JP2020536898A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020536898A5 JP2020536898A5 JP2020520223A JP2020520223A JP2020536898A5 JP 2020536898 A5 JP2020536898 A5 JP 2020536898A5 JP 2020520223 A JP2020520223 A JP 2020520223A JP 2020520223 A JP2020520223 A JP 2020520223A JP 2020536898 A5 JP2020536898 A5 JP 2020536898A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- preparing
- prepare
- methyl
- temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 claims description 40
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims 3
- JAEIBKXSIXOLOL-UHFFFAOYSA-N pyrrolidin-1-ium-3-carboxylate Chemical compound OC(=O)C1CCNC1 JAEIBKXSIXOLOL-UHFFFAOYSA-N 0.000 claims 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 12
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 6
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- 239000010410 layer Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- CIBIQCRUDYBRJO-IBGZPJMESA-N (5s)-7-methyl-2-[4-methyl-6-[4-(trifluoromethyl)phenyl]pyrimidin-2-yl]-1,7-diazaspiro[4.4]non-1-en-6-one Chemical compound O=C1N(C)CC[C@]11N=C(C=2N=C(C=C(C)N=2)C=2C=CC(=CC=2)C(F)(F)F)CC1 CIBIQCRUDYBRJO-IBGZPJMESA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 239000012044 organic layer Substances 0.000 description 2
- 229910000160 potassium phosphate Inorganic materials 0.000 description 2
- 235000011009 potassium phosphates Nutrition 0.000 description 2
- 229960004889 salicylic acid Drugs 0.000 description 2
- LODHFNUFVRVKTH-ZHACJKMWSA-N 2-hydroxy-n'-[(e)-3-phenylprop-2-enoyl]benzohydrazide Chemical compound OC1=CC=CC=C1C(=O)NNC(=O)\C=C\C1=CC=CC=C1 LODHFNUFVRVKTH-ZHACJKMWSA-N 0.000 description 1
- BOCIWLBENJQNBZ-UHFFFAOYSA-N CN(CCC1(CC#C)C(O)=O)C1=O Chemical compound CN(CCC1(CC#C)C(O)=O)C1=O BOCIWLBENJQNBZ-UHFFFAOYSA-N 0.000 description 1
- 101150003085 Pdcl gene Proteins 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 239000012455 biphasic mixture Substances 0.000 description 1
- 239000012267 brine Substances 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000012065 filter cake Substances 0.000 description 1
- JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropanol acetate Natural products CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 description 1
- 229940011051 isopropyl acetate Drugs 0.000 description 1
- GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 150000003839 salts Chemical group 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762570269P | 2017-10-10 | 2017-10-10 | |
| US62/570,269 | 2017-10-10 | ||
| PCT/US2018/055227 WO2019075073A2 (en) | 2017-10-10 | 2018-10-10 | PROCESS FOR THE PREPARATION OF SPIRO DERIVATIVES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020536898A JP2020536898A (ja) | 2020-12-17 |
| JP2020536898A5 true JP2020536898A5 (enExample) | 2021-12-02 |
Family
ID=66100090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020520223A Withdrawn JP2020536898A (ja) | 2017-10-10 | 2018-10-10 | スピロ誘導体を調製するためのプロセス |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11149039B2 (enExample) |
