JP2021104048A5 - - Google Patents
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- Publication number
- JP2021104048A5 JP2021104048A5 JP2021063957A JP2021063957A JP2021104048A5 JP 2021104048 A5 JP2021104048 A5 JP 2021104048A5 JP 2021063957 A JP2021063957 A JP 2021063957A JP 2021063957 A JP2021063957 A JP 2021063957A JP 2021104048 A5 JP2021104048 A5 JP 2021104048A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- mil
- bone marrow
- mils
- expressing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000013255 MILs Substances 0.000 claims 26
- 210000001185 bone marrow Anatomy 0.000 claims 25
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 21
- 229910052760 oxygen Inorganic materials 0.000 claims 21
- 239000001301 oxygen Substances 0.000 claims 21
- 210000004698 lymphocyte Anatomy 0.000 claims 18
- 206010021143 Hypoxia Diseases 0.000 claims 16
- 230000001146 hypoxic effect Effects 0.000 claims 16
- 210000004027 cell Anatomy 0.000 claims 9
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims 6
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 208000034578 Multiple myelomas Diseases 0.000 claims 4
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 102000008070 Interferon-gamma Human genes 0.000 claims 2
- 108010074328 Interferon-gamma Proteins 0.000 claims 2
- 108010002350 Interleukin-2 Proteins 0.000 claims 2
- 239000011324 bead Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229960003130 interferon gamma Drugs 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 1
- 230000008595 infiltration Effects 0.000 claims 1
- 238000001764 infiltration Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462045782P | 2014-09-04 | 2014-09-04 | |
| US62/045,782 | 2014-09-04 | ||
| US201562186040P | 2015-06-29 | 2015-06-29 | |
| US62/186,040 | 2015-06-29 | ||
| JP2017512293A JP6865160B2 (ja) | 2014-09-04 | 2015-09-04 | 正常酸素条件と交互になった低酸素条件における骨髄浸潤リンパ球の活性化 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017512293A Division JP6865160B2 (ja) | 2014-09-04 | 2015-09-04 | 正常酸素条件と交互になった低酸素条件における骨髄浸潤リンパ球の活性化 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021104048A JP2021104048A (ja) | 2021-07-26 |
| JP2021104048A5 true JP2021104048A5 (https=) | 2021-11-18 |
| JP7197213B2 JP7197213B2 (ja) | 2022-12-27 |
Family
ID=55440392
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017512293A Expired - Fee Related JP6865160B2 (ja) | 2014-09-04 | 2015-09-04 | 正常酸素条件と交互になった低酸素条件における骨髄浸潤リンパ球の活性化 |
| JP2021063957A Active JP7197213B2 (ja) | 2014-09-04 | 2021-04-05 | 正常酸素条件と交互になった低酸素条件における骨髄浸潤リンパ球の活性化 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017512293A Expired - Fee Related JP6865160B2 (ja) | 2014-09-04 | 2015-09-04 | 正常酸素条件と交互になった低酸素条件における骨髄浸潤リンパ球の活性化 |
Country Status (13)
| Country | Link |
|---|---|
| US (7) | US9687510B2 (https=) |
| EP (2) | EP3922254A1 (https=) |
| JP (2) | JP6865160B2 (https=) |
| KR (1) | KR20170067751A (https=) |
| CN (1) | CN107109364A (https=) |
| AU (2) | AU2015311761B2 (https=) |
| CA (1) | CA2959994C (https=) |
| DK (1) | DK3188740T3 (https=) |
| ES (1) | ES2877108T3 (https=) |
| IL (2) | IL250746B (https=) |
| MX (1) | MX391017B (https=) |
| PT (1) | PT3188740T (https=) |
| WO (1) | WO2016037054A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015157636A1 (en) | 2014-04-10 | 2015-10-15 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Enhanced expansion of tumor-infiltrating lymphocytes for adoptive cell therapy |
