JP2021167346A5 - - Google Patents
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- JP2021167346A5 JP2021167346A5 JP2021118771A JP2021118771A JP2021167346A5 JP 2021167346 A5 JP2021167346 A5 JP 2021167346A5 JP 2021118771 A JP2021118771 A JP 2021118771A JP 2021118771 A JP2021118771 A JP 2021118771A JP 2021167346 A5 JP2021167346 A5 JP 2021167346A5
- Authority
- JP
- Japan
- Prior art keywords
- mass
- ethynyl
- pyrazolo
- dimethoxyphenyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims description 17
- -1 4-amino-3-((3,5-dimethoxyphenyl) ethynyl) -1H-pyrazolo [3,4-d] pyrimidin-1-yl Chemical group 0.000 claims description 14
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 12
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 claims description 11
- 150000003839 salts Chemical class 0.000 claims description 11
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 6
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 6
- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 claims description 6
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 6
- 229950008138 carmellose Drugs 0.000 claims description 6
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 5
- 229960000913 crospovidone Drugs 0.000 claims description 5
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims description 5
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims description 5
- 239000011734 sodium Substances 0.000 claims description 5
- 229910052708 sodium Inorganic materials 0.000 claims description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 3
- 239000011575 calcium Substances 0.000 claims description 3
- 229910052791 calcium Inorganic materials 0.000 claims description 3
- 239000008101 lactose Substances 0.000 claims description 3
- 235000010355 mannitol Nutrition 0.000 claims description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- HGINCPLSRVDWNT-UHFFFAOYSA-N Acrolein Chemical compound C=CC=O HGINCPLSRVDWNT-UHFFFAOYSA-N 0.000 claims 5
- 239000007884 disintegrant Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229940126062 Compound A Drugs 0.000 description 5
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 5
- 125000000719 pyrrolidinyl group Chemical group 0.000 description 5
- 238000010828 elution Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- KEIPNCCJPRMIAX-HNNXBMFYSA-N 1-[(3s)-3-[4-amino-3-[2-(3,5-dimethoxyphenyl)ethynyl]pyrazolo[3,4-d]pyrimidin-1-yl]pyrrolidin-1-yl]prop-2-en-1-one Chemical compound COC1=CC(OC)=CC(C#CC=2C3=C(N)N=CN=C3N([C@@H]3CN(CC3)C(=O)C=C)N=2)=C1 KEIPNCCJPRMIAX-HNNXBMFYSA-N 0.000 description 1
- 108091008794 FGF receptors Proteins 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 102000052178 fibroblast growth factor receptor activity proteins Human genes 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018051620 | 2018-03-19 | ||
| JP2018051620 | 2018-03-19 | ||
| JP2020507802A JP6918204B2 (ja) | 2018-03-19 | 2019-03-18 | アルキル硫酸ナトリウムを含む医薬組成物 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020507802A Division JP6918204B2 (ja) | 2018-03-19 | 2019-03-18 | アルキル硫酸ナトリウムを含む医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021167346A JP2021167346A (ja) | 2021-10-21 |
| JP2021167346A5 true JP2021167346A5 (enExample) | 2022-03-16 |
| JP7322103B2 JP7322103B2 (ja) | 2023-08-07 |
Family
ID=67987327
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020507802A Active JP6918204B2 (ja) | 2018-03-19 | 2019-03-18 | アルキル硫酸ナトリウムを含む医薬組成物 |
| JP2021118771A Active JP7322103B2 (ja) | 2018-03-19 | 2021-07-19 | アルキル硫酸ナトリウムを含む医薬組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020507802A Active JP6918204B2 (ja) | 2018-03-19 | 2019-03-18 | アルキル硫酸ナトリウムを含む医薬組成物 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US11833151B2 (enExample) |
| EP (3) | EP4353222A1 (enExample) |
| JP (2) | JP6918204B2 (enExample) |
| KR (1) | KR102473372B1 (enExample) |
