BR112013030824A8 - Bactéria gram-positiva, ácido necleico recombinante, composição farmacêutica e vetor - Google Patents

Bactéria gram-positiva, ácido necleico recombinante, composição farmacêutica e vetor

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Publication number
BR112013030824A8
BR112013030824A8 BR112013030824A BR112013030824A BR112013030824A8 BR 112013030824 A8 BR112013030824 A8 BR 112013030824A8 BR 112013030824 A BR112013030824 A BR 112013030824A BR 112013030824 A BR112013030824 A BR 112013030824A BR 112013030824 A8 BR112013030824 A8 BR 112013030824A8
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BR
Brazil
Prior art keywords
gram
positive bacteria
vector
pharmaceutical composition
recombinant
Prior art date
Application number
BR112013030824A
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English (en)
Other versions
BR112013030824A2 (pt
Inventor
Vandenbroucke Klaas
Van Huynegem Karolien
Steidler Lothar
Original Assignee
Actogenix Nv
Intrexon Actobiotics N V
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Publication date
Application filed by Actogenix Nv, Intrexon Actobiotics N V filed Critical Actogenix Nv
Publication of BR112013030824A2 publication Critical patent/BR112013030824A2/pt
Publication of BR112013030824A8 publication Critical patent/BR112013030824A8/pt

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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)

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  • Health & Medical Sciences (AREA)
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  • Wood Science & Technology (AREA)
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Abstract

BACTÉRIA GRAM-POSITIVA, ÁCIDOS NUCLEICOS RECOMBINANTES, COMPOSIÇÃO FARMACÊUTICA, VETOR E USO DA BACTÉRIA GRAM-POSITIVA. A invenção refere-se a uma expressão policistrônica em bactéria gram-positiva e, em particular, é relacionada a unidades de expressão policistrônica que compreendem um ou mais genes endógenos à bactéria gram-positiva acoplados de forma transcricional a um ou mais genes exógenos à bactéria.
BR112013030824A 2011-06-01 2012-06-01 Bactéria gram-positiva, ácido necleico recombinante, composição farmacêutica e vetor BR112013030824A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11168495 2011-06-01
EP11173588 2011-07-12
PCT/EP2012/060431 WO2012164083A1 (en) 2011-06-01 2012-06-01 Polycistronic expression system for bacteria

Publications (2)

Publication Number Publication Date
BR112013030824A2 BR112013030824A2 (pt) 2016-12-06
BR112013030824A8 true BR112013030824A8 (pt) 2018-04-03

Family

ID=46354175

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013030824A BR112013030824A8 (pt) 2011-06-01 2012-06-01 Bactéria gram-positiva, ácido necleico recombinante, composição farmacêutica e vetor

Country Status (14)

Country Link
US (3) US9920324B2 (pt)
EP (2) EP3360967B1 (pt)
JP (3) JP6175428B2 (pt)
KR (1) KR102066292B1 (pt)
CN (2) CN103562390B (pt)
AU (2) AU2012264589B2 (pt)
BR (1) BR112013030824A8 (pt)
CA (2) CA3136084A1 (pt)
DK (1) DK2714912T3 (pt)
ES (1) ES2676877T3 (pt)
HK (2) HK1244033A1 (pt)
HU (1) HUE039577T2 (pt)
RU (2) RU2766157C2 (pt)
WO (1) WO2012164083A1 (pt)

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RU2768027C2 (ru) * 2016-09-02 2022-03-23 Интрексон Актобиотикс Н.В. Генетически модифицированные бактерии, стабильно экспрессирующие ил-10 и инсулин
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CA2837634A1 (en) 2012-12-06
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