KR20200068678A - 스피로 유도체를 제조하기 위한 공정 - Google Patents

스피로 유도체를 제조하기 위한 공정 Download PDF

Info

Publication number
KR20200068678A
KR20200068678A KR1020207011962A KR20207011962A KR20200068678A KR 20200068678 A KR20200068678 A KR 20200068678A KR 1020207011962 A KR1020207011962 A KR 1020207011962A KR 20207011962 A KR20207011962 A KR 20207011962A KR 20200068678 A KR20200068678 A KR 20200068678A
Authority
KR
South Korea
Prior art keywords
compound
preparing
methyl
solution
stirred
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020207011962A
Other languages
English (en)
Korean (ko)
Inventor
제라드 엠.피. 지블린
데이빗 티. 맥퍼슨
오사마 술레이만
마이클 윌리엄스
데이빗 알. 위티
티에리 보나우드
리처드 에드워즈
Original Assignee
바이오젠 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 바이오젠 인크. filed Critical 바이오젠 인크.
Publication of KR20200068678A publication Critical patent/KR20200068678A/ko
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
    • C07C65/05—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring o-Hydroxy carboxylic acids
    • C07C65/10—Salicylic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Measuring Volume Flow (AREA)
  • Exhaust Gas After Treatment (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020207011962A 2017-10-10 2018-10-10 스피로 유도체를 제조하기 위한 공정 Withdrawn KR20200068678A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762570269P 2017-10-10 2017-10-10
US62/570,269 2017-10-10
PCT/US2018/055227 WO2019075073A2 (en) 2017-10-10 2018-10-10 PROCESS FOR THE PREPARATION OF SPIRO DERIVATIVES

Publications (1)

Publication Number Publication Date
KR20200068678A true KR20200068678A (ko) 2020-06-15

Family

ID=66100090

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020207011962A Withdrawn KR20200068678A (ko) 2017-10-10 2018-10-10 스피로 유도체를 제조하기 위한 공정

Country Status (12)

Country Link
US (2) US11149039B2 (enExample)
EP (1) EP3694510A4 (enExample)
JP (1) JP2020536898A (enExample)
KR (1) KR20200068678A (enExample)
CN (1) CN111526874A (enExample)
AU (1) AU2018347349A1 (enExample)
CA (1) CA3077088A1 (enExample)
IL (1) IL273695A (enExample)
MA (1) MA50371A (enExample)
MX (2) MX2020003821A (enExample)
SG (1) SG11202002707VA (enExample)
WO (1) WO2019075073A2 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA50371A (fr) 2017-10-10 2021-03-31 Biogen Inc Procédé de préparation de dérivés spiro

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US814396A (en) 1905-05-22 1906-03-06 Joseph R Russell Burner for liquid fuel.
KR0178475B1 (ko) * 1995-09-14 1999-03-20 윤덕용 신규한 n-비닐락탐 유도체 및 그의 중합체
DE60330456D1 (de) 2002-07-05 2010-01-21 Targacept Inc N-aryl diazaspirozyklische verbindungen, deren verwendung und das verfahren zu ihren herstellung
US7501528B2 (en) * 2005-03-15 2009-03-10 Hoffmann-La Roche Inc. Method for preparing enantiomerically pure 4-pyrrolidino phenylbenzyl ether derivatives
GB0520578D0 (en) 2005-10-10 2005-11-16 Glaxo Group Ltd Novel compounds
US8143306B2 (en) 2005-10-10 2012-03-27 Convergence Pharmaceuticals Limited Methods of treating bipolar disorders
TW200728258A (en) 2005-10-10 2007-08-01 Glaxo Group Ltd Novel compounds
EP1943216B1 (en) 2005-10-10 2010-06-30 Glaxo Group Limited Prolinamide derivatives as sodium channel modulators
TW200730494A (en) 2005-10-10 2007-08-16 Glaxo Group Ltd Novel compounds
CA2666136A1 (en) 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Tricyclic spiro-oxindole derivatives and their uses as therapeutic agents
AU2007307638A1 (en) 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Spiro (furo [3, 2-C] pyridine-3-3 ' -indol) -2' (1'H)-one derivatives and related compounds for the treatment of sodium-channel mediated diseases, such as pain
GB0701365D0 (en) 2007-01-24 2007-03-07 Glaxo Group Ltd Novel pharmaceutical compositions
CN101641099A (zh) 2007-01-24 2010-02-03 葛兰素集团有限公司 包含3,5-二氨基-6-(2,3-二氯苯基)-1,2,4-三嗪或r(-)-2,4-二氨基-5-(2,3-二氯苯基)-6-氟甲基嘧啶和nk1的药物组合物
GB0701366D0 (en) 2007-01-24 2007-03-07 Glaxo Group Ltd Novel pharmaceutical compositions
GB0706630D0 (en) 2007-04-04 2007-05-16 Glaxo Group Ltd Novel compounds
AR077252A1 (es) 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
TWI466885B (zh) * 2009-07-31 2015-01-01 Japan Tobacco Inc 含氮螺環化合物及其醫藥用途
EP2477964B1 (en) 2009-09-14 2015-02-11 Convergence Pharmaceuticals Limited Process for preparing alpha-carboxamide derivatives
US8618303B2 (en) * 2011-01-07 2013-12-31 Hoffmann-La Roche Inc. Pyrrolidine derivatives
PH12013501895A1 (en) * 2011-04-26 2013-10-14 Hoffmann La Roche Ethynyl derivatives as positive allosteric modulators of the mglur5
GB201122113D0 (en) * 2011-12-22 2012-02-01 Convergence Pharmaceuticals Novel compounds
GB201209015D0 (en) 2012-05-22 2012-07-04 Convergence Pharmaceuticals Novel compounds
GB201209670D0 (en) 2012-05-31 2012-07-18 Convergence Pharmaceuticals Novel compounds
HUE042064T2 (hu) * 2014-08-04 2019-06-28 Merck Patent Gmbh Pirrolidinon-származékok MetAP-2 inhibitorokként
SG11202002200UA (en) 2017-09-28 2020-04-29 Biogen Inc Novel salts
MA50371A (fr) 2017-10-10 2021-03-31 Biogen Inc Procédé de préparation de dérivés spiro