| CN (1) | CN111867594A (enExample) |
| AU (1) | AU2019239404B2 (enExample) |
| BR (1) | BR112020018697A2 (enExample) |
| CA (1) | CA3094431C (enExample) |
| DK (1) | DK3769765T3 (enExample) |
| ES (1) | ES2980333T3 (enExample) |
| FI (1) | FI3769765T3 (enExample) |
| HU (1) | HUE067430T2 (enExample) |
| MA (1) | MA52093A (enExample) |
| MX (1) | MX2020009762A (enExample) |
| MY (1) | MY203305A (enExample) |
| PH (1) | PH12020551412A1 (enExample) |
| PL (1) | PL3769765T3 (enExample) |
| PT (1) | PT3769765T (enExample) |
| RU (1) | RU2759746C1 (enExample) |
| SG (1) | SG11202008435SA (enExample) |
| TW (1) | TWI790364B (enExample) |
| WO (1) | WO2019181876A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102793563B1 (ko) | 2016-03-04 | 2025-04-11 | 다이호야쿠힌고교 가부시키가이샤 | 악성 종양 치료용 제제 및 조성물 |
| US11883404B2 (en) | 2016-03-04 | 2024-01-30 | Taiho Pharmaceuticals Co., Ltd. | Preparation and composition for treatment of malignant tumors |
| EP4353222A1 (en) * | 2018-03-19 | 2024-04-17 | Taiho Pharmaceutical Co., Ltd. | Use of sodium alkyl sulfate |
| WO2020110974A1 (ja) * | 2018-11-26 | 2020-06-04 | 大鵬薬品工業株式会社 | 線維芽細胞増殖因子受容体阻害剤と内分泌療法との併用による内分泌療法が適用される腫瘍の治療及び予防方法 |
| WO2023238929A1 (ja) * | 2022-06-10 | 2023-12-14 | 大鵬薬品工業株式会社 | ピミテスピブを含有する医薬組成物 |
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| EP4353222A1 (en) * | 2018-03-19 | 2024-04-17 | Taiho Pharmaceutical Co., Ltd. | Use of sodium alkyl sulfate |
| US20210387990A1 (en) | 2018-11-09 | 2021-12-16 | Taiho Pharmaceutical Co., Ltd. | Method for producing dimethoxybenzene compound |
| KR102742083B1 (ko) | 2018-11-09 | 2024-12-16 | 다이호야쿠힌고교 가부시키가이샤 | 디메톡시벤젠 화합물의 제조 방법 |
| WO2020110974A1 (ja) | 2018-11-26 | 2020-06-04 | 大鵬薬品工業株式会社 | 線維芽細胞増殖因子受容体阻害剤と内分泌療法との併用による内分泌療法が適用される腫瘍の治療及び予防方法 |
| WO2020170355A1 (ja) | 2019-02-20 | 2020-08-27 | 大鵬薬品工業株式会社 | Ｆｇｆｒ１変異腫瘍の治療方法 |
| EP3932427A4 (en) | 2019-02-28 | 2022-12-07 | Taiho Pharmaceutical Co., Ltd. | CANCER THERAPY USING A 3,5-DISUBSTITUTED BENZOLALKYNYL COMPOUND AND PEMBROLIZUMAB |
| MA56549A (fr) | 2019-06-21 | 2022-04-27 | Taiho Pharmaceutical Co Ltd | Méthode de traitement d'une tumeur maligne |
-
2019
- 2019-03-18 EP EP24160537.7A patent/EP4353222A1/en not_active Withdrawn
- 2019-03-18 PT PT197719982T patent/PT3769765T/pt unknown
- 2019-03-18 KR KR1020207029418A patent/KR102473372B1/ko active Active
- 2019-03-18 MA MA052093A patent/MA52093A/fr unknown
- 2019-03-18 US US16/982,377 patent/US11833151B2/en active Active
- 2019-03-18 SG SG11202008435SA patent/SG11202008435SA/en unknown
- 2019-03-18 RU RU2020133810A patent/RU2759746C1/ru active
- 2019-03-18 CN CN201980020022.5A patent/CN111867594A/zh active Pending
- 2019-03-18 EP EP19771998.2A patent/EP3769765B1/en active Active
- 2019-03-18 CA CA3094431A patent/CA3094431C/en active Active
- 2019-03-18 EP EP24207166.0A patent/EP4470621A3/en active Pending
- 2019-03-18 PL PL19771998.2T patent/PL3769765T3/pl unknown
- 2019-03-18 AU AU2019239404A patent/AU2019239404B2/en active Active
- 2019-03-18 FI FIEP19771998.2T patent/FI3769765T3/fi active
- 2019-03-18 ES ES19771998T patent/ES2980333T3/es active Active
- 2019-03-18 MY MYPI2020004844A patent/MY203305A/en unknown
- 2019-03-18 JP JP2020507802A patent/JP6918204B2/ja active Active
- 2019-03-18 TW TW108109195A patent/TWI790364B/zh active
- 2019-03-18 MX MX2020009762A patent/MX2020009762A/es unknown
- 2019-03-18 DK DK19771998.2T patent/DK3769765T3/da active
- 2019-03-18 HU HUE19771998A patent/HUE067430T2/hu unknown
- 2019-03-18 WO PCT/JP2019/011251 patent/WO2019181876A1/ja not_active Ceased
- 2019-03-18 BR BR112020018697-0A patent/BR112020018697A2/pt unknown
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2020
- 2020-09-09 PH PH12020551412A patent/PH12020551412A1/en unknown
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2021
- 2021-07-19 JP JP2021118771A patent/JP7322103B2/ja active Active
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