| EP (1) | EP3694510A4 (enExample) |
| JP (1) | JP2020536898A (enExample) |
| KR (1) | KR20200068678A (enExample) |
| CN (1) | CN111526874A (enExample) |
| AU (1) | AU2018347349A1 (enExample) |
| CA (1) | CA3077088A1 (enExample) |
| IL (1) | IL273695A (enExample) |
| MA (1) | MA50371A (enExample) |
| MX (2) | MX2020003821A (enExample) |
| SG (1) | SG11202002707VA (enExample) |
| WO (1) | WO2019075073A2 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200068678A (ko) | 2017-10-10 | 2020-06-15 | 바이오젠 인크. | 스피로 유도체를 제조하기 위한 공정 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US814396A (en) | 1905-05-22 | 1906-03-06 | Joseph R Russell | Burner for liquid fuel. |
| KR0178475B1 (ko) * | 1995-09-14 | 1999-03-20 | 윤덕용 | 신규한 n-비닐락탐 유도체 및 그의 중합체 |
| BR0312414A (pt) | 2002-07-05 | 2005-05-10 | Targacept Inc | Compostos de n-aril diazaespirociclico e métodos para a preparação e uso dos mesmos |
| US7501528B2 (en) * | 2005-03-15 | 2009-03-10 | Hoffmann-La Roche Inc. | Method for preparing enantiomerically pure 4-pyrrolidino phenylbenzyl ether derivatives |
| GB0520578D0 (en) | 2005-10-10 | 2005-11-16 | Glaxo Group Ltd | Novel compounds |
| US8143306B2 (en) | 2005-10-10 | 2012-03-27 | Convergence Pharmaceuticals Limited | Methods of treating bipolar disorders |
| EP1943216B1 (en) | 2005-10-10 | 2010-06-30 | Glaxo Group Limited | Prolinamide derivatives as sodium channel modulators |
| TW200730494A (en) | 2005-10-10 | 2007-08-16 | Glaxo Group Ltd | Novel compounds |
| TW200728258A (en) | 2005-10-10 | 2007-08-01 | Glaxo Group Ltd | Novel compounds |
| RU2009117605A (ru) | 2006-10-12 | 2010-11-20 | Ксенон Фармасьютикалз Инк. (Ca) | ПРОИЗВОДНЫЕ СПИРО-(ФУРО[3,2-c]ПИРИДИН-3-3'-ИНДОЛ)-2'(1'H)-ОНА И РОДСТВЕННЫЕ ИМ СОЕДИНЕНИЯ ДЛЯ ЛЕЧЕНИЯ ОПОСРЕДОВАННЫХ НАТРИЕВЫМИ КАНАЛАМИ ЗАБОЛЕВАНИЙ, ТАКИХ КАК БОЛЬ |
| JP2010522690A (ja) | 2006-10-12 | 2010-07-08 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 三環式スピロオキシインドール誘導体および治療薬としてのその使用 |
| JP2010516734A (ja) | 2007-01-24 | 2010-05-20 | グラクソ グループ リミテッド | ３，５−ジアミノ−６−（２，３−ジクロロフェニル）−１，２，４−トリアジンまたはｒ（−）−２，４−ジアミノ−５−（２，３−ジクロロフェニル）−６−フルオロメチルピリミジンを含む医薬組成物 |
| GB0701366D0 (en) | 2007-01-24 | 2007-03-07 | Glaxo Group Ltd | Novel pharmaceutical compositions |
| GB0701365D0 (en) | 2007-01-24 | 2007-03-07 | Glaxo Group Ltd | Novel pharmaceutical compositions |
| GB0706630D0 (en) | 2007-04-04 | 2007-05-16 | Glaxo Group Ltd | Novel compounds |
| AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| TWI466885B (zh) * | 2009-07-31 | 2015-01-01 | Japan Tobacco Inc | 含氮螺環化合物及其醫藥用途 |
| PT2477964E (pt) | 2009-09-14 | 2015-06-04 | Convergence Pharmaceuticals | Processo para a preparação de derivados de alfa-carboxamida |
| US8618303B2 (en) * | 2011-01-07 | 2013-12-31 | Hoffmann-La Roche Inc. | Pyrrolidine derivatives |
| CA2829170C (en) * | 2011-04-26 | 2019-02-26 | F. Hoffmann-La Roche Ag | Ethynyl derivatives as positive allosteric modulators of the mglur5 |
| GB201122113D0 (en) | 2011-12-22 | 2012-02-01 | Convergence Pharmaceuticals | Novel compounds |
