JP2021020924A5 - - Google Patents
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- Publication number
- JP2021020924A5 JP2021020924A5 JP2020173954A JP2020173954A JP2021020924A5 JP 2021020924 A5 JP2021020924 A5 JP 2021020924A5 JP 2020173954 A JP2020173954 A JP 2020173954A JP 2020173954 A JP2020173954 A JP 2020173954A JP 2021020924 A5 JP2021020924 A5 JP 2021020924A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrazole
- carboxamide
- pyridin
- thiazole
- furan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562151274P | 2015-04-22 | 2015-04-22 | |
| US62/151,274 | 2015-04-22 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017555270A Division JP6835739B2 (ja) | 2015-04-22 | 2016-04-22 | ピラゾール化合物ならびにこの化合物を作製および使用するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021020924A JP2021020924A (ja) | 2021-02-18 |
| JP2021020924A5 true JP2021020924A5 (enExample) | 2021-04-22 |
| JP7050879B2 JP7050879B2 (ja) | 2022-04-08 |
Family
ID=55858915
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017555270A Active JP6835739B2 (ja) | 2015-04-22 | 2016-04-22 | ピラゾール化合物ならびにこの化合物を作製および使用するための方法 |
| JP2020173954A Active JP7050879B2 (ja) | 2015-04-22 | 2020-10-15 | ピラゾール化合物ならびにこの化合物を作製および使用するための方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017555270A Active JP6835739B2 (ja) | 2015-04-22 | 2016-04-22 | ピラゾール化合物ならびにこの化合物を作製および使用するための方法 |
Country Status (30)
| Country | Link |
|---|---|
| US (6) | US9982000B2 (enExample) |
| EP (1) | EP3286181B1 (enExample) |
| JP (2) | JP6835739B2 (enExample) |
| KR (1) | KR102677905B1 (enExample) |
| CN (2) | CN107438603B (enExample) |
| AU (1) | AU2016252869B2 (enExample) |
| BR (1) | BR112017022349B1 (enExample) |
| CA (1) | CA2980800C (enExample) |
| CL (1) | CL2017002640A1 (enExample) |
| CO (1) | CO2017010583A2 (enExample) |
| CY (1) | CY1124422T1 (enExample) |
| DK (1) | DK3286181T3 (enExample) |
| EA (1) | EA039043B1 (enExample) |
| ES (1) | ES2861351T3 (enExample) |
| HR (1) | HRP20210433T1 (enExample) |
| HU (1) | HUE054042T2 (enExample) |
| IL (1) | IL254615B (enExample) |
| LT (1) | LT3286181T (enExample) |
| MX (1) | MX380940B (enExample) |
| MY (1) | MY189941A (enExample) |
| PE (1) | PE20180118A1 (enExample) |
| PH (1) | PH12017501925A1 (enExample) |
| PL (1) | PL3286181T3 (enExample) |
| PT (1) | PT3286181T (enExample) |
| RS (1) | RS61636B1 (enExample) |
| SG (2) | SG10201912656SA (enExample) |
| SI (1) | SI3286181T1 (enExample) |
| SM (1) | SMT202100186T1 (enExample) |
| WO (1) | WO2016172560A1 (enExample) |
| ZA (1) | ZA201706545B (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3286181T3 (da) * | 2015-04-22 | 2021-04-06 | Rigel Pharmaceuticals Inc | Pyrazolforbindelser og fremgangsmåde til fremstilling og anvendelse af forbindelserne |
| GB201506872D0 (en) | 2015-04-22 | 2015-06-03 | Ge Oil & Gas Uk Ltd | Novel compounds |
| CN110234637B (zh) | 2016-10-26 | 2022-11-01 | 里格尔药品股份有限公司 | 用作irak抑制剂的吡唑酰胺化合物 |
| CN110099899B (zh) * | 2016-10-26 | 2024-01-02 | 里格尔药品股份有限公司 | 用作irak抑制剂的噁唑衍生物及其制备方法 |
| TW202340194A (zh) | 2017-02-16 | 2023-10-16 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒𠯤衍生物 |
| JP7167069B2 (ja) * | 2017-06-29 | 2022-11-08 | ライジェル ファーマシューティカルズ， インコーポレイテッド | キナーゼ阻害剤ならびに作製および使用のための方法 |
| MX2020003190A (es) | 2017-09-22 | 2020-11-11 | Kymera Therapeutics Inc | Degradadores de proteinas y usos de los mismos. |
| WO2019060693A1 (en) | 2017-09-22 | 2019-03-28 | Kymera Therapeutics, Inc. | CRBN LIGANDS AND USES THEREOF |
