-05-08
US20250381379A1 (en) 2025-12-18
PL3892219T3 (pl) 2022-10-03
KR102651496B1 (ko) 2024-03-25

Similar Documents

Publication Publication Date Title
HUE058160T2 (hu) Váltakozó elektromos mezõk alkalmazása a vér-agy gát permeabilitásának növelésére
EP2843669A4 (en) TRANSDUCER OVERVOLTAGE SAFE INSULATED WIRE
FR3004467B1 (fr) Fabrication d&#39;une elpasolite stoechiometrique
EP2970511A4 (en) INSULIN CONJUGATES incretin
EP2929128A4 (en) RETURNABLE THRESHOLD PACKER
EP3020100A4 (en) Interconnection seal
BR302012004277S1 (pt) &#34;configuração aplicada à cápsula&#34;
EP2950874A4 (en) KÖRPERLUMENOKKLUSION
BR302012004271S1 (pt) &#34;configuração aplicada à cápsula&#34;
BR302012004276S1 (pt) &#34;configuração aplicada à cápsula&#34;
FR3028909B3 (fr) Structure amelioree d&#39;actionneur lineaire
BR302012004275S1 (pt) &#34;configuração aplicada à cápsula&#34;
EP3347334A4 (en) DEHYDROHALOGENICATION OF FLUOROCHOLE HYDROGEN
EP3457004A4 (en) SEAL STRUCTURE
EP3727328C0 (en) LIPOSOMES CONTAINING SPHINGOMYELIN
BR302012004274S1 (pt) &#34;configuração aplicada à cápsula&#34;
EP3418282A4 (en) TRICYCLIC CONNECTION AS IMMUNOMODULATOR
EP2971880A4 (en) WEAR-RESISTANT COMPLETE SEAL
DK3595818T3 (da) Modulær magnetisk samling
EP3021013A4 (en) SEAL STRUCTURE
BR302012004270S1 (pt) &#34;configuração aplicada à cápsula&#34;
BR302012004273S1 (pt) &#34;configuração aplicada à cápsula&#34;
EP3060986A4 (en) INSTALLING APPLICATIONS FOR RESTORING AN INCORRECT BACKUP
FR3028575B1 (fr) Secteur d&#39;aubage de stator d&#39;une turbomachine
BR302012004272S1 (pt) &#34;configuração aplicada à cápsula&#34;