| GB201209015D0 (en) | 2012-05-22 | 2012-07-04 | Convergence Pharmaceuticals | Novel compounds |
| GB201209670D0 (en) | 2012-05-31 | 2012-07-18 | Convergence Pharmaceuticals | Novel compounds |
| PT3177603T (pt) * | 2014-08-04 | 2019-02-06 | Merck Patent Gmbh | Derivados de pirrolidinona como inibidores de metap-2 |
| EA202090853A1 (ru) | 2017-09-28 | 2020-08-27 | Байоджен Инк. | Новые соли |
| KR20200068678A (ko) | 2017-10-10 | 2020-06-15 | 바이오젠 인크. | 스피로 유도체를 제조하기 위한 공정 |
-
2018
- 2018-10-10 KR KR1020207011962A patent/KR20200068678A/ko not_active Withdrawn
- 2018-10-10 MA MA050371A patent/MA50371A/fr unknown
- 2018-10-10 AU AU2018347349A patent/AU2018347349A1/en not_active Withdrawn
- 2018-10-10 MX MX2020003821A patent/MX2020003821A/es unknown
- 2018-10-10 JP JP2020520223A patent/JP2020536898A/ja not_active Withdrawn
- 2018-10-10 WO PCT/US2018/055227 patent/WO2019075073A2/en not_active Ceased
- 2018-10-10 CN CN201880066263.9A patent/CN111526874A/zh not_active Withdrawn
- 2018-10-10 CA CA3077088A patent/CA3077088A1/en not_active Withdrawn
- 2018-10-10 EP EP18866634.1A patent/EP3694510A4/en not_active Withdrawn
- 2018-10-10 SG SG11202002707VA patent/SG11202002707VA/en unknown
- 2018-10-10 US US16/754,044 patent/US11149039B2/en not_active Expired - Fee Related
-
2020
- 2020-03-30 IL IL273695A patent/IL273695A/en unknown
- 2020-07-13 MX MX2022013928A patent/MX2022013928A/es unknown
-
2021
- 2021-10-15 US US17/502,653 patent/US20220033408A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6811717B2 (ja) | トピロキソスタット及びその中間体の調製のための方法 | |
| TWI847144B (zh) | 奧美卡替莫卡必爾的合成 | |
| JP5117493B2 (ja) | ヒンバシン類似体の合成において使用される｛［５−（３−フルオロフェニル）−ピリジン−２−イル］メチル｝ホスホン酸ジエチルの合成 | |
| TWI580675B (zh) | Preparation of 4- [5- (pyridin-4-yl) -1H-1,2,4-triazol-3-yl] pyridine-2-carbonitrile and intermediates | |
| TW201609694A (zh) | 用於製備３－（３－氯－１ｈ－吡唑－１－基）吡啶的方法（一） | |
| JP6592085B2 (ja) | レバプラザン塩酸塩の調製方法 | |
| CN106279104A (zh) | 一种制备琥珀酸曲格列汀的工艺改进方法 | |
| CN101563348A (zh) | 西地那非的制备方法及其中间体 | |
| JP2020536898A5 (enExample) | ||
| EP3292112B1 (en) | Process for the preparation of alogliptin | |
| JP6228210B2 (ja) | フルボキサミン遊離塩基の精製方法およびそれを用いた高純度フルボキサミンマレイン酸塩の製造方法 | |
| CN106316885B (zh) | 一种3-[5-(2-氟苯基)-1,2,4-噁二唑-3-基]苯甲酸的制备方法 | |
| CN100352818C (zh) | 一种改进的制备阿折地平的方法 | |
| WO2012027951A1 (zh) | 一种合成培南类药物的中间体及其制备方法和应用 | |
| RU2646603C2 (ru) | УЛУЧШЕННЫЙ СПОСОБ ПОЛУЧЕНИЯ 2-АМИНО-5,8-ДИАЛКОКСИ[1,2,4]ТРИАЗОЛО[1,5-с]ПИРИМИДИНА ИЗ 4-АМИНО-2,5-ДИАЛКОКСИПИРИМИДИНА | |
| CN103724248B (zh) | 维格列汀工艺杂质的制备方法 | |
| CN111349045A (zh) | 乐伐替尼的合成方法及新的中间体 | |
| TWI884151B (zh) | 製備4-苯基-5-烷氧基羰基-2-噻唑-2-基-1,4-二氫嘧啶-6-基]甲基]-3-側氧-5,6,8,8a-四氫-1H-咪唑并[1,5-a]吡-2-基]-羧酸之替代方法 | |
| US11149039B2 (en) | Process for preparing spiro derivatives | |
| CN105294697B (zh) | 2-氨基-5,8-二甲氧基[1,2,4]三唑并[1,5-c]嘧啶的合成方法 | |
| CN105294689B (zh) | 一种四取代吡唑并异喹啉化合物及其合成方法 | |
| KR100963520B1 (ko) | 이르베사르탄의 개선된 제조방법 | |
| CN102382070A (zh) | N',n'',n''',n''''-四苄基环烯化合物的制备方法 | |
| CN104961706B (zh) | 一种合成胰岛素降解酶抑制剂ml345的方法 | |
| CN104109175B (zh) | 一种四苯基氨化膦衍生物及其合成方法 |