JP2021097671A5 - - Google Patents
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- Publication number
- JP2021097671A5 JP2021097671A5 JP2021015026A JP2021015026A JP2021097671A5 JP 2021097671 A5 JP2021097671 A5 JP 2021097671A5 JP 2021015026 A JP2021015026 A JP 2021015026A JP 2021015026 A JP2021015026 A JP 2021015026A JP 2021097671 A5 JP2021097671 A5 JP 2021097671A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- seq
- nos
- sequences
- intergenic region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108020004707 nucleic acids Proteins 0.000 claims 10
- 150000007523 nucleic acids Chemical class 0.000 claims 10
- 102000039446 nucleic acids Human genes 0.000 claims 10
- 108091029795 Intergenic region Proteins 0.000 claims 5
- 241000894006 Bacteria Species 0.000 claims 4
- 230000037430 deletion Effects 0.000 claims 3
- 238000012217 deletion Methods 0.000 claims 3
- 230000037431 insertion Effects 0.000 claims 3
- 238000003780 insertion Methods 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 241000194035 Lactococcus lactis Species 0.000 claims 1
- 235000014897 Streptococcus lactis Nutrition 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11168495.7 | 2011-06-01 | ||
| EP11168495 | 2011-06-01 | ||
| EP11173588.2 | 2011-07-12 | ||
| EP11173588 | 2011-07-12 | ||
| JP2017093388A JP6867866B2 (ja) | 2011-06-01 | 2017-05-09 | 細菌のポリシストロン性発現系 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017093388A Division JP6867866B2 (ja) | 2011-06-01 | 2017-05-09 | 細菌のポリシストロン性発現系 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021097671A JP2021097671A (ja) | 2021-07-01 |
| JP2021097671A5 true JP2021097671A5 (https=) | 2021-08-12 |
Family
ID=46354175
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014513212A Expired - Fee Related JP6175428B2 (ja) | 2011-06-01 | 2012-06-01 | 細菌のポリシストロン性発現系 |
| JP2017093388A Active JP6867866B2 (ja) | 2011-06-01 | 2017-05-09 | 細菌のポリシストロン性発現系 |
| JP2021015026A Pending JP2021097671A (ja) | 2011-06-01 | 2021-02-02 | 細菌のポリシストロン性発現系 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014513212A Expired - Fee Related JP6175428B2 (ja) | 2011-06-01 | 2012-06-01 | 細菌のポリシストロン性発現系 |
| JP2017093388A Active JP6867866B2 (ja) | 2011-06-01 | 2017-05-09 | 細菌のポリシストロン性発現系 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US9920324B2 (https=) |
| EP (2) | EP3360967B1 (https=) |
| JP (3) | JP6175428B2 (https=) |
| KR (1) | KR102066292B1 (https=) |
| CN (2) | CN103562390B (https=) |
| AU (2) | AU2012264589B2 (https=) |
| BR (1) | BR112013030824A8 (https=) |
| CA (2) | CA3136084A1 (https=) |
| DK (1) | DK2714912T3 (https=) |
| ES (1) | ES2676877T3 (https=) |
| HU (1) | HUE039577T2 (https=) |
| RU (2) | RU2644346C2 (https=) |
| WO (1) | WO2012164083A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012164083A1 (en) | 2011-06-01 | 2012-12-06 | Actogenix N.V. | Polycistronic expression system for bacteria |
| US9593339B1 (en) * | 2013-02-14 | 2017-03-14 | David Gordon Bermudes | Bacteria carrying bacteriophage and protease inhibitors for the treatment of disorders and methods of treatment |
| WO2015022798A1 (ja) * | 2013-08-13 | 2015-02-19 | 学校法人北里研究所 | 新規テルペノイド化合物およびその製造方法 |
| DK3228706T3 (da) | 2014-12-03 | 2021-07-26 | Azusapharma Sciences Inc | Coekspressionsplasmid |
| US10696974B2 (en) | 2014-12-23 | 2020-06-30 | Ilya Pharma Ab | Methods for wound healing |