| US9687510B2 (en) * | 2014-09-04 | 2017-06-27 | The Johns Hopkins University | Activation of marrow infiltrating lymphocytes in hypoxic alternating with normoxic conditions |
| CA2991040A1 (en) * | 2015-06-29 | 2017-01-05 | The Johns Hopkins University | Immune checkpoint chimeric receptors therapy |
| EP3320087A4 (en) * | 2015-07-08 | 2019-01-23 | The Johns Hopkins University | BONE MARROW FILTRATION LYMPHOCYTES (MILS) AS A T-CELL SOURCE FOR CHIMERIC ANTIGEN RECEPTOR (CAR) THERAPY |
| MX2019004707A (es) | 2016-10-26 | 2019-08-12 | Iovance Biotherapeutics Inc | Reestimulacion de linfocitos infiltrantes de tumor crioconservados. |
| TWI788307B (zh) | 2016-10-31 | 2023-01-01 | 美商艾歐凡斯生物治療公司 | 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞 |
| US11401507B2 (en) | 2016-11-17 | 2022-08-02 | Iovance Biotherapeutics, Inc. | Remnant tumor infiltrating lymphocytes and methods of preparing and using the same |
| JP2020512284A (ja) * | 2016-12-22 | 2020-04-23 | ウィンドミル セラピューティクス インコーポレイテッド | 免疫系調節組成物および方法 |
| CA3049165A1 (en) | 2017-01-06 | 2018-07-12 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof |
| JOP20190224A1 (ar) | 2017-03-29 | 2019-09-26 | Iovance Biotherapeutics Inc | عمليات من أجل إنتاج الخلايا اللمفاوية المرتشحة للأورام واستخداماتها في العلاج المناعي |
| US11254913B1 (en) | 2017-03-29 | 2022-02-22 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
| SG11202006541UA (en) | 2018-01-08 | 2020-08-28 | Iovance Biotherapeutics Inc | Processes for generating til products enriched for tumor antigen-specific t-cells |
| EP3735256A4 (en) | 2018-03-22 | 2021-10-13 | Windmil Therapeutics, Inc. | BONE MARROW LYMPHOCYTES SPECIFIC TO PROSTATE CANCER AND ASSOCIATED USES |
| WO2019217753A1 (en) | 2018-05-10 | 2019-11-14 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
| JP2022507113A (ja) * | 2018-11-05 | 2022-01-18 | ウィンドミル セラピューティクス インコーポレイテッド | クローン性の増大した骨髄浸潤リンパ球およびそれらの使用 |
| TW202039830A (zh) | 2018-11-05 | 2020-11-01 | 美商艾歐凡斯生物治療公司 | 用於製造腫瘤浸潤性淋巴細胞之方法及其在免疫療法中之用途 |
| SG11202104637VA (en) * | 2018-11-30 | 2021-06-29 | Windmil Therapeutics Inc | MARROW INFILTRATING LYMPHOCYTES (MILs) EXPRESSING CHIMERIC ANTIGEN RECEPTORS (CAR), METHOD OF MANUFACTURING SAME, AND METHOD OF USING IN THERAPY |
| WO2020198031A1 (en) * | 2019-03-22 | 2020-10-01 | Windmil Therapeutics Inc. | Lung cancer specific marrow infiltrating lymphocytes and uses thereof |
| US20230100744A1 (en) * | 2020-02-28 | 2023-03-30 | Windmil Therapeutics, Inc. | Methods for enriching marrow infiltrating lymphocytes ("mils"), compositions containing enriched mils, and methods of using enriched mils |
| WO2022066872A1 (en) * | 2020-09-24 | 2022-03-31 | Windmil Therapeutics, Inc. | Marrow infiltrating lymphocytes (mils) expressing t cell receptors, methods of manufacturing same, and method of using in therapy |
| US20230372397A1 (en) | 2020-10-06 | 2023-11-23 | Iovance Biotherapeutics, Inc. | Treatment of nsclc patients with tumor infiltrating lymphocyte therapies |
| AU2022246174A1 (en) | 2021-03-25 | 2023-09-14 | Iovance Biotherapeutics, Inc. | Methods and compositions for t-cell coculture potency assays and use with cell therapy products |
| CA3248034A1 (en) | 2022-04-15 | 2023-10-19 | Iovance Biotherapeutics, Inc. | METHODS FOR EXPANSION OF TIL CELLS BY MEANS OF SPECIFIC CYTOKINE COMBINATIONS AND/OR AKT INHIBITOR TREATMENT |
| WO2025160242A1 (en) * | 2024-01-23 | 2025-07-31 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Method of generating tils from cerebro spinal fluid for leptomeningeal disease |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3243600A (en) | 1999-02-23 | 2000-09-14 | Kathleen S. Carswell | Improved method of culturing t cells |
