BR112016028023A2 - Composições e métodos de administração de tratamentos para infecções virais latentes - Google Patents

Composições e métodos de administração de tratamentos para infecções virais latentes

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Publication number
BR112016028023A2
BR112016028023A2 BR112016028023A BR112016028023A BR112016028023A2 BR 112016028023 A2 BR112016028023 A2 BR 112016028023A2 BR 112016028023 A BR112016028023 A BR 112016028023A BR 112016028023 A BR112016028023 A BR 112016028023A BR 112016028023 A2 BR112016028023 A2 BR 112016028023A2
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BR
Brazil
Prior art keywords
methods
compositions
administration
treatments
therapeutic agents
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BR112016028023A
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English (en)
Inventor
R Quake Stephen
Wang Jianbin
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Univ Leland Stanford Junior
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Publication of BR112016028023A2 publication Critical patent/BR112016028023A2/pt

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    • A61P31/12—Antivirals
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    • A61K38/00—Medicinal preparations containing peptides
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/12—Antivirals
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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    • C12N9/14—Hydrolases (3)
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    • C12N9/22—Ribonucleases RNAses, DNAses
    • A—HUMAN NECESSITIES
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    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

COMPOSIÇÕES E MÉTODOS DE ADMINISTRAÇÃO DE TRATAMENTOS PARA INFECÇÕES VIRAIS LATENTES. A presente invenção refere-se a métodos de administração e composições para agentes terapêuticos antivirais. São providos métodos e composições para administração direcionada de agentes terapêuticos antivirais a células de interesse usando, por exemplo, vetores virais tais como adenovírus, AAV e HSV incompetente em replicação. Estes e outros sistemas de administração podem ser usados como veículos para administrar vetores de DNA codificando uma nuclease ou um gene assassino de célula. Estes métodos de administração podem ser também usados para administrar DNA ou RNA nu, produtos de proteína, plasmídeos contendo um promotor que é ativo apenas em um estado viral latente que aciona um gene assassino de célula, ou outros agentes terapêuticos.
BR112016028023A 2014-05-30 2015-05-29 Composições e métodos de administração de tratamentos para infecções virais latentes BR112016028023A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462005395P 2014-05-30 2014-05-30
US201462029072P 2014-07-25 2014-07-25
PCT/US2015/033186 WO2015184262A1 (en) 2014-05-30 2015-05-29 Compositions and methods of delivering treatments for latent viral infections

Publications (1)

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BR112016028023A2 true BR112016028023A2 (pt) 2017-08-22

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BR112016028023A BR112016028023A2 (pt) 2014-05-30 2015-05-29 Composições e métodos de administração de tratamentos para infecções virais latentes

Country Status (10)

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US (7) US10066241B2 (pt)
EP (3) EP3149169A1 (pt)
JP (3) JP2017518075A (pt)
KR (1) KR20170005494A (pt)
CN (2) CN107002094A (pt)
AU (3) AU2015266776A1 (pt)
BR (1) BR112016028023A2 (pt)
CA (2) CA2949713A1 (pt)
SG (1) SG11201610028TA (pt)
WO (3) WO2015184268A1 (pt)

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