| CA2984701C (en) * | 2015-05-10 | 2023-09-26 | Ventana Medical Systems, Inc. | Compositions and methods for simultaneous inactivation of alkaline phosphatase and peroxidase enzymes during automated multiplex tissue staining assays |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US10905727B2 (en) | 2016-01-14 | 2021-02-02 | Intrexon Actobiotics N.V. | Compositions and methods for the treatment of type 1 diabetes |
| CN118813511A (zh) | 2016-09-02 | 2024-10-22 | 英特瑞克斯顿阿克图比奥帝克斯有限公司 | 稳定表达il-10和胰岛素的遗传修饰的细菌 |
| RU2021135949A (ru) | 2016-09-13 | 2022-04-14 | Интрексон Актобиотикс Н.В. | Мукоадгезивный микроорганизм |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| GB201906775D0 (en) * | 2019-05-14 | 2019-06-26 | Res & Innovation Uk | Synthetic genome |
| CA3156035A1 (en) | 2019-09-27 | 2021-04-01 | Intrexon Actobiotics Nv D/B/A Precigen Actobio | Treatment of celiac disease |
| WO2024003873A1 (en) | 2022-06-30 | 2024-01-04 | Intrexon Actobiotics Nv D/B/A Precigen Actobio | Single variable domain antibodies against tumor necrosis factor-alpha |
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|---|---|---|---|---|
| GB227835A (en) | 1924-01-15 | 1925-04-09 | Harry Odell | Improvements in feeding mechanism for embossing and other printing presses |
| JPS58116498A (ja) | 1981-12-28 | 1983-07-11 | Takeda Chem Ind Ltd | Ｉｌ‐２をコードする新規伝令ｒｎａの製造法 |
| DE3377363D1 (en) | 1982-03-31 | 1988-08-18 | Ajinomoto Kk | Gene coding for interleukin-2 polypeptide, recombinant dna carrying said gene, cell lines possessing the recombinant dna,and method for producing interleukin-2 using said cells |
| US4518584A (en) | 1983-04-15 | 1985-05-21 | Cetus Corporation | Human recombinant interleukin-2 muteins |
| US4752585A (en) | 1985-12-17 | 1988-06-21 | Cetus Corporation | Oxidation-resistant muteins |
| JPH01196296A (ja) * | 1988-01-29 | 1989-08-08 | Toray Ind Inc | 動物細胞用発現ベクター |
| US4919918A (en) | 1988-03-14 | 1990-04-24 | Spectrum Consumer Products Co., Inc. | Non-alcoholic mouthwash |
| US5972685A (en) | 1988-07-21 | 1999-10-26 | Iowa State University Research Foundation, Inc. | Oral administration of coprostanol producing microorganisms to humans to decrease plasma cholesterol concentration |
| GB9006400D0 (en) | 1990-03-22 | 1990-05-23 | Ciba Geigy Ag | Bacterial vectors |
| US6221840B1 (en) | 1991-02-14 | 2001-04-24 | The General Hospital Corporation | Intestinal trefoil proteins |
| DE69232619T2 (de) | 1991-02-14 | 2002-09-12 | The General Hospital Corp., Charlestown | Intestinale kleeblatt-proteine |
| US6277969B1 (en) | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
| GB9126306D0 (en) | 1991-12-11 | 1992-02-12 | Unilever Plc | Mouthwash compositions |
| WO1993017117A1 (en) | 1992-02-27 | 1993-09-02 | Lynxvale Limited | Heterologous gene expression in lactococcus, and the expression products therefrom |
| US5223285A (en) | 1992-03-31 | 1993-06-29 | Abbott Laboratories | Nutritional product for pulmonary patients |
| EP0569604A1 (en) | 1992-04-07 | 1993-11-18 | Societe Des Produits Nestle S.A. | Integrative gene-expression in Streptococcus salivarius ssp.thermophilus |
| US5229109A (en) | 1992-04-14 | 1993-07-20 | Board Of Regents, The University Of Texas System | Low toxicity interleukin-2 analogues for use in immunotherapy |
| US5700782A (en) | 1993-05-28 | 1997-12-23 | Abbott Laboratories | Enteral nutritional product |