Also Published As

Publication number Publication date
EP3694510A2 (en) 2020-08-19
CN111526874A (zh) 2020-08-11
JP2020536898A (ja) 2020-12-17
US20200325144A1 (en) 2020-10-15
IL273695A (en) 2020-05-31
MA50371A (fr) 2021-03-31
MX2020003821A (es) 2023-01-12
US20220033408A1 (en) 2022-02-03
EP3694510A4 (en) 2021-06-30
MX2022013928A (es) 2022-11-30
US11149039B2 (en) 2021-10-19
WO2019075073A2 (en) 2019-04-18
SG11202002707VA (en) 2020-04-29
AU2018347349A1 (en) 2020-04-23
WO2019075073A3 (en) 2020-04-02
CA3077088A1 (en) 2019-04-18

Similar Documents

Publication Publication Date Title
JP5279789B2 (ja) キラルプロピオン酸誘導体の製造方法
JP2019506379A (ja) ルキソリチニブの合成プロセス
CN111448192B (zh) 用于制备驱蠕虫的4-氨基-喹啉-3-甲酰胺衍生物的方法
KR20200018664A (ko) 오메캄티브 메카빌의 합성
CN109890790B (zh) 一种奥司他韦及其异构体的制备方法
CN102295660A (zh) 泰诺福韦的合成工艺
CN103524487A (zh) 一种西他沙星的制备方法
HK1226396A1 (en) Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate
TW202237584A (zh) 合成經取代的吡啶酮-吡啶基化合物之方法
CN113717176B (zh) 一种制备瑞马唑仑的方法
KR20170032328A (ko) 피라졸 유도체의 제조 방법
CN114096529A (zh) 化学方法
KR20180030582A (ko) Cgrp 수용체 길항제
CN111574444A (zh) 一种贝达喹啉的制备方法
CN112062712A (zh) 一种2-（5-溴-3-甲基吡啶-2-基）乙酸盐酸盐的制备方法
JP7227925B2 (ja) １－［５－（２－フルオロフェニル）－１－（ピリジン－３－イルスルホニル）－１ｈ－ピロ－ル－３－イル］－ｎ－メチルメタンアミンモノフマル酸塩の製造法
KR20200068678A (ko) 스피로 유도체를 제조하기 위한 공정
CN107698574A (zh) 一种高纯度阿瑞匹坦的精制制备工艺
TW200815388A (en) Chromane and chromene derivatives and uses thereof
CN104193643A (zh) 用于合成抗艾滋病药物增强剂cobicistat的新中间体
HK40035061A (en) Process for preparing spiro derivatives
CN112159402A (zh) 一种利伐沙班的制备方法
WO2020213714A1 (ja) シス－（－）－フロシノピペリドールの製造方法
CN108821992A (zh) 一种左乙拉西坦杂质以及合成方法
CN106588841B (zh) 合成2,3-二氢-1-苯并呋喃-4-甲醛的方法

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

PC1202 Submission of document of withdrawal before decision of registration

St.27 status event code: N-1-6-B10-B11-nap-PC1202