| US6811788B2 (en) * | 2000-01-19 | 2004-11-02 | Baofa Yu | Combinations and methods for treating neoplasms |
| WO2008147482A2 (en) * | 2007-02-13 | 2008-12-04 | Northeastern University | Methods and compositions for improving immune responses |
| WO2010062742A2 (en) * | 2008-11-03 | 2010-06-03 | The Johns Hopkins University | Methods for freparation and use of marrow infiltrating lymphocytes (mils) |
| WO2014085437A2 (en) * | 2012-11-27 | 2014-06-05 | The Johns Hopkins University | Use of post-transplant cyclophosphamide treated allogeneic marrow infiltrating lymphocytes to augment anti-tumor immunity |
| BR112014007947A2 (pt) | 2011-10-03 | 2017-04-18 | Univ Los Andes | método para monitoramento, diagnóstico e/ou prognóstico de distúrbios relacionados à hipoxia usando nfat5 |
| WO2013109759A1 (en) * | 2012-01-17 | 2013-07-25 | Northeastern University | Methods and compositions for expanding immunosuppressive t regulatory cells in vitro and uses thereof |
| JP2014090678A (ja) * | 2012-11-01 | 2014-05-19 | Ito En Ltd | 容器詰野菜汁及び／又は果汁含有飲料及びその製造方法、並びに容器詰野菜汁及び／又は果汁含有飲料の呈味劣化防止方法 |
| US9687510B2 (en) | 2014-09-04 | 2017-06-27 | The Johns Hopkins University | Activation of marrow infiltrating lymphocytes in hypoxic alternating with normoxic conditions |
| JP2020512284A (ja) * | 2016-12-22 | 2020-04-23 | ウィンドミル セラピューティクス インコーポレイテッド | 免疫系調節組成物および方法 |
| EP3735256A4 (en) * | 2018-03-22 | 2021-10-13 | Windmil Therapeutics, Inc. | BONE MARROW LYMPHOCYTES SPECIFIC TO PROSTATE CANCER AND ASSOCIATED USES |
| SG11202104637VA (en) * | 2018-11-30 | 2021-06-29 | Windmil Therapeutics Inc | MARROW INFILTRATING LYMPHOCYTES (MILs) EXPRESSING CHIMERIC ANTIGEN RECEPTORS (CAR), METHOD OF MANUFACTURING SAME, AND METHOD OF USING IN THERAPY |
-
2015
- 2015-09-04 US US15/112,353 patent/US9687510B2/en active Active
- 2015-09-04 EP EP21167891.7A patent/EP3922254A1/en not_active Withdrawn
- 2015-09-04 WO PCT/US2015/048536 patent/WO2016037054A1/en not_active Ceased
- 2015-09-04 DK DK15838358.8T patent/DK3188740T3/da active
- 2015-09-04 EP EP15838358.8A patent/EP3188740B1/en active Active
- 2015-09-04 PT PT158383588T patent/PT3188740T/pt unknown
- 2015-09-04 MX MX2017002852A patent/MX391017B/es unknown
- 2015-09-04 ES ES15838358T patent/ES2877108T3/es active Active
- 2015-09-04 JP JP2017512293A patent/JP6865160B2/ja not_active Expired - Fee Related
- 2015-09-04 CA CA2959994A patent/CA2959994C/en active Active
- 2015-09-04 CN CN201580059448.3A patent/CN107109364A/zh active Pending
- 2015-09-04 AU AU2015311761A patent/AU2015311761B2/en not_active Ceased
- 2015-09-04 KR KR1020177009084A patent/KR20170067751A/ko not_active Abandoned
-
2017
- 2017-02-23 IL IL250746A patent/IL250746B/en active IP Right Grant
- 2017-05-26 US US15/606,766 patent/US10406178B2/en active Active
- 2017-05-26 US US15/606,951 patent/US10172887B2/en active Active
-
2018
- 2018-12-03 US US16/207,864 patent/US11160830B2/en not_active Expired - Fee Related
-
2019
- 2019-07-30 US US16/526,656 patent/US11406666B2/en active Active
-
2020
- 2020-07-28 IL IL276347A patent/IL276347B/en unknown
-
2021
- 2021-02-02 AU AU2021200648A patent/AU2021200648A1/en not_active Abandoned
- 2021-04-05 JP JP2021063957A patent/JP7197213B2/ja active Active
- 2021-09-30 US US17/490,691 patent/US20220016172A1/en not_active Abandoned
-
2022
- 2022-07-14 US US17/864,546 patent/US20230000919A1/en active Pending
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