| WO1996032486A1 (en) | 1995-04-11 | 1996-10-17 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Method for the construction of vectors for lactic acid bacteria like lactobacillus such that the bacteria can efficiently express, secrete and display proteins at the surface |
| US5695746A (en) | 1995-07-28 | 1997-12-09 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Liquid dentifrice with mouthwash fresh taste |
| GB9521568D0 (en) | 1995-10-20 | 1995-12-20 | Lynxvale Ltd | Delivery of biologically active polypeptides |
| WO1997026855A1 (en) | 1996-01-24 | 1997-07-31 | Warner-Lambert Company | Peroxide/essential oils containing mouthwash compositions and two-part mouthwash systems |
| GB9611364D0 (en) | 1996-05-31 | 1996-08-07 | Smithkline Beecham Plc | Composition |
| US5993785A (en) | 1996-09-18 | 1999-11-30 | Erling Johansen | Mouthwash compositions |
| US5869118A (en) | 1996-11-13 | 1999-02-09 | Abbott Laboratories | Gellan gum to improve physical stability of liquid nutritional products |
| US6171611B1 (en) | 1997-11-12 | 2001-01-09 | Dante J. Picciano | Iodine-containing nasal moisturizing saline and mouthwash solutions |
| US5897872A (en) | 1997-11-12 | 1999-04-27 | Picciano; Dante J. | Iodine-containing nasal moisturizing saline solution |
| MXPA01003197A (es) | 1998-09-28 | 2004-04-21 | Warner Lambert Co | Suministro enterico y colonico utilizando capsulas de chpm. |
| WO2000022909A2 (en) | 1998-10-19 | 2000-04-27 | Biotech Australia Pty. Limited | Systems for oral delivery |
| DE69914932T2 (de) | 1998-10-20 | 2004-12-09 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Verwendung eines zytokine-produzierenden lactococcus stammes zur behandlung von kolitis |
| BR0012632A (pt) | 1999-06-30 | 2002-06-04 | Produites Nestle S A Soc D | Operon de lactose de lactobacillus delbrueckii e uso do mesmo para controlar a transcrição eiou expressão de gene em células bacterianas |
| PT1739178E (pt) | 1999-07-05 | 2010-11-17 | Actogenix Nv | Libertação de péptidos trifólios |
| AU2001238582A1 (en) * | 2000-02-24 | 2001-09-03 | Siga Pharmaceuticals, Inc | Intergenic and intragenic integration sites for foreign gene expression in recombinant s. gordonii strains |
| US7029842B2 (en) * | 2000-04-07 | 2006-04-18 | Novozymes A/S | Signal sequence trapping |
| GB0013810D0 (en) | 2000-06-06 | 2000-07-26 | Celltech Chiroscience Ltd | Biological products |
| DK1383897T3 (da) | 2001-05-03 | 2006-10-30 | Vlaams Interuniv Inst Biotech | Selv-containing Lactococcus-stamme |
| EP1319410A1 (en) * | 2001-12-11 | 2003-06-18 | Société des Produits Nestlé S.A. | Use of micro-organisms for a directed delivery of substances to specific parts of the gut |
| EP1536749A2 (en) | 2002-07-08 | 2005-06-08 | Joe S. Wilkins, Jr. | Antibacterial formulations |
| AU2003298291A1 (en) | 2002-11-15 | 2004-06-15 | Universiteit Gent | Self-containing lactobacillus strain |
| WO2004069177A2 (en) | 2003-01-31 | 2004-08-19 | The Trustees Of The University Of Pennsylvania | Methods for modulating an inflammatory response |
| EP1493816A1 (en) * | 2003-07-02 | 2005-01-05 | Friesland Brands B.V. | Methods and means for regulating gene expression |
| US7569215B2 (en) | 2003-07-18 | 2009-08-04 | Massachusetts Institute Of Technology | Mutant interleukin-2 (IL-2) polypeptides |
| US7842289B2 (en) * | 2003-12-24 | 2010-11-30 | Aduro Biotech | Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof |
| EP1708741B1 (en) * | 2003-12-24 | 2016-03-30 | Aduro Biotech | Recombinant nucleic acid molecules encoding fusion proteins comprising antigens and bacterial secretory signal polypeptides, expression cassettes, and bacteria, and methods of use thereof |
| US20060234205A1 (en) | 2004-03-05 | 2006-10-19 | Chiron Corporation | In vitro test system for predicting patient tolerability of therapeutic agents |
| US7495092B2 (en) * | 2005-01-14 | 2009-02-24 | North Carolina State University | Compositions comprising promoter sequences and methods of use |
| US7764366B2 (en) | 2006-07-11 | 2010-07-27 | Besi North America, Inc. | Robotic die sorter with optical inspection system |
| JP2009544679A (ja) * | 2006-07-25 | 2009-12-17 | ザ ユニヴァーシティー コート オブ ザ ユニヴァーシティー オブ ダンディー | 異常な細胞増殖に関連する疾患の治療におけるレチノイド及び小分子のＮｒｆ２アンタゴニストとしての使用 |
| AU2008204442B2 (en) * | 2007-01-12 | 2013-03-14 | Intrexon Actobiotics Nv | Lactococcus promoters and uses thereof |
| CA2760248C (en) | 2009-04-30 | 2019-05-28 | Actogenix Nv | Cryoprotectants for freeze drying of lactic acid bacteria |
| SG192673A1 (en) | 2011-02-10 | 2013-09-30 | Roche Glycart Ag | Mutant interleukin-2 polypeptides |
| BR112013023151A2 (pt) | 2011-03-11 | 2020-09-15 | Assistance Publique - Hôpitaux De Paris | interleucina-2 para uso no tratamento de desordem auto-imune, !muno-relacionada ou inflamatória e método para determinar se um regime ou dose de il-2 tem de ser modificado |
| WO2012164083A1 (en) | 2011-06-01 | 2012-12-06 | Actogenix N.V. | Polycistronic expression system for bacteria |
| WO2013036914A1 (en) | 2011-09-08 | 2013-03-14 | University Of Florida Research Foundation, Inc. | Materials and methods for modulating immune responses |
| US10905727B2 (en) | 2016-01-14 | 2021-02-02 | Intrexon Actobiotics N.V. | Compositions and methods for the treatment of type 1 diabetes |
-
2012
- 2012-06-01 WO PCT/EP2012/060431 patent/WO2012164083A1/en not_active Ceased
- 2012-06-01 CN CN201280026763.2A patent/CN103562390B/zh not_active Expired - Fee Related
- 2012-06-01 HU HUE12729396A patent/HUE039577T2/hu unknown
- 2012-06-01 CA CA3136084A patent/CA3136084A1/en not_active Abandoned
- 2012-06-01 CN CN201710467009.7A patent/CN107267546B/zh not_active Expired - Fee Related
- 2012-06-01 KR KR1020137033153A patent/KR102066292B1/ko not_active Expired - Fee Related
- 2012-06-01 RU RU2013157300A patent/RU2644346C2/ru active
- 2012-06-01 BR BR112013030824A patent/BR112013030824A8/pt not_active IP Right Cessation
- 2012-06-01 DK DK12729396.7T patent/DK2714912T3/en active
- 2012-06-01 JP JP2014513212A patent/JP6175428B2/ja not_active Expired - Fee Related
- 2012-06-01 US US14/122,545 patent/US9920324B2/en active Active
- 2012-06-01 ES ES12729396.7T patent/ES2676877T3/es active Active
- 2012-06-01 EP EP18163611.9A patent/EP3360967B1/en active Active
- 2012-06-01 RU RU2018102374A patent/RU2766157C2/ru active
- 2012-06-01 CA CA2837634A patent/CA2837634C/en active Active
- 2012-06-01 AU AU2012264589A patent/AU2012264589B2/en not_active Ceased
- 2012-06-01 EP EP12729396.7A patent/EP2714912B1/en active Active
-
2017
- 2017-05-09 JP JP2017093388A patent/JP6867866B2/ja active Active
- 2017-05-16 AU AU2017203281A patent/AU2017203281B2/en not_active Ceased
-
2018
- 2018-02-15 US US15/897,427 patent/US10988770B2/en active Active
-
2020
- 2020-12-04 US US17/112,611 patent/US20210163961A1/en not_active Abandoned
-
2021
- 2021-02-02 JP JP2021015026A patent/JP2021097671A/ja active Pending
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