| WO2019111218A1 (en) | 2017-12-08 | 2019-06-13 | Cadila Healthcare Limited | Novel heterocyclic compounds as irak4 inhibitors |
| IL315310A (en) | 2017-12-26 | 2024-10-01 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| CN107857758B (zh) * | 2017-12-31 | 2018-08-24 | 广东莱恩医药研究院有限公司 | 一种酰胺类化合物及其作为hsp90抑制剂和抗肿瘤药物的应用 |
| CN107987063A (zh) * | 2017-12-31 | 2018-05-04 | 窦玉玲 | 一种hsp90抑制剂及其在抗肿瘤药物的应用 |
| US11512080B2 (en) | 2018-01-12 | 2022-11-29 | Kymera Therapeutics, Inc. | CRBN ligands and uses thereof |
| EP3737666A4 (en) | 2018-01-12 | 2022-01-05 | Kymera Therapeutics, Inc. | PROTEIN DEGRADATION AGENTS AND ASSOCIATED USES |
| KR20210028144A (ko) * | 2018-04-06 | 2021-03-11 | 블랙 벨트 티엑스 리미티드 | Atf6 저해제 및 그의 용도 |
| US12454520B2 (en) | 2018-07-06 | 2025-10-28 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| US11292792B2 (en) | 2018-07-06 | 2022-04-05 | Kymera Therapeutics, Inc. | Tricyclic CRBN ligands and uses thereof |
| TWI721483B (zh) | 2018-07-13 | 2021-03-11 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒𠯤衍生物 |
| CA3108065C (en) | 2018-07-31 | 2025-10-07 | Loxo Oncology, Inc. | SPRAY-DRIED DISPERSIONS, FORMULATIONS AND POLYMORPHIES OF (S)-5-AMINO-3-(4-((5-FLUORO-2-METHOXYBENZAMIDO)METHYL)PHENYL)(1,1,1-TRIFLUOROPROPANE-2-YL)-1H-PYRAZOLE-4-CARBOXAMIDE |
| CN110862375B (zh) * | 2018-08-27 | 2022-10-25 | 深圳铂立健医药有限公司 | 吡唑化合物及其药物组合物和应用 |
| AU2019389174A1 (en) | 2018-11-30 | 2021-07-01 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| PH12022500002A1 (en) | 2019-06-28 | 2023-04-03 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| US12558427B2 (en) | 2019-07-17 | 2026-02-24 | Kymera Therapeutics, Inc. | IRAK degraders and uses thereof |
| EP4009974A1 (en) | 2019-08-08 | 2022-06-15 | Rigel Pharmaceuticals, Inc. | Compounds and method for treating cytokine release syndrome |
| JP2022545542A (ja) * | 2019-08-30 | 2022-10-27 | ライジェル ファーマシューティカルズ， インコーポレイテッド | ピラゾール化合物、その製剤並びに化合物及び／又は製剤を使用する方法 |
| KR20220087464A (ko) | 2019-10-09 | 2022-06-24 | 프락시스 바이오테크 엘엘씨 | Atf6 조정제 및 그의 용도 |
| WO2021119159A1 (en) | 2019-12-10 | 2021-06-17 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| EP4076524A4 (en) | 2019-12-17 | 2023-11-29 | Kymera Therapeutics, Inc. | IRAQ DEGRADERS AND USES THEREOF |
| CA3161878A1 (en) | 2019-12-17 | 2021-06-24 | Matthew M. Weiss | Irak degraders and uses thereof |
| TW202210483A (zh) | 2020-06-03 | 2022-03-16 | 美商凱麥拉醫療公司 | Irak降解劑之結晶型 |
| EP4161521A4 (en) | 2020-06-03 | 2024-07-10 | Kymera Therapeutics, Inc. | DEUTERED IRAQ DEGRADERS AND USES THEREOF |
| AR124547A1 (es) | 2020-12-30 | 2023-04-05 | Kymera Therapeutics Inc | Degradadores de irak y sus usos |
| WO2022174268A1 (en) | 2021-02-15 | 2022-08-18 | Kymera Therapeutics, Inc. | Irak4 degraders and uses thereof |
| WO2022187303A1 (en) * | 2021-03-03 | 2022-09-09 | Rigel Pharmaceuticals, Inc. | A method for treating a disease or condition using a pyrazole compound or formulation thereof |
| EP4308115A4 (en) * | 2021-03-17 | 2025-01-22 | Merck Sharp & Dohme LLC | HETEROAROYL AMIDES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF |
| CA3217792A1 (en) | 2021-05-07 | 2022-11-10 | Kymera Therapeutics, Inc | Cdk2 degraders and uses thereof |
| KR20240016323A (ko) * | 2021-06-01 | 2024-02-06 | 리얼타 라이프 사이언시즈, 인크. | 펩티드 및 사용 방법 |
| EP4399208A4 (en) * | 2021-09-08 | 2025-07-16 | Rigel Pharmaceuticals Inc | IRAK INHIBITOR FOR TREATING CYTOKINE RELEASE CONDITIONS ASSOCIATED WITH RESPIRATORY VIRUS INFECTION |
| JP2024540080A (ja) | 2021-10-29 | 2024-10-31 | カイメラ セラピューティクス， インコーポレイテッド | Ｉｒａｋ４分解剤およびその合成 |
| EP4472967A4 (en) | 2022-01-31 | 2026-04-15 | Kymera Therapeutics Inc | Iraqi Degradation Agents and Their Uses |
| ES3075943T3 (en) * | 2022-03-23 | 2026-08-10 | Rigel Pharmaceuticals Inc | Pyrimid-2-yl-pyrazole compounds as irak inhibitors |
| WO2024011116A2 (en) * | 2022-07-07 | 2024-01-11 | Dana-Farber Cancer Institute, Inc. | Potent and selective irreversible inhibitors of irak1 |
| CN117209489B (zh) * | 2023-05-30 | 2024-07-26 | 杭州邦顺制药有限公司 | Irak激酶抑制剂 |
| WO2025111251A1 (en) * | 2023-11-20 | 2025-05-30 | Exelixis, Inc. | Compounds that inhibit polo-like kinase 4 |
| CN121270516A (zh) * | 2024-07-03 | 2026-01-06 | 科辉智药(深圳)新药研究中心有限公司 | 一种irak抑制剂化合物的晶型及其制备方法和应用 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003287965A1 (en) * | 2002-10-24 | 2004-05-13 | Carex Sa | Modulation of peroxisome proliferator activated receptors activity |
| TWI372050B (en) * | 2003-07-03 | 2012-09-11 | Astex Therapeutics Ltd | (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles |
| WO2006070202A1 (en) * | 2004-12-30 | 2006-07-06 | Astex Therapeutics Limited | Pyrazole derivatives having kinase modulating activity |
| EP1836188A1 (en) * | 2004-12-30 | 2007-09-26 | Astex Therapeutics Limited | Pyrazole derivatives as that modulate the activity of cdk, gsk and aurora kinases |
| SI2206707T1 (sl) * | 2007-10-24 | 2014-11-28 | Astellas Pharma Inc. | Azolkarboksamidna spojina ali njena sol |
| EP2070925A1 (de) | 2007-12-10 | 2009-06-17 | Bayer Schering Pharma Aktiengesellschaft | Neue 2-substituierte Tiazol-4-carbonsäureamid-Derivative deren Herstellung und Verwendung als Arzneimittel |
| US8987309B2 (en) | 2009-04-17 | 2015-03-24 | The Translational Genomics Research Institute | Compounds, pharmaceutical compositions and methods of use of 2-aryl pyridylazoles |
| EP2243481A1 (en) | 2009-04-24 | 2010-10-27 | PamGene B.V. | Irak kinase family as novel drug target for Alzheimer |
| JP2012254939A (ja) * | 2009-10-07 | 2012-12-27 | Astellas Pharma Inc | オキサゾール化合物 |
| WO2011043771A1 (en) | 2009-10-07 | 2011-04-14 | Nitto Denko Corporation | Narrow band excitation light source for fluorescence sensing system |
| CA2794801C (en) | 2010-04-07 | 2019-01-15 | F. Hoffmann-La Roche Ag | Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use |
| RU2632900C2 (ru) | 2010-11-19 | 2017-10-11 | Лиганд Фармасьютикалс Инкорпорейтед | Гетероциклические амины и их применение |
| WO2012072685A1 (en) | 2010-12-02 | 2012-06-07 | Katholieke Universiteit Leuven, K.U.Leuven R&D | Irak-related interventions and diagnosis |
| HUE029617T2 (en) | 2010-12-20 | 2017-03-28 | Merck Serono Sa | Indazolyl triazole derivatives as IRAK inhibitors |
| EP3239154A1 (en) | 2011-01-10 | 2017-11-01 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| CN103347873A (zh) * | 2011-02-09 | 2013-10-09 | 日产化学工业株式会社 | 吡唑衍生物和有害生物防除剂 |
| US8575336B2 (en) | 2011-07-27 | 2013-11-05 | Pfizer Limited | Indazoles |
| EP2760857A1 (en) | 2011-09-27 | 2014-08-06 | F.Hoffmann-La Roche Ag | Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use |
| TW201728592A (zh) | 2012-01-10 | 2017-08-16 | 林伯士艾瑞斯公司 | Ｉｒａｋ抑制劑及其用途 |
| WO2014048939A1 (en) * | 2012-09-26 | 2014-04-03 | F. Hoffmann-La Roche Ag | Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use |
| WO2014058691A1 (en) * | 2012-10-08 | 2014-04-17 | Merck Sharp & Dohme Corp. | Inhibitors of irak4 activity |
| JP6483624B2 (ja) | 2013-02-07 | 2019-03-13 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | ピリダジノン−アミド誘導体 |
| ES2639717T3 (es) | 2013-02-07 | 2017-10-30 | Merck Patent Gmbh | Derivados de piridazinona macrocíclicos |
| ES2728403T3 (es) | 2014-01-09 | 2019-10-24 | Merck Patent Gmbh | Derivados de pirimidin pirazolilo y su uso como inhibidores de IRAK |
| LT3221306T (lt) | 2014-11-20 | 2020-03-10 | Merck Patent Gmbh | Heteroarilo junginiai, kaip irak inhibitoriai ir jų panaudojimas |
| DK3286181T3 (da) | 2015-04-22 | 2021-04-06 | Rigel Pharmaceuticals Inc | Pyrazolforbindelser og fremgangsmåde til fremstilling og anvendelse af forbindelserne |
| HK1256242A1 (zh) * | 2015-08-04 | 2019-09-20 | Rigel Pharmaceuticals, Inc. | 吲哚化合物以及制备和使用该化合物的方法 |
-
2016
- 2016-04-22 DK DK16719191.5T patent/DK3286181T3/da active
- 2016-04-22 LT LTEP16719191.5T patent/LT3286181T/lt unknown
- 2016-04-22 HR HRP20210433TT patent/HRP20210433T1/hr unknown
- 2016-04-22 EP EP16719191.5A patent/EP3286181B1/en active Active
- 2016-04-22 BR BR112017022349-0A patent/BR112017022349B1/pt active IP Right Grant
- 2016-04-22 SG SG10201912656SA patent/SG10201912656SA/en unknown
- 2016-04-22 CA CA2980800A patent/CA2980800C/en active Active
- 2016-04-22 SI SI201631128T patent/SI3286181T1/sl unknown
- 2016-04-22 WO PCT/US2016/028957 patent/WO2016172560A1/en not_active Ceased
- 2016-04-22 ES ES16719191T patent/ES2861351T3/es active Active
- 2016-04-22 MX MX2017013413A patent/MX380940B/es unknown
- 2016-04-22 SG SG11201707752SA patent/SG11201707752SA/en unknown
- 2016-04-22 JP JP2017555270A patent/JP6835739B2/ja active Active
- 2016-04-22 CN CN201680021522.7A patent/CN107438603B/zh active Active
- 2016-04-22 HU HUE16719191A patent/HUE054042T2/hu unknown
- 2016-04-22 KR KR1020177031696A patent/KR102677905B1/ko active Active
- 2016-04-22 EA EA201791927A patent/EA039043B1/ru unknown
- 2016-04-22 CN CN202110865696.4A patent/CN113750094A/zh active Pending
- 2016-04-22 PE PE2017002190A patent/PE20180118A1/es unknown
- 2016-04-22 SM SM20210186T patent/SMT202100186T1/it unknown
- 2016-04-22 PL PL16719191T patent/PL3286181T3/pl unknown
- 2016-04-22 US US15/136,508 patent/US9982000B2/en active Active
- 2016-04-22 RS RS20210394A patent/RS61636B1/sr unknown
- 2016-04-22 MY MYPI2017001562A patent/MY189941A/en unknown
- 2016-04-22 AU AU2016252869A patent/AU2016252869B2/en active Active
- 2016-04-22 PT PT167191915T patent/PT3286181T/pt unknown
-
2017
- 2017-09-24 IL IL254615A patent/IL254615B/en unknown
- 2017-09-28 ZA ZA2017/06545A patent/ZA201706545B/en unknown
- 2017-10-17 CL CL2017002640A patent/CL2017002640A1/es unknown
- 2017-10-17 CO CONC2017/0010583A patent/CO2017010583A2/es unknown
- 2017-10-20 PH PH12017501925A patent/PH12017501925A1/en unknown
-
2018
- 2018-03-22 US US15/928,335 patent/US10208074B2/en active Active
- 2018-03-23 US US15/934,692 patent/US10208075B2/en active Active
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2019
- 2019-01-28 US US16/259,685 patent/US11370808B2/en active Active
-
2020
- 2020-10-15 JP JP2020173954A patent/JP7050879B2/ja active Active
-
2021
- 2021-04-07 CY CY20211100301T patent/CY1124422T1/el unknown
-
2022
- 2022-05-18 US US17/747,342 patent/US20220289776A1/en not_active Abandoned
-
2024
- 2024-11-27 US US18/963,039 patent/US20250326778A1/en